Skip header and navigation

Refine By

11 records – page 1 of 2.

Comparative analysis of genomes of tick-borne encephalitis virus strains isolated from mosquitoes and ticks.

https://arctichealth.org/en/permalink/ahliterature289442
Source
Vopr Virusol. 2017; 62(1):30-5
Publication Type
Comparative Study
Journal Article
Author
N M Pukhovskaya
Olga V Morozova
N B Belozerova
S V Bakhmetyeva
N P Vysochina
N I Zdanovskaya
L I Ivanov
Source
Vopr Virusol. 2017; 62(1):30-5
Language
English
Publication Type
Comparative Study
Journal Article
Keywords
Aedes - virology
Amino Acid Sequence
Animals
Animals, Newborn
Disease Vectors
Dogs
Encephalitis Viruses, Tick-Borne - classification - genetics - isolation & purification
Encephalitis, Tick-Borne - epidemiology - transmission - virology
Far East - epidemiology
Genome, Viral
Genotype
Humans
Ixodes - virology
Mice
Mice, Inbred ICR
Nucleic Acid Conformation
Phylogeny
RNA, Viral - chemistry - genetics - isolation & purification
Rodentia - virology
Sequence Alignment
Sequence Homology, Amino Acid
Siberia - epidemiology
Abstract
The tick-borne encephalitis virus (TBEV) strain Lazo MP36 was isolated from the pool of mosquitoes Aedes vexans collected in Lazo region of Khabarovsk territory in August 2014. Phylogenetic analysis of the strain Lazo MP36 complete genome (GenBank accession number KT001073) revealed its correspondence to the TBEV Far Eastern subtype and differences from the following strains: 1) from ticks Ixodes persulcatus P. Schulze, 1930 [vaccine strain 205 (JX498939) and strains Khekhtzir 1230 (KF880805), Chichagovka (KP844724), Birobidzhan 1354 (KF880805) isolated in 2012-2013]; 2) from mosquitoes [strain Malyshevo (KJ744034) isolated in 1978 from Aedes vexans nipponii in Khabarovsk territory; strain Sakhalin 6-11 isolated from the pool of mosquitoes in 2011 (KF826916)]; 3) from human brain [vaccine strain Sofjin (JN229223), Glubinnoe/2004(DQ862460). Kavalerovo (DQ862460), Svetlogorie (DQ862460)]. The fusion peptide necessary for flavivirus entry to cells of the three TBEV strains isolated from mosquitoes (Lazo MP36, Malyshevo and Sakhalin 6-11) has the canonical structure 98-DRGWGNHCGLFGKGSI-113 for the tick-borne flaviviruses. Amino acid transition H104G typical for the mosquito-borne flaviviruses was not found. Structures of 5’- and 3’-untranslated (UTR) regions of the TBEV strains from mosquitoes were 85-98% homologous to the TBEV strains of all subtypes without recombination with mosquito-borne flaviviruses found in the Far East of Russia. Secondary structures of 5’- and 3'-UTR as well as cyclization sequences (CS) of types a and B are highly homologous for all TBEV isolates independently of the biological hosts and vectors. similarity of the genomes of the TBEV isolates from mosquitoes, ticks and patients as well as pathogenicity of the isolates for new-borne laboratory mice and tissue cultures might suggest a possible role of mosquitoes in the TBEV circulation in natural foci as an accidental or additional virus carrier.
PubMed ID
29323844 View in PubMed
Less detail

Comparative analysis of genomes of tick-borne encephalitis virus strains isolated from mosquitoes and ticks.

https://arctichealth.org/en/permalink/ahliterature289600
Source
Vopr Virusol. 2017; 62(1):30-5
Publication Type
Comparative Study
Journal Article
Author
N M Pukhovskaya
Olga V Morozova
N B Belozerova
S V Bakhmetyeva
N P Vysochina
N I Zdanovskaya
L I Ivanov
Source
Vopr Virusol. 2017; 62(1):30-5
Language
English
Publication Type
Comparative Study
Journal Article
Keywords
Aedes - virology
Amino Acid Sequence
Animals
Animals, Newborn
Disease Vectors
Dogs
Encephalitis Viruses, Tick-Borne - classification - genetics - isolation & purification
Encephalitis, Tick-Borne - epidemiology - transmission - virology
Far East - epidemiology
Genome, Viral
Genotype
Humans
Ixodes - virology
Mice
Mice, Inbred ICR
Nucleic Acid Conformation
Phylogeny
RNA, Viral - chemistry - genetics - isolation & purification
Rodentia - virology
Sequence Alignment
Sequence Homology, Amino Acid
Siberia - epidemiology
Abstract
The tick-borne encephalitis virus (TBEV) strain Lazo MP36 was isolated from the pool of mosquitoes Aedes vexans collected in Lazo region of Khabarovsk territory in August 2014. Phylogenetic analysis of the strain Lazo MP36 complete genome (GenBank accession number KT001073) revealed its correspondence to the TBEV Far Eastern subtype and differences from the following strains: 1) from ticks Ixodes persulcatus P. Schulze, 1930 [vaccine strain 205 (JX498939) and strains Khekhtzir 1230 (KF880805), Chichagovka (KP844724), Birobidzhan 1354 (KF880805) isolated in 2012-2013]; 2) from mosquitoes [strain Malyshevo (KJ744034) isolated in 1978 from Aedes vexans nipponii in Khabarovsk territory; strain Sakhalin 6-11 isolated from the pool of mosquitoes in 2011 (KF826916)]; 3) from human brain [vaccine strain Sofjin (JN229223), Glubinnoe/2004(DQ862460). Kavalerovo (DQ862460), Svetlogorie (DQ862460)]. The fusion peptide necessary for flavivirus entry to cells of the three TBEV strains isolated from mosquitoes (Lazo MP36, Malyshevo and Sakhalin 6-11) has the canonical structure 98-DRGWGNHCGLFGKGSI-113 for the tick-borne flaviviruses. Amino acid transition H104G typical for the mosquito-borne flaviviruses was not found. Structures of 5’- and 3’-untranslated (UTR) regions of the TBEV strains from mosquitoes were 85-98% homologous to the TBEV strains of all subtypes without recombination with mosquito-borne flaviviruses found in the Far East of Russia. Secondary structures of 5’- and 3'-UTR as well as cyclization sequences (CS) of types a and B are highly homologous for all TBEV isolates independently of the biological hosts and vectors. similarity of the genomes of the TBEV isolates from mosquitoes, ticks and patients as well as pathogenicity of the isolates for new-borne laboratory mice and tissue cultures might suggest a possible role of mosquitoes in the TBEV circulation in natural foci as an accidental or additional virus carrier.
PubMed ID
29323844 View in PubMed
Less detail

FOXA transcription factors determine the amplitude of glucocorticoid induction of tyrosine aminotransferase in mice.

https://arctichealth.org/en/permalink/ahliterature92613
Source
Bull Exp Biol Med. 2007 Nov;144(5):722-4
Publication Type
Article
Date
Nov-2007
Author
Bryzgalov L O
Ershov N I
Ilnitskaya S I
Author Affiliation
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk. leon_l@ngs.ru
Source
Bull Exp Biol Med. 2007 Nov;144(5):722-4
Date
Nov-2007
Language
English
Publication Type
Article
Keywords
Animals
Enzyme Activation - drug effects
Forkhead Transcription Factors - metabolism
Glucocorticoids - pharmacology
Liver - drug effects - metabolism - pathology
Liver Neoplasms - chemically induced - metabolism
Methyldimethylaminoazobenzene
Mice
Mice, Inbred ICR
Protein Binding - drug effects
Time Factors
Tyrosine Transaminase - metabolism
o-Aminoazotoluene
Abstract
o-Aminoazotoluene was more potent than 3'-methyl-4-dimethylaminoazobenzene in modulating glucocorticoid induction of tyrosine aminotransferase and DNA-binding activity of FOXA (HNF3) in 12-day-old ICR mice. In adult animals, induction of tyrosine aminotransferase and FOXA activity were modulated by o-aminoazotoluene, while 3'-methyl-4-dimethylaminoazobenzene was ineffective. Our results suggest that FOXA proteins determine glucocorticoid induction of tyrosine aminotransferase in mice (similarly to rats).
PubMed ID
18683506 View in PubMed
Less detail

Growth inhibition of Streptococcus mutans by cellular extracts of human intestinal lactic acid bacteria.

https://arctichealth.org/en/permalink/ahliterature238376
Source
Infect Immun. 1985 Sep;49(3):692-4
Publication Type
Article
Date
Sep-1985
Author
K. Ishihara
H. Miyakawa
A. Hasegawa
I. Takazoe
Y. Kawai
Source
Infect Immun. 1985 Sep;49(3):692-4
Date
Sep-1985
Language
English
Publication Type
Article
Keywords
Animals
Bacteria - pathogenicity
Bacterial Physiological Phenomena
Hot Temperature
Humans
Intestines - microbiology
Lactates - metabolism
Lactic Acid
Lactobacillus - physiology
Male
Mice
Mice, Inbred ICR
Saliva - physiology
Streptococcus mutans - growth & development
Abstract
The in vitro growth of Streptococcus mutans was completely inhibited by water-soluble extracts from cells of various intestinal lactic acid bacteria identified as Streptococcus faecium, Streptococcus equinus, Lactobacillus fermentum, and Lactobacillus salivarius. The growth inhibition was dependent on the concentrations of the extracts. In contrast, the extracts did not inhibit the growth of the major indigenous intestinal lactic acid bacteria isolated from humans. These lactic acid bacteria were not acutely toxic in mice.
Notes
Cites: Nihon Saikingaku Zasshi. 1969 Jun;24(6):261-804898422
Cites: Infect Immun. 1975 Dec;12(6):1375-851107225
Cites: J Bacteriol. 1963 Dec;86:1275-8214086101
Cites: Infect Immun. 1982 Mar;35(3):861-87068219
Cites: J Infect Dis. 1962 May-Jun;110:258-6713889379
Cites: J Med Microbiol. 1975 Nov;8(4):491-501812997
PubMed ID
4030098 View in PubMed
Less detail

[Mechanisms and frequency of nuclear divisions in trophoblast and decidua cells during postimplantation embryogenesis in the mouse]

https://arctichealth.org/en/permalink/ahliterature63421
Source
Ontogenez. 2003 Nov-Dec;34(6):472-7
Publication Type
Article
Author
G K Isakova
T E Skvortsova
Author Affiliation
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, pr. Lavrent'eva 10, Novosibirsk, 630090, Russia.
Source
Ontogenez. 2003 Nov-Dec;34(6):472-7
Language
Russian
Publication Type
Article
Keywords
Animals
Cell Division - physiology
Cell Nucleus - physiology
Cells, Cultured
Decidua - cytology - physiology
Embryonic Development - physiology
Embryonic and Fetal Development
English Abstract
Female
Mice
Mice, Inbred ICR
Mitosis
Pregnancy
Trophoblasts - cytology - physiology
Abstract
The finding of amitotic division of trophoblast cell nuclei in blastocysts of the American mink (Mustela vison), which has an obligatory period of delay in implantation (obligatory embryonic diapause) in its ontogenesis, led us to study the mechanisms and frequencies of division of trophoblast and decidua cell nuclei during the postimplantation embryogenesis of mouse (Mus musculus), which does not exhibit an obligatory diapause nor amitosis in blastocysts. It has been established that the main mechanism underlying the cell nuclei division in both tissues (trophoblast and decidua) forming the placenta is amitosis. These data suggest that the occurrence of an obligatory embryonic diapause in ontogenesis of certain animal species is related not only to the delay in implantation, but also to the alteration in the chronology of all processes of embryogenesis.
PubMed ID
14714456 View in PubMed
Less detail

Mechanisms of cell number regulation in the peri-implantation mouse blastocyst.

https://arctichealth.org/en/permalink/ahliterature64425
Source
J Exp Zool. 1996 Oct 15;276(3):201-8
Publication Type
Article
Date
Oct-15-1996
Author
S V Evsikov
I N Vagyna
A P Solomko
Author Affiliation
Department of Biochemical Genetics, National Academy of Sciences of the Ukraine, Kiev, Ukraine.
Source
J Exp Zool. 1996 Oct 15;276(3):201-8
Date
Oct-15-1996
Language
English
Publication Type
Article
Keywords
Animals
Blastocyst - cytology - physiology
Cell Survival
Embryo Implantation
Fallopian Tubes
Female
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred ICR
Morula - cytology - physiology
Pregnancy
Pseudopregnancy
Research Support, Non-U.S. Gov't
Superovulation
Time Factors
Abstract
Low viability of manipulated or in vitro cultured is caused primarily by the reduced cell number in the implanting blastocysts. In order to investigate the effect of implantation delay on embryo viability and cell number, mouse blastocysts were transferred into oviducts of day 0 pseudopregnant females. This type of transfer improved embryo survival rates, indicating that embryos retarded by in vitro culture restored their viability during 3 days of delayed implantation. Our results showed that even in the cases when the initial cell count was as low as 28.2 +/- 0.7 cells per blastocyst (vs 60.5 +/- 1.4 cells in the control blastocysts, developed in vivo), implantation delay increased this number to 107.2 +/- 3.5 cells (control blastocysts had at this stage on average 111.0 +/- 3.7 cells). Half-blastocysts, developed from the single blastomeres of the 2-cell embryos or from experimentally produced tetraploids, had around 50 cells after 3 days of implantation delay. This indicates that the start of blastocyst dormancy is triggered during the eighth cell cycle and independent of the absolute cell number or the number cytokineses. Implantation-delayed blastocysts, developed from the half-embryos with the doubled volume of cytoplasm, had on average 70.5 +/- 2.4 cells, suggesting that embryo fall into quiescence is also dependent upon the attainment of a definite nucleo-cytoplasmic ratio. We conclude that blastocyst readiness for implantation is determined by two factors: number of cell cycles and nucleo-cytoplasmic ratio.
PubMed ID
8914279 View in PubMed
Less detail

Methoxychlor given in the periimplantation period blocks sexual arousal in male mice.

https://arctichealth.org/en/permalink/ahliterature64020
Source
Reprod Toxicol. 1999 Sep-Oct;13(5):405-11
Publication Type
Article
Author
S Y Amstislavsky
T G Amstislavskaya
V P Eroschenko
Author Affiliation
Novosibirsk State University, Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Division.
Source
Reprod Toxicol. 1999 Sep-Oct;13(5):405-11
Language
English
Publication Type
Article
Keywords
Animals
Arousal - drug effects - physiology
Embryo Implantation
Estradiol - toxicity
Female
Fertility - drug effects - physiology
Insecticides - toxicity
Litter Size - drug effects
Male
Methoxychlor - toxicity
Mice
Mice, Inbred ICR
Paternal Exposure - adverse effects
Pregnancy
Prenatal Exposure Delayed Effects
Research Support, Non-U.S. Gov't
Sex Behavior, Animal - drug effects - physiology
Testosterone - blood
Abstract
To determine whether pesticide methoxychlor (MXC) alters sexual arousal in male offspring, pregnant ICR mice remained untreated or received daily subcutaneous injections (s.c.) of olive oil, 33.0 mg/kg bw purified (95%) MXC, or 0.33 mg/kg bw estradiol-173 in vehicle on Days 5 to 7 of pregnancy. Live births were recorded in all groups except the estradiol group. At 4 months, untreated or olive oil-treated male offspring exhibited normal sexual arousal. When placed near a plastic partition with an estrus female behind it, these males spent significantly more time near the partition than near a vacant half of the cage and exhibited a sharp increase in plasma testosterone. MXC-exposed males showed no sexual arousal, spent much less time near the partition with an estrus female, and exhibited significantly lower plasma testosterone levels. Exposure to purified MXC close to implantation alters the function of the hypothalamic-pituitary-testicular axis and compromises male sexual behavior in offspring.
PubMed ID
10560590 View in PubMed
Less detail

Preimplantation mouse embryo development as a target of the pesticide methoxychlor.

https://arctichealth.org/en/permalink/ahliterature63581
Source
Reprod Toxicol. 2003 Jan-Feb;17(1):79-86
Publication Type
Article
Author
Sergei Y Amstislavsky
Elena A Kizilova
Victor P Eroschenko
Sergei Y Amstislavksy
Author Affiliation
Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Division, Novosibirsk State University, Novosibirsk, Russia.
Source
Reprod Toxicol. 2003 Jan-Feb;17(1):79-86
Language
English
Publication Type
Article
Keywords
Abnormalities, Drug-Induced
Animals
Blastocyst - drug effects - pathology
Cell Nucleus - drug effects - pathology
Dose-Response Relationship, Drug
Embryonic Development - physiology
Embryonic and Fetal Development - drug effects
Estradiol - administration & dosage - toxicity
Female
Injections, Subcutaneous
Insecticides - administration & dosage - toxicity
Male
Methoxychlor - administration & dosage - toxicity
Mice
Mice, Inbred ICR
Micronuclei, Chromosome-Defective - drug effects - pathology
Pregnancy
Research Support, Non-U.S. Gov't
Abstract
Effects of methoxychlor (MXC) and estradiol-17beta (E) were studied in mouse preimplantation embryos. Pregnant mice received s.c. injections of sesame oil only, 10 microg E, or 0.5 mg purified (95%) MXC on Days 2-4 of pregnancy (plug = Day 1). Another group received a single dose of 2.5 microg E on Day 2 only. Based on the average weight of pregnant females, 10 microg of estradiol was equivalent to 0.33 mg/kg of bw, 2.5 microg of estradiol was equivalent to 0.082 mg/kg of bw, and the 0.5-mg dose of MXC was equivalent to 16.5 mg/kg of bw. All embryos were collected for analyses on Day 4. MXC and both estradiol-17beta doses suppressed embryonic development to blastocyst, decreased embryo cell numbers, and caused abnormal blastocyst formation. The high estradiol-17beta dose significantly increased the percent degenerating embryos and caused a tube-locking effect, with retention of embryos in the oviduct. In contrast to estradiol-17beta, MXC at the dose used in this study did not alter tubal transport of embryos. Also in contrast to estradiol-17beta, MXC increased the percentage of nuclear fragmentation and micronuclei. In preimplantation embryos, MXC and estradiol-17beta both suppressed embryo development. MXC effects were, however, different from those of estradiol-17beta, indicating a difference in mechanism of action, possibly due to cytotoxicity and induction of apoptosis.
Notes
Erratum In: Reprod Toxicol. 2003 May-Jun;17(3):359Amstislavksy Sergei Y [corrected to Amstislavsky Sergei Y]
PubMed ID
12507662 View in PubMed
Less detail

Promoting effect of o-aminoazotoluene on hepatocarcinogenesis is accompanied by the increase in inflammatory and proliferative processes in liver tissue and decrease in the concentration of free thyroxin in the blood.

https://arctichealth.org/en/permalink/ahliterature91640
Source
Bull Exp Biol Med. 2007 Dec;144(6):821-4
Publication Type
Article
Date
Dec-2007
Author
Baginskaya N V
Il'nitskaya S I
Nikitenko E V
Kaledin V I
Author Affiliation
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk. bagin@bionet.nsc.ru
Source
Bull Exp Biol Med. 2007 Dec;144(6):821-4
Date
Dec-2007
Language
English
Publication Type
Article
Keywords
Animals
Carcinogens - pharmacology
Carcinoma, Hepatocellular - chemically induced
Cell Proliferation - drug effects
Diethylnitrosamine
Female
Inflammation - chemically induced
Liver - pathology
Liver Neoplasms - chemically induced
Mice
Mice, Inbred ICR
Thyroxine - blood
o-Aminoazotoluene - pharmacology
Abstract
o-Aminoazotoluene in noncarcinogenic doses promoted the development of liver tumors in female ICR mice induced by administration of diethylnitrosamine during early ontogeny. Severe inflammatory infiltration and proliferation of oval cells were found in liver tissue of these animals. The concentration of free thyroxin decreased in the blood. Our results supplement published data that promoters of hepatocarcinogenesis inhibit thyroid function.
PubMed ID
18856210 View in PubMed
Less detail

Schistosome cercariae as the causative agent of swimmer's itch in Iceland.

https://arctichealth.org/en/permalink/ahliterature33110
Source
J Helminthol. 1999 Sep;73(3):215-20
Publication Type
Article
Date
Sep-1999
Author
L. Kolárová
K. Skirnisson
P. Horák
Author Affiliation
Department of Tropical Medicine, Charles University, Faculty Hospital Bulovka, Prague, Czech Republic. lkolar@lfl.cuni.cz
Source
J Helminthol. 1999 Sep;73(3):215-20
Date
Sep-1999
Language
English
Publication Type
Article
Keywords
Animals
Child
Dermatitis - parasitology
Humans
Iceland
Lymnaea - parasitology
Mice
Mice, Inbred ICR
Pruritus - parasitology
Research Support, Non-U.S. Gov't
Schistosoma - anatomy & histology - isolation & purification
Schistosomiasis - parasitology - pathology
Skin Diseases, Parasitic - parasitology - pathology
Swimming
Abstract
During late summer in 1995 to 1997, repeated outbreaks of maculopapular skin eruptions were noted on the legs of children after wading in the pond in the Family Park in Laugardalur, Reykjavík, Iceland. Clinical symptoms developing on the legs resembled those of cercarial dermatitis. An examination of Lymnaea peregra snails from this pond and from the adjacent Lake Tjornin resulted in detection of previously undescribed schistosome cercariae. This is the first report of schistosomes in Iceland and also the most northern occurrence of these parasites in Europe.
PubMed ID
10526413 View in PubMed
Less detail

11 records – page 1 of 2.