Great experience with treatment and a comprehensive investigation of the severe combined trauma allowed the authors to choose six basic principles to be followed in diagnosing and treatment of this surgical pathology whose peculiarity is the phenomenon of mutual aggravation of the injuries. Following these principles, especially at surgical hospitals, promotes complete diagnosing, choice of the rational treatment policy in order to avoid medical errors and severe posttraumatic and postshock complications and to improve the outcomes. The authors prove expediency of organization of the multifield specialized centers for treatment of patients with the severe combined traumas.
The article is devoted to the anniversary of Consultation-and-diagnostic outpatient hospital of 442nd District military clinical hospital in Saint-Petersburg. This outpatient hospital was founded in on the 20th March 1938. Work of garrison outpatient hospital was especially difficult during the Great Patriotic War. Employees of this hospital heroically fulfilled their duties in conditions of severe blocade winter 1941-1942. The outpatient hospital was nominally garrison, in fact this hospital operated units of Leningrad front-line. In 1993 the garrison outpatient hospital was renamed as 104th Consultation-and-diagnostic. The main branch of activity is health maintenance of participants in the rectification of the consequences of the accident at the Chernobyl Atomic Electric Power Station and veterans (case follow up) belonging to special risk subunits. Nowadays there are 30 treatment-and-diagnostic departments including staff military physician board.
Polymorphisms in the gene coding for low-density lipoprotein receptor-related protein 5 (LRP5) contribute to variation in bone mass in the general population. Whether this is due to influence on bone mass acquisition or on bone loss thereafter has not been established.
We studied the association of LRP5 polymorphisms with peak bone mass in young men. The study included 235 Finnish men, aged 18.3 to 20.6 years. Lifestyle factors and fracture history were recorded. Bone mineral content (BMC), density (BMD) and scan area were measured for the lumbar spine and proximal femur by dual energy X-ray absorptiometry (DXA). Blood and urine were collected for determination of bone turnover markers, serum 25-OHD and PTH. Genomic DNA was extracted from peripheral blood for genetic analysis of LRP5. Ten single nucleotide polymorphisms in LRP5 were analyzed and correlated with bone parameters.
Only the A1330V polymorphism of LRP5 significantly associated with bone parameters. In comparison with subjects with the AlaAla genotype (n=215), those with AlaVal genotype (n=20) had lower femoral neck BMC (P=0.029) and BMD (P=0.012), trochanter BMC (P=0.0067) and BMD (P=0.015), and total hip BMC (P=0.0044) and BMD (P=0.0089). Fracture history was similar for the genotypes.
The polymorphic valine variant at position 1330 of LRP5 was significantly associated with reduced BMC and BMD values in healthy young Finnish men. The results provide evidence for the crucial role of LRP5 in peak bone mass acquisition.
Respiratory tract infections and pyodermia are typical for personnel doing military service under conscription. Risk of progression of these infections is connected with activation of carry-over of causative agents among military personnel during replacement and decrease in immunity of conscripts. Usage of medication "Karmolis Kapli" for the purpose of prophylaxis allows to reduce cases of respiratory tract infections among the military personnel. Among the military servicemen who had take "Karmolis Kapli" was noted reduction of community-acquired pneumonia, tonsillitis and pyodermia morbidity. Non-specific protective effect of medication "Karmolis Kapli" is conditioned by increase of the common resistance of the body. For the purpose of prophylaxis it is necessary to use this medication during the personnel formation before the beginning of seasonal morbidity.
For determinination of the significance of asymptomatic bacteriuria (AB) among the conscripts in the North was performed a comparative study of 101 volunteers who had no complaints and urinary tract infection (UTI) and a history of 206 patients treated at the stationary UTI. Diagnostically important AB in soldiers was 3% and corresponded to inflammation of the urethra and prostate. Negative impact of subextreme conditions of service in the development of AB from the soldiers in the 12 months has not been established. AB in young men in 27% of such cases was accompanied by leukocyturia, in 36% with bacteriuria, determined by the overall analysis of urine, which is a comprehensive method of identifying the primary UTI.
Flue and other respiratory diseases morbidity of servicemen of training students are researched. Epidemiological and economic effectiveness of flue vaccine "Bakcuspun" (Vaksigrip) is estimated. Its non-specific protective effect in case of acute respiratory diseases and pyodermia is shown.