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A 3-year clinical follow-up of adult patients with 3243A>G in mitochondrial DNA.

https://arctichealth.org/en/permalink/ahliterature82145
Source
Neurology. 2006 May 23;66(10):1470-5
Publication Type
Article
Date
May-23-2006
Author
Majamaa-Voltti K A M
Winqvist S.
Remes A M
Tolonen U.
Pyhtinen J.
Uimonen S.
Kärppä M.
Sorri M.
Peuhkurinen K.
Majamaa K.
Author Affiliation
Department of Internal Medicine, University of Oulu, Oulu, Finland. kirsi.majamaa-voltti@oulu.fi
Source
Neurology. 2006 May 23;66(10):1470-5
Date
May-23-2006
Language
English
Publication Type
Article
Keywords
Adult
Alleles
Blood Glucose - analysis
Cognition Disorders - genetics
DNA, Mitochondrial - genetics
Diabetes Mellitus - blood - genetics
Disease Progression
Electrocardiography, Ambulatory
Electroencephalography
Female
Finland - epidemiology
Follow-Up Studies
Hearing Loss, Sensorineural - genetics
Humans
Hypertrophy, Left Ventricular - genetics - ultrasonography
Lactates - blood
MELAS Syndrome - genetics - mortality
Male
Middle Aged
Mitochondria, Muscle - metabolism
Mosaicism
Neuropsychological Tests
Point Mutation
Pyruvates - blood
Abstract
OBJECTIVE: To follow the clinical course of patients with the mitochondrial DNA mutation 3243A>G for 3 years. METHODS: Thirty-three adult patients with the 3243A>G mutation entered a 3-year follow-up study. They were clinically evaluated annually, audiometry was performed, and samples were drawn for the analysis of blood chemistry and mutation heteroplasmy in leukocytes. Holter recording was performed three times during the follow-up and echocardiography, neuropsychological assessment, and quantitative EEG and brain imaging conducted at entry and after 3 years. RESULTS: The incidence of new neurologic events was low during the 3-year follow-up. Sensorineural hearing impairment (SNHI) progressed, left ventricular wall thickness increased, mean alpha frequency in the occipital and parietal regions decreased, and the severity of disease index (modified Rankin score) progressed significantly. The rate of SNHI progression correlated with mutation heteroplasmy in muscle. The increase in left ventricular wall thickness was seen almost exclusively in diabetic patients. Seven patients died during the follow-up, and they were generally more severely affected than those who survived. CONCLUSIONS: Significant changes in the severity of disease, sensorineural hearing impairment, left ventricular hypertrophy, and quantitative EEG were seen in adult patients with 3243A>G during the 3-year follow-up.
Notes
Comment In: Neurology. 2007 Jan 9;68(2):163-417210904
PubMed ID
16717204 View in PubMed
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[Action of gamma irradiation on the infectivity of the potato virus X, the TMV and their RNAs]

https://arctichealth.org/en/permalink/ahliterature69126
Source
Mikrobiol Zh. 1976 Jan-Feb;38(1):78-80
Publication Type
Article

[Action of some polysaccharide containing complexes of microbial origin on the tobacco mosaic virus and on the influenza virus]

https://arctichealth.org/en/permalink/ahliterature69128
Source
Mikrobiol Zh. 1976;38(3):347-50
Publication Type
Article
Date
1976

[An analysis of the cDNA nucleotide sequence for the C-terminal fragment of the coat protein in tobacco mosaic virus isolates from tobacco growing in an ecological niche of Polesye, Ukraine]

https://arctichealth.org/en/permalink/ahliterature69071
Source
Tsitol Genet. 1998 Apr-May;32(3):30-5
Publication Type
Article
Author
A L Boiko
S A Stepaniuk
O M Garifulin
Source
Tsitol Genet. 1998 Apr-May;32(3):30-5
Language
Russian
Publication Type
Article
Keywords
Amino Acid Sequence
Base Sequence
Capsid - chemistry - genetics
Cesium radioisotopes
Cloning, Molecular - methods
DNA, Complementary - genetics
DNA, Viral - genetics
Ecosystem
English Abstract
Molecular Sequence Data
Peptide Fragments - chemistry - genetics
Plants, Toxic
Radioactive Pollutants
Tobacco - virology
Tobacco Mosaic Virus - genetics - isolation & purification
Ukraine
Abstract
Two identical strains of tobacco type TVM have been isolated in the region with 137Cs nuclear contamination with density of 12.6 Cu/km2 recombinant plasmids (pTVM9, pTVM9,5) containing cDNA of complete provirus and C-end sequence of cDNA of specific capsid protein from one of isolated viruses have been obtained. The capsule proteins of isolated strains have the higher 19.5 +/- 1.9 kDa molecular weight than standard TVM strain (17.5 kDa) as to SDS-PAAG electrophoresis data. No differences in distribution of fragments immunoactive to control antiserum have been found when using immunoblot analysis of capsid proteins of isolates and standard strain treated by tripsin. Sequencing analysis of cDNA pTVM9,5 has revealed non-conservative amino acid replacement of serine by tyrosine in position 149 for homologous region of capsid protein of standard TVM strain, which allows to suppose the mediated effect of specific ecological situation on the appearance of such replacement.
PubMed ID
9879105 View in PubMed
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[Antiphytoviral activity of capsule substances of Cryptococcus albidus yeast]

https://arctichealth.org/en/permalink/ahliterature69023
Source
Mikrobiol Z. 2005 May-Jun;67(3):81-4
Publication Type
Article
Author
O H Kovalenko
A O Barkalova
S S Nahorrna
Source
Mikrobiol Z. 2005 May-Jun;67(3):81-4
Language
Ukrainian
Publication Type
Article
Keywords
Antiviral Agents - pharmacology
Carbohydrates - pharmacology
Cryptococcus - isolation & purification - metabolism - physiology
Cucumis sativus - anatomy & histology
Culture Media - chemistry
Datura - microbiology
English Abstract
Plant Leaves - microbiology
Proteins - pharmacology
Sonication
Tobacco - microbiology
Tobacco Mosaic Virus - drug effects
Zea mays - anatomy & histology
Abstract
The yeast Cryptococcus albidus isolated from the leaves of maize (strain 1003) and cucumbers (strain 1014) produce the capsule substances which can protect the tobacco and datura plants from tobacco mosaic virus. Proteins, carbohydrates and ash elements have been isolated from culture liquids treated by supersound.
PubMed ID
16018209 View in PubMed
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[Antiviral action of some soil mycobacteria on the tobacco mosaic virus]

https://arctichealth.org/en/permalink/ahliterature69150
Source
Mikrobiol Zh. 1972;33(2):265-7
Publication Type
Article
Date
1972
Author
K P Mil'chenko
L F Orishchuk
Source
Mikrobiol Zh. 1972;33(2):265-7
Date
1972
Language
Ukrainian
Publication Type
Article
Keywords
Antibiosis
Antiviral Agents
Mycobacterium
Soil Microbiology - analysis
Tobacco Mosaic Virus
PubMed ID
4663650 View in PubMed
Less detail

[Antiviral activity of some aryliden pyridines and pyridile ethyl thiazolidines]

https://arctichealth.org/en/permalink/ahliterature69153
Source
Mikrobiol Zh. 1971;33(1):88-92
Publication Type
Article
Date
1971

[Antiviral and phytostimulating properties of the individual components of imanine]

https://arctichealth.org/en/permalink/ahliterature69149
Source
Mikrobiol Zh. 1972 Sep-Oct;34(5):620-4
Publication Type
Article

87 records – page 1 of 9.