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Cancer in asbestos-mining and other areas of Quebec.

https://arctichealth.org/en/permalink/ahliterature249536
Source
J Natl Cancer Inst. 1977 Oct;59(4):1139-45
Publication Type
Article
Date
Oct-1977
Author
S. Graham
M. Blanchet
T. Rohrer
Source
J Natl Cancer Inst. 1977 Oct;59(4):1139-45
Date
Oct-1977
Language
English
Publication Type
Article
Keywords
Asbestos - adverse effects
Epidemiologic Methods
Female
Humans
Intestinal Neoplasms - etiology
Intestine, Small
Lip Neoplasms - etiology
Male
Mining
Neoplasms - epidemiology - etiology
New York
Occupational Diseases - epidemiology - etiology
Peritoneal Neoplasms - etiology
Pleural Neoplasms - etiology
Quebec
Risk
Rural Population
Salivary Gland Neoplasms - etiology
Tongue Neoplasms - etiology
Urban Population
Abstract
Employing incidence data from the Quebec Tumor Registry, we examined the relative risks of cancer of all sites for the years 1969-73 in the asbestos-mining, rural, and metropolitan counties of Quebec Province, Canada. Generally, rates for males exceeded those for females, and the relative risks in the asbestos-mining counties for 7-10 different sites of cancer, all of low incidence, were from 1.50 to 8.08 times those of other rural counties of the Province for both sexes. Metropolitan counties exhibited equally high risk for many of these sites. We discovered higher risks among males in asbestos-mining counties for cancer of the pleura, peritoneum, lip, tongue, salivary gland, mouth, and small intestine and higher risks among females for cancer of the pleura, lip, kidney, salivary gland, and for melanoma. Because of the likelihood of a long latent period for asbestos-related cancers, the risks we observed were possibly the product of since-altered occupational and environmental conditions existing 20-30 years ago in the asbestos-mining areas. The similarities in risks for most cancers in asbestos-mining and urban areas were noteworthy.
PubMed ID
903992 View in PubMed
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Chrysotile, tremolite, and mesothelioma.

https://arctichealth.org/en/permalink/ahliterature215812
Source
Science. 1995 Feb 10;267(5199):776-7
Publication Type
Article
Date
Feb-10-1995

Clinical measurement in Quebec chrysotile miners: use for future protection of workers.

https://arctichealth.org/en/permalink/ahliterature247778
Source
Ann N Y Acad Sci. 1979;330:23-9
Publication Type
Article
Date
1979
Author
M R Becklake
Source
Ann N Y Acad Sci. 1979;330:23-9
Date
1979
Language
English
Publication Type
Article
Keywords
Asbestos - adverse effects
Asbestosis - etiology - prevention & control
Humans
Male
Mining
Occupational Diseases - etiology - prevention & control
Public Health
Quebec
Abstract
There is a relationship between dust exposure, on the one hand, and serious disease and death, on the other, in chrysotile asbestos mine and mill workers of Quebec. Studies in current working populations indicate that prevalence of abnormality increases with increasing exposure. However, the relationship is weak and offers only a partial explanation of between-subject variability. In addition, there is no certain way to detect or predict change. Because of the relative nonspecificity of the health measurements examined and their poor relationship to exposure, control should be based on environmental monitoring, with biologic monitoring considered in a complementary role. This leaves the clinician with the dilemma of how best to advise the worker in whom questionable changes have been detected. At present, there appears little doubt that the decision must remain essentially clinical, based, on one hand, on all available information about the man, his job, and the plant or mine in which he works, from which an estimate of likely outcome must be made, and, on the other hand, on the social and human factors concerned, including the fact that removal from exposure does not necessarily prevent the appearance of abnormality.
PubMed ID
294176 View in PubMed
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The combination of effects on lung cancer of cigarette smoking and exposure in quebec chrysotile miners and millers.

https://arctichealth.org/en/permalink/ahliterature190229
Source
Ann Occup Hyg. 2002 Jan;46(1):5-13
Publication Type
Article
Date
Jan-2002
Author
F D K Liddell
B G Armstrong
Author Affiliation
Department of Epidemiology and Biostatistics, McGill University, Montreal, Canada.
Source
Ann Occup Hyg. 2002 Jan;46(1):5-13
Date
Jan-2002
Language
English
Publication Type
Article
Keywords
Air Pollutants, Occupational - adverse effects
Asbestos, Serpentine - adverse effects
Causality
Cause of Death
Cohort Studies
Humans
Lung Neoplasms - etiology
Male
Mining
Models, Statistical
Quebec
Risk assessment
Smoking - adverse effects
Abstract
Although it is well known that both cigarette smoke and microscopic airborne asbestos fibres can cause lung cancer, evidence as to how these two agents combine is nebulous. Many workers have believed in the multiplicative theory, whereby asbestos increases the risk in proportion to the risk from other causes. However, evidence against this theory is mounting: a recent review concluded that the multiplicative hypothesis was untenable, and that the relative risk of lung cancer from asbestos exposure was about twice as high in non-smokers as in smokers, a finding largely independent of type of asbestos fibre. The criteria for entry to the current study were met by 7279 men in the 1891-1920 birth cohort of Quebec chrysotile miners and millers. The data consisted of date of birth, place of employment, smoking habit, asbestos exposure accumulated to age 55 and, for those 5527 who died between 1950 and June 1992, date and cause of death; 533 of the deaths were from lung cancer. For the principal analyses, ex-smokers were excluded from the study cohort, which comprised 5888 men, of whom 473 died of lung cancer. The conventional form of analysis is simply of the double dichotomy: non-smokers of cigarettes, 'unexposed' and exposed; all others, 'unexposed' and exposed. The respective standardized lung cancer mortality ratios (SMRs) were 0.29 and 0.62; and 1.37 and 1.72. Thus, the differences in relative risk, due to exposure, were closely similar, 0.33 and 0.35. On the other hand, the effects of asbestos measured by the corresponding ratios, 2.12 and 1.25, did differ, being 1.7 times as high in non-smokers as in others. The principal analysis was much more penetrating: the method was to fit models to a 'disaggregated' 6 x 10 array, by smoking habit (excluding ex-smokers) and asbestos exposure, of lung cancer SMRs. Both linear and log-linear models were fitted: the former included the additive and linear-multiplicative; the latter embraced the more conventional multiplicative form. The additive model fitted much the best. The fit of each multiplicative model was improved by the introduction of an interaction term that implied a less than multiplicative relationship. Thus smoking and exposure to chrysotile appear to have acted independently in causing lung cancer, with 10 cigarettes a day having an effect roughly equivalent to exposure amounting to 700 million particles per cubic foot x years. The refutation of the multiplicative hypothesis in these data reinforces its inapplicability in general; but the additive hypothesis is not generally applicable either. Indeed, there seems to be no good reason to believe that interactions conform to any simple theory. The implications are important.
PubMed ID
12005133 View in PubMed
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Comment on McDonald et al's study on mortality in asbestos industry.

https://arctichealth.org/en/permalink/ahliterature255574
Source
Arch Environ Health. 1972 Apr;24(4):294-5
Publication Type
Article
Date
Apr-1972

Dust exposure and mortality in chrysotile mining, 1910-75.

https://arctichealth.org/en/permalink/ahliterature246109
Source
Br J Ind Med. 1980 Feb;37(1):11-24
Publication Type
Article
Date
Feb-1980
Author
J C McDonald
F D Liddell
G W Gibbs
G E Eyssen
A D McDonald
Source
Br J Ind Med. 1980 Feb;37(1):11-24
Date
Feb-1980
Language
English
Publication Type
Article
Keywords
Accidents
Aged
Asbestos - adverse effects
Asbestosis - mortality
Cerebrovascular Disorders - mortality
Dust
Employment
Environmental Exposure
Female
Follow-Up Studies
Heart Diseases - mortality
Humans
Lung Neoplasms - mortality
Male
Middle Aged
Mining
Neoplasms - mortality
Occupational Diseases - mortality
Quebec
Respiration Disorders - mortality
Smoking - complications
Time Factors
Abstract
We report a further follow-up of a birth cohort of 11 379 workers exposed to chrysotile. The cohort consisted of 10 939 men and 440 women, born 1891-1920, who had worked for at least a month in the mines and mills of Asbestos and Thetford Mines in Quebec. For all subjects, length of service and estimates of accumulated dust exposure were obtained, with a smoking history for the vast majority. Three methods of analysis, two based on the "man-years" methods, the other a "case-and-multiple-controls" approach, gave results consistent with one another and with previous analyses. By the end of 1975, 4463 men and 84 women had died. Among men, the overall excess mortality, 1926-75 was 2% at Asbestos and 10% at Thetford Mines, much the dustier region. The women, mostly employed at Asbestos, had a standardised mortality ratio (SMR) all causes, 1936-75) of 0.90. Analysis of deaths 20 years or more after first employment showed that in men with short service (less than five years) there was no discernible correlation with dust exposure. Among men employed at least 20 years, there were clear excesses in those exposed to the heaviest dust concentrations. Reanalysis in terms of exposure to age 45 showed definite and consistent trends for SMRs for total mortality, for lung cancer, and for pneumoconiosis to be higher the heavier the exposure. The response to increasing dose was effectively linear for lung cancer and for pneumoconiosis. Lung cancer deaths occurred in non-smokers, and showed a greater increase of incidence with increasing exposure than did lung cancer in smokers, but there was insufficient evidence to distinguish between multiplicative and additive risk models. There were no excess deaths from laryngeal cancer, but a clear association with smoking. Ten men and one woman died from pleural mesothelioma. If the only subjects studied had been the 1904 men with at least 20 years' employment in the lower dust concentrations, averaging 6.6 million particles per cubic foot (or about 20 fibres/cc), excess mortality would not have been considered statistically significant, except for pneumoconiosis. The inability of such a large epidemiological survey to detect increased risk at what, today, are considered unacceptable dust concentrations, and the consequent importance of exposure-response models are therefore emphasised.
Notes
Cites: Biometrics. 1969 Jun;25(2):339-555794104
Cites: Arch Environ Health. 1971 Jun;22(6):677-865574010
Cites: Arch Environ Health. 1972 Mar;24(3):189-975059627
Cites: Arch Environ Health. 1974 Feb;28(2):61-84809914
Cites: Arch Environ Health. 1974 Feb;28(2):69-714809915
Cites: Arch Environ Health. 1975 May;30(5):266-71130842
Cites: Br J Prev Soc Med. 1976 Dec;30(4):225-301009272
Cites: Int J Cancer. 1977 Sep 15;20(3):323-31903186
Cites: Prev Med. 1977 Sep;6(3):426-42333420
Cites: J Occup Med. 1977 Nov;19(11):737-40915568
Cites: Lancet. 1978 Mar 4;1(8062):484-976030
Cites: Br J Ind Med. 1964 Oct;21:304-714253230
PubMed ID
7370189 View in PubMed
Less detail

Dust exposure and mortality in chrysotile mining, 1910-75. 1980.

https://arctichealth.org/en/permalink/ahliterature219708
Source
Br J Ind Med. 1993 Dec;50(12):1058-72
Publication Type
Article
Date
Dec-1993
Author
J C McDonald
F D Liddell
G W Gibbs
G E Eyssen
A D McDonald
Source
Br J Ind Med. 1993 Dec;50(12):1058-72
Date
Dec-1993
Language
English
Publication Type
Article
Keywords
Asbestos, Serpentine
Asbestosis - history - mortality
Dust
History, 20th Century
Humans
Mining - history
Occupational Exposure - history
Quebec
Notes
Cites: Int J Cancer. 1977 Sep 15;20(3):323-31903186
Cites: Br J Prev Soc Med. 1976 Dec;30(4):225-301009272
Cites: Prev Med. 1977 Sep;6(3):426-42333420
Cites: J Occup Med. 1977 Nov;19(11):737-40915568
Cites: Lancet. 1978 Mar 4;1(8062):484-976030
Cites: Environ Res. 1978 Dec;17(3):340-6233818
Cites: Br J Ind Med. 1964 Oct;21:304-714253230
Cites: Biometrics. 1969 Jun;25(2):339-555794104
Cites: Arch Environ Health. 1971 Jun;22(6):677-865574010
Cites: Arch Environ Health. 1972 Mar;24(3):189-975059627
Cites: Arch Environ Health. 1974 Feb;28(2):61-84809914
Cites: Arch Environ Health. 1974 Feb;28(2):69-714809915
Cites: Arch Environ Health. 1975 May;30(5):266-71130842
Cites: N Engl J Med. 1976 Mar 25;294(13):687-9055969
Comment In: Occup Environ Med. 1994 Jun;51(6):4318044238
PubMed ID
8280637 View in PubMed
Less detail

[Environmental asbestos pollution and public health in Quebec].

https://arctichealth.org/en/permalink/ahliterature243213
Source
Union Med Can. 1982 May;111(5):475-82, 487-9
Publication Type
Article
Date
May-1982

39 records – page 1 of 4.