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Source
Scand J Work Environ Health. 1987 Feb;13(1):26-31
Publication Type
Article
Date
Feb-1987
Author
R S Koskela
M. Klockars
E. Järvinen
P J Kolari
A. Rossi
Source
Scand J Work Environ Health. 1987 Feb;13(1):26-31
Date
Feb-1987
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Finland
Follow-Up Studies
Humans
Middle Aged
Mining
Neoplasms - etiology - mortality
Occupational Diseases - etiology - mortality
Respiration Disorders - etiology - mortality
Silicon Dioxide - adverse effects
Abstract
A retrospective cohort study was undertaken to investigate the cancer mortality of granite workers. The study comprised 1,026 workers hired between 1940 and 1971. The number of person-years was 20,165, and the number of deaths 235. During the total follow-up 46 tumors were observed and 44.9 were expected. An excess mortality from tumors was observed for the workers followed for 20 years or more, the greatest excess occurring during the follow-up period of 25-29 years (observed 11, expected 5.2). Of the 46 tumors, 22 were lung cancers (expected 17.1) and 15 were gastrointestinal cancers (expected 9.7), nine of which were cancers of the stomach (expected 6.0). Mortality from lung cancer was excessive for workers with at least 15 years since entry into granite work (latency) (21 observed and 9.5 expected), being highest during the follow-up period of 25-29 years (observed 8, expected 2.1). The results indicate that granite exposure per se may be an etiologic factor in the initiation or promotion of malignant neoplasms.
PubMed ID
3033818 View in PubMed
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Mortality and disability among granite workers.

https://arctichealth.org/en/permalink/ahliterature235618
Source
Scand J Work Environ Health. 1987 Feb;13(1):18-25
Publication Type
Article
Date
Feb-1987
Author
R S Koskela
M. Klockars
E. Järvinen
P J Kolari
A. Rossi
Source
Scand J Work Environ Health. 1987 Feb;13(1):18-25
Date
Feb-1987
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Bone Diseases - etiology
Cardiovascular Diseases - etiology
Chronic Disease
Finland
Follow-Up Studies
Humans
Middle Aged
Mining
Muscular Diseases - etiology
Neoplasms - etiology
Occupational Diseases - epidemiology - etiology
Respiration Disorders - etiology
Abstract
The objective of the present study was to investigate the mortality, disability, and long-term morbidity of granite workers. The study included 1,026 workers hired between 1940 and 1971 and followed until the end of 1981. The total number of deaths was 235, and the expected number was 229.7. Excess mortality rates were observed for respiratory diseases (observed/expected = 28/13.9). The number of tumor deaths was 46 (expected 44.9). Excess lung cancer mortality was evident at 15 to 35 years of latency; the observed number of lung cancer deaths for the follow-up period of 25 to 29 years was 8, while 2.1 were expected. Mortality from cardiovascular diseases and violent deaths was slightly less than expected. The results for disability and long-term morbidity showed elevated incidence and prevalence rates for respiratory diseases and rheumatoid arthritis. The observed number of disability pensions due to rheumatoid arthritis in 1981 was 10 observed versus 1.8 expected, and the observed number of patients granted free medication was 19 versus 8.1 expected. The results indicate that granite dust exposure per se may be an etiologic and pathogenetic factor for lung cancer, cancer of the gastrointestinal tract, and some extrapulmonary nonmalignant chronic diseases.
PubMed ID
3576141 View in PubMed
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Silica exposure and rheumatoid arthritis: a follow up study of granite workers 1940-81.

https://arctichealth.org/en/permalink/ahliterature235315
Source
Br Med J (Clin Res Ed). 1987 Apr 18;294(6578):997-1000
Publication Type
Article
Date
Apr-18-1987
Author
M. Klockars
R S Koskela
E. Järvinen
P J Kolari
A. Rossi
Author Affiliation
Institute of Occupational Health, Helsinki, Finland.
Source
Br Med J (Clin Res Ed). 1987 Apr 18;294(6578):997-1000
Date
Apr-18-1987
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Arthritis, Rheumatoid - etiology
Dust - adverse effects
Finland
Follow-Up Studies
Humans
Male
Middle Aged
Mining
Occupational Diseases - etiology
Quartz - adverse effects
Retrospective Studies
Silicon Dioxide - adverse effects
Workers' Compensation
Abstract
The incidence and prevalence of subjects awarded disability pensions and the prevalence of subjects receiving free medicines because of rheumatoid arthritis were studied in a Finnish cohort of 1026 granite workers hired between 1940 and 1971 and followed up until 31 December 1981. The incidence of awards of disability pensions because of rheumatoid arthritis during 1969-81, the prevalence of rheumatoid arthritis on 31 December 1981, and the prevalence of subjects receiving free medicines for rheumatoid arthritis at the end of 1981 were significantly higher among the granite workers than in the general male population of the same age. Retrospective analysis of the records of all patients with rheumatoid arthritis in the cohort showed a predominance of a severe, serologically positive and erosive form of rheumatoid arthritis, usually with an age at onset of 50 or over. The possible aetiological or pathophysiological role of granite dust in rheumatoid arthritis may be based on the effects of quartz on the immune system.
Notes
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PubMed ID
2823951 View in PubMed
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