Skip header and navigation

Refine By

54 records – page 1 of 6.

7-Alkoxyquinoline O-dealkylation by microsomes from human liver and placenta.

https://arctichealth.org/en/permalink/ahliterature64902
Source
Br J Clin Pharmacol. 1992 Nov;34(5):415-20
Publication Type
Article
Date
Nov-1992
Author
J. Hakkola
J. Mäenpää
R T Mayer
S S Park
H V Gelboin
O. Pelkonen
Author Affiliation
Department of Pharmacology and Toxicology, University of Oulu, Finland.
Source
Br J Clin Pharmacol. 1992 Nov;34(5):415-20
Date
Nov-1992
Language
English
Publication Type
Article
Keywords
Animals
Antibodies, Monoclonal - diagnostic use
Benzyl Compounds - metabolism
Cytochrome P-450 Enzyme System - antagonists & inhibitors - metabolism
Dealkylation
Female
Humans
In Vitro
Male
Mice
Mice, Inbred Strains
Microsomes - enzymology - metabolism
Microsomes, Liver - enzymology - metabolism
Placenta - enzymology - metabolism
Pregnancy
Quinolines - metabolism
Rats
Rats, Wistar
Research Support, Non-U.S. Gov't
Smoking - metabolism
Abstract
1. The O-dealkylation of seven 7-alkoxyquinoline derivatives by human hepatic and placental microsomes and the effect of maternal cigarette smoking on placental 7-alkoxyquinoline metabolism was studied. 2. None of several monoclonal antibodies to isoenzymes of cytochrome P450 had a clear effect on metabolism of the compounds by liver microsomes. 3. Maternal cigarette smoking induced the O-dealkylation of all of the 7-alkoxyquinoline derivatives, being greatest for 7-butoxy- and 7-benzyloxyquinoline. 4. Placental 7-alkoxyquinoline metabolism induced by smoking was partially inhibited by the monoclonal antibody 1-7-1 raised against 3-methylcholanthrene-induced rat liver P450. 5. None of the 7-alkoxyquinoline O-dealkylations could be assigned specifically to any known P450 isoenzyme in human liver or placenta.
PubMed ID
1467136 View in PubMed
Less detail

Abstracts of papers presented at the Workshop on Molecular Genetics of the Mouse September 4-6, 1978 at the Institute of Ecology and Genetics University of Aarhus, Denmark.

https://arctichealth.org/en/permalink/ahliterature27637
Source
Hereditas. 1978;89(2):137-50
Publication Type
Conference/Meeting Material
Date
1978

Activation of P2-purino-, alpha 1-adreno and H1-histamine receptors triggers cytoplasmic calcium signalling in cerebellar Purkinje neurons.

https://arctichealth.org/en/permalink/ahliterature11198
Source
Neuroscience. 1996 Aug;73(3):643-7
Publication Type
Article
Date
Aug-1996
Author
S. Kirischuk
V. Matiash
A. Kulik
N. Voitenko
P. Kostyuk
A. Verkhratsky
Author Affiliation
Bogomoletz Institute of Physiology, Kiev, Ukraine.
Source
Neuroscience. 1996 Aug;73(3):643-7
Date
Aug-1996
Language
English
Publication Type
Article
Keywords
Adenosine Triphosphate - pharmacology
Animals
Calcium - metabolism
Cerebellum - drug effects
Dose-Response Relationship, Drug
Epinephrine - pharmacology
Histamine - pharmacology
Mice
Mice, Inbred Strains
Purkinje Cells - drug effects
Receptors, Adrenergic, alpha-1 - drug effects
Receptors, Histamine - drug effects
Receptors, Purinergic - drug effects
Research Support, Non-U.S. Gov't
Abstract
The cytoplasmic calcium concentration ([Ca2+]i) was measured from Purkinje neurons in acutely prepared cerebellar slices. Neurons were loaded with calcium indicator Fura-2 by 40-min slice incubation in Tyrode solution containing 5 microM Fura-2/AM and 0.02% pluronic-F127. Bath applications of ATP (100 microM), epinephrine (10 microM) and histamine (100 microM) triggered a transient increase of [Ca2+]i in Purkinje neurons. ATP-induced [Ca2+]i elevation in Purkinje neurons was mimicked by ADP, but not AMP or adenosine pointing to the involvement of P2Y metabotropic purinoreceptors. Epinephrine-triggered [Ca2+]i responses were blocked by the selective alpha 1-antagonist prazosin and were mimicked by the alpha 1-adrenoreceptor agonist phenylephrine, and were not affected by beta- and alpha 2-adrenoreceptor agonists (isoproterenol and clonidine) and antagonists (propranolol and yohimbine). Histamine-induced [Ca2+]i responses demonstrated specific sensitivity to selective H1 antagonist chlorpheniramine, and were not sensitive to H2 and H3 histamine receptors modulators. The [Ca2+]i responses to all three agonists persisted in Ca(2+)-free extracellular media and were blocked by slice preincubation with thapsigargin (500 nM). We conclude that cerebellar Purkinje neurons are endowed with metabotropic P2 gamma purinoreceptors, alpha 1-adrenoreceptors and H1 histamine receptors which mediate the generation of intracellular [Ca2+]i signals via activation of Ca2+ release from inositol-1,4,5-trisphosphate-sensitive intracellular stores.
PubMed ID
8809785 View in PubMed
Less detail

Autoimmune interstitial nephritis induced in inbred mice. Analysis of mouse tubular basement membrane antigen and genetic control of immune response to it.

https://arctichealth.org/en/permalink/ahliterature57816
Source
Am J Pathol. 1988 Aug;132(2):304-18
Publication Type
Article
Date
Aug-1988
Author
S. Ueda
M. Wakashin
Y. Wakashin
H. Yoshida
R. Azemoto
K. Iesato
T. Mori
Y. Mori
M. Ogawa
K. Okuda
Author Affiliation
First Department of Internal Medicine, School of Medicine, Chiba University, Japan.
Source
Am J Pathol. 1988 Aug;132(2):304-18
Date
Aug-1988
Language
English
Publication Type
Article
Keywords
Animals
Antibodies - analysis
Antibody formation
Antigens - immunology
Autoimmune Diseases - genetics - immunology
Basement Membrane - immunology
Cell Division
Crosses, Genetic
Hybridization, Genetic
Immunization, Passive
Kidney - immunology
Kidney Tubules - immunology
Lymphocytes - immunology - pathology
Mice
Mice, Inbred Strains - genetics - immunology
Nephritis, Interstitial - genetics - immunology
Spleen - immunology - pathology
Abstract
Purified murine tubular basement membrane (TBM) antigen (molecular weight, 32,000) induced interstitial lesions in Brown Norway (BN) rats. TBM antigen prepared from mice of 3 inbred strains--BALB/c, C3H/He, and C57BL/6--and outbred ddY mice possessed both antigenicity and nephritogenecity. Using these TBM antigens, the roles of humoral and cellular immunity in the development of interstitial nephritis (IN) and the genetic control of the induction of IN in inbred mice were investigated. BALB/c mice were highly susceptible to IN and showed a high antibody response and a high lymphocyte proliferative response to syngeneic and allogeneic TBM antigen, whereas C57BL/6 mice did not. C3H/He mice, in which minimal interstitial lesions developed, showed a high antibody response but a low proliferative response of T cells to TBM antigen. TBM antigen sensitized T cells induced interstitial lesions, but anti-TBM antisera did not do so. Thus, the development of IN seemed to be related closely to cellular immunity. Further studies with their hybrids, backcrosses, congenic mice, and recombinant mice suggested that the induction of IN and the immune response to TBM antigen are controlled by 1 or a few dominant genes, whose loci are within, or closely linked to, the H-2 complex.
PubMed ID
3400774 View in PubMed
Less detail

Bacteria associated with crabs from cold waters with emphasis on the occurrence of potential human pathogens.

https://arctichealth.org/en/permalink/ahliterature240526
Source
Appl Environ Microbiol. 1984 May;47(5):1054-61
Publication Type
Article
Date
May-1984
Author
M A Faghri
C L Pennington
L S Cronholm
R M Atlas
Source
Appl Environ Microbiol. 1984 May;47(5):1054-61
Date
May-1984
Language
English
Publication Type
Article
Keywords
Alaska
Animals
Bacteria - classification - isolation & purification - pathogenicity
Brachyura - microbiology - ultrastructure
Humans
Maine
Male
Mice
Mice, Inbred Strains
Microscopy, Electron, Scanning
Oregon
Seawater
Sewage
Washington
Water Microbiology
Abstract
A diverse array of bacterial species, including several potential human pathogens, was isolated from edible crabs collected in cold waters. Crabs collected near Kodiak Island, Alaska, contained higher levels of bacteria than crabs collected away from regions of human habitation. The bacteria associated with the crabs collected near Kodiak included Yersinia enterocolitica, Klebsiella pneumoniae, and coagulase-negative Staphylococcus species; the pathogenicity of these isolates was demonstrated in mice. Although coliforms were not found, the bacterial species associated with the tissues of crabs collected near Kodiak indicate possible fecal contamination that may have occurred through contact with sewage. Compared with surrounding waters and sediments, the crab tissues contained much higher proportions of gram-positive cocci. As revealed by indirect plate counts and direct scanning electron microscopic observations, muscle and hemolymph tissues contained much lower levels of bacteria than shell and gill tissues. After the death of a crab, however, the numbers of bacteria associated with hemolymph and muscle tissues increased significantly. Microcosm studies showed that certain bacterial populations, e.g., Vibrio cholerae, can be bioaccumulated in crab gill tissues. The results of this study indicate the need for careful review of waste disposal practices where edible crabs may be contaminated with microorganisms that are potential human pathogens and the need for surveillance of shellfish for pathogenic microorganisms that naturally occur in marine ecosystems.
Notes
Cites: Appl Microbiol. 1970 Aug;20(2):176-84921056
Cites: Appl Microbiol. 1970 Aug;20(2):179-864921057
Cites: Appl Microbiol. 1971 May;21(5):965-65574329
Cites: J Bacteriol. 1973 Jan;113(1):24-324567138
Cites: Am J Epidemiol. 1974 Dec;100(6):487-984447110
Cites: Appl Microbiol. 1975 Feb;29(2):269-74234715
Cites: Appl Microbiol. 1975 Mar;29(3):388-921090257
Cites: Appl Microbiol. 1975 Mar;29(3):393-91090258
Cites: Appl Microbiol. 1975 Apr;29(4):557-91124924
Cites: Appl Microbiol. 1975 Aug;30(2):251-71164012
Cites: J Clin Microbiol. 1975 Jan;1(1):82-8170303
Cites: Appl Microbiol. 1975 Oct;30(4):625-38811167
Cites: Appl Environ Microbiol. 1976 May;31(5):723-30776085
Cites: Appl Environ Microbiol. 1976 Oct;32(4):527-36825042
Cites: Zentralbl Bakteriol Orig B. 1977 Dec;165(5-6):487-97610254
Cites: Ann Intern Med. 1978 May;88(5):602-6646241
Cites: Appl Environ Microbiol. 1978 May;35(5):829-33350153
Cites: Appl Environ Microbiol. 1979 Jan;37(1):91-103367273
Cites: N Engl J Med. 1980 Feb 7;302(6):305-97350497
Cites: Annu Rev Microbiol. 1980;34:341-677002028
Cites: Annu Rev Microbiol. 1980;34:559-927002032
Cites: Appl Environ Microbiol. 1981 Sep;42(3):484-927294785
Cites: Appl Environ Microbiol. 1982 May;43(5):1080-56896621
Cites: Appl Environ Microbiol. 1982 May;43(5):1092-77103475
Cites: Appl Environ Microbiol. 1982 Sep;44(3):640-67138004
Cites: J Appl Bacteriol. 1982 Aug;53(1):127-97174559
Cites: Appl Environ Microbiol. 1982 Dec;44(6):1404-147159083
Cites: Appl Environ Microbiol. 1982 Dec;44(6):1466-707159088
Cites: Appl Environ Microbiol. 1983 Jun;45(6):1870-66349527
Cites: Appl Microbiol. 1959 Nov;7:388-9213807798
PubMed ID
6742824 View in PubMed
Less detail

Biochemical characterization of endogenous carbohydrate-binding proteins from spontaneous murine rhabdomyosarcoma, mammary adenocarcinoma, and ovarian teratoma.

https://arctichealth.org/en/permalink/ahliterature26699
Source
J Natl Cancer Inst. 1984 Dec;73(6):1349-57
Publication Type
Article
Date
Dec-1984
Author
H J Gabius
R. Engelhardt
S. Rehm
F. Cramer
Source
J Natl Cancer Inst. 1984 Dec;73(6):1349-57
Date
Dec-1984
Language
English
Publication Type
Article
Keywords
Adenocarcinoma - analysis - pathology
Animals
Electrophoresis, Polyacrylamide Gel
Female
Glycoproteins - analysis
Lectins - analysis
Mammary Neoplasms, Experimental - analysis - pathology
Mice
Mice, Inbred Strains
Molecular Weight
Ovarian Neoplasms - analysis - pathology
Rats
Rats, Inbred Strains
Rhabdomyosarcoma - analysis - pathology
Teratoma - analysis - pathology
Abstract
Three entirely different tumor types were investigated biochemically for the presence and characteristics of endogenous carbohydrate-binding proteins in an inbred Brown Norway rat, an outbred Sprague-Dawley rat, and an outbred Han:NMRI mouse. The patterns under investigation included specificities for alpha- and beta-galactosyl, alpha-mannosyl, and alpha-fucosyl moieties, respectively, and specificities for heparin, analyzed by affinity chromatography on resins with immobilized sugars or glycoproteins and polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. The patterns were divided into categories according to dependence of the binding activity on the presence of Ca2+ and dependence on extraction conditions. Rhabdomyosarcoma revealed only Ca2+-independent activities, i.e., activities with specificity for beta-galactosides at a molecular weight of 12,000, with specificity for alpha-galactosides at molecular weights of 29,000, 43,000, and 45,000, with specificity for heparin at molecular weights of 13,000 and 16,000, and with specificities for mannose and fucose at molecular weights ranging from 62,000 to 70,000. For the spontaneous mammary adenocarcinoma the pattern was entirely different and more diverse, including species with the Ca2+ requirement. Extracts with the use of 0.2 M NaCl (salt) and 2% Triton X-100 (detergent) from teratoma contained at least nine different carbohydrate-binding proteins. The only similarities between the pattern of endogenous carbohydrate-binding proteins from teratoma and from mammary adenocarcinoma were beta-galactoside-binding proteins, one with a Ca2+ requirement and one without a Ca2+ requirement, and the heparin-binding proteins. These heparin-binding proteins were the only types of carbohydrate-binding proteins common to all three tumor types. The analysis indicates that certain bands represented newly identified proteins capable of binding to galactose-, mannose- or fucose-containing glycoconjugates, respectively. When assayed with rabbit erythrocytes, the different fractions showed agglutination activity. They can thus be termed "endogenous lectins." The use of endogenous lectin patterns as potential diagnostic markers in addition to the corresponding changes in the glycoconjugate composition is proposed.
PubMed ID
6595444 View in PubMed
Less detail

Biomarkers of aging: correlation of DNA I-compound levels with median lifespan of calorically restricted and ad libitum fed rats and mice.

https://arctichealth.org/en/permalink/ahliterature52833
Source
Mutat Res. 1993 Dec;295(4-6):247-63
Publication Type
Article
Date
Dec-1993
Author
K. Randerath
G D Zhou
R W Hart
A. Turturro
E. Randerath
Author Affiliation
Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030.
Source
Mutat Res. 1993 Dec;295(4-6):247-63
Date
Dec-1993
Language
English
Publication Type
Article
Keywords
Aging - genetics
Animals
DNA - metabolism
Energy intake
Genotype
Kidney - metabolism
Life expectancy
Liver - metabolism
Mice
Mice, Inbred Strains
Nucleotides - metabolism
Rats
Rats, Inbred Strains
Research Support, U.S. Gov't, P.H.S.
Abstract
I-compounds are species-, tissue-, genotype-, gender-, and diet-dependent bulky DNA modifications whose levels increase with animal age. While a few of these DNA modifications represent oxidation products, the majority of I-compounds appear to be derived from as yet unidentified endogenous DNA-reactive intermediates other than reactive oxygen species. Circadian rhythms of certain I-compounds in rodent liver imply that levels of these DNA modifications are precisely regulated. Caloric restriction (CR), the currently most effective method available to retard aging and carcinogenesis, has been previously shown to elicit significant elevations of I-compound levels in tissue DNA from Brown-Norway (BN) and F-344 rats as compared to age-matched ad libitum fed (AL) animals. The present investigation has extended this work by examining liver and kidney DNA I-compound levels in three genotypes of rats (F-344, BN, and F-344 x BN) and two genotypes of mice (C57BL/6N and B6D2F1) under identical experimental conditions in order to determine whether correlations exist between I-compound levels, measured in middle-aged animals, and median lifespan. Levels of a number of liver and kidney I-compounds were found to display genotype- and diet-dependent, statistically significant positive linear correlations with median lifespan in both species. In particular, the longer-lived hybrid F-344 x BN rats and B6D2F1 mice tended to exhibit higher I-compound levels than the parent strains. CR enhanced I-compound levels substantially in both rats and mice. Thus, I-compounds, measured at middle age, reflected the functional capability ('health') of the organism at old age, suggesting their predictive value as biomarkers of aging. The positive linear correlations between levels of certain I-compounds (designated as type I) and lifespan suggest that these modifications may be functionally important and thus not represent endogenous DNA lesions (type II), whose levels would be expected to correlate inversely with lifespan.
PubMed ID
7507561 View in PubMed
Less detail

Characterization of a potential animal model of an idiosyncratic drug reaction: nevirapine-induced skin rash in the rat.

https://arctichealth.org/en/permalink/ahliterature7276
Source
Chem Res Toxicol. 2003 Sep;16(9):1078-89
Publication Type
Article
Date
Sep-2003
Author
Jacintha M Shenton
Munehiro Teranishi
Mones S Abu-Asab
Julie A Yager
Jack P Uetrecht
Author Affiliation
Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Source
Chem Res Toxicol. 2003 Sep;16(9):1078-89
Date
Sep-2003
Language
English
Publication Type
Article
Keywords
Administration, Oral
Animals
CD4 Lymphocyte Count
CD8-Positive T-Lymphocytes - immunology
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Eruptions - etiology
Drug Evaluation, Preclinical - methods
Exanthema - chemically induced - pathology - physiopathology
Female
Food
Forecasting
Hepatomegaly - chemically induced - complications - pathology
Liver - drug effects - pathology - ultrastructure
Macrophages - immunology
Male
Mice
Mice, Inbred Strains
Nevirapine - administration & dosage - adverse effects
Rats
Rats, Inbred Lew
Rats, Sprague-Dawley
Research Support, Non-U.S. Gov't
Skin - drug effects - pathology - ultrastructure
Spleen - cytology - physiopathology - transplantation
Time Factors
Abstract
Idiosyncratic drug reactions are difficult to study in humans due to their unpredictability. Unfortunately, this characteristic also hinders the development of animal models needed for mechanistic studies. Nevirapine, used to treat human immunodeficiency virus (HIV) infections, results in a severe idiosyncratic skin rash in some patients. We found that nevirapine can also cause a significant rash in some strains of rats. At a dose of 150 mg/kg/day, the incidence in female Sprague-Dawley rats was 6/28 (21%), in female Brown Norway rats 32/32 (100%), and in female Lewis rats 0/6 (0%) while no male Sprague-Dawley or Brown Norway rats developed a rash. Female SJL mice 0/7 also did not develop nevirapine-induced skin lesions. The first sign of a reaction in Brown Norway rats was red ears at days 7-10 followed by a rash with scabbing mainly on the back; this was a shorter time to onset than in Sprague-Dawley rats. Light microscopy of the skin revealed a primarily mononuclear inflammatory infiltrate and lesions typical of self-trauma. Immunohistochemistry results suggest that the infiltrate was composed of CD4 and CD8 T cells as well as macrophages. A lower dose of either 40 or 75 mg/kg/day did not lead to a rash and, in fact, 2 weeks of the lower doses induced tolerance to the 150 mg/kg/day dose in female Brown Norway rats. A dose of 100 mg/kg/day resulted in rash in 2/4 (50%) of female Brown Norway rats. Rechallenge of Brown Norway rats that had been allowed to recuperate after a nevirapine-induced rash led to red ears in less than 24 h followed by hair loss and occasional skin lesions. Although the skin rash was less evident on rechallenge, microscopically, the cellular infiltrate was more prominent, especially surrounding the hair follicles. Moreover, there were lesions of interface dermatitis with apoptosis and satellitosis, indicative of a cell-mediated immune attack on the epidermis. While systemic signs of illness did not accompany the rash on primary exposure, on rechallenge, the animals appeared generally unwell and this forced sacrifice after 2 weeks or less of treatment. Importantly, splenocytes isolated from rechallenged animals were able to transfer susceptibility to nevirapine-induced skin rash to naïve female Brown Norway recipients, which was illustrated by a faster time to onset of rash in the recipients. The characteristics of this adverse reaction are similar to that seen in humans; that is, it is idiosyncratic in that it only occurs in some strains of animals, is delayed in onset, is more common in females, is dose-dependent, and appears to be immune-mediated. Therefore, it may represent a good animal model for the study of idiosyncratic drug reactions.
PubMed ID
12971795 View in PubMed
Less detail

Characterization of tick-borne encephalitis virus from Latvia.

https://arctichealth.org/en/permalink/ahliterature49223
Source
J Med Virol. 2000 Feb;60(2):216-22
Publication Type
Article
Date
Feb-2000
Author
V. Mavtchoutko
S. Vene
M. Haglund
M. Forsgren
A. Duks
V. Kalnina
J. Hörling
A. Lundkvist
Author Affiliation
National Environmental Health Centre, Riga, Latvia.
Source
J Med Virol. 2000 Feb;60(2):216-22
Date
Feb-2000
Language
English
Publication Type
Article
Keywords
Animals
Antibodies, Monoclonal
Arvicolinae
Brain - virology
Cercopithecus aethiops
Encephalitis Viruses, Tick-Borne - genetics - immunology - isolation & purification - pathogenicity
Encephalitis, Tick-Borne - immunology - virology
Female
Humans
Latvia
Mice
Mice, Inbred Strains
Phylogeny
RNA, Viral - analysis
Reverse Transcriptase Polymerase Chain Reaction
Sequence Alignment
Serologic Tests
Vero Cells
Viral Envelope Proteins - analysis - genetics - immunology
Virulence
Abstract
Viruses of the tick-borne encephalitis (TBE) antigenic complex, within the family Flaviviridae, cause a variety of diseases including uncomplicated febrile illness, encephalitis, meningo-encephalitis, hemorrhagic fever and chronic disease in humans, domesticated animals or wildlife species. TBE is a serious problem in Latvia with up to a 1,000 patients confirmed serologically annually 1994-1995. No previous data had been reported on the causative agent of TBE in Latvia. In the present study, a virus was isolated from serum of a patient with clinical symptoms of an acute TBE infection. Nucleotide sequence information obtained by direct reverse transcription-polymerase chain reaction (RT-PCR) and the serological characteristics of the isolated virus strain, designated TBE-Latvia-1-96, indicated a closer relationship to the Vasilchenko strain, isolated in Novosibirsk (Siberia, Russia), as compared to the western European or far eastern subtypes of TBE viruses. In a mouse neurovirulence assay, a significant difference in survival rates (days) was shown between Latvia-1-96 and the western European TBE virus subtype.
PubMed ID
10596024 View in PubMed
Less detail

54 records – page 1 of 6.