In a consecutive series of 137 affective disorder patients with a family history of suicide, bipolar disorder formed the biggest group. Of the 137 patients, 61 (44.5%) had made a total of 117 attempts at suicide. The patients who had attempted suicide, compared with those who had not, had a significantly earlier age of onset and longer duration of illness, and more of them were unmarried.
In a matched controlled study 72 Canadian patients with a major depressive episode were compared with non-depressed and never depressed orthopedic patients. Significantly more of the depressives had parental loss before 17 years of age, a poor marriage before the onset of depression and a family history of depression.