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[Diseases of the upper respiratory tract in workers in "dusty" jobs].

https://arctichealth.org/en/permalink/ahliterature225140
Source
Gig Tr Prof Zabol. 1992;(7):9-12
Publication Type
Article
Date
1992
Author
V B Pankova
Source
Gig Tr Prof Zabol. 1992;(7):9-12
Date
1992
Language
Russian
Publication Type
Article
Keywords
Chronic Disease
Dust - adverse effects
Humans
Mucociliary Clearance
Otorhinolaryngologic Diseases - epidemiology - etiology
Pneumoconiosis - epidemiology - etiology
Prevalence
Prospective Studies
Retrospective Studies
Russia - epidemiology
Abstract
Diseases of the upper respiratory tract are wide spread in the workers exposed to dust and closely correlate with the length of service. Pathologic process grows severe and disseminates the upper respiratory tract according to prolongation of the exposure to dust. The main pathologic mechanisms of process in the upper respiratory tract mucosa are: disorder of mucociliary clearance, disturbance of the regional immunity and the acid-base balance of tissues. Criteria of occupational connection of the nose, throat and larynx dystrophic diseases in workers exposed to dust are given.
PubMed ID
1296921 View in PubMed
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Follow-up study of pulmonary function and respiratory tract symptoms in workers in a Swedish iron ore mine.

https://arctichealth.org/en/permalink/ahliterature67970
Source
J Occup Med. 1988 Dec;30(12):953-8
Publication Type
Article
Date
Dec-1988
Author
H S Jörgensen
B. Kolmodin-Hedman
N. Stjernberg
Author Affiliation
LKAB, Medical Department, Kiruna, Sweden.
Source
J Occup Med. 1988 Dec;30(12):953-8
Date
Dec-1988
Language
English
Publication Type
Article
Keywords
Adult
Aged
Bronchitis - diagnosis - epidemiology - etiology
Cough - diagnosis - etiology
Follow-Up Studies
Humans
Iron
Male
Middle Aged
Mining
Mucociliary Clearance
Occupational Diseases - diagnosis - etiology
Respiratory Function Tests
Smoking - adverse effects
Sweden
Abstract
In 1967, 240 workers in the Kiruna, Sweden, mine were examined with regard to lung function and respiratory symptoms. Seventeen years later, 167 of these workers were reexamined using a structured interview which covered respiratory symptoms, smoking habits, and workplace, and lung function tests, including dynamic spirometry and closing volume. The prevalence of chronic bronchitis in the present study was 9.6%. There was a strong relationship between chronic bronchitis and smoking but no relationship between chronic bronchitis and working underground in the mine. Only three persons had chronic obstructive lung disease. In the still active mine workers, dynamic spirometry results showed no difference between smokers or nonsmokers or between underground and surface workers. Thus, we found no excess of chronic obstructive lung disease or lung function disturbances in the mine workers studied. This probably reflects a self-selection process whereby the workers with airway obstruction due to smoking or underground exposure have left underground work and also the company. Underground workers with chronic mucous hypersecretion, on the other hand, have not felt motivated, because of this, to leave underground work. Some, however, may have stopped smoking but not necessarily because of the hypersecretion.
PubMed ID
3230447 View in PubMed
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Improved nasal clearance among pulp-mill workers after the reduction of lime dust.

https://arctichealth.org/en/permalink/ahliterature75078
Source
Scand J Work Environ Health. 1996 Apr;22(2):102-7
Publication Type
Article
Date
Apr-1996
Author
K. Torén
J. Brisman
S. Hagberg
G. Karlsson
Author Affiliation
Occupational Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
Source
Scand J Work Environ Health. 1996 Apr;22(2):102-7
Date
Apr-1996
Language
English
Publication Type
Article
Keywords
Air Pollutants, Occupational - adverse effects - analysis
Calcium Compounds - adverse effects - analysis
Dust - adverse effects - analysis - prevention & control
Follow-Up Studies
Heat
Humans
Intervention Studies
Male
Matched-Pair Analysis
Metals - analysis
Middle Aged
Mucociliary Clearance - drug effects
Nasal Lavage Fluid - chemistry - cytology
Nasal Obstruction - chemically induced - prevention & control
Occupational Diseases - chemically induced - prevention & control
Oxides - adverse effects - analysis
Peak Expiratory Flow Rate - drug effects
Pulmonary Ventilation - drug effects
Research Support, Non-U.S. Gov't
Rhinitis - chemically induced - prevention & control
Safety Management
Sweden
Workplace - organization & administration
Abstract
OBJECTIVES: The purpose of this study was to investigate nasal symptoms and function among workers exposed to lime dust and to determine if a reconstruction of the workplace improved the worker's nasal health. METHODS: In 1992, pulp-mill workers (N = 15) exposed to lime dust and an equal number of matched unexposed referents were examined by questionnaires, nasal peak expiratory flow, the saccharin test, nasal lavage, and a clinical examination of the upper airways. The study was repeated one year later, after the pulp mill had been rebuilt. Dust levels were measured on both occasions with stationary and personal samplings. RESULTS: In 1992 the total dust level was 1.2 mg.m-3. The saccharin test showed a significantly increased nasal transit time for the exposed workers in comparison with that of the unexposed referents (difference 3.5 min, 95% confidence interval 0.1-6.9 min). One year later the dust levels had decreased to 0.1 mg. m-3, and the difference in nasal transit time had decreased (difference- 0.8 min, 95% confidence interval -4.8-3.3 min). CONCLUSIONS: Workers exposed to lime dust have an impaired mucociliary function. This impairment is probably due to the alkalinity of the lime. When dust levels are reduced, mucociliary function improves; therefore renovating a workplace to reduce dust levels has a positive effect.
PubMed ID
8738887 View in PubMed
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Late-phase allergy and eustachian tube dysfunction.

https://arctichealth.org/en/permalink/ahliterature63059
Source
Otolaryngol Head Neck Surg. 2001 Oct;125(4):339-45
Publication Type
Article
Date
Oct-2001
Author
S M Hardy
S B Heavner
D R White
C T McQueen
J. Prazma
H C Pillsbury
Author Affiliation
Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, 27599-7070, USA. hardys@med.unc.edu
Source
Otolaryngol Head Neck Surg. 2001 Oct;125(4):339-45
Date
Oct-2001
Language
English
Publication Type
Article
Keywords
Animals
Eustachian Tube - physiopathology
Male
Mucociliary Clearance
Otitis Media with Effusion - physiopathology
Pressure
Rats
Rats, Inbred BN
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Time Factors
Abstract
OBJECTIVE: This study investigated the role of late-phase allergy in the development of otitis media with effusion. METHODS: Brown Norway rats were sensitized to ovalbumin and later challenged transtympanically. Eustachian tube ventilatory function was assessed 2, 4, 8, 24, 28, and 32 hours postchallenge by measuring passive opening and closing pressures, active clearance of positive and negative middle ear pressure, and mucociliary clearance. RESULTS: The results demonstrate that exposure to transtympanic allergen induces eustachian tube dysfunction and subsequent formation of effusion. Allergic animals showed significant increases in passive and active opening pressures, as well as a decreased ability to actively clear middle ear pressure. Finally, the mucociliary was significantly impaired in all sensitized rats exposed to transtympanic allergen. CONCLUSION: These findings demonstrate that late-phase allergy leads to significant eustachian tube dysfunction and subsequent formation of effusion by impairing the ventilatory and clearance functions of the eustachian tube.
PubMed ID
11593168 View in PubMed
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Physical and transport properties of sputum from children with idiopathic bronchiectasis.

https://arctichealth.org/en/permalink/ahliterature155460
Source
Chest. 2008 Dec;134(6):1129-34
Publication Type
Article
Date
Dec-2008
Author
Gregory J Redding
Chikako Kishioka
Patricia Martinez
Bruce K Rubin
Author Affiliation
Children's Hospital & Regional Medical Center, Seattle, WA 98105, USA. gredding@u.washington.edu
Source
Chest. 2008 Dec;134(6):1129-34
Date
Dec-2008
Language
English
Publication Type
Article
Keywords
Adhesiveness
Adolescent
Adult
Bronchiectasis - metabolism - physiopathology
Bronchitis, Chronic - metabolism - physiopathology
Case-Control Studies
Child
Cough - etiology - metabolism - physiopathology
Cystic Fibrosis - metabolism - physiopathology
Elasticity - physiology
Humans
Mucociliary Clearance - physiology
Sputum - chemistry - physiology
Viscosity
Young Adult
Abstract
Childhood idiopathic bronchiectasis (IB) unrelated to cystic fibrosis (CF) or known immunodeficiency remains a common problem among indigenous populations in developed and developing countries. The physical and transport properties of sputum among children with IB have not been described, and these properties may suggest therapies that would be particularly effective for this group of children.
Sputum from children in stable condition with IB and chronic daily productive cough was collected to measure viscosity, elasticity, cohesivity, adhesivity, and mucociliary and cough transportability in vitro. The results were compared to banked data from the sputa of children with CF and adults with chronic bronchitis (CB) measured by the same methods.
Sputa from children with CF and adults with CB had similar values for viscosity, elasticity, frictional adhesion, cough transportability, and mucociliary transportability. The elasticity of sputum from children with IB was 12 to 20%, respectively, of the value of CB and CF sputum (p 0.05).
The physical and transport properties of sputum from children with IB who are stable in the outpatient setting are substantially different and lead to improved cough transportability compared to sputum from children with CF or adults with CB. Therapies that focus on cough may be sufficient to improve airway mucus clearance in children with IB. Sputum properties may explain in part the different clinical course of children with IB compared to children with CF.
PubMed ID
18753467 View in PubMed
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The role of soluble interleukin-4 receptor and interleukin-5 antibody in preventing late-phase allergy-induced eustachian tube dysfunction.

https://arctichealth.org/en/permalink/ahliterature63058
Source
Otolaryngol Head Neck Surg. 2002 Sep;127(3):169-76
Publication Type
Article
Date
Sep-2002
Author
Hoke W Pollock
Charles S Ebert
Marc G Dubin
David R White
Jiri Prazma
Harold C Pillsbury
Author Affiliation
Department of Surgery, Division of Otolaryngology/HNS, University of North Carolina Hospitals, Chapel Hill 27599-7070, USA. hpollock@med.unc.edu
Source
Otolaryngol Head Neck Surg. 2002 Sep;127(3):169-76
Date
Sep-2002
Language
English
Publication Type
Article
Keywords
Animals
Deglutition
Disease Models, Animal
Drug Evaluation, Preclinical
Eustachian Tube
Hypersensitivity, Delayed - chemically induced - complications - immunology
Instillation, Drug
Interleukin-5 - antagonists & inhibitors - immunology
Male
Middle Ear Ventilation
Mucociliary Clearance - drug effects
Otitis Media with Effusion - etiology - pathology - physiopathology - prevention & control
Ovalbumin
Random Allocation
Rats
Receptors, Interleukin-4 - immunology - therapeutic use
Research Support, Non-U.S. Gov't
Time Factors
Abstract
OBJECTIVES: We investigated the role of soluble interleukin (IL)-4 receptors (sIL-4R) and IL-5 antibodies (IL-5Ab) in preventing allergic eustachian tube dysfunction (ETD) and middle ear effusion (MEE). STUDY DESIGN: Brown-Norway rats were sensitized to ovalbumin (OVA) and challenged transtympanically. Two groups of rats received either IL-4R or IL-5Ab transtympanically 1 hour before challenge. Three additional groups were used as controls. Following the second transtympanic challenge, the ventilatory and clearance functions of the eustachian tube (ET) were assessed at 0, 2, and 8 hours. Histology was prepared using cut paraffin sections stained with hematoxylin and eosin. RESULTS: sIL-4R-pretreated rats showed no significant changes in ventilatory or clearance functions of the ET or inflammatory changes in ET mucosa, whereas IL-5Ab pretreatment showed significant late ventilatory and clearance dysfunction as well as inflammatory mucosal changes. CONCLUSION: These data demonstrate that the late-phase allergic inflammatory response that leads to subsequent formation of ETD and MEE is prevented by pretreatment with sIL-4R and, more modestly, with IL-5Ab.
PubMed ID
12297806 View in PubMed
Less detail

[The state of the nasal mucosa and the paranasal sinuses in the late postoperative period following radical and minimally invasive surgery].

https://arctichealth.org/en/permalink/ahliterature280534
Source
Vestn Otorinolaringol. 2016;81(5):54-56
Publication Type
Article
Author
M M Magomedov
D F Zeinalova
D V Andriyashkin
N M Magomedova
A E Starostina
M V Zvereva
Source
Vestn Otorinolaringol. 2016;81(5):54-56
Language
Russian
Publication Type
Article
Keywords
Adult
Female
Humans
Male
Minimally Invasive Surgical Procedures - adverse effects - methods
Mucociliary Clearance
Nasal Mucosa - pathology - physiopathology
Nasal Surgical Procedures - adverse effects - methods
Outcome and Process Assessment (Health Care)
Postoperative Complications - pathology - physiopathology
Postoperative Period
Rhinitis - pathology - physiopathology - surgery
Russia
Sinusitis - pathology - physiopathology - surgery
Abstract
We have investigated the functional state of the mucous membrane of the nasal cavity and maxillary sinus after radical and minimally invasive surgical procedures during the log-term postoperative period, i.e. three and more months after the intervention. The materials for the study were brushings and histological biopsies; in addition, the functional parameters of the mucous membranes of the nose and maxillary sinuses were estimated before and after surgery. It has been found that the type of the surgical intervention on the inferior turbinate bones for the treatment of chronic rhinitis, such as gentle turbinotomy, has no significant influence on the state of the mucous membrane. The study has demonstrated that 48% of the patients presenting with the chronic maxilloethmoidal mixed form of sinusitis experience epithelial metaplasia resulting in atrophic scarring of the mucosa whereas in the remaining 52% the ciliary epithelium becomes either damaged or detached and the ciliary beat frequency (CBF) decreases. In the exudative form of the disease, CBF and some other functional characteristics are improved but the stromal oedema persists and ciliated epithelium integrity gets compromised.
PubMed ID
27876739 View in PubMed
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Work related impairment of nasal function in Swedish woodwork teachers.

https://arctichealth.org/en/permalink/ahliterature212725
Source
Occup Environ Med. 1996 Feb;53(2):112-7
Publication Type
Article
Date
Feb-1996
Author
M. Ahman
M. Holmström
I. Cynkier
E. Söderman
Author Affiliation
Department of Medicine, Karolinska Institute, Huddinge, Sweden.
Source
Occup Environ Med. 1996 Feb;53(2):112-7
Date
Feb-1996
Language
English
Publication Type
Article
Keywords
Adult
Dust
Female
Humans
Male
Manometry
Mucociliary Clearance
Nasal Obstruction - etiology
Nose - physiopathology
Occupational Exposure - adverse effects
Smell - physiology
Sweden
Teaching
Terpenes - analysis
Wood
Abstract
To study the relation between exposure and nasal function in woodwork teachers.
39 selected woodwork teachers employed full time and 32 control subjects (other school personnel) were examined at the beginning and at the end of a working week with symptom rating, nose and throat inspection, rhinomanometry, nasal mucociliary clearance test, and a smell identification test. During one working day of the same week climate, dust and terpene concentrations were measured in all 39 schools.
The ventilation rate was highest in rooms with mechanical ventilation. Range of total dust (personally sampled) was 0.12-1.18 mg/m3, respirable dust 0.02-0.21 mg/m3, and terpenes (area sampled) 0.02-6.8 mg/m3. In contrast to the control subjects, the woodwork teachers had more nasal symptoms on the Thursday afternoon than on the Monday morning, especially those working in rooms without mechanical ventilation. Their mucociliary clearance worsened during the week (mean increase 4 min, P
Notes
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PubMed ID
8777447 View in PubMed
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8 records – page 1 of 1.