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468 records – page 1 of 47.

A 3-month evaluation of the efficacy of nedocromil sodium in asthma: a randomized, double-blind, placebo-controlled trial of nedocromil sodium conducted by a Canadian multicenter study group.

https://arctichealth.org/en/permalink/ahliterature229565
Source
J Allergy Clin Immunol. 1990 Mar;85(3):612-7
Publication Type
Article
Date
Mar-1990
Author
A S Rebuck
S. Kesten
L P Boulet
A. Cartier
D. Cockcroft
J. Gruber
F. Laberge
E. Lee-Chuy
M. Keshmiri
G F MacDonald
Author Affiliation
Edmonton General Hospital, Canada.
Source
J Allergy Clin Immunol. 1990 Mar;85(3):612-7
Date
Mar-1990
Language
English
Publication Type
Article
Keywords
Adult
Anti-Inflammatory Agents, Non-Steroidal - adverse effects - therapeutic use
Asthma - drug therapy - physiopathology
Canada
Chronic Disease
Double-Blind Method
Drug Therapy, Combination
Drug Tolerance
Female
Humans
Male
Middle Aged
Multicenter Studies as Topic
Nedocromil
Peak Expiratory Flow Rate - drug effects - physiology
Quinolones - adverse effects - therapeutic use
Randomized Controlled Trials as Topic
Time Factors
Abstract
Nedocromil sodium is a pyranoquinoline dicarboxylic acid derivative, formulated in a metered-dose inhaler. Because nedocromil sodium has in vitro and in vivo anti-inflammatory properties, it was evaluated in a group of steroid-dependent patients with asthma to observe how well it might be tolerated and for evidence of any beneficial effects. In a double-blind, group-comparative study, 127 patients received nedocromil sodium and 61 received placebo, administered as two puffs of 2 mg, four times per day, for 12 weeks. Ten patients developed adverse reactions, seven receiving active drug and three patients receiving placebo. Two patients of each group withdrew because of worsening asthma. Despite selecting patients whose asthma was stable, when they were receiving established therapeutic regimens that included steroids and bronchodilators, it was found that diary-card symptom scores, morning and evening peak expiratory flow rate values, and inhaled beta-agonist usage all demonstrated slight but significant benefit with addition of nedocromil sodium. It is concluded that the inhaled, anti-inflammatory agent, nedocromil sodium, may be added to asthma-treatment regimens with the reasonable expectation of further modest symptomatic benefit.
PubMed ID
2155958 View in PubMed
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7 years experience of photopatch testing with sunscreen allergens in Sweden.

https://arctichealth.org/en/permalink/ahliterature33993
Source
Contact Dermatitis. 1998 Feb;38(2):61-4
Publication Type
Article
Date
Feb-1998
Author
B. Berne
A M Ros
Author Affiliation
Department of Dermatology, University Hospital, Uppsala, Sweden.
Source
Contact Dermatitis. 1998 Feb;38(2):61-4
Date
Feb-1998
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Allergens - administration & dosage - adverse effects
Child
Dermatitis, Allergic Contact - diagnosis - etiology
Dermatitis, Photoallergic - diagnosis - etiology
Female
Humans
Male
Middle Aged
Multicenter Studies
Patch Tests
Severity of Illness Index
Skin - drug effects - pathology - radiation effects
Sunscreening Agents - administration & dosage - adverse effects
Sweden
Ultraviolet Rays - adverse effects
Urticaria - chemically induced
Abstract
Since 1990 7 sunscreen allergens have been included in the standard photopatch protocol at 2 Swedish dermatology clinics. 355 consecutive patients with suspected photosensitivity were tested, and in 28 of these (7.9%), a total of 42 allergic reactions were found. 80% of the reactions were of photocontact origin. The most common allergen was benzophenone-3 (Eusolex 4360), with 15 photocontact and 1 contact allergic reactions, followed by isopropyl dibenzoylmethane (Eusolex 8020) (8 photocontact, 4 contact) and butyl methoxydibenzoylmethane (Parsol 1789), with 6 photocontact reactions. There were 2 cases of photocontact allergy to phenylbenzimidazole sulfonic acid (Eusolex 232), which has not been reported previously. 1 case of contact urticaria from benzophenone-3 was accidentally found. In addition, 21 + reactions of doubtful relevance were noted in 14 patients: 16 on irradiated and 5 on non-irradiated test sites. Among these, irritant and phototoxic reactions may be included. These results indicate that the inclusion of UV filters in the standard photopatch protocol is important. Immediate-type testing for urticaria could also be of value.
PubMed ID
9506215 View in PubMed
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A 2011 updated systematic review and clinical practice guideline for the management of malignant extradural spinal cord compression.

https://arctichealth.org/en/permalink/ahliterature126132
Source
Int J Radiat Oncol Biol Phys. 2012 Oct 1;84(2):312-7
Publication Type
Article
Date
Oct-1-2012
Author
D Andrew Loblaw
Gunita Mitera
Michael Ford
Normand J Laperriere
Author Affiliation
Department of Radiation Oncology, Sunnybrook Health Science Centre, University of Toronto, Toronto, Canada. andrew.loblaw@sunnybrook.ca
Source
Int J Radiat Oncol Biol Phys. 2012 Oct 1;84(2):312-7
Date
Oct-1-2012
Language
English
Publication Type
Article
Keywords
Adult
Decompression, Surgical - methods
Dose Fractionation
Humans
Meta-Analysis as Topic
Multicenter Studies as Topic
Neoplasm Recurrence, Local - radiotherapy
Ontario
Randomized Controlled Trials as Topic
Retrospective Studies
Spinal Cord Compression - diagnosis - therapy
Spinal Cord Neoplasms - secondary - therapy
Steroids - therapeutic use
Walking
Abstract
To update the 2005 Cancer Care Ontario practice guidelines for the diagnosis and treatment of adult patients with a suspected or confirmed diagnosis of extradural malignant spinal cord compression (MESCC).
A review and analysis of data published from January 2004 to May 2011. The systematic literature review included published randomized control trials (RCTs), systematic reviews, meta-analyses, and prospective/retrospective studies.
An RCT of radiation therapy (RT) with or without decompressive surgery showed improvements in pain, ambulatory ability, urinary continence, duration of continence, functional status, and overall survival. Two RCTs of RT (30 Gy in eight fractions vs. 16 Gy in two fractions; 16 Gy in two fractions vs. 8 Gy in one fraction) in patients with a poor prognosis showed no difference in ambulation, duration of ambulation, bladder function, pain response, in-field failure, and overall survival. Retrospective multicenter studies reported that protracted RT schedules in nonsurgical patients with a good prognosis improved local control but had no effect on functional or survival outcomes.
If not medically contraindicated, steroids are recommended for any patient with neurologic deficits suspected or confirmed to have MESCC. Surgery should be considered for patients with a good prognosis who are medically and surgically operable. RT should be given to nonsurgical patients. For those with a poor prognosis, a single fraction of 8 Gy should be given; for those with a good prognosis, 30 Gy in 10 fractions could be considered. Patients should be followed up clinically and/or radiographically to determine whether a local relapse develops. Salvage therapies should be introduced before significant neurologic deficits occur.
PubMed ID
22420969 View in PubMed
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Acceptability and profile of the clinical drug trials underway in Finnish university hospitals in the 1990s: applications reviewed by ethics committees.

https://arctichealth.org/en/permalink/ahliterature192044
Source
Methods Find Exp Clin Pharmacol. 2001 Sep;23(7):415-23
Publication Type
Article
Date
Sep-2001
Author
T. Keinonen
S. Nieminen
V. Saareks
V. Saano
P. Ylitalo
Author Affiliation
Department of Pharmacology and Toxicology, University of Kuopio, Finland. tuija.keinonen@medfiles.fi
Source
Methods Find Exp Clin Pharmacol. 2001 Sep;23(7):415-23
Date
Sep-2001
Language
English
Publication Type
Article
Keywords
Clinical Protocols - standards
Clinical Trials Data Monitoring Committees - statistics & numerical data
Clinical Trials as Topic - standards - statistics & numerical data
Ethics Committees, Research - statistics & numerical data
Finland
Hospitals, University - statistics & numerical data
Humans
Informed Consent - statistics & numerical data
Multicenter Studies as Topic - statistics & numerical data
Patient Selection
Practice Guidelines as Topic
Research Design - standards - statistics & numerical data
Retrospective Studies
Abstract
There is scarce information in literature about the decisions made by ethics committees concerning the clinical studies they have reviewed. A retrospective, detailed review of 666 applications, their amendments and the ethics committees' statements was undertaken. All protrocols of clinical studies on medicinal products submitted to and reviewed by the ethics committees of two university hospitals during the years 1992, 1994, 1996 and 1998 were investigated. Most of the studies were international (50%), multicenter (71%), phase III trials (41%) on a new clinical entity, (38%). Validity of the clinical drug study applications was acceptable in more than half of the cases (364; 55%), while 91 (14%) were approved with advisory comments, 153 (23%) had to be amended, 35 (5%) were left pending and 23 (3%) were rejected. Most of the questions pertained to informed consent and the study protcol. In accordance with precious results, our findings support the opinion that the submitted documents need to be improved, especially with regard to informed consent and study protocols, in order to gain better Good Clinical Practice (GCP) compliance. Well-defined, documented operating procedures of the ethics committees would have facilitated the practical issues in the review process.
PubMed ID
11771857 View in PubMed
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Acceptance and Commitment Therapy preceded by an experimental Attention Bias Modification procedure in recurrent depression: study protocol for a randomized controlled trial.

https://arctichealth.org/en/permalink/ahliterature299363
Source
Trials. 2018 Mar 27; 19(1):203
Publication Type
Clinical Trial Protocol
Journal Article
Date
Mar-27-2018
Author
Tom Østergaard
Tobias Lundgren
Robert Zettle
Rune Jonassen
Catherine J Harmer
Tore C Stiles
Nils Inge Landrø
Vegard Øksendal Haaland
Author Affiliation
Department of Psychiatry, Sørlandet Hospital, Arendal, Norway. tom.ostergaard@sshf.no.
Source
Trials. 2018 Mar 27; 19(1):203
Date
Mar-27-2018
Language
English
Publication Type
Clinical Trial Protocol
Journal Article
Keywords
Acceptance and Commitment Therapy
Adolescent
Adult
Aged
Attentional Bias
Depression - diagnosis - psychology - therapy
Female
Humans
Male
Middle Aged
Multicenter Studies as Topic
Norway
Psychotherapy, Group
Randomized Controlled Trials as Topic
Recurrence
Remission Induction
Time Factors
Treatment Outcome
Young Adult
Abstract
This project studies the effect of group-based Acceptance and Commitment Therapy (ACT) following Attention Bias Modification (ABM) on residual symptoms in recurrent depression. ACT is a cognitive-behavioral intervention combining acceptance and mindfulness processes with commitment and behavior-change processes. ACT enjoys modest empirical support in treating depression and has also shown promising results in secondary prevention of depression. The experimental cognitive bias modification (ABM) procedure has been shown to reduce surrogate markers of depression vulnerability in patients in remission from depression. The aim of the current project is to investigate if the effect of group-based ACT on reducing residual depressive symptoms can be enhanced by preceding it with ABM. Also, assessment of the relationship between conceptually relevant therapeutic processes and outcome will be investigated.
An invitation to participate in this project was extended to 120 individuals within a larger sample who had just completed a separate randomized, multisite, clinical trial (referred to hereafter as Phase 1) in which they received either ABM (n = 60) or a control condition without bias modification (n = 60). This larger Phase-1 sample consisted of 220 persons with a history of at least two episodes of major depression who were currently in remission or not fulfilling the criteria of major depression. After its inclusion, Phase-1 participants from the Sørlandet site (n = 120) were also recruited for this study in which they received an 8-week group-based ACT intervention. Measures will be taken immediately after Phase 1, 1 month, 2 months, 6 months, and 1 year after the conclusion of Phase 1.
This study sequentially combines acceptable, nondrug interventions from neuropsychology and cognitive-behavioral psychology in treating residual symptoms in depression. The results will provide information about the effectiveness of treatment and on mechanisms and processes of change that may be valuable in understanding and further developing ABM and ACT, combined and alone.
ClinicalTrials.gov, Identifier: NCT02648165 . Registered on 6 January 2016.
PubMed ID
29587807 View in PubMed
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Acute sarcoid arthritis: a favourable outcome? A retrospective survey of 49 patients with review of the literature.

https://arctichealth.org/en/permalink/ahliterature14315
Source
Scand J Rheumatol. 1996;25(2):70-3
Publication Type
Article
Date
1996
Author
J T Gran
E. Bøhmer
Author Affiliation
Department of Rheumatology, Central Hospital of Aust Agder, Arendal, Norway.
Source
Scand J Rheumatol. 1996;25(2):70-3
Date
1996
Language
English
Publication Type
Article
Keywords
Acute Disease
Adrenal Cortex Hormones - therapeutic use
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arthritis - complications - drug therapy - etiology
Female
Humans
Male
Middle Aged
Multicenter Studies
Retrospective Studies
Sarcoidosis - complications
Time Factors
Treatment Outcome
Abstract
Forty-nine patients, 30 males and 19 females with acute sarcoid arthritis admitted to three different hospitals in Norway were studied retrospectively. All patients had peripheral arthritis and hilar adenopathy, and 87.8% also presented with erythema nodosum (EN). Mean duration of arthritis was 3.7 months (0.5-12 months), but in 26% of the cases, duration of the inflammatory joint disease exceeded three months. Radiological bony erosions were not seen. Two patients had recurrence of acute sarcoid arthritis, 14 months and 10 years after the initial episode, respectively. Two other patients developed chronic myalgia and fibromyalgia. Four patients, one female and three males, developed chronic pulmonal sarcoidosis. Of these, two patients had simultaneous onset of acute sarcoid arthritis and parenchymal disease while two patients developed chronic lung disease three months after onset of acute sarcoid arthritis. We thus tentatively suggest that although acute sarcoid arthritis is usually a self-limiting joint disease, recurrences may occasionally occur and some cases develop chronic sarcoidosis of the lungs.
PubMed ID
8614769 View in PubMed
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The ADDITION study: proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening.

https://arctichealth.org/en/permalink/ahliterature47804
Source
Int J Obes Relat Metab Disord. 2000 Sep;24 Suppl 3:S6-11
Publication Type
Article
Date
Sep-2000
Author
T. Lauritzen
S. Griffin
K. Borch-Johnsen
N J Wareham
B H Wolffenbuttel
G. Rutten
Author Affiliation
Department of General Practice, University of Aarhus, Denmark.
Source
Int J Obes Relat Metab Disord. 2000 Sep;24 Suppl 3:S6-11
Date
Sep-2000
Language
English
Publication Type
Article
Keywords
Adult
Aged
Blood Glucose - analysis
Cost-Benefit Analysis
Denmark - epidemiology
Diabetes Mellitus, Type 2 - diagnosis - economics - epidemiology - therapy
England - epidemiology
Female
Humans
Hyperglycemia - complications - economics - therapy
Intervention Studies
Male
Mass Screening - economics
Middle Aged
Multicenter Studies
Netherlands - epidemiology
Practice Guidelines
Prevalence
Primary Health Care - economics
Randomized Controlled Trials - methods
Risk factors
Vascular Diseases - etiology - mortality - therapy
Abstract
OBJECTIVE: The overall aims of the ADDITION study are to evaluate whether screening for prevalent undiagnosed Type 2 diabetes is feasible, and whether subsequent optimised intensive treatment of diabetes, and associated risk factors, is feasible and beneficial. DESIGN: Population-based screening in three European countries followed by an open, randomised controlled trial. SUBJECTS AND METHODS: People aged 40-69 y in the community, without known diabetes, will be offered a random capillary blood glucose screening test by their primary care physicians, followed, if equal to or greater than 5.5 mmol/l, by fasting and 2-h post-glucose-challenge blood glucose measurements. Three thousand newly diagnosed patients will subsequently receive conventional treatment (according to current national guidelines) or intensive multifactorial treatment (lifestyle advice, prescription of aspirin and ACE-inhibitors, in addition to protocol-driven tight control of blood glucose, blood pressure and cholesterol). Patients allocated to intensive treatment will be further randomised to centre-specific interventions to motivate adherence to lifestyle changes and medication. Duration of follow-up is planned for 5 y. Endpoints will include mortality, macrovascular and microvascular complications, patient health status and satisfaction, process-of-care indicators and costs.
PubMed ID
11063279 View in PubMed
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Adherence and perception of medication in patients with chronic heart failure during a five-year randomised trial.

https://arctichealth.org/en/permalink/ahliterature83288
Source
Patient Educ Couns. 2006 Jun;61(3):348-53
Publication Type
Article
Date
Jun-2006
Author
Ekman Inger
Andersson Gull
Boman Kurt
Charlesworth Andrew
Cleland John G F
Poole-Wilson Philip
Swedberg Karl
Author Affiliation
The Sahlgrenska Academy, Faculty of Health and Caring Sciences, Institute of Nursing, Göteborg University, Box 457, SE 405 30, Göteborg, Sweden. inger.ekman@fhs.gu.se
Source
Patient Educ Couns. 2006 Jun;61(3):348-53
Date
Jun-2006
Language
English
Publication Type
Article
Keywords
Activities of Daily Living
Adrenergic beta-Antagonists - therapeutic use
Aged
Aged, 80 and over
Analysis of Variance
Carbazoles - therapeutic use
Chi-Square Distribution
Chronic Disease
Female
Follow-Up Studies
Health Knowledge, Attitudes, Practice
Health status
Heart Failure, Congestive - drug therapy - psychology
Humans
Male
Metoprolol - therapeutic use
Multicenter Studies
Patient Compliance - psychology - statistics & numerical data
Patient Education
Propanolamines - therapeutic use
Questionnaires
Randomized Controlled Trials
Severity of Illness Index
Stroke Volume
Sweden
Time Factors
Abstract
OBJECTIVE: Many patients with chronic heart failure (CHF) are thought to be non-adherent to their prescribed medications. The objective was to describe perceptions about and adherence to regular medicines and study medication at baseline and study end in CHF patients participating in a clinical trial. METHODS: In the carvedilol or metoprolol European trial (COMET), patients (N = 3029) with CHF were randomised and followed during a 58-month period. Patients at some Swedish centres answered a questionnaire at baseline and study end concerning their perception of their regular heart medication and study medication. Adherence was established through estimation of drug usage. RESULTS: In the Swedish sub-study, 302 patients responded once to the questionnaire while 107 patients responded both at baseline and at follow-up. At baseline, 94% of the patients stated that they believed that the study medication would make them feel better and 82% believed that their regular heart medication would do so. During the study, patients' belief in their regular cardiac medication significantly increased. Lack of belief in medication at the start of the study was a strong predictor of withdrawal from the trial (64% versus 6.8%; p
PubMed ID
16139468 View in PubMed
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Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis.

https://arctichealth.org/en/permalink/ahliterature90870
Source
Lancet. 2009 Jan 10;373(9658):137-46
Publication Type
Article
Date
Jan-10-2009
Author
Blake P.
Swart Ann Marie
Orton J.
Kitchener H.
Whelan T.
Lukka H.
Eisenhauer E.
Bacon M.
Tu D.
Parmar M K B
Amos C.
Murray C.
Qian W.
Source
Lancet. 2009 Jan 10;373(9658):137-46
Date
Jan-10-2009
Language
English
Publication Type
Article
Keywords
Brachytherapy - adverse effects - methods
Endometrial Neoplasms - mortality - pathology - radiotherapy
Female
Humans
Kaplan-Meiers Estimate
Multicenter Studies as Topic
Neoplasm Recurrence, Local
Postoperative Period
Radiotherapy, Adjuvant - adverse effects
Randomized Controlled Trials as Topic
Abstract
BACKGROUND: Early endometrial cancer with low-risk pathological features can be successfully treated by surgery alone. External beam radiotherapy added to surgery has been investigated in several small trials, which have mainly included women at intermediate risk of recurrence. In these trials, postoperative radiotherapy has been shown to reduce the risk of isolated local recurrence but there is no evidence that it improves recurrence-free or overall survival. We report the findings from the ASTEC and EN.5 trials, which investigated adjuvant external beam radiotherapy in women with early-stage disease and pathological features suggestive of intermediate or high risk of recurrence and death from endometrial cancer. METHODS: Between July, 1996, and March, 2005, 905 (789 ASTEC, 116 EN.5) women with intermediate-risk or high-risk early-stage disease from 112 centres in seven countries (UK, Canada, Poland, Norway, New Zealand, Australia, USA) were randomly assigned after surgery to observation (453) or to external beam radiotherapy (452). A target dose of 40-46 Gy in 20-25 daily fractions to the pelvis, treating five times a week, was specified. Primary outcome measure was overall survival, and all analyses were by intention to treat. These trials were registered ISRCTN 16571884 (ASTEC) and NCT 00002807 (EN.5). FINDINGS: After a median follow-up of 58 months, 135 women (68 observation, 67 external beam radiotherapy) had died. There was no evidence that overall survival with external beam radiotherapy was better than observation, hazard ratio 1.05 (95% CI 0.75-1.48; p=0.77). 5-year overall survival was 84% in both groups. Combining data from ASTEC and EN.5 in a meta-analysis of trials confirmed that there was no benefit in terms of overall survival (hazard ratio 1.04; 95% CI 0.84-1.29) and can reliably exclude an absolute benefit of external beam radiotherapy at 5 years of more than 3%. With brachytherapy used in 53% of women in ASTEC/EN.5, the local recurrence rate in the observation group at 5 years was 6.1%. INTERPRETATION: Adjuvant external beam radiotherapy cannot be recommended as part of routine treatment for women with intermediate-risk or high-risk early-stage endometrial cancer with the aim of improving survival. The absolute benefit of external beam radiotherapy in preventing isolated local recurrence is small and is not without toxicity.
Notes
Comment In: Lancet. 2009 Jan 10;373(9658):97-919070890
PubMed ID
19070891 View in PubMed
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Admission hyperglycemia predicts a worse outcome in stroke patients treated with intravenous thrombolysis.

https://arctichealth.org/en/permalink/ahliterature153259
Source
Diabetes Care. 2009 Apr;32(4):617-22
Publication Type
Article
Date
Apr-2009
Author
Alexandre Y Poppe
Sumit R Majumdar
Thomas Jeerakathil
William Ghali
Alastair M Buchan
Michael D Hill
Author Affiliation
University of Calgary, Calgary, Alberta, Canada. alexander.poppe@albertahealthservices.ca
Source
Diabetes Care. 2009 Apr;32(4):617-22
Date
Apr-2009
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Anticoagulants - administration & dosage - therapeutic use
Canada
Cerebral Hemorrhage - complications - drug therapy - mortality
Cohort Studies
Diabetes Complications - drug therapy - mortality
Female
Humans
Hyperglycemia - complications
Infusions, Intravenous
Male
Middle Aged
Multicenter Studies as Topic
Multivariate Analysis
Prospective Studies
Regression Analysis
Risk factors
Stroke - complications - drug therapy - mortality
Tissue Plasminogen Activator - administration & dosage - therapeutic use
Treatment Outcome
Abstract
Admission hyperglycemia has been associated with worse outcomes in ischemic stroke. We hypothesized that hyperglycemia (glucose >8.0 mmol/l) in the hyperacute phase would be independently associated with increased mortality, symptomatic intracerebral hemorrhage (SICH), and poor functional status at 90 days in stroke patients treated with intravenous tissue plasminogen activator (IV-tPA).
Using data from the prospective, multicenter Canadian Alteplase for Stroke Effectiveness Study (CASES), the association between admission glucose >8.0 mmol/l and mortality, SICH, and poor functional status at 90 days (modified Rankin Scale >1) was examined. Similar analyses examining glucose as a continuous measure were conducted.
Of 1,098 patients, 296 (27%) had admission hyperglycemia, including 18% of those without diabetes and 70% of those with diabetes. After multivariable logistic regression, admission hyperglycemia was found to be independently associated with increased risk of death (adjusted risk ratio 1.5 [95% CI 1.2-1.9]), SICH (1.69 [0.95-3.00]), and a decreased probability of a favorable outcome at 90 days (0.7 [0.5-0.9]). An incremental risk of death and SICH and unfavorable 90-day outcomes was observed with increasing admission glucose. This observation held true for patients with and without diabetes.
In this cohort of IV-tPA-treated stroke patients, admission hyperglycemia was independently associated with increased risk of death, SICH, and poor functional status at 90 days. Treatment trials continue to be urgently needed to determine whether this is a modifiable risk factor for poor outcome.
Notes
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PubMed ID
19131465 View in PubMed
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468 records – page 1 of 47.