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Clinical measurement in Quebec chrysotile miners: use for future protection of workers.

https://arctichealth.org/en/permalink/ahliterature247778
Source
Ann N Y Acad Sci. 1979;330:23-9
Publication Type
Article
Date
1979
Author
M R Becklake
Source
Ann N Y Acad Sci. 1979;330:23-9
Date
1979
Language
English
Publication Type
Article
Keywords
Asbestos - adverse effects
Asbestosis - etiology - prevention & control
Humans
Male
Mining
Occupational Diseases - etiology - prevention & control
Public Health
Quebec
Abstract
There is a relationship between dust exposure, on the one hand, and serious disease and death, on the other, in chrysotile asbestos mine and mill workers of Quebec. Studies in current working populations indicate that prevalence of abnormality increases with increasing exposure. However, the relationship is weak and offers only a partial explanation of between-subject variability. In addition, there is no certain way to detect or predict change. Because of the relative nonspecificity of the health measurements examined and their poor relationship to exposure, control should be based on environmental monitoring, with biologic monitoring considered in a complementary role. This leaves the clinician with the dilemma of how best to advise the worker in whom questionable changes have been detected. At present, there appears little doubt that the decision must remain essentially clinical, based, on one hand, on all available information about the man, his job, and the plant or mine in which he works, from which an estimate of likely outcome must be made, and, on the other hand, on the social and human factors concerned, including the fact that removal from exposure does not necessarily prevent the appearance of abnormality.
PubMed ID
294176 View in PubMed
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Follow-up respiratory measurements in Quebec chrysotile asbestos miners and millers.

https://arctichealth.org/en/permalink/ahliterature243680
Source
Scand J Work Environ Health. 1982;8 Suppl 1:105-10
Publication Type
Article
Date
1982
Author
M R Becklake
D. Thomas
F. Liddell
J C McDonald
Source
Scand J Work Environ Health. 1982;8 Suppl 1:105-10
Date
1982
Language
English
Publication Type
Article
Keywords
Adult
Asbestos - adverse effects
Follow-Up Studies
Humans
Lung Diseases - epidemiology - radiography
Lung Volume Measurements
Male
Middle Aged
Mining
Occupational Diseases - epidemiology - radiography
Quebec
Abstract
In 1974 changes in dyspnea, lung function, and pneumoconiotic radiographic abnormalities were recorded among the 1,015 Quebec chrysotile miners and millers surveyed in 1967-1968. The aim was to relate these changes to dust exposure--age, smoking, and earlier health status being taken into account. Dyspnea and lung function were assessed in 722 men, and for 277 recent radiographs were read separately by three experts for changes in the parenchyma and pleura. Each measure was analyzed independently for men without any abnormality when first seen (eligible for "attack") and for others (eligible for progression/regression). Age significantly influenced the rate of attack of pleural abnormality and the rates of attack and progression of dyspnea and lung function decline. Smoking had comparatively minor effects. The only associations with exposure were for progression of parenchymal change (one reader), and for progression of dyspnea. These essentially negative findings are similar to those obtained in a previous longitudinal survey of radiographs from the same workforce.
PubMed ID
7100836 View in PubMed
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Lung function profiles in the chrysotile asbestos mines and mills of Quebec.

https://arctichealth.org/en/permalink/ahliterature251366
Source
Chest. 1976 Feb;69(2 Suppl):303
Publication Type
Article
Date
Feb-1976

Rheumatic complaints and pulmonary response to chrysotile dust inhalation in the mines and mills of Quebec.

https://arctichealth.org/en/permalink/ahliterature253159
Source
Can Med Assoc J. 1974 Sep 21;111(6):533-5
Publication Type
Article
Date
Sep-21-1974
Author
F M White
J. Swift
M R Becklake
Source
Can Med Assoc J. 1974 Sep 21;111(6):533-5
Date
Sep-21-1974
Language
English
Publication Type
Article
Keywords
Adult
Asbestos - poisoning
Asbestosis - diagnosis
Dust
Environmental Exposure
Humans
Male
Middle Aged
Mining
Occupational Diseases - chemically induced
Quebec
Questionnaires
Rheumatic Diseases - chemically induced
Abstract
In 1967-68 an age-stratified random sample of 1069 current workers in Quebec asbestos mines and mills was surveyed. Questions concerning rheumatic complaints were included in a modified MRC questionnaire used at that time, and on this basis a rheumatic severity gradient was devised. No relationship could be detected between rheumatic complaints and pulmonary radiologic response to chrysotile dust exposure, despite implications in the literature that such a relationship might exist.
Notes
Cites: Ann N Y Acad Sci. 1965 Dec 31;132(1):112-205219543
Cites: Chest. 1970 Jul;58(1):15425298
Cites: Lille Med. 1968 Feb;13(2):201-105745959
Cites: Br Med J. 1970 Aug 29;3(5721):492-54918296
Cites: Union Med Can. 1971 Aug;100(8):1588-914934790
Cites: Arch Environ Health. 1972 Jun;24(6):388-4005031565
Cites: Scand J Respir Dis. 1971;52(3):153-615161827
Cites: Thorax. 1953 Mar;8(1):29-3713038735
Cites: Br Med J. 1953 Dec 5;2(4848):1231-613106392
Cites: Thorax. 1958 Sep;13(3):185-9313580972
Cites: Thorax. 1961 Dec;16:372-713920165
Cites: Thorax. 1964 Sep;19:433-514216972
PubMed ID
4547295 View in PubMed
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Temporal patterns of exposure and nonmalignant pulmonary abnormality in Quebec chrysotile workers.

https://arctichealth.org/en/permalink/ahliterature239079
Source
Arch Environ Health. 1985 Mar-Apr;40(2):80-7
Publication Type
Article
Author
R. Copes
D. Thomas
M R Becklake
Source
Arch Environ Health. 1985 Mar-Apr;40(2):80-7
Language
English
Publication Type
Article
Keywords
Adult
Aged
Asbestos - adverse effects
Dust
Epidemiologic Methods
Humans
Lung Diseases - epidemiology - etiology - radiography
Male
Middle Aged
Mining
Occupational Diseases - epidemiology - etiology - radiography
Quebec
Questionnaires
Smoking
Abstract
Questionnaire, radiographic, and lung function information for 983 Quebec chrysotile workers at work in 1966 was used to develop five clinical response scales (i.e., parenchymal and pleural fibrosis, airflow limitation, chronic bronchitis, and airway reactivity). The relationship of the scales to variables describing temporal patterns of exposure was studied, taking into account cumulative exposure, age, and smoking. All response scales related to variables containing only time information, and in all cases temporal patterns of exposure influenced exposure response relationships. For pulmonary fibrosis, the strongest relationships were to cumulative exposure; for pleural fibrosis to exposure peaks and residence time of dust in the lung; for airway reactivity to early and recent exposure; and for airflow limitation and chronic bronchitis to smoking and to dust level and load over time. These results add to the gathering evidence that exposures to environments containing airborne asbestos may result in airway abnormalities.
PubMed ID
4004346 View in PubMed
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8 records – page 1 of 1.