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[Activation of dopaminergic system stimulates an immune response in mice with opposite type of behaviour]

https://arctichealth.org/en/permalink/ahliterature57436
Source
Ross Fiziol Zh Im I M Sechenova. 2002 Nov;88(11):1394-400
Publication Type
Article
Date
Nov-2002
Author
G V Idova
M A Cheido
E N Zhukova
L V Devoino
Author Affiliation
Institute of Physiology of the Russian Acad. Med. Sci., Siberian Branch, 4 Timakov St., Novosibirsk 630117, Russia.
Source
Ross Fiziol Zh Im I M Sechenova. 2002 Nov;88(11):1394-400
Date
Nov-2002
Language
Russian
Publication Type
Article
Keywords
Aggression - physiology
Animals
Behavior, Animal - physiology
Conditioning, Classical - physiology
Dopamine Agonists - pharmacology
English Abstract
Escape Reaction - physiology
Immunization
Male
Mice
Mice, Inbred CBA
Neuroimmunomodulation - immunology - physiology
Receptors, Dopamine - immunology - metabolism - physiology
Rosette Formation
Spleen - cytology - immunology
Abstract
It was shown that activation of dopaminergic (Daergic) system induced an increase of the immune responsiveness independent of the CBA mice behaviour typeanimals without experience of victories and defeats (control), with aggression and submission. Administration of SKF-38393, a selective agonist of DA D1-receptors, resulted in enhanced immune response as tested by plaque-forming cells and rosette-forming cells number. Similar immunostimulation was observed after injection of p-chlorophenylalanine realizing its influence on the immune response through DA D2-receptors as shown by us elsewhere. It was suggested that activation of Da-ergic system produces a new neurochemical pattern (Daergic neurochemical set) which are responsible for character and intensity changes of the immune response in mice with alternative form of social behaviour.
PubMed ID
12587267 View in PubMed
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Activity and concentration of cathepsin B as prognostic criteria for the development of mouse LS lymphosarcoma and Lewis lung adenocarcinoma.

https://arctichealth.org/en/permalink/ahliterature18997
Source
Bull Exp Biol Med. 2002 Apr;133(4):392-5
Publication Type
Article
Date
Apr-2002
Author
T A Korolenko
S Ya Zhyanaeva
O N Poteryaeva
O V Falameeva
O A Levina
V I Kaledin
I. Shandula
Author Affiliation
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. T.A.Korolenko@iph.ma.ru
Source
Bull Exp Biol Med. 2002 Apr;133(4):392-5
Date
Apr-2002
Language
English
Publication Type
Article
Keywords
Animals
Carcinoma, Lewis Lung - enzymology - pathology
Cathepsin B - metabolism
Liver - enzymology
Lymphoma, Diffuse - enzymology - pathology
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Prognosis
Spleen - enzymology
Tumor Markers, Biological - metabolism
Abstract
We measured activity and content of cathepsin B in tumor tissues, liver, and spleen in mice with Lewis adenocarcinoma and LS-lymphosarcoma. Cathepsin B activity in Lewis adenocarcinoma cells was lower than in LS-lymphosarcoma cells, which was probably related to differences in their metastatic properties. Antitumor therapy increased activity and content of cathepsin B in tumor tissues. Changes in the content and activity of cathepsin B in tumor tissues can serve as a prognostic criterion for tumor regression during therapy. Cathepsin B is probably involved in apoptosis of tumor cells during chemotherapy of lymphosarcoma-LS with cyclophosphamide.
PubMed ID
12124655 View in PubMed
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[Activity and induction of CYP2B, CYP2C, and CYP3A in tissues of cyclophosphane-sensitive and resistant neoplasms and the liver of neoplasm-carrying mice]

https://arctichealth.org/en/permalink/ahliterature18154
Source
Biomed Khim. 2003 Jan-Feb;49(1):27-34
Publication Type
Article
Author
A Iu Grishanov
V I Kaledin
T V Zueva
E K Nekhoroshkova
V P Nikolin
V V Liakhovich
Author Affiliation
Institute of Molecular Biology and Biophysics, Siberian Branch of Russian Academy of Medical Sciences, Timakova str., 2, Novosibirsk, 630117, Russia. agrish@cyber.ma.nsc.ru
Source
Biomed Khim. 2003 Jan-Feb;49(1):27-34
Language
Russian
Publication Type
Article
Keywords
Animals
Antineoplastic Agents - pharmacology - therapeutic use
Aryl Hydrocarbon Hydroxylases - biosynthesis - metabolism
Cyclophosphamide - pharmacology - therapeutic use
Cytochrome P-450 CYP2B1 - biosynthesis - metabolism
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System - biosynthesis - metabolism
Drug Resistance, Neoplasm
English Abstract
Enzyme Induction
Liver Neoplasms - drug therapy - enzymology
Lymphoma, Diffuse - drug therapy - enzymology
Male
Mice
Mice, Inbred CBA
Microsomes - enzymology
Neoplasm Transplantation
Oxidoreductases, N-Demethylating - biosynthesis - metabolism
Abstract
The activities of three cytochrome P450 families involved in metabolic transformation of cyclophosphamide (CP) (CYP2B and CYP2C responsible for metabolic activation of CP and CYP3A responsible for inactivation of CP) have been investigated in lymphosarcoma and liver microsomes of tumor-bearing CBA mice. Two strains of mouse lymphosarcoma distinguished by their sensitivity to cytostatic action of CP were used in this study for implantation in mice femur muscle. There was certain relationship between CP resistance of lymphosarcoma and tumor P450s activity. CYP2B, CYP2C and CYP3A activities in the CP sensitive tumor were comparable to those in liver, and CYP2B, CYP2C were induced by phenobarbital and dexamethasone. CYP2B and CYP2C in the CP resistant tumor were inactive and only slightly induced by dexamethasone. CYP3A activity was lower than in LS tumor and unchanged during drug treatment. Implantation of LS and RLS tumor in mice caused different effects on P450 activities. LS insignificantly influenced liver CYP2B, CYP2C and CYP3A activities and their inducibility by phenobarbital and dexamethasone was similar to that obtained in liver of mice without tumor. At the same time, CYP2B and CYP2C activity in liver of RLS-bearing mice were essentially reduced, the activity CYP3A remained unchanged, and inducibility of CYP2B, CYP2C and CYP3A by phenobarbital and dexamethasone was similar to that in liver of mice without tumor. These results prove the role of cytochromes P450 activating CP in formation drug resistant phenotype of mice lymphosarcoma and suggest possibility of overcoming of this resistance using cytochrome P450 inducers.
PubMed ID
14569871 View in PubMed
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Activity of lysosomal enzymes in the bile and serum of mice with intrahepatic cholestasis.

https://arctichealth.org/en/permalink/ahliterature90427
Source
Bull Exp Biol Med. 2008 May;145(5):560-3
Publication Type
Article
Date
May-2008
Author
Korolenko T A
Savchenko N G
Yuz'ko Ju V
Alexeenko T V
Sorochinskaya N V
Author Affiliation
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. t.a.korolenko@iph.ma.nsc.ru
Source
Bull Exp Biol Med. 2008 May;145(5):560-3
Date
May-2008
Language
English
Publication Type
Article
Keywords
1-Naphthylisothiocyanate - toxicity
Alkaline Phosphatase - blood - metabolism
Animals
Bile - enzymology
Cholestasis, Intrahepatic - blood - chemically induced - enzymology
Cholesterol - biosynthesis - blood
Hexosaminidases - blood - metabolism
Lysosomes - enzymology
Male
Mice
Mice, Inbred CBA
Polyethylene Glycols - toxicity
beta-Galactosidase - blood - metabolism
beta-N-Acetylhexosaminidases - blood - metabolism
gamma-Glutamyltransferase - blood - metabolism
Abstract
Lysosomal enzyme activity in the bile and blood serum was compared in mice with experimental intrahepatic cholestasis induced by alpha-naphthyl isothiocyanate and Triton WR 1339. Triton WR 1339 increases the synthesis of cholesterol (fatty acid precursor) in liver cells. The development of intrahepatic cholestasis was confirmed by the increase in activities of alkaline phosphatase and gamma-glutamyltransferase in blood serum. Administration of Triton WR 1339 in a dose of 100 mg/100 g was followed by a 10-fold increase in beta-galactosidase activity (hepatocyte lysosomal enzyme) in the bile, but not in the serum of mice. beta-Galactosidase activity significantly increased in the bile, but decreased in the serum of mice after treatment with a-naphthyl isothiocyanate in a dose of 200 mg/kg. Our results indicate that intrahepatic cholestasis is manifested in increased secretion of lysosomal glycosidases into the bile. Bile components can aggravate damage to liver cells by affecting the processes of hepatocyte apoptosis and necrosis.
PubMed ID
19145281 View in PubMed
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Activity of sympathoadrenal system and myelokaryocyte death during aging in AKR/JY mice.

https://arctichealth.org/en/permalink/ahliterature20209
Source
Bull Exp Biol Med. 2000 Jun;129(6):519-21
Publication Type
Article
Date
Jun-2000
Author
I A Khlusov
L A Stavrova
T I Fomina
T A Luk'yanova
A M Dygai
E D Gol'dberg
Author Affiliation
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Source
Bull Exp Biol Med. 2000 Jun;129(6):519-21
Date
Jun-2000
Language
English
Publication Type
Article
Keywords
Adrenal Medulla - metabolism
Aging
Animals
Apoptosis - physiology
Bone Marrow Cells - cytology - pathology
Catecholamines - metabolism
Cell Survival
Female
Leukemia - metabolism - pathology
Mice
Mice, Inbred AKR
Mice, Inbred CBA
Statistics, nonparametric
Stress
Abstract
Accelerated bone marrow cell death and activation of the sympathoadrenal system were observed during aging of highly leukemic 2-7-month-old AKR/JY mice compared to that in (CBA/CaLacxAKR/JY)F1 strain. Close correlation was revealed between activity of the sympathoadrenal system and necrotic and apoptotic forms of cell death. This can promote tumor process, because maximum changes in hemopoietic cells occur during advanced stage of the disease.
PubMed ID
11022236 View in PubMed
Less detail

Adrenergic regulation of erythropoiesis during cytostatic-induced myelosuppressions.

https://arctichealth.org/en/permalink/ahliterature88844
Source
Bull Exp Biol Med. 2008 Oct;146(4):405-10
Publication Type
Article
Date
Oct-2008
Author
Skurikhin E G
Pershina O V
Minakova M Yu
Ermakova N N
Firsova T V
Dygai A M
Gol'dberg E D
Author Affiliation
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
Source
Bull Exp Biol Med. 2008 Oct;146(4):405-10
Date
Oct-2008
Language
English
Publication Type
Article
Keywords
Animals
Bone Marrow - drug effects - metabolism
Cell Differentiation - drug effects
Cell Proliferation - drug effects
Central Nervous System - drug effects - physiology
Cyclophosphamide - pharmacology
Cytostatic Agents - pharmacology
Erythroid Precursor Cells - cytology - drug effects
Erythropoiesis - drug effects
Erythropoietin - metabolism
Female
Fluorouracil - pharmacology
Hematopoiesis - drug effects - physiology
Mice
Mice, Inbred CBA
Norepinephrine - pharmacology
S Phase
Abstract
The role of central adrenergic structures in the regulation of the erythroid hematopoietic stem was studied during administration of cyclophosphamide and 5-fluorouracil. The central nervous system contributed to suppression of erythropoiesis during cytostatic treatment. The suppressive effect of brain adrenergic structures on the erythron after treatment with cyclophosphamide and 5-fluorouracil was related to dysfunction of adherent cells in the hemopoiesis-inducing microenvironment (formation of hemopoietic islets and secretion of erythropoietic activity) and production of growth factors by myelokaryocytes, respectively. Brain norepinephrine had an inhibitory effect on proliferative activity and differentiation of erythroid precursors that were associated with the erythropoietin and peripheral alpha-adrenergic structures. However, stimulation of beta-adrenergic structures was followed by an increase in the rate of erythroid cell maturation.
PubMed ID
19489307 View in PubMed
Less detail

[Age-related characteristics of the melatonin-producing epiphyseal function in CBA mice immunized by T-dependent antigen]

https://arctichealth.org/en/permalink/ahliterature57367
Source
Fiziol Zh. 2005;51(4):45-50
Publication Type
Article
Date
2005
Author
I F Labunets'
Source
Fiziol Zh. 2005;51(4):45-50
Date
2005
Language
Ukrainian
Publication Type
Article
Keywords
Aging - immunology - metabolism
Animals
Antigens - immunology
Corticosterone - metabolism
English Abstract
Female
Immunization
Melatonin - metabolism
Mice
Mice, Inbred CBA
Pineal Gland - immunology - metabolism
T-Lymphocytes - immunology
Thymic Factor, Circulating - metabolism
Time Factors
Abstract
It was investigated both melatonin blood level in the adult and old CBA-mice after immunization by sheep erythrocytes and the link between thymus and adrenal glands function in the old immunizated mice with high melatonin content in the pineal gland. It has been revealed that in the adult mice blood melatonin level was influenced by the phase changes in dynamic of immunization, namely raised significantly in 20 min with following suppression after 3 hrs and rehabilitation up to normal in 4 days. In the old mice fluctuations of melatonin level were impaired and characterized by gradually decrease in dynamics of immunization. The increase of melatonin content in pineal gland by administration of epithalamine improved the dynamics of fluctuations of thymic hormone and corticosterone level in the immunizated old mice.
PubMed ID
16201149 View in PubMed
Less detail

[Age-related characteristics of the thymus and adrenal cortex function in CBA mice immunized by T-dependent antigen]

https://arctichealth.org/en/permalink/ahliterature57377
Source
Fiziol Zh. 2005;51(1):77-83
Publication Type
Article
Date
2005
Author
I F Labunets'
Source
Fiziol Zh. 2005;51(1):77-83
Date
2005
Language
Ukrainian
Publication Type
Article
Keywords
Adrenal Glands - immunology
Aging - immunology
Animals
Antigens - immunology
Corticosterone - blood - immunology
English Abstract
Erythrocytes - immunology
Immunization
Mice
Mice, Inbred CBA
T-Lymphocytes - immunology
Thymic Factor, Circulating - immunology
Thymus Gland - immunology
Thymus Hormones - pharmacology
Abstract
The thymic serum factor (FTS) titer and corticosterone level in blood of adult and old CBA mice after immunization by T-dependent antigen was investigated. It has been revealed that in adult mice these indices influenced by phase changes in dynamics of immunization whereas in old mice fluctuations of FFS and corticosterone levels were monotonous. In both adult and old mice the correlation exists between thymic hormone and corticosterone. The increasing of thymic function by thymaline administration did not improve the dynamics of FTS titer and corticosterone level in immunized old mice.
PubMed ID
15801203 View in PubMed
Less detail

Alternative splicing of interleukin-6 mRNA in mice.

https://arctichealth.org/en/permalink/ahliterature63300
Source
Bull Exp Biol Med. 2004 Jul;138(1):73-6
Publication Type
Article
Date
Jul-2004
Author
O P Yatsenko
M L Filipenko
E A Khrapov
E N Voronina
S V Sennikov
V A Kozlov
Author Affiliation
Laboratory for Regulation of Immunopoiesis, Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences.
Source
Bull Exp Biol Med. 2004 Jul;138(1):73-6
Date
Jul-2004
Language
English
Publication Type
Article
Keywords
Alternative Splicing
Amino Acid Sequence
Animals
Binding Sites
Crosses, Genetic
Erythrocytes - immunology
Exons
Female
Interleukin-6 - chemistry - genetics
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Molecular Sequence Data
Placenta - metabolism
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Protein Biosynthesis
Protein Isoforms - chemistry
Protein Structure, Secondary
RNA, Messenger - metabolism
Sequence Deletion
Sequence Homology, Amino Acid
Sheep
Spleen - metabolism
Abstract
Expression of mRNA for interleukin-6, interleukin-6Delta3, and interleukin-6Delta5 was detected in placental tissue (second and third trimesters of pregnancy) and spleen of mice immunized with sheep erythrocytes in high dose. We hypothesize that translation of mRNA yields proteins capable of binding to individual subunits of the interleukin-6 receptor and possessing effector functions.
PubMed ID
15514729 View in PubMed
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Analysis of immunogenic properties of nonapeptide TVGRGDPHQ from Bordetella pertussis filamentous hemagglutinin.

https://arctichealth.org/en/permalink/ahliterature57705
Source
Ukr Biokhim Zh. 1994 Mar-Apr;66(2):90-3
Publication Type
Article
Author
E M Kavoon
E G Pkhakadze
A V Marinets
V A Chechot
J L Radavsky
S V Komissarenko
Author Affiliation
A.V. Palladin Institute of Biochemistry, Academy of Sciences of Ukraine, Kyiv.
Source
Ukr Biokhim Zh. 1994 Mar-Apr;66(2):90-3
Language
English
Publication Type
Article
Keywords
Amino Acid Sequence
Animals
Antibody Specificity
Bordetella pertussis - chemistry
Cross Reactions
Hemagglutinins
Mice
Mice, Inbred BALB C
Mice, Inbred CBA
Molecular Sequence Data
Oligopeptides - chemistry - immunology
Serum Albumin, Bovine - chemistry
Abstract
Immunogenic properties of TVGRGDPHQ nonapeptide which is correspondent to the region 1094-1102 of B. pertussis filamentous hemagglutinin (FHA) were studied. The conjugate of bovine serum albumin with nonapeptide was used for immunization of BALB/c and CBA mice. Antisera of the both lines of mice cross-reacted with a number of antigens, but using affinity chromatography peptide and FHA specific antibodies were extracted. Affinity purified rabbit antibodies to TVGRGPHQ which recognize FHA were also obtained. Therefore the antibodies to the peptide which placed RGD-containing region responsible for macrophage CR3-integrin interaction are capable to distinguish the native antigen. Thus these data are an additional evidence for the nonapeptide use as a component of synthetic vaccine against whooping-cough.
PubMed ID
7998347 View in PubMed
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107 records – page 1 of 11.