The authors studied distribution of biochemical markers for HP, GC, EsD, AcP genes, polymorphism of GSTT1 (GST-theta 1), GSTM1 (GST-mu 1), locus WNTR of NOS3 gene (alleles A/B) in chronic dust bronchitis patients and in apparently healthy individuals. Genotypes EsD 1-2 and AcP bb individuals were proved to be most prone to the disease. Endogenous resistent factors for chronic dust bronchitis are genotypes GC 1-1, EsD 1-1, AcP bc.
Work conditions on open-cast minest of Kuzbass include complex of unfavorable natural climate, mining technical occupational factors (microclimate, industrial noise, vibration, aerosols, toxic chemicals, hardiness and intensity of work). According to those occupational factors, the authors calculated risks of morbidity and safe length of service.
Findings are that coal miners having long contact with vibration instruments and coal dust develop endothelial dysfunction, increased platelets aggregation, hypercoagulation and lower anticoagulation activity. The hemostasis disorders revealed could result in earlier coronary atherosclerosis development in workers exposed to vibration.
Miners working in the North are exposed to more pronounced effects of unfavourable occupational factors (hand drillers, bulldozer operators, etc.) and are found to have higher morbidity rates. With their longer stay in the North, the incidence of gastrointestinal disorders increases. Among the migrants from the regions with contrasting climatic conditions. (Caucasus, Central Asia), the morbidity is higher than among those from other regions of this country.
The article presents data testifying demographic problems in numerous okrugs of the Russian Federation. It is emphasized that in the Siberian federal okrug reside 13.48% of population of Russia. In spite of it younger age (by 1.4 years) and on the assumption of situation of 2011-2012. The life expectancy of males is lower by 2.35±0.01 years as compared with the rest of Russian male population and in females is lower by 1.84±0.02 years as compared with the rest of Russianfemale population. In Kemerovskaia oblast with numerous population, where the coal mining industry is a city-formingfactor males live less by 4.2 years than males in whole Russia. The higher levels of mortality of population of able-bodied age in the Kemerovskaia oblast as compared with the Siberian federal okrug and Russia are presented The results of comparative analysis are used to demonstrate that even partial implementation in Novokuznetsk, the largest city of the Kemerovskaia oblast, of program activities targeted to prevent occupational morbidity ofworkers of coal mining industry of Kuzbass impacted alteration of indicator of mortality of population of able-bodied age. It is stated that the research institute of complex problems of hygiene and occupational diseases of the Russian academy of medical sciences has at its disposal experience and scientific base to develop program activities targeted to health protection and maintenance of labor potential of population of various territorial formations of the Russian Federation. The official permit of applying new medical technology to evaluate occupational risks for health of workers of industrial enterprises is available.
The distribution of genotypes of HP, GC, EsD, AsP and polymorphisms GSTT1 (GST-theta1) and GSTM1 (GST-micro1) and NOS3 (polymorphism VNTR4) in miners with chronic dust bronchitis, and in those without this occupational disease has been studied The carriers of genotypes of genotypes EsD 1-2, AsP bb were shown to be more prone to develop chronic dust bronchitis. Endogenous factors of resistance to the disease are the genotypes GC 1-1, EsD 1-1, AsP bc.