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The 14q restless legs syndrome locus in the French Canadian population.

https://arctichealth.org/en/permalink/ahliterature179886
Source
Ann Neurol. 2004 Jun;55(6):887-91
Publication Type
Article
Date
Jun-2004
Author
Anastasia Levchenko
Jacques-Yves Montplaisir
Marie-Pierre Dubé
Jean-Baptiste Riviere
Judith St-Onge
Gustavo Turecki
Lan Xiong
Pascale Thibodeau
Alex Desautels
Dominique J Verlaan
Guy A Rouleau
Author Affiliation
Centre for Research in Neuroscience, McGill University Health Centre Research Institute, Montreal General Hospital, Quebec, Canada.
Source
Ann Neurol. 2004 Jun;55(6):887-91
Date
Jun-2004
Language
English
Publication Type
Article
Keywords
Canada
Chromosome Mapping
Chromosomes, Human, Pair 14 - genetics
Family Health
Female
France - ethnology
Genes, Dominant
Genes, Recessive
Genetic Linkage
Genetic Predisposition to Disease
Genotype
Humans
Lod Score
Male
Pedigree
Restless Legs Syndrome - genetics
Abstract
A new restless legs syndrome locus on chromosome 14 recently has been reported in one family of Italian origin. Our study aimed to replicate this finding and determine the importance of this locus in the French Canadian population. Markers spanning the region were genotyped in 14 large families and linkage assessed using two-point and multipoint logarithm of odds scores. Possible linkage to this locus was found in one of our kindreds providing support for the existence of this locus and indicating that this locus may be responsible for a small fraction of French Canadian restless legs syndrome.
PubMed ID
15174026 View in PubMed
Less detail

Absence of linkage of phonological coding dyslexia to chromosome 6p23-p21.3 in a large family data set.

https://arctichealth.org/en/permalink/ahliterature204108
Source
Am J Hum Genet. 1998 Nov;63(5):1448-56
Publication Type
Article
Date
Nov-1998
Author
L L Field
B J Kaplan
Author Affiliation
Department of Medical Genetics, Faculty of Medicine, Alberta Children's Hospital, University of Calgary, Calgry, Alberta, Canada. field@ucalgary.ca
Source
Am J Hum Genet. 1998 Nov;63(5):1448-56
Date
Nov-1998
Language
English
Publication Type
Article
Keywords
African Continental Ancestry Group - genetics
Alberta
Alleles
Auditory Perception
Child
Chromosome Mapping
Chromosomes, Human, Pair 6
Dyslexia - genetics - physiopathology
Europe - ethnology
European Continental Ancestry Group - genetics
Gene Frequency
Genetic Linkage
Genetic markers
Genotype
Humans
Lod Score
Nuclear Family
Abstract
Previous studies have suggested that a locus predisposing to specific reading disability (dyslexia) resides on chromosome 6p23-p21.3. We investigated 79 families having at least two siblings affected with phonological coding dyslexia, the most common form of reading disability (617 people genotyped, 294 affected), and we tested for linkage with the genetic markers reported to be linked to dyslexia in those studies. No evidence for linkage was found by LOD score analysis or affected-sib-pair methods. However, using the affected-pedigree-member (APM) method, we detected significant evidence for linkage and/or association with some markers when we used published allele frequencies with weighting of rarer alleles. APM results were not significant when we used marker allele frequencies estimated from parents. Furthermore, results were not significant with the more robust SIMIBD method using either published or parental marker frequencies. Finally, family-based association analysis using the AFBAC program showed no evidence for association with any marker. We conclude that the APM method should be used only with extreme caution, because it appears to have generated false-positive results. In summary, using a large data set with high power to detect linkage, we were unable to find evidence for linkage or association between phonological coding dyslexia and chromosome 6p markers.
Notes
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Erratum In: Am J Hum Genet 1999 Jan;64(1):334
PubMed ID
9792873 View in PubMed
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Age-dependent penetrance and mapping of the locus for juvenile and early-onset open-angle glaucoma on chromosome 1q (GLC1A) in a French family.

https://arctichealth.org/en/permalink/ahliterature210795
Source
Hum Genet. 1996 Nov;98(5):567-71
Publication Type
Article
Date
Nov-1996
Author
A. Meyer
A. Béchetoille
F. Valtot
S. Dupont de Dinechin
M F Adam
A. Belmouden
A P Brézin
L. Gomez
J F Bach
H J Garchon
Author Affiliation
INSERM U25, Hôpital Necker, Paris, France.
Source
Hum Genet. 1996 Nov;98(5):567-71
Date
Nov-1996
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Canada
Child
Chromosome Mapping
Chromosomes, Human, Pair 1
Female
France - ethnology
Genetic Linkage
Glaucoma, Open-Angle - genetics
Haploidy
Humans
Lod Score
Male
Middle Aged
Pedigree
Phenotype
Software
Abstract
The GLC1A locus for autosomal dominant primary open-angle glaucoma (POAG) with juvenile onset (before 20 years) has been mapped to chromosome 1q21-q31. Recently, a French-Canadian family was described in which both juvenile-onset and middle-age or early-onset POAG were observed and linked to GLC1A. We now describe a second POAG family with variable age of onset (range 11-51, median 36 years of age). Linkage to GLC1A was established with a maximum lod score of 6.21 at the D1S452 locus. A recombination event in a severely glaucomatous patient restricted the distal boundary of the GLC1A interval proximal to the AFM154xc9 marker. This study strengthens the idea that early-onset POAG may also be determined by the GLC1A genetic region.
PubMed ID
8882876 View in PubMed
Less detail

Allergic rhinitis--a total genome-scan for susceptibility genes suggests a locus on chromosome 4q24-q27.

https://arctichealth.org/en/permalink/ahliterature15411
Source
Eur J Hum Genet. 2001 Dec;9(12):945-52
Publication Type
Article
Date
Dec-2001
Author
A. Haagerup
T. Bjerke
P O Schøitz
H G Binderup
R. Dahl
T A Kruse
Author Affiliation
Institute of Human Genetics, Aarhus University, Aarhus, Denmark. AH@humgen.au.dk
Source
Eur J Hum Genet. 2001 Dec;9(12):945-52
Date
Dec-2001
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Chromosome Mapping
Chromosomes, Human, Pair 4 - genetics
Denmark
Female
Genetic Predisposition to Disease
Humans
Lod Score
Male
Research Support, Non-U.S. Gov't
Rhinitis, Allergic, Perennial - genetics
Rhinitis, Allergic, Seasonal - genetics
Abstract
Allergic rhinitis is a common disease of complex inheritance and is characterised by mucosal inflammation caused by allergen exposure. The genetics of closely related phenotypes such as asthma, atopy and to some extend atopic dermatitis has attracted attention in recent years. Genetic reports of allergic rhinitis on the contrary have as yet been most sparse. To identify candidate regions holding genes for allergic rhinitis we performed a total genome-scan on affected sib-pair families. From 100 Danish sib-pair families selected for allergy, families containing sib-pairs matching a phenotype definition of both clinical allergic rhinitis and confirmed specific allergy were chosen. Thirty-three affected sib-pair families qualified for the scan that was undertaken using 446 microsatellite markers. Non-parametric linkage results were obtained from MAPMAKER/SIBS computer program. The study revealed one major candidate region on chromosome 4q24-q27 (LOD=2.83) and eight minor candidate regions 2q12-q33, 3q13, 4p15-q12, 5q13-q15, 6p24-p23, 12p13, 22q13, and Xp21 (LOD=1.04-1.63) likely to contain susceptibility genes for allergic rhinitis. Our findings did not support a previous report of linkage of allergic rhinitis to chromosome 12q14-q24 but they added positive evidence to the asthma and atopy candidate regions 2q33 and 6p23. Further identification of the specific genes involved in allergic rhinitis will give opportunities for improved diagnosis and treatment.
PubMed ID
11840197 View in PubMed
Less detail

Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family.

https://arctichealth.org/en/permalink/ahliterature218798
Source
Neurosci Lett. 1994 Feb 28;168(1-2):254-6
Publication Type
Article
Date
Feb-28-1994
Author
L. Lannfelt
N. Bogdanovic
H. Appelgren
K. Axelman
L. Lilius
G. Hansson
D. Schenk
J. Hardy
B. Winblad
Source
Neurosci Lett. 1994 Feb 28;168(1-2):254-6
Date
Feb-28-1994
Language
English
Publication Type
Article
Keywords
Aged
Alzheimer Disease - genetics - pathology
Amyloid beta-Protein Precursor - genetics
Brain - pathology
Female
Genetic Linkage
Heterozygote Detection
Humans
Lod Score
Male
Middle Aged
Mutation
Neurofibrillary Tangles - pathology
Organ Specificity
Sweden
Abstract
Since the report of a double mutation at codons 670 and 671 of the amyloid precursor protein (APP) gene identified in two Swedish families with clinically diagnosed Alzheimer's disease (AD), a carrier with dementia has died. Neuropathology confirmed the clinical diagnosis of AD. Genealogical investigations have confirmed that the two families are related to common founders. Two-point linkage analysis of the mutation versus the disease in the revised pedigree now gives a lod score of 7.62.
PubMed ID
8028788 View in PubMed
Less detail

Analysis of HPC1, HPCX, and PCaP in Icelandic hereditary prostate cancer.

https://arctichealth.org/en/permalink/ahliterature20087
Source
Hum Genet. 2000 Oct;107(4):372-5
Publication Type
Article
Date
Oct-2000
Author
J T Bergthorsson
G. Johannesdottir
A. Arason
K R Benediktsdottir
B A Agnarsson
J E Bailey-Wilson
E. Gillanders
J. Smith
J. Trent
R B Barkardottir
Author Affiliation
Department of Pathology, University Hospital of Iceland, Reykjavik.
Source
Hum Genet. 2000 Oct;107(4):372-5
Date
Oct-2000
Language
English
Publication Type
Article
Keywords
Alleles
Chromosomes, Human, Pair 1 - genetics
Genetic markers
Humans
Iceland
Linkage (Genetics)
Lod Score
Male
Oncogenes
Prostatic Neoplasms - genetics
Research Support, Non-U.S. Gov't
X Chromosome - genetics
Abstract
Putative prostate cancer susceptibility loci have recently been identified by genetic linkage analysis on chromosomes 1q24-25 (HPC1). 1q44.243 (PCaP), and Xq27-28 (HPCX). In order to estimate the genetic linkage in Icelandic prostate cancer families, we genotyped 241 samples from 87 families with eleven markers in the HPC1 region, six markers at PCaP, and eight at HPCX. Concurrently, we assessed allelic imbalance at the HPC1 and PCaP loci in selected tumors from the patients. For each of the candidate regions, the combined parametric and non-parametric LOD scores were strongly negative. Evidence for linkage allowing for genetic heterogeneity was also insignificant for all the regions. The results were negative irrespective of whether calculations were performed for the whole material or for a selected set of early age at onset families. The prevalence of allelic imbalance was relatively low in both the HPC1 (0%-9%) and PCaP (5%-20%) regions and was not elevated in tumors from positively linked families. Our studies indicate that the putative cancer susceptibility genes at chromosomes 1q24-25, 1q44.2-43, and Xq27-28 are unlikely to contribute significantly to hereditary prostate cancer in Iceland and that selective loss of the HPC1 and PCaP loci is a relatively rare somatic event in prostate cancers.
PubMed ID
11129338 View in PubMed
Less detail

Analysis of three suggested psoriasis susceptibility loci in a large Swedish set of families: confirmation of linkage to chromosome 6p (HLA region), and to 17q, but not to 4q.

https://arctichealth.org/en/permalink/ahliterature203590
Source
Hum Hered. 1999 Jan;49(1):2-8
Publication Type
Article
Date
Jan-1999
Author
F. Enlund
L. Samuelsson
C. Enerbäck
A. Inerot
J. Wahlström
M. Yhr
A. Torinsson
T. Martinsson
G. Swanbeck
Author Affiliation
Department of Clinical Genetics, Gothenburg University, Sahlgrenska University Hospital, Gothenburg, Sweden.
Source
Hum Hered. 1999 Jan;49(1):2-8
Date
Jan-1999
Language
English
Publication Type
Article
Keywords
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 6
Family Health
Genetic Linkage - genetics
Genetic Predisposition to Disease
HLA Antigens - genetics
Humans
Linkage Disequilibrium
Lod Score
Psoriasis - genetics
Sweden
Abstract
Psoriasis is known to be a heterogeneous disease with so far three reported major psoriasis susceptibility loci on chromosome 4q, 6p and 17q. In this study we investigated three reported gene locations by nonparametric and parametric linkage analysis in a large family set consisting of 104 families (153 sib pairs) from Sweden. We could confirm linkage to chromosome 6p. A maximum heterogeneous lod score of 2.78 was reached at locus D6S276 (alpha = 0.60). Allelic association studies within the HLA region indicated linkage disequilibrium at locus TNFbeta with a significant p value of 0.0009. Furthermore, we obtained weak evidence of linkage to the locus on chromosome 17q while no evidence of linkage could be found to the chromosome 4q region.
PubMed ID
9858851 View in PubMed
Less detail

An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium.

https://arctichealth.org/en/permalink/ahliterature23409
Source
Am J Hum Genet. 1995 Jan;56(1):254-64
Publication Type
Article
Date
Jan-1995
Author
S A Narod
D. Ford
P. Devilee
R B Barkardottir
H T Lynch
S A Smith
B A Ponder
B L Weber
J E Garber
J M Birch
Author Affiliation
Department of Medicine, McGill University, Montreal, Quebec, Canada.
Source
Am J Hum Genet. 1995 Jan;56(1):254-64
Date
Jan-1995
Language
English
Publication Type
Article
Keywords
Adult
Age of Onset
BRCA1 Protein
Breast Neoplasms - epidemiology - genetics
Breast Neoplasms, Male - epidemiology - genetics
Chromosomes, Human, Pair 17
Female
Genetic Heterogeneity
Genetic Predisposition to Disease
Humans
Iceland - epidemiology
Lod Score
Male
Middle Aged
Neoplasm Proteins - genetics
Neoplasms, Multiple Primary - epidemiology - genetics
Neoplastic Syndromes, Hereditary - epidemiology - genetics
Netherlands - epidemiology
Ovarian Neoplasms - epidemiology - genetics
Pedigree
Transcription Factors - genetics
Abstract
The breast-ovary cancer-family syndrome is a dominant predisposition to cancer of the breast and ovaries which has been mapped to chromosome region 17q12-q21. The majority, but not all, of breast-ovary cancer families show linkage to this susceptibility locus, designated BRCA1. We report here the results of a linkage analysis of 145 families with both breast and ovarian cancer. These families contain either a total of three or more cases of early-onset (before age 60 years) breast cancer or ovarian cancer. All families contained at least one case of ovarian cancer. Overall, an estimated 76% of the 145 families are linked to the BRCA1 locus. None of the 13 families with cases of male breast cancer appear to be linked, but it is estimated that 92% (95% confidence interval 76%-100%) of families with no male breast cancer and with two or more ovarian cancers are linked to BRCA1. These data suggest that the breast-ovarian cancer-family syndrome is genetically heterogeneous. However, the large majority of families with early-onset breast cancer and with two or more cases of ovarian cancer are likely to be due to BRCA1 mutations.
PubMed ID
7825586 View in PubMed
Less detail

Anxiety with panic disorder linked to chromosome 9q in Iceland.

https://arctichealth.org/en/permalink/ahliterature185955
Source
Am J Hum Genet. 2003 May;72(5):1221-30
Publication Type
Article
Date
May-2003
Author
Thorgeir E Thorgeirsson
Högni Oskarsson
Natasa Desnica
Jelena Pop Kostic
Jon G Stefansson
Halldor Kolbeinsson
Eirikur Lindal
Nikolai Gagunashvili
Michael L Frigge
Augustine Kong
Kari Stefansson
Jeffrey R Gulcher
Author Affiliation
deCode Genetics, Reykjavík, Iceland. thorgeir@decode.is
Source
Am J Hum Genet. 2003 May;72(5):1221-30
Date
May-2003
Language
English
Publication Type
Article
Keywords
Anxiety - diagnosis - epidemiology - genetics
Chromosome Mapping
Chromosomes, Human, Pair 9 - genetics
Comorbidity
Genetic Linkage
Genetic markers
Genetic Predisposition to Disease
Genotype
Humans
Iceland - epidemiology
Lod Score
Mass Screening
Microsatellite Repeats
Panic Disorder - diagnosis - epidemiology - genetics
Questionnaires
Abstract
The results of a genomewide scan for genes conferring susceptibility to anxiety disorders in the Icelandic population are described. The aim of the study was to locate genes that predispose to anxiety by utilizing the extensive genealogical records and the relative homogeneity of the Icelandic population. Participants were recruited in two stages: (1) Initial case-identification by a population screening for anxiety disorders, using the Stamm Screening Questionnaire, was followed by aggregation into extended families, with the help of our genealogy database; and (2) those who fulfilled the diagnostic and family aggregation criteria underwent a more detailed diagnostic workup based on the Composite International Diagnostic Interview. Screening for anxiety in close relatives also identified additional affected members within the families. After genotyping was performed with 976 microsatellite markers, affected-only linkage analysis was done, and allele-sharing LOD scores were calculated using the program Allegro. Linkage analysis of 25 extended families, in each of which at least one affected individual had panic disorder (PD), resulted in a LOD score of 4.18 at D9S271, on chromosome 9q31. The intermarker distance was 4.4 cM on average, whereas it was 1.5 cM in the linked region as additional markers were added to increase the information content. The linkage results may be relevant not only to PD but also to anxiety in general, since our linkage study included patients with other forms of anxiety.
Notes
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PubMed ID
12679899 View in PubMed
Less detail

The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease.

https://arctichealth.org/en/permalink/ahliterature218459
Source
Am J Hum Genet. 1994 Apr;54(4):631-42
Publication Type
Article
Date
Apr-1994
Author
C E Yu
H. Payami
J M Olson
M. Boehnke
E M Wijsman
H T Orr
W A Kukull
K A Goddard
E. Nemens
J A White
Author Affiliation
Division of Neurology, University of Washington, Seattle 98195.
Source
Am J Hum Genet. 1994 Apr;54(4):631-42
Date
Apr-1994
Language
English
Publication Type
Article
Keywords
Adult
Age of Onset
Aged
Aged, 80 and over
Alleles
Alzheimer Disease - genetics
Apolipoprotein C-I
Apolipoprotein C-II
Apolipoproteins C - genetics
Apolipoproteins E - genetics
Chromosomes, Human, Pair 19
Female
Gene Frequency
Genetic Linkage
Germany - ethnology
Humans
Likelihood Functions
Lod Score
Male
Middle Aged
Multigene Family
Pedigree
Polymorphism, Genetic
Russia
Abstract
The chromosome 19 apolipoprotein E/CI/CII gene cluster was examined for evidence of linkage to a familial Alzheimer disease (FAD) locus. The family groups studied were Volga German (VG), early-onset non-VG (ENVG; mean age at onset
Notes
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PubMed ID
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