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[A comparative study of the immunological (antimicrosomal antibodies) and cytogenetic indices of children living in radioactively contaminated areas of Bryansk Province]

https://arctichealth.org/en/permalink/ahliterature34277
Source
Radiats Biol Radioecol. 1997 May-Jun;37(3):404-7
Publication Type
Article
Author
A P Shinkarkina
A A Zhloba
V K Podgorodnichewnko
A V Sevan'kaev
A M Poverennyi
Source
Radiats Biol Radioecol. 1997 May-Jun;37(3):404-7
Language
Russian
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Autoantibodies - blood
Cells, Cultured
Child
Chromosome Aberrations
Comparative Study
English Abstract
Humans
Lymphocytes - radiation effects
Microsomes - immunology
Nuclear Reactors
Power Plants
Radioactive Fallout - adverse effects
Russia
Thyroid Gland - immunology - radiation effects
Ukraine
Abstract
The chromosome dicentric aberrations in the lymphocytes and levels of antibodies to human thyroid microsomal antigen in the serum of the children lived in the area of Bryansk Province suffered from the Chernobyl accident was examined. Correlation between those tests was not estimated: the autoantibodies were revealed in group with dicentrics and without those in 4.0% and 4.5% of cases correspondingly. Antimicrosomal antibodies were revealed more frequently (5.0%) and in higher titers in the children from the more polluted Bryansk Province than in those from Kaluga Province (3.1%). These data can testify about the role of inside radiation of thyroid gland in appearance of autoimmune thyroiditis signs.
PubMed ID
9244530 View in PubMed
Less detail

Affects of ionizing radiation on T-cell population lymphocyte: a risk factor of irritable bowel syndrome.

https://arctichealth.org/en/permalink/ahliterature97544
Source
Toxicol Ind Health. 2010 Jul;26(6):323-30
Publication Type
Article
Date
Jul-2010
Author
M R Sheikh Sajjadieh
L V Kuznetsova
V B Bojenko
Author Affiliation
Department of Clinical Immunology & Allergology, National Medical Academy for Post Graduate Education, Kiev, Ukraine. mohammad_esfahan@yahoo.com
Source
Toxicol Ind Health. 2010 Jul;26(6):323-30
Date
Jul-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Antigens, CD3 - immunology
CD4-CD8 Ratio
CD4-Positive T-Lymphocytes - radiation effects
CD8-Positive T-Lymphocytes - radiation effects
Case-Control Studies
Cesium Radioisotopes - adverse effects
Chernobyl Nuclear Accident
Child
Child, Preschool
Dose-Response Relationship, Radiation
Humans
Immunity, Cellular - radiation effects
Irritable Bowel Syndrome - etiology
Lymphocyte Count
Risk factors
T-Lymphocytes - radiation effects
Abstract
Irritable bowel syndrome is observed mostly in Ukrainian children and may be related to adverse health effects as a result of the Chernobyl disaster. The aim of this study was to determine status of T-cell population lymphocytes in children with clinical symptom of irritable bowel syndrome. The test population consisted of 95 participants: 75 rural patients aged 4 to 18 who lived in a contaminated area exposed to natural environmental radiation with clinical symptom of irritable bowel syndrome (categorized in three groups) and 20 healthy urban participants from Kiev aged 5 to 15 as control group. Internal radiation activity has been measured by gamma-ray spectrometry. Peripheral blood leukocytes were analyzed for T-lymphocytes subset such as T-lymphocytes (CD3(+)), T-helper (CD4(+)) and T-cytotoxic (CD8(+)) and then CD4/CD8 ratio was calculated. Percentage of CD3(+) and CD4(+) in all study groups decreased significantly in comparison to control group (p
PubMed ID
20348276 View in PubMed
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[Analysis of the epidemiological data concerning radiation carcinogenic effects and approaches to the low doses' upper limits determination in the aspect of a threshold of the unhealthy influences of ionizing radiation]

https://arctichealth.org/en/permalink/ahliterature18426
Source
Radiats Biol Radioecol. 2003 Mar-Apr;43(2):227-36
Publication Type
Article
Author
L M Rozhdestvenskii
Author Affiliation
State Research Center-Institute of Biophysics, Russian Ministry of Health, Moscow, 123182 Russia. rol@scribph.ru
Source
Radiats Biol Radioecol. 2003 Mar-Apr;43(2):227-36
Language
Russian
Publication Type
Article
Keywords
Accidents, Radiation
Cell Nucleus - radiation effects
Cells, Cultured
Chromosome Aberrations
Cohort Studies
Comparative Study
Dose-Response Relationship, Radiation
English Abstract
Humans
Japan - epidemiology
Leukemia, Radiation-Induced - epidemiology - mortality
Lymphocytes - radiation effects
Models, Theoretical
Neoplasms, Radiation-Induced - epidemiology - mortality
Nuclear Warfare
Occupations
Power Plants
Radiation Dosage
Radiation Injuries - epidemiology - mortality
Radiation, Ionizing
Radioactive fallout
Radiometry
Time Factors
Ukraine - epidemiology
Abstract
The analysis of the epidemiological data regarding cancer mortality in cohorts of Japanese A-bomb survivors and Chermobyl liquidators exposed to different doses suggests that there are good reasons for recognizing the threshold of the radiocarcinogenic effect in the region of about 200 Gy (mSv). The analysis of solid cancer mortality in Japanese cohort, which exceeded the expected one in a dose diapason of 5-200 mSv, revealed a (quasi) plateau in a dose-effect curve and led to the conclusion that the nature of the overshoot is non-radiogenic. The analysis of supposedly dose dependent leucosis incidence in the limited low dose diapason in the Chernobyl cohort showed that the real coefficient of the excess absolute or relative radiation risk could not be received in the case because the larger part curve was placed under the control level. In supporting the principle of single hit in a cell nucleus as a base of microdosimetric determination of low radiation doses, the approach to objective delimitation between low, intermediate and high doses regions has been proposed. The low doses upper limit of sparse ionizing radiation for cell nucleus of 8 microns in diameter has been evaluated as 0.65 mGy. It can serve for evaluation of the dose rate threshold regarding the safe chronic radiation levels in the environment.
PubMed ID
12754817 View in PubMed
Less detail

Assessing the level of chromosome aberrations in peripheral blood lymphocytes in long-term resident children under conditions of high exposure to radon and its decay products.

https://arctichealth.org/en/permalink/ahliterature274296
Source
Mutagenesis. 2015 Sep;30(5):677-83
Publication Type
Article
Date
Sep-2015
Author
Vladimir G Druzhinin
Maxim Yu Sinitsky
Aleksey V Larionov
Valentin P Volobaev
Varvara I Minina
Tatiana A Golovina
Source
Mutagenesis. 2015 Sep;30(5):677-83
Date
Sep-2015
Language
English
Publication Type
Article
Keywords
Adolescent
Child
Chromosome Aberrations - radiation effects
DNA - radiation effects
DNA Damage
Female
Humans
Lymphocytes - radiation effects
Male
Radiation Exposure
Radioactivity
Radon - toxicity
Russia
Young Adult
Abstract
In this study, the frequency and spectrum of chromosomal aberrations were analysed in samples of peripheral blood from 372 (mean age = 12.24 ± 2.60 years old) long-term resident children in a boarding school (Tashtagol city, Kemerovo Region, Russian Federation) under conditions of high exposure to radon and its decay products. As a control group, we used blood samples from people living in Zarubino village (Kemerovo Region, Russian Federation). We discovered that the average frequencies of single and double fragments, chromosomal exchanges, total number of aberrations, chromatid type, chromosome type and all types of aberrations were significantly increased in the exposed group. This is evidence of considerable genotoxicity to children living under conditions of high exposure to radon compared to children living under ecological conditions without increased radon radiation.
PubMed ID
25904585 View in PubMed
Less detail

[Candidate gene association study of the radiosensitivity of human chromosomes with candidate gene polymorphisms upon exposure to gamma-irradiation in vitro and in vitro].

https://arctichealth.org/en/permalink/ahliterature128616
Source
Gig Sanit. 2011 Sep-Oct;(5):14-8
Publication Type
Article
Author
S K Abilev
L E Sal'nikova
A V Rubanovich
Source
Gig Sanit. 2011 Sep-Oct;(5):14-8
Language
Russian
Publication Type
Article
Keywords
Adult
Alleles
Case-Control Studies
Chernobyl Nuclear Accident
Chromosome Aberrations - radiation effects - statistics & numerical data
DNA Repair - genetics
Female
Gamma Rays - adverse effects
Gene Frequency
Genetic Association Studies
Genotype
Humans
Lymphocytes - radiation effects
Male
Metabolic Detoxication, Drug - genetics
Russia
Ukraine
Xenobiotics - pharmacokinetics
Young Adult
Abstract
The genotypic associations of the frequencies of spontaneous and radiation-induced chromosome aberrations in human lymphocytes were studied to develop genetic tests for elevated and reduced radiosensitivity. Cytogenetic analysis and genotyping (19 sites of detoxification and DNA repair genes) were carried out for a sample of Chernobyl cleanup workers (n = 83) and for a homogenous control sample of volunteers (n = 99). In both groups, the frequency of chromosome-type aberrations proved to be elevated in carriers of minor alleles in the XPD gene (sites T2251G (Lys751Gln) and G862A (Asp312Asn)) and a combination of GSTM1-GSTT1-positive genotypes. The polymorphism of these gene did not affect the frequency of gamma-radiation-induced aberrations in the controls (1 Gy in vitro), which was associated with the alleles of the OGG1, XRCC1, and CYP1A1 genes. Thus, the frequencies of spontaneous and in vitro induced chromosome-type aberrations are associated with the alleles of different xenobiotic detoxification and DNA repair genes. At the same time, among the cleanup workers (irradiated in vivo), the elevated frequency of aberrations was observed in the carriers of the genotypes associated with the higher rate of spontaneous (but not induced in vitro) cytogenetic damages in the controls.
PubMed ID
22184993 View in PubMed
Less detail

[Changes in cellular radiosensitivity after low dose irradiation].

https://arctichealth.org/en/permalink/ahliterature118259
Source
Radiats Biol Radioecol. 2012 Sep-Oct;52(5):481-6
Publication Type
Article
Author
I I Pelevina
A V Aleshchenko
M M Antoshchina
O V Kudriashova
N I Riabchenko
A V Akleev
Source
Radiats Biol Radioecol. 2012 Sep-Oct;52(5):481-6
Language
Russian
Publication Type
Article
Keywords
Adaptation, Physiological - genetics
Adult
Cells, Cultured
Chernobyl Nuclear Accident
Child
Chromosome Aberrations - radiation effects
Dose-Response Relationship, Radiation
Hodgkin Disease - genetics - radiotherapy
Humans
Lymphocytes - radiation effects
Micronucleus Tests
Radiation
Radiation Tolerance - radiation effects
Russia
Abstract
When the adaptive response (AR) was studied on human blood lymphocytes, a new dependence was discovered. This dependence defines the direction of the radiosensitivity change after a low dose of irradiation. Using micronucleus (MN) test with cytochalasin B the dependence between the cell reaction after low level irradiation and radiosensititvity (the effect after irradiation at the dose of 1 Gy) was observed. The negative correlation between the frequency of AR manifestation, sensibilization, intermediate links and radiosensitivity was discovered. This regularity is observed in the population of Moscow, Obninsk, Chelyabinsk region (irradiated and control) inhabitants, Chernobyl accident liquidators, Moscow children, in individuals with Hodgkin's lymphoma before and during treatment. The negative correlation is also noted by AR determination with two irradiation schemes: in one or two different cell cycle phases (G1-G1 or G1-G2). Similar links are observed using the chromosome methaphase analysis (the frequency of cells with chromosome aberrations). So, the results of the experiments conducted allow us to suppose that the connection between the cell radiosensitivity and a different type of reaction after low dose irradiation--from AR to the increase in radiosensitivity (sensibilization) is a general regularity. AR is induced by low level irradiation and high cell radiosensitivity, while sensibilization is induced by low radiosensitivity. Since AR and sensibilization can be induced not only by irradiation, but many different chemicals and physical agents, the described correlation can be observed in the case of different exposures. Cellular AR and sensibilization are integral indexes depending on many genetic and epigenetic factors, as well as on the initiation of a large number of events. However, the discovered mechanisms of interrelations are still difficult to explain.
PubMed ID
23227711 View in PubMed
Less detail

Chromosome aberrations in human lymphocytes apparently induced by Chernobyl fallout.

https://arctichealth.org/en/permalink/ahliterature36276
Source
Health Phys. 1993 May;64(5):531-4
Publication Type
Article
Date
May-1993
Author
W. Scheid
J. Weber
S. Petrenko
H. Traut
Author Affiliation
Institute of Radiation Biology, University of Münster, F.R.G.
Source
Health Phys. 1993 May;64(5):531-4
Date
May-1993
Language
English
Publication Type
Article
Keywords
Accidents
Adolescent
Adult
Byelarus
Child
Chromosome Aberrations
Female
Humans
Lymphocytes - radiation effects
Male
Middle Aged
Nuclear Reactors
Radiation Genetics
Radioactive fallout
Research Support, Non-U.S. Gov't
Ukraine
Abstract
Sixteen people (15 from Byelorussia, one from Kiev) possibly exposed to radioactivity released by the Chernobyl accident were investigated for chromosome aberrations induced in lymphocytes. Statistically significant increases of the yield of dicentric chromosomes were observed in five people.
PubMed ID
8491604 View in PubMed
Less detail

[Chromosome and cytome analysis of the somatic cells of nuclear-chemical production workers with incorporated 239Pu].

https://arctichealth.org/en/permalink/ahliterature135925
Source
Radiats Biol Radioecol. 2010 Nov-Dec;50(6):672-80
Publication Type
Article
Author
V A Timoshevskii
I N Lebedev
S A Vasil'ev
N N Sukhanova
Iu S Iakovleva
N B Torkhova
V P Puzyrev
Source
Radiats Biol Radioecol. 2010 Nov-Dec;50(6):672-80
Language
Russian
Publication Type
Article
Keywords
Adult
Aged
Body Burden
Case-Control Studies
Chemical Industry
Chromosome Aberrations - radiation effects
Humans
In Situ Hybridization, Fluorescence
Lymphocytes - radiation effects
Middle Aged
Occupational Exposure - adverse effects
Plutonium - adverse effects
Russia
Abstract
The analysis of plutonium production factors has been carried out by using two methodical approaches: assessment of chromosomal aberrations level in routine and G-banded metaphases and molecular-cytogenetic investigation of aneugenic/clastogenic damages in cytokinesis-block binuclear lymphocytes by FISH with centromere specific DNA probes. The obtaining data point out for the first time about both aneugenic and clastogenic influences of incorporated 239Pu with activity range from 0.37 to 6.95 kBq. Correlation analysis of chromosome aberrations with cytome abnormalities allowed finding significant connection between number parameters of metaphase and interphase approaches. The results of this study support the suggestion that aberrant chromosomes are involved preferable in aneugenic events. The FISH technique in binucleated cytokinesis-blocked lymphocytes allows extending of detecting spectrum of chromosome damages and glance of aneugenic mechanisms. Correlations between metaphase and interphase-FISH results point out a high sensitivity of FISH cytome assay, which could be used as an independent test for detection both clastogenic and aneugenic environment influences.
PubMed ID
21434394 View in PubMed
Less detail

[Chromosome instability revealed in children of fathers irradiated during Chernobyl accident]

https://arctichealth.org/en/permalink/ahliterature29276
Source
Tsitol Genet. 2005 Jul-Aug;39(4):32-40
Publication Type
Article
Author
M A Pilins'ka
S S Dybs'kyi
O B Dybs'ka
L R Pedan
Source
Tsitol Genet. 2005 Jul-Aug;39(4):32-40
Language
Ukrainian
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Chernobyl Nuclear Accident
Child
Chromosome Aberrations - radiation effects
English Abstract
Humans
Karyotyping
Lymphocytes - radiation effects
Male
Paternal Exposure - adverse effects
Radioactive Pollutants - toxicity
Ukraine
Abstract
Four children groups with and without thyroid pathology born to fathers exposed to ionizing irradiation in 1986 during Chernobyl accident as liquidators as well as residents of territory with radioactive contamination have been cytogenetically observed. The frequency and spectrum of chromosome aberrations in peripheral blood lymphocytes have been studied using two-termed cultivation (during 48 and 144 hours). Under the short-term incubation the observed groups did not significantly differ on the mean-group integral cytogenetic parameters which corresponded to age norm, but in progeny of parents from radionuclide contaminated territory the increased level of chromosome type exchanges has been revealed. In long-termed lymphocyte cultures of children with chronic thyroiditis the significantly increased cytogenetic effects of both chromatid (single fragments) and chromosome types (abnormal monocentrics, centric rings) have been established. The data received testified the reality of the transmissible chromosome instability phenomenon in progeny of irradiated parents and confirmed the possibility of its expression in consequent mitoses.
PubMed ID
16396329 View in PubMed
Less detail

A critique of 'Collaborative exercise on the use of FISH chromosome painting for retrospective biodosimetry of Mayak nuclear-industrial personnel'.

https://arctichealth.org/en/permalink/ahliterature187797
Source
Int J Radiat Biol. 2002 Sep;78(9):867-71; author reply 871-3
Publication Type
Article
Date
Sep-2002

65 records – page 1 of 7.