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20 years follow-up after the first microsurgical lumbar discectomies in Iceland.

https://arctichealth.org/en/permalink/ahliterature165998
Source
Acta Neurochir (Wien). 2007 Jan;149(1):51-8; discussion 57-8
Publication Type
Article
Date
Jan-2007
Author
M. Jensdottir
K. Gudmundsson
B. Hannesson
G. Gudmundsson
Author Affiliation
Department of Neurosurgery, Landspítali University Hospital, Reykjavík, Iceland. margretjens@gmail.com
Source
Acta Neurochir (Wien). 2007 Jan;149(1):51-8; discussion 57-8
Date
Jan-2007
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Diskectomy
Employment
Female
Follow-Up Studies
Humans
Iceland
Intervertebral Disc Displacement - surgery
Lumbar Vertebrae
Male
Microsurgery
Middle Aged
Patient satisfaction
Recurrence
Retrospective Studies
Treatment Outcome
Abstract
Microsurgical discectomies are an established procedure in spinal surgery. This operating technique was first used in the Department of Neurosurgery in Iceland in 1981 and has become standard operative treatment for herniated lumbar discs. There is a great variability in outcome reports regarding recurrence rate and re-operation rate. Few articles are based on follow-up of more than 10 years. This article presents the results of a 20 years follow-up study.
A retrospective study of all patients undergoing microsurgical discectomy for herniated lumbar disc, from June 1, 1981 to December 31, 1984. Outcome, based on recurrence rate, return to work and patient satisfaction was determined by a self-evaluation questionnaire, phone interviews and patient medical records.
Of the 170 patients, 134 (78.8%) were included in the study (M:F, 58:42%). Preoperative symptoms: back pain with sciatica 108 (80.6%), sciatica 20 (14.9%), back pain 2 (1.5%). Mean follow-up time was 20.7 years (19.5-22.8). Recurrence rate was 12.7%. 19 patients (14.2%) underwent a subsequent lumbar operation at a different level or side. A majority of patients 108 (80.6%) returned to previous level of work, 26 (19.4%) lost some or all working capabilities. Patient satisfaction was high, 91.1% reporting excellent (68.7%) or good (22.4%) results. 5.2% of patients rated the outcome fair and 3.7% poor. Women reported worse outcome than men, excellent M:F 74.7:60.7%, and poor 7.1:1.3%. There was no significant difference in patient satisfaction in patients undergoing additional operations or those with recurrence of the herniated disc.
Outcome was very good with 92.0% return to work and 91.1% patient satisfaction. The recurrence rate was 12.7% with a substantial number of cases occurring 10-20 years after operation. To conclude, microsurgical discectomies maintain a high success rate in the long-term.
PubMed ID
17180308 View in PubMed
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1991 Volvo Award in clinical sciences. Smoking and lumbar intervertebral disc degeneration: an MRI study of identical twins.

https://arctichealth.org/en/permalink/ahliterature65039
Source
Spine. 1991 Sep;16(9):1015-21
Publication Type
Article
Date
Sep-1991
Author
M C Battié
T. Videman
K. Gill
G B Moneta
R. Nyman
J. Kaprio
M. Koskenvuo
Author Affiliation
Department of Orthopaedics, University of Washington, Seattle.
Source
Spine. 1991 Sep;16(9):1015-21
Date
Sep-1991
Language
English
Publication Type
Article
Keywords
Awards and Prizes
Comparative Study
Diseases in Twins - epidemiology
Finland - epidemiology
Humans
Intervertebral Disk Displacement - diagnosis - epidemiology - etiology
Lumbar Vertebrae - pathology
Magnetic Resonance Imaging
Male
Middle Aged
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Smoking - adverse effects
Sweden
Twins, Monozygotic
Abstract
The primary objective of this study was to determine whether disc degeneration, as assessed through magnetic resonance imaging, is greater in smokers than in nonsmokers. To control for the maximum number of potentially confounding variables, pairs of identical twins highly discordant for cigarette smoking were selected as study subjects. Data analyses revealed 18% greater mean disc degeneration scores in the lumbar spines of smokers as compared with nonsmokers. The effect was present across the entire lumbar spine, implicating a mechanism acting systemically. This investigation demonstrates the efficiency of using carefully selected controls in studying conditions of multifactorial etiology, such as disc degeneration.
PubMed ID
1948392 View in PubMed
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The 2002 Canadian bone densitometry recommendations: take-home messages.

https://arctichealth.org/en/permalink/ahliterature187804
Source
CMAJ. 2002 Nov 12;167(10):1141-5
Publication Type
Article
Date
Nov-12-2002
Author
Aliya A Khan
Jacques P Brown
David L Kendler
William D Leslie
Brian C Lentle
E Michael Lewiecki
Paul D Miller
R Lawrence Nicholson
Wojciech P Olszynski
Nelson B Watts
Author Affiliation
Division of Geriatrics, McMaster University, Hamilton, ON. Avkhan@aol.com
Source
CMAJ. 2002 Nov 12;167(10):1141-5
Date
Nov-12-2002
Language
English
Publication Type
Article
Keywords
Bone Density
Canada
Female
Hip
Humans
Lumbar Vertebrae
Middle Aged
Osteoporosis, Postmenopausal - diagnosis
Practice Guidelines as Topic
Risk factors
Notes
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Comment In: CMAJ. 2003 Jan 21;168(2):14912538531
PubMed ID
12427706 View in PubMed
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[Accelerated development of spinal degenerative changes during low back pain in young people]

https://arctichealth.org/en/permalink/ahliterature31687
Source
Lik Sprava. 2001 Sep-Dec;(5-6):98-101
Publication Type
Article
Author
V V Gongal'skyi
R M Ambartsumov
Ie G Kopyl
Source
Lik Sprava. 2001 Sep-Dec;(5-6):98-101
Language
Ukrainian
Publication Type
Article
Keywords
Adolescent
Back Pain - complications - physiopathology - ultrasonography
Child
English Abstract
Female
Humans
Inflammation - physiopathology
Lumbar Vertebrae - physiopathology
Magnetic Resonance Imaging
Male
Spinal Diseases - etiology - physiopathology - ultrasonography
Tomography, X-Ray Computed
Ultrasonography
Abstract
A possibility has been explored of an accelerated development of degenerative changes in the vertebral column in those young people whose activity is connected with high physical loads on the lumbar spine. A comparative analysis was done of results of the ultrasound investigation and magnetic-resonance tomography of spinal soft tissues. Sonographic techniques permit the conclusion to be reached that there develop degenerative and inflammatory processes at the level of certain vertebral segments at the preX-ray stage when it is only the soft-tissue structures that are involved.
PubMed ID
11881396 View in PubMed
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Adjacent level degeneration and facet arthropathy after disc prosthesis surgery or rehabilitation in patients with chronic low back pain and degenerative disc: second report of a randomized study.

https://arctichealth.org/en/permalink/ahliterature123374
Source
Spine (Phila Pa 1976). 2012 Dec 1;37(25):2063-73
Publication Type
Article
Date
Dec-1-2012
Author
Christian Hellum
Linda Berg
Øivind Gjertsen
Lars Gunnar Johnsen
Gesche Neckelmann
Kjersti Storheim
Anne Keller
Oliver Grundnes
Ansgar Espeland
Author Affiliation
Department of Orthopaedics, Oslo University Hospital and University of Oslo, Oslo, Norway. christian.hellum@medisin.uio.no
Source
Spine (Phila Pa 1976). 2012 Dec 1;37(25):2063-73
Date
Dec-1-2012
Language
English
Publication Type
Article
Keywords
Adult
Chronic Pain - diagnosis - etiology - rehabilitation - surgery - therapy
Disability Evaluation
Female
Humans
Intervertebral Disc - pathology - surgery
Intervertebral Disc Degeneration - diagnosis - etiology - rehabilitation - surgery - therapy
Low Back Pain - diagnosis - etiology - rehabilitation - surgery - therapy
Lumbar Vertebrae - pathology - surgery
Magnetic Resonance Imaging
Male
Middle Aged
Norway
Pain Measurement
Postoperative Complications - etiology - pathology
Predictive value of tests
Sacrum - pathology - surgery
Time Factors
Total Disc Replacement - adverse effects
Treatment Outcome
Zygapophyseal Joint - pathology
Abstract
Randomized clinical trial with 2-year follow-up.
To assess the development of adjacent level degeneration (ALD) and index level facet arthropathy (FA) in patients treated with disc prosthesis compared with patients treated with rehabilitation.
There is controversy about the natural history of disc degeneration and the development of ALD and FA in patients who undergo disc prosthesis surgery.
The study included 116 patients with a history of low back pain for at least 1 year, Oswestry Disability Index 30 points or more, and degenerative changes in 1 or 2 lower lumbar spine levels. Magnetic resonance imaging was performed before treatment and at the 2-year follow-up. ALD and index level FA were determined on the basis of the majority assessment of 3, independent, experienced radiologists. ALD was assessed by evaluating Modic changes, posterior high intensity zone in the disc, nucleus pulposus signal, disc height, disc contour, and FA. Data were analyzed with Fischer exact test and t test.
ALD developed with similar frequencies in patients who were (n = 59) and were not (n = 57) treated with surgery. In patients treated with surgery, index level FA appeared or increased in 20 patients (34%) and decreased in 1 patient. In patients treated with rehabilitation, 2 (4%) had new or increased FA at the index/degenerated disc level and 1 had decreased FA (P
PubMed ID
22706091 View in PubMed
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Advanced vertebral fracture among newly diagnosed children with acute lymphoblastic leukemia: results of the Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) research program.

https://arctichealth.org/en/permalink/ahliterature152682
Source
J Bone Miner Res. 2009 Jul;24(7):1326-34
Publication Type
Article
Date
Jul-2009
Author
Jacqueline Halton
Isabelle Gaboury
Ronald Grant
Nathalie Alos
Elizabeth A Cummings
Maryann Matzinger
Nazih Shenouda
Brian Lentle
Sharon Abish
Stephanie Atkinson
Elizabeth Cairney
David Dix
Sara Israels
David Stephure
Beverly Wilson
John Hay
David Moher
Frank Rauch
Kerry Siminoski
Leanne M Ward
Author Affiliation
University of Ottawa, Ontario, Canada.
Source
J Bone Miner Res. 2009 Jul;24(7):1326-34
Date
Jul-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Bone Density - drug effects
Canada - epidemiology
Child
Child, Preschool
Female
Glucocorticoids - administration & dosage - adverse effects
Humans
Infant
Infant, Newborn
Lumbar Vertebrae - injuries
Male
Osteoporosis - chemically induced - epidemiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis - drug therapy - epidemiology
Prevalence
Spinal Fractures - chemically induced - epidemiology
Thoracic Vertebrae - injuries
Abstract
Vertebral compression is a serious complication of childhood acute lymphoblastic leukemia (ALL). The prevalence and pattern of vertebral fractures, as well as their relationship to BMD and other clinical indices, have not been systematically studied. We evaluated spine health in 186 newly diagnosed children (median age, 5.3 yr; 108 boys) with ALL (precursor B cell: N = 167; T cell: N = 19) who were enrolled in a national bone health research program. Patients were assessed within 30 days of diagnosis by lateral thoraco-lumbar spine radiograph, bone age (also used for metacarpal morphometry), and BMD. Vertebral morphometry was carried out by the Genant semiquantitative method. Twenty-nine patients (16%) had a total of 75 grade 1 or higher prevalent vertebral compression fractures (53 thoracic, 71%; 22 lumbar). Grade 1 fractures as the worst grade were present in 14 children (48%), 9 patients (31%) had grade 2 fractures, and 6 children (21%) had grade 3 fractures. The distribution of spine fracture was bimodal, with most occurring in the midthoracic and thoraco-lumbar regions. Children with grade 1 or higher vertebral compression had reduced lumbar spine (LS) areal BMD Z-scores compared with those without (mean +/- SD, -2.1 +/- 1.5 versus -1.1 +/- 1.2; p
Notes
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PubMed ID
19210218 View in PubMed
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Agreement in the interpretation of magnetic resonance images of the lumbar spine.

https://arctichealth.org/en/permalink/ahliterature151073
Source
Acta Radiol. 2009 Jun;50(5):497-506
Publication Type
Article
Date
Jun-2009
Author
F M Kovacs
A. Royuela
T S Jensen
A. Estremera
G. Amengual
A. Muriel
I. Galarraga
C. Martínez
E. Arana
H. Sarasíbar
R M Salgado
V. Abraira
O. López
C. Campillo
M T Gil del Real
J. Zamora
Author Affiliation
Departamento Científico, Fundación Kovacs, Palma de Majorca, Spain. kovacs@kovacs.org
Source
Acta Radiol. 2009 Jun;50(5):497-506
Date
Jun-2009
Language
English
Publication Type
Article
Keywords
Adult
Denmark
Female
Humans
Lumbar Vertebrae - pathology
Magnetic Resonance Imaging - methods - statistics & numerical data
Male
Observer Variation
Reproducibility of Results
Severity of Illness Index
Spain
Spinal Diseases - diagnosis
Supine Position
Abstract
Correlation between clinical features and magnetic resonance imaging (MRI) findings is essential in low-back-pain patients. Most previous studies have analyzed concordance in the interpretation of lumbar MRI among a few radiologists who worked together. This may have overestimated concordance.
To evaluate intra- and interobserver agreement in the interpretation of lumbar MRI performed in an open 0.2 T system.
Seven radiologists from two different geographic settings in Spain interpreted the lumbar MRIs of 50 subjects representative of the general Danish population aged 40 years. The radiologists interpreted the images in routine clinical practice, having no knowledge of the clinical and demographic characteristics of the subjects and blinded to their colleagues' assessments. Six of the radiologists evaluated the same MRIs 14 days later, having no knowledge of the previous results. Data on the existence of disc degeneration, high-intensity zones, disc contour, Schmorl nodes, Modic changes, osteophytes, spondylolisthesis, and spinal stenosis were collected in the Nordic Modic Consensus Group Classification form. Intra- and interobserver agreement was analyzed for variables with a prevalence >or=10% and
PubMed ID
19431057 View in PubMed
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Alcohol consumption and bone mineral density in elderly women.

https://arctichealth.org/en/permalink/ahliterature122594
Source
Public Health Nutr. 2013 Apr;16(4):704-12
Publication Type
Article
Date
Apr-2013
Author
Isolde Sommer
Arja T Erkkilä
Ritva Järvinen
Jaakko Mursu
Joonas Sirola
Jukka S Jurvelin
Heikki Kröger
Marjo Tuppurainen
Author Affiliation
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. Isolde.Sommer@port.ac.uk
Source
Public Health Nutr. 2013 Apr;16(4):704-12
Date
Apr-2013
Language
English
Publication Type
Article
Keywords
Aged
Alcohol Drinking
Alcoholic Beverages - analysis
Anthropometry
Bone Density
Cohort Studies
Female
Femur Neck - radiography
Finland - epidemiology
Follow-Up Studies
Humans
Life Style
Lumbar vertebrae - radiography
Osteoporosis - epidemiology - prevention & control
Questionnaires
Risk factors
Abstract
Findings regarding alcohol consumption and bone mineral density (BMD) in elderly women have been inconsistent. The objective of the present study was to explore the association of alcohol intake with BMD in elderly women.
This cohort study included women from the population-based Kuopio Osteoporosis Risk Factor and Prevention - Fracture Prevention Study (OSTPRE-FPS). Alcohol intake and potential confounders were assessed at baseline and after 3 years of follow-up using a lifestyle questionnaire. In addition, an FFQ was distributed in the third year to measure dietary intake, including alcohol. Women underwent BMD measurements at the femoral neck and lumbar spine at baseline and after 3 years of follow-up.
Kuopio Province, Finland.
Three hundred elderly women (mean age 67·8 years) who provided both BMD measurements and FFQ data.
Alcohol consumption estimated from the FFQ and lifestyle questionnaire was significantly associated with BMD at both measurement sites after adjustment for potential confounders, including lifestyle and dietary factors (P 3 alcoholic drinks/week had significantly higher BMD than abstainers, 12·0 % at the femoral neck and 9·2 % at the lumbar spine. Results based on the lifestyle questionnaire showed higher BMD values for all alcohol-consuming women at the femoral neck and for women drinking 1-3 alcoholic beverages/week at the lumbar spine, compared with non-users.
The results from OSTPRE-FPS suggest that low to moderate alcohol intake may exert protective effects on bone health in elderly women.
PubMed ID
22800300 View in PubMed
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Alendronate once weekly for the prevention and treatment of bone loss in Canadian adult cystic fibrosis patients (CFOS trial).

https://arctichealth.org/en/permalink/ahliterature156077
Source
Chest. 2008 Oct;134(4):794-800
Publication Type
Article
Date
Oct-2008
Author
Alexandra Papaioannou
Courtney C Kennedy
Andreas Freitag
George Ioannidis
John O'Neill
Colin Webber
Margaret Pui
Yves Berthiaume
Harvey R Rabin
Nigel Paterson
Alphonse Jeanneret
Elias Matouk
Josee Villeneuve
Madeline Nixon
Jonathan D Adachi
Author Affiliation
Department of Medicine, McMaster University, Hamilton Health Sciences, Chedoke Site, Building 74, 1200 Main St West, Hamilton, ON, Canada L8N 3Z5. papaioannou@hhsc.ca
Source
Chest. 2008 Oct;134(4):794-800
Date
Oct-2008
Language
English
Publication Type
Article
Keywords
Administration, Oral
Adult
Alendronate - administration & dosage
Bone Density
Bone Density Conservation Agents - administration & dosage
Canada
Cohort Studies
Cystic Fibrosis - complications
Double-Blind Method
Drug Administration Schedule
Female
Humans
Lumbar Vertebrae - injuries
Male
Osteoporosis - complications - diagnosis - drug therapy
Spinal Fractures - diagnosis - epidemiology - prevention & control
Abstract
Patients with cystic fibrosis (CF) are at risk for early bone loss, and demonstrate increased risks for vertebral fractures and kyphosis. A multicenter, randomized, controlled trial was conducted to assess the efficacy, tolerability, and safety of therapy with oral alendronate (FOSAMAX; Merck; Whitehouse Station, NJ) in adults with CF and low bone mass.
Participants received placebo or alendronate, 70 mg once weekly, for 12 months. All participants received 800 IU of vitamin D and 1,000 mg of calcium daily. Adults with confirmed CF with a bone mineral density (BMD) T score of
PubMed ID
18641106 View in PubMed
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433 records – page 1 of 44.