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Associations between prenatal cigarette smoke exposure and externalized behaviors at school age among Inuit children exposed to environmental contaminants.
Neurotoxicol Teratol. 2013 Sep-Oct;39:84-90
Publication Type
  1 document  
Caroline Desrosiers
Olivier Boucher
Nadine Forget-Dubois
Eric Dewailly
Pierre Ayotte
Sandra W Jacobson
Joseph L Jacobson
Gina Muckle
Author Affiliation
Université Laval, Québec City, Québec, Canada; Centre de recherche du Centre Hospitalier Universitaire de Québec, Québec City, Québec, Canada.
Neurotoxicol Teratol. 2013 Sep-Oct;39:84-90
Publication Type
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Attention - drug effects
Attention Deficit Disorder with Hyperactivity - chemically induced - epidemiology - psychology
Attention Deficit and Disruptive Behavior Disorders - chemically induced - psychology
Drug Interactions
Environmental Pollutants - analysis - toxicity
Fetal Blood - chemistry
Inuits - psychology
Lead Poisoning, Nervous System, Childhood - blood - psychology
Mercury Poisoning, Nervous System - blood - psychology
Prenatal Exposure Delayed Effects - chemically induced - psychology
Quebec - epidemiology
Tobacco Smoke Pollution - adverse effects
Smoking during pregnancy is common among Inuit women from the Canadian Arctic. Yet prenatal cigarette smoke exposure (PCSE) is seen as a major risk factor for childhood behavior problems. Recent data also suggest that co-exposure to neurotoxic environmental contaminants can exacerbate the effects of PCSE on behavior. This study examined the association between PCSE and behavior at school age in a sample of Inuit children from Nunavik, Qu?bec, where co-exposure to environmental contaminants is also an important issue. Interactions with lead (Pb) and mercury (Hg), two contaminants associated with behavioral problems, were also explored.
Participants were 271 children (mean age=11.3years) involved in a prospective birth-cohort study. PCSE was assessed through maternal recall. Assessment of child behavior was obtained from the child's classroom teacher on the Teacher Report Form (TRF) and the Disruptive Behavior Disorders Rating Scale (DBD). Exposure to contaminants was assessed from umbilical cord and child blood samples. Other confounders were documented by maternal interview.
After control for contaminants and confounders, PCSE was associated with increased externalizing behaviors and attention problems on the TRF and higher prevalence of attention deficit hyperactivity disorder (ADHD) assessed on the DBD. No interactions were found with contaminants.
This study extends the existing empirical evidence linking PCSE to behavioral problems in school-aged children by reporting these effects in a population where tobacco use is normative rather than marginal. Co-exposure to Pb and Hg do not appear to exacerbate tobacco effects, suggesting that these substances act independently.
Cites: J Am Acad Child Adolesc Psychiatry. 2003 Jul;42(7):826-3312819442
Cites: Environ Health Perspect. 2000 Nov;108(11):1079-8311102300
Cites: Environ Health Perspect. 2003 Oct;111(13):1660-414527847
Cites: Early Hum Dev. 2003 Dec;75(1-2):21-3314652157
Cites: J Clin Psychol. 2004 Jun;60(6):689-9315141400
Cites: Nicotine Tob Res. 2004 Apr;6 Suppl 2:S125-4015203816
Cites: Arch Gen Psychiatry. 2004 Aug;61(8):836-4315289282
Cites: J Am Acad Child Adolesc Psychiatry. 1992 Mar;31(2):210-81564021
Cites: Psychol Bull. 1993 Sep;114(2):376-908416037
Cites: Neurotoxicol Teratol. 2005 May-Jun;27(3):395-40615939200
Cites: Biol Psychiatry. 2005 Jun 1;57(11):1377-8415950011
Cites: Pediatrics. 2005 Aug;116(2):462-716061604
Cites: Arch Gen Psychiatry. 2005 Oct;62(10):1142-716203959
Cites: Hum Mol Genet. 2006 Jul 15;15(14):2276-8416774975
Cites: J Clin Psychiatry. 2006;67 Suppl 8:7-1216961424
Cites: Acta Paediatr. 2007 Mar;96(3):377-8217407460
Cites: Environ Health Perspect. 2001 Dec;109(12):1291-911748038
Cites: Biol Psychiatry. 2003 Jan 15;53(2):130-512547468
Cites: Ann Epidemiol. 2007 Jan;17(1):27-3517027287
Cites: Am J Addict. 2006 Nov-Dec;15(6):450-617182447
Cites: Neuropsychopharmacology. 2007 Mar;32(3):693-916554741
Cites: J Am Acad Child Adolesc Psychiatry. 2007 Mar;46(3):362-917314722
Cites: Biol Psychiatry. 2007 Jun 15;61(12):1320-817157268
Cites: Arch Pediatr Adolesc Med. 2007 Sep;161(9):857-6417768285
Cites: Child Psychiatry Hum Dev. 2007 Dec;38(4):255-6917520361
Cites: Dev Psychopathol. 2008 Winter;20(1):139-6418211732
Cites: Nicotine Tob Res. 2008 Feb;10(2):267-7818236291
Cites: Environ Health Perspect. 2008 Jul;116(7):956-6218629321
Cites: Neurotoxicology. 2008 Sep;29(5):783-80118652843
Cites: Vital Health Stat 10. 2008 Jul;(237):1-1418998276
Cites: Int J Epidemiol. 2009 Jun;38(3):698-70518250076
Cites: Int J Epidemiol. 2009 Jun;38(3):680-918775874
Cites: Nicotine Tob Res. 2009 Oct;11(10):1166-7419640836
Cites: Pediatrics. 2009 Dec;124(6):e1054-6319933729
Cites: Acta Paediatr. 2010 Jan;99(1):106-1119793315
Cites: Environ Health Perspect. 2010 Jan;118(1):150-420056582
Cites: Prev Med. 2010 Jan-Feb;50(1-2):13-820026103
Cites: J Epidemiol Community Health. 2010 Jul;64(7):622-919703906
Cites: Pediatrics. 2010 Oct;126(4):705-1120855396
Cites: J Psychiatr Res. 2010 Nov;44(15):1058-6220413131
Cites: Neurotoxicol Teratol. 2011 Jan-Feb;33(1):137-4421256428
Cites: Am J Clin Nutr. 2011 May;93(5):1025-3721389181
Cites: CMAJ. 2011 May 17;183(8):E480-621555383
Cites: Alcohol Clin Exp Res. 2011 Jun;35(6):1081-9121332531
Cites: Environ Res. 2011 Nov;111(8):1173-921764051
Cites: Am J Clin Nutr. 2011 Dec;94(6):1592-922071708
Cites: Am J Med Genet B Neuropsychiatr Genet. 2012 Apr;159B(3):289-9722259195
Cites: Psychopharmacology (Berl). 2012 Oct;223(4):401-1522562524
Cites: Environ Health Perspect. 2012 Oct;120(10):1456-6123008274
Cites: J Pediatr. 2003 Jul;143(1):104-1012915833
PubMed ID
23916943 View in PubMed
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