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Cancer of the respiratory system in Circumpolar Inuit.

https://arctichealth.org/en/permalink/ahliterature3547
Source
Acta Oncol. 1996;35(5):571-6
Publication Type
Article
Date
1996
Author
A B Miller
L A Gaudette
Author Affiliation
Department of Preventive Medicine and Biostatistics, Faculty of Medicine, University of Toronto, Ontario, Canada.
Source
Acta Oncol. 1996;35(5):571-6
Date
1996
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Distribution
Aged
Alaska - epidemiology - ethnology
Arctic Regions - epidemiology - ethnology
Canada - epidemiology - ethnology
Child
Child, Preschool
Female
Greenland - epidemiology - ethnology
Humans
Incidence
Infant
Inuits - statistics & numerical data
Laryngeal Neoplasms - epidemiology - ethnology
Lung Neoplasms - epidemiology - ethnology - etiology
Male
Middle Aged
Nose Neoplasms - epidemiology - ethnology
Sex Distribution
Abstract
Cancer incidence of the nasal cavities in Inuit men are high (ASR=3.0 1984-1988), and higher than seen in Denmark, Connecticut (USA) and Canada. Lung cancer incidence is among the highest in the world, for both men and women, and larynx cancer among the lowest. The smoking pattern among Inuit, possibly combined with co-factors related to environment and diet, are believed to be the relevant causal factors.
PubMed ID
8813063 View in PubMed
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Silica and cancer associations from a multicancer occupational exposure case-referent study.

https://arctichealth.org/en/permalink/ahliterature103646
Source
IARC Sci Publ. 1990;(97):29-42
Publication Type
Article
Date
1990
Author
J. Siemiatycki
M. Gérin
R. Dewar
R. Lakhani
D. Begin
L. Richardson
Author Affiliation
Centre de Recherche en Epidémiologie et Médicine Préventive, Institut Armand-Frappier, Laval-des-Rapides, Québec, Canada.
Source
IARC Sci Publ. 1990;(97):29-42
Date
1990
Language
English
Publication Type
Article
Keywords
Adult
Aged
Case-Control Studies
Dust - adverse effects
Humans
Lung Neoplasms - epidemiology - ethnology - etiology
Male
Middle Aged
Occupational Diseases - epidemiology - ethnology - etiology
Quebec - ethnology
Questionnaires
Risk factors
Silicon Dioxide
Smoking
Abstract
A multicancer site, multifactor case-control study was undertaken to generate hypotheses about possible occupational carcinogens. Eligible cases, comprising all incident cases of cancer at 14 sites who were male, aged 35-70 and resident in Montreal, were subjected to probing interviews designed to obtain detailed lifetime job histories and information on potential confounders. Each job history was reviewed by a team of chemists who translated it into a history of occupational exposures. These occupational exposures were then analysed as potential risk factors in relation to the sites of cancer included. Over 3700 cases were interviewed and processed. For each site of cancer analysed as a case series, controls were selected from subjects with cancer at the other sites covered in the study. This report concerns the associations between silica exposure and each site of cancer. In initial screening analyses, there were significantly elevated odds ratios for silica and stomach cancer and for silica and non-adenocarcinoma lung cancer. More detailed analyses confirmed these associations, though there was no evidence of a dose-response relationship for stomach cancer. For lung cancer, there were significantly elevated risks in those with high-level long-term exposure. These results, which took into account several potential confounders including cigarette smoking and asbestos exposure, lend credence to the hypothesis that silica exposure increases the risk of lung cancer, and suggest the possibility of an effect on stomach cancer.
PubMed ID
2164501 View in PubMed
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