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[Occurrence of complement defects in meningococcal disease: who should be examined?].

https://arctichealth.org/en/permalink/ahliterature226508
Source
Ugeskr Laeger. 1991 Apr 15;153(16):1113-6
Publication Type
Article
Date
Apr-15-1991
Author
H E Nielsen
P. Magnussen
I. Lind
Author Affiliation
Statens Seruminstitut, København.
Source
Ugeskr Laeger. 1991 Apr 15;153(16):1113-6
Date
Apr-15-1991
Language
Danish
Publication Type
Article
Keywords
Complement System Proteins - deficiency - genetics
Humans
Meningitis, Meningococcal - genetics - immunology
Neisseria meningitidis - classification - immunology
Recurrence
Scandinavia - epidemiology
Serotyping
Abstract
Congenital complement deficiency states occur very rarely. These deficiencies are associated with a high risk of meningococcal disease (MD). We suggest that the following groups of individuals with MD are examined for complement deficiencies: 1. Individuals belonging to families, in which more than one case of MD has occurred with an interval exceeding one month. 2. Individuals infected with the low-virulent meningococcal serogroups W-135, 29E, X, Y, Z. 3. Individuals with recurrent MD. Since properdin deficiency probably is the most common deficiency associated with MD it is important that the screening includes the alternative complement pathway.
PubMed ID
1902602 View in PubMed
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