Skip header and navigation

Refine By

1369 records – page 1 of 137.

Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program.

https://arctichealth.org/en/permalink/ahliterature75564
Source
J Gerontol A Biol Sci Med Sci. 1999 Nov;54(11):B492-501
Publication Type
Article
Date
Nov-1999
Author
A. Turturro
W W Witt
S. Lewis
B S Hass
R D Lipman
R W Hart
Author Affiliation
Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079-9502, USA. aturturro@nctr.fda.gov
Source
J Gerontol A Biol Sci Med Sci. 1999 Nov;54(11):B492-501
Date
Nov-1999
Language
English
Publication Type
Article
Keywords
Aging
Animals
Biological Markers
Body Weight
Eating
Female
Growth
Longevity
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred DBA
Rats
Rats, Inbred BN
Rats, Inbred F344
Abstract
The collaborative Interagency Agreement between the National Center for Toxicological Research (NCTR) and the National Institute on Aging (NIA) was aimed at identifying and validating a panel of biomarkers of aging in rodents in order to rapidly test the efficacy and safety of interventions designed to slow aging. Another aim was to provide a basis for developing biomarkers of aging in humans, using the assumption that biomarkers that were useful across different genotypes and species were sensitive to fundamental processes that would extrapolate to humans. Caloric restriction (CR), the only intervention that consistently extends both mean and maximal life span in a variety of species, was used to provide a model with extended life span. C57BI/6NNia, DBA/2JNia, B6D2F1, and B6C3F1 mice and Brown Norway (BN/RijNia), Fischer (F344/NNia) and Fischer x Brown Norway hybrid (F344 x BN F1) rats were bred and maintained on study. NCTR generated data from over 60,000 individually housed animals of the seven different genotypes and both sexes, approximately half ad libitum (AL) fed, the remainder CR. Approximately half the animals were shipped to offsite NIA investigators internationally, with the majority of the remainder maintained at NCTR until they died. The collaboration supplied a choice of healthy, long-lived rodent models to investigators, while allowing for the development of some of the most definitive information on life span, food consumption, and growth characteristics in these genotypes under diverse feeding paradigms.
PubMed ID
10619312 View in PubMed
Less detail

Immune reactions in different mouse strains.

https://arctichealth.org/en/permalink/ahliterature57440
Source
Bull Exp Biol Med. 2002 Oct;134(4):376-8
Publication Type
Article
Date
Oct-2002
Author
N V Masnaya
A A Churin
O S Borsuk
E Yu Sherstoboev
Author Affiliation
Institute of Pharmacology, Tomsk Research Center, Siberian Branch of Russian Academy of Medical Sciences, Russia.
Source
Bull Exp Biol Med. 2002 Oct;134(4):376-8
Date
Oct-2002
Language
English
Publication Type
Article
Keywords
Animals
Antibody formation
Antibody-Producing Cells - immunology
Comparative Study
Genotype
Immunization
Macrophages, Peritoneal - immunology
Mice
Mice, Inbred C57BL - immunology
Mice, Inbred CBA - immunology
Mice, Inbred DBA - immunology
Mice, Inbred Strains - immunology
Species Specificity
Spleen - immunology
Thymus Gland - immunology
Abstract
The responses of immunocompetent cells to thymus-dependent antigen differ in mice of different strains. Immunization stimulated phagocytic activity of peritoneal macrophages in CBA/CaLac, DBA/2, and BALB/c mice and suppressed it in CC57W mice. By the formation of antibody-producing cells in the spleen in response to thymus-dependent antigen DBA/2 and CBA/CaLac mice can be classified as high responders, BALB/c mice as medium-responders, and C57Bl/6 and CC57W mice as low responders.
PubMed ID
12533764 View in PubMed
Less detail

Stimulation of immune reactivity by methoxy-substituted glycerol ethers incorporated into the feed.

https://arctichealth.org/en/permalink/ahliterature62452
Source
Eur J Immunol. 1978 Sep;8(9):678-80
Publication Type
Article
Date
Sep-1978
Author
B. Boeryd
T. Nilsson
L. Lindholm
S. Lange
B. Hallgren
G. Ställberg
Source
Eur J Immunol. 1978 Sep;8(9):678-80
Date
Sep-1978
Language
English
Publication Type
Article
Keywords
Animals
Dermatitis, Contact - immunology
Diet
Glycerides - pharmacology
Graft vs Host Reaction - drug effects
Immunity - drug effects
Methyl Ethers - pharmacology
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Inbred DBA
Abstract
In mice, the plaque-forming cell response to sheep red blood cells was stimulated by a mixture of methoxy-substituted glycerol ethers isolated from Greenland shark liver oil and by synthetic 1-0-(2-methoxyhexadecyl)-glycerol, given in the diet. In preliminary experiments, this synthetic compound also increased the ability of parental spleen cells to induce graft-vs.-host reactions in F1 hybrid mice. Glycerol ethers occur in the bone marrow fat of mammals and in the membrane phospholipids. It is postulated that the methoxy-substituted glycerol ethers supplied in the diet may stimulate the bone marrow and/or may be incorporated into membrane lipids, thereby changing the structure and function of the membranes.
PubMed ID
30635 View in PubMed
Less detail

[State of lymphoid tissue in mice following immunization and benzene poisoning]

https://arctichealth.org/en/permalink/ahliterature57952
Source
Fiziol Zh. 1976 Sep-Oct;22(5):696-9
Publication Type
Article

Predisposition to alcoholism, tryptophan oxygenase activity, and structure of intron 6 in the corresponding gene of C57BL/6J, CC57BR/Mv, and BALB/cJ mice.

https://arctichealth.org/en/permalink/ahliterature9550
Source
Bull Exp Biol Med. 2003 Oct;136(4):385-7
Publication Type
Article
Date
Oct-2003
Author
V I Kaledin
N V Klimova
G V Vasil'ev
E A Ivanova
E D Vasil'eva
S I Il'nitskaya
Author Affiliation
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk.
Source
Bull Exp Biol Med. 2003 Oct;136(4):385-7
Date
Oct-2003
Language
English
Publication Type
Article
Keywords
Alcoholism - genetics
Animals
Base Sequence - genetics
Comparative Study
Genetic Predisposition to Disease
Hybridization, Genetic
Introns
Liver - metabolism
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Inbred DBA
Research Support, Non-U.S. Gov't
Sequence Deletion
Tryptophan Oxygenase - genetics - metabolism
Abstract
Crossbred CC57BR/Mv mice inherited tryptophan oxygenase gene and predisposition to alcohol consumption from parent BALB/c and C57BL mice, respectively. In CC57BR/Mv mice no relationships were found between alcohol consumption, tryptophan oxygenase activity, and single nucleotide substitutions in intron 6 of the TDO2 gene associated with predisposition to alcoholism in humans.
PubMed ID
14714090 View in PubMed
Less detail

Genetic differences in immune reactions to radiation exposure in humans and experimental animals.

https://arctichealth.org/en/permalink/ahliterature31360
Source
Bull Exp Biol Med. 2002 Mar;133(3):268-71
Publication Type
Article
Date
Mar-2002
Author
V I Konenkov
V A Trufakin
Author Affiliation
Institute of Clinical Immunology; Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. dir@online.nsk.ru
Source
Bull Exp Biol Med. 2002 Mar;133(3):268-71
Date
Mar-2002
Language
English
Publication Type
Article
Keywords
Animals
Comparative Study
HLA Antigens - genetics
Humans
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Radiation Injuries - immunology
Radiation Injuries, Experimental - immunology
Abstract
Examination of populations living in regions of fallout radiation revealed changes in the distribution of HLA genes not only in irradiated individuals, but also in their children and grandchildren. Combined irradiation of inbred mice in comparable doses showed that H-2 genes determine immune reactions in animals and their offspring to radiation. Our results indicate that the immune system in mammals is immunogenetically regulated by low-dose radiation.
PubMed ID
12360349 View in PubMed
Less detail

Immnune response in mice of a new strain ASC (antidepressants sensitive catalepsy).

https://arctichealth.org/en/permalink/ahliterature86910
Source
Bull Exp Biol Med. 2007 Aug;144(2):221-3
Publication Type
Article
Date
Aug-2007
Author
Alperina E L
Kulikov A V
Popova N K
Idova G V
Author Affiliation
Laboratory for Mechanisms of Neurochemical Modulation, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences. liza@iph.ma.nsc.ru
Source
Bull Exp Biol Med. 2007 Aug;144(2):221-3
Date
Aug-2007
Language
English
Publication Type
Article
Keywords
Animals
Antidepressive Agents - pharmacology
Catalepsy - drug therapy - genetics - immunology
Freezing Reaction, Cataleptic - drug effects - physiology
Genetic Predisposition to Disease
Male
Mice
Mice, Inbred AKR
Mice, Inbred CBA
Mice, Inbred Strains
Neuroimmunomodulation
Species Specificity
Abstract
Inherited predisposition of ASC mice with depressive behavior to catalepsy was accompanied by a significant decrease in the immune response to sheep erythrocytes (compared to parent strains CBA and AKR). The degree of immunosuppression was highest on day 5 after immunization.
PubMed ID
18399285 View in PubMed
Less detail

Effect of RNA from brain of immunized mice on the specific immune response.

https://arctichealth.org/en/permalink/ahliterature57509
Source
Cytokine. 2000 Jul;12(7):1147-50
Publication Type
Article
Date
Jul-2000
Author
V V Abramov
T J Abramova
V A Kozlov
Author Affiliation
Laboratory of Neuroimmunology, Institute of Clinical Immunology of Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk.
Source
Cytokine. 2000 Jul;12(7):1147-50
Date
Jul-2000
Language
English
Publication Type
Article
Keywords
Animals
Brain - immunology
Erythrocytes
Immunization
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
RNA - immunology
Rabbits
Rats
Research Support, Non-U.S. Gov't
Sheep
Abstract
The objective of the investigation was to study the influence of RNA isolated from the brains of immunized mice on the immune response in syngeneic recipients. (CBAxC57BL/6)F1 male mice immunized by SRBC and RRBC were used for isolation of experimental RNA. Mice injected with medium 199 were used for isolation of control RNA. Experimental and control RNA was injected into syngeneic mice recipients immunized by SRBC, RRBC or rat RBC preliminary. It was shown that experimental RNA stimulate the specific immune response only.
PubMed ID
10880266 View in PubMed
Less detail

[Use of the "graft vs host" reaction to study the immunosuppressive effect of methylenediphosphonic acid]

https://arctichealth.org/en/permalink/ahliterature46810
Source
Fiziol Zh. 1977 Nov-Dec;23(6):786-8
Publication Type
Article

Social success and voluntary ethanol consumption in mice of C57BL/6J and CBA/Lac strains.

https://arctichealth.org/en/permalink/ahliterature12012
Source
Physiol Behav. 1991 Jul;50(1):143-6
Publication Type
Article
Date
Jul-1991
Author
N N Kudryavtseva
I A Madorskaya
I V Bakshtanovskaya
Author Affiliation
Institute of Cytology and Genetics, Siberian Department of USSR Academy of Sciences, Novosibirsk.
Source
Physiol Behav. 1991 Jul;50(1):143-6
Date
Jul-1991
Language
English
Publication Type
Article
Keywords
Agonistic Behavior
Alcohol Drinking - psychology
Animals
Arousal
Dominance-Subordination
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Social Behavior
Social Environment
Species Specificity
Abstract
Voluntary ethanol (20% solution) consumption in mice of C57BL/6J (C57) and CBA/Lac (CBA) strains with consecutive experience of victories (winners) or defeats (losers) in daily intermale agonistic confrontations were studied. Winners and losers of the CBA strain maintained the ethanol consumption on the same level. Losers of the C57 strain increased the ethanol consumption most dramatically during the second week of testing, while winners of this strain did not change the ethanol intake. The aspiration to the social contact estimated by behavioral activity as a reaction to the other male significantly increased in "drinking" losers of the C57 strain. The influence of heredity and emotional state of animals formed by their social success on voluntary ethanol consumption are discussed.
PubMed ID
1946707 View in PubMed
Less detail

1369 records – page 1 of 137.