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Caprine arthritis encephalitis and caseous lymphadenitis in goats: use of bulk tank milk ELISAs for herd-level surveillance.

https://arctichealth.org/en/permalink/ahliterature266314
Source
Vet Rec. 2015 Feb 14;176(7):173
Publication Type
Article
Date
Feb-14-2015
Author
G E Nagel-Alne
P S Valle
R. Krontveit
L S Sølverød
Source
Vet Rec. 2015 Feb 14;176(7):173
Date
Feb-14-2015
Language
English
Publication Type
Article
Keywords
Animals
Arthritis-Encephalitis Virus, Caprine - isolation & purification
Corynebacterium Infections - blood - diagnosis - epidemiology - veterinary
Corynebacterium pseudotuberculosis - isolation & purification
Cost-Benefit Analysis
Enzyme-Linked Immunosorbent Assay - veterinary
Female
Goat Diseases - blood - diagnosis - epidemiology
Goats
Lentivirus Infections - blood - diagnosis - epidemiology - veterinary
Lymphadenitis - blood - diagnosis - epidemiology - veterinary
Milk - microbiology - virology
Norway - epidemiology
Population Surveillance - methods
Sensitivity and specificity
Serologic Tests - veterinary
Abstract
The objective of this study was to evaluate the diagnostic performance of two ELISA tests applied to bulk tank milk (BTM) as the first part of a two-step test scheme for the surveillance of caprine arthritis encephalitis (CAE) and caseous lymphadenitis (CLA) infections in goats. The herd-level BTM tests were assessed by comparing them to the test results of individual serological samples. The potential for refining the cut-off levels for BTM tests used as surveillance tools in a population recently cleared of infection was also investigated. Data was gathered on serum (nCAE =9702 and nCLA=13426) and corresponding BTM (nCAE=78 and nCLA=123) samples from dairy goat herds enrolled in the Norwegian disease control and eradication programme 'Healthier Goats'. The results showed that the sensitivity and specificity of the CAE ELISA BTM test with respect to detecting =2 per cent within-herd prevalence were 72.7 per cent and 86.6 per cent, respectively. For the CLA ELISA BTM the sensitivity and specificity were 41.4 per cent and 81.7 per cent, respectively, for the same goal of detection. The results suggest that BTM testing can be applied as a cost-effective first step for early detection of CAE and CLA infection.
PubMed ID
25344573 View in PubMed
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