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1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents.

https://arctichealth.org/en/permalink/ahliterature273208
Source
PLoS One. 2015;10(8):e0135018
Publication Type
Article
Date
2015
Author
Cilius Esmann Fonvig
Elizaveta Chabanova
Ehm Astrid Andersson
Johanne Dam Ohrt
Oluf Pedersen
Torben Hansen
Henrik S Thomsen
Jens-Christian Holm
Source
PLoS One. 2015;10(8):e0135018
Date
2015
Language
English
Publication Type
Article
Keywords
Adolescent
Anthropometry
Blood Glucose - analysis
Blood pressure
Body mass index
Body Weight
Cardiovascular Diseases - physiopathology
Child
Cross-Sectional Studies
Denmark
Dyslipidemias - blood
Fatty Liver - pathology
Female
Humans
Insulin - blood
Insulin Resistance
Intra-Abdominal Fat - pathology
Linear Models
Lipids - blood
Liver - metabolism - pathology
Male
Muscles - pathology
Overweight
Pediatric Obesity - blood - pathology
Proton Magnetic Resonance Spectroscopy
Puberty
Sex Factors
Subcutaneous Fat - pathology
Abstract
This cross sectional study aims to investigate the associations between ectopic lipid accumulation in liver and skeletal muscle and biochemical measures, estimates of insulin resistance, anthropometry, and blood pressure in lean and overweight/obese children.
Fasting plasma glucose, serum lipids, serum insulin, and expressions of insulin resistance, anthropometry, blood pressure, and magnetic resonance spectroscopy of liver and muscle fat were obtained in 327 Danish children and adolescents aged 8-18 years.
In 287 overweight/obese children, the prevalences of hepatic and muscular steatosis were 31% and 68%, respectively, whereas the prevalences in 40 lean children were 3% and 10%, respectively. A multiple regression analysis adjusted for age, sex, body mass index z-score (BMI SDS), and pubertal development showed that the OR of exhibiting dyslipidemia was 4.2 (95%CI: [1.8; 10.2], p = 0.0009) when hepatic steatosis was present. Comparing the simultaneous presence of hepatic and muscular steatosis with no presence of steatosis, the OR of exhibiting dyslipidemia was 5.8 (95%CI: [2.0; 18.6], p = 0.002). No significant associations between muscle fat and dyslipidemia, impaired fasting glucose, or blood pressure were observed. Liver and muscle fat, adjusted for age, sex, BMI SDS, and pubertal development, associated to BMI SDS and glycosylated hemoglobin, while only liver fat associated to visceral and subcutaneous adipose tissue and intramyocellular lipid associated inversely to high density lipoprotein cholesterol.
Hepatic steatosis is associated with dyslipidemia and liver and muscle fat depositions are linked to obesity-related metabolic dysfunctions, especially glycosylated hemoglobin, in children and adolescents, which suggest an increased cardiovascular disease risk.
Notes
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PubMed ID
26252778 View in PubMed
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7-Alkoxyquinoline O-dealkylation by microsomes from human liver and placenta.

https://arctichealth.org/en/permalink/ahliterature64902
Source
Br J Clin Pharmacol. 1992 Nov;34(5):415-20
Publication Type
Article
Date
Nov-1992
Author
J. Hakkola
J. Mäenpää
R T Mayer
S S Park
H V Gelboin
O. Pelkonen
Author Affiliation
Department of Pharmacology and Toxicology, University of Oulu, Finland.
Source
Br J Clin Pharmacol. 1992 Nov;34(5):415-20
Date
Nov-1992
Language
English
Publication Type
Article
Keywords
Animals
Antibodies, Monoclonal - diagnostic use
Benzyl Compounds - metabolism
Cytochrome P-450 Enzyme System - antagonists & inhibitors - metabolism
Dealkylation
Female
Humans
In Vitro
Male
Mice
Mice, Inbred Strains
Microsomes - enzymology - metabolism
Microsomes, Liver - enzymology - metabolism
Placenta - enzymology - metabolism
Pregnancy
Quinolines - metabolism
Rats
Rats, Wistar
Research Support, Non-U.S. Gov't
Smoking - metabolism
Abstract
1. The O-dealkylation of seven 7-alkoxyquinoline derivatives by human hepatic and placental microsomes and the effect of maternal cigarette smoking on placental 7-alkoxyquinoline metabolism was studied. 2. None of several monoclonal antibodies to isoenzymes of cytochrome P450 had a clear effect on metabolism of the compounds by liver microsomes. 3. Maternal cigarette smoking induced the O-dealkylation of all of the 7-alkoxyquinoline derivatives, being greatest for 7-butoxy- and 7-benzyloxyquinoline. 4. Placental 7-alkoxyquinoline metabolism induced by smoking was partially inhibited by the monoclonal antibody 1-7-1 raised against 3-methylcholanthrene-induced rat liver P450. 5. None of the 7-alkoxyquinoline O-dealkylations could be assigned specifically to any known P450 isoenzyme in human liver or placenta.
PubMed ID
1467136 View in PubMed
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210Pb and 210Po in tissues of some Alaskan residents as related to consumption of caribou or reindeer meat.

https://arctichealth.org/en/permalink/ahliterature5061
Source
Health Physics. 1970 Feb;18(2):127-134
Publication Type
Article
Date
Feb-1970

Abdominal injuries sustained in severe traffic accidents by seatbelt wearers.

https://arctichealth.org/en/permalink/ahliterature235383
Source
J Trauma. 1987 Apr;27(4):393-7
Publication Type
Article
Date
Apr-1987
Author
E. Arajärvi
S. Santavirta
J. Tolonen
Source
J Trauma. 1987 Apr;27(4):393-7
Date
Apr-1987
Language
English
Publication Type
Article
Keywords
Abdominal Injuries - epidemiology - etiology - mortality
Accidents, Traffic
Adult
Aged
Aged, 80 and over
Deceleration
Female
Finland
Humans
Intestine, Small - injuries
Liver - injuries
Male
Seat Belts - adverse effects
Spleen - injuries
Thoracic Injuries - complications
Abstract
In Finland during the period 1972-1983, there were 3,564 severe traffic accidents involving one or more victims dying within 30 days of the accident. Forty-two of the victims had been wearing a seatbelt and had an abdominal trauma as the main cause of death or as first diagnosis of injury. Small intestine and colon injuries were more common in the severely injured victims than was the case with the fatally injured ones and in these accidents the injury mechanism was always deceleration or contusion, which was in most cases caused by the seatbelt. Liver injuries seem to be the major abdominal cause of fatality, and in the fatally injured group, half of the victims sustained the fatal abdominal injury through gross crushing impact. When the direction of the impact was analyzed, all the victims seated on the receiving side of the vehicle in lateral impact collisions sustained an abdominal injury with fatal outcome. It seems that the seatbelt is less effective in protecting wearers from severe or fatal abdominal injuries in lateral impact collisions.
PubMed ID
3573085 View in PubMed
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Abdominal malignancies in patients with Wilson's disease.

https://arctichealth.org/en/permalink/ahliterature18250
Source
QJM. 2003 Sep;96(9):657-62
Publication Type
Article
Date
Sep-2003
Author
J M Walshe
E. Waldenström
V. Sams
H. Nordlinder
K. Westermark
Author Affiliation
Department of Neurology, The Middlesex Hospital, London, UK. penicillamine@waitrose.com
Source
QJM. 2003 Sep;96(9):657-62
Date
Sep-2003
Language
English
Publication Type
Article
Keywords
Abdominal Neoplasms - complications - epidemiology - genetics
Adenocarcinoma - complications - epidemiology - genetics
Adolescent
Adult
Age of Onset
Biliary Tract Neoplasms - complications - epidemiology - genetics
Carcinoma, Hepatocellular - complications - epidemiology - genetics
Child
Cholangiocarcinoma - complications - epidemiology - genetics
Female
Hepatolenticular Degeneration - complications - epidemiology - genetics
Humans
Incidence
Liver Neoplasms - complications - epidemiology - genetics
Long-Term Care
Male
Mutation
Pancreatic Neoplasms - complications - epidemiology - genetics
Retrospective Studies
Sweden - epidemiology
Time Factors
Abstract
BACKGROUND: Wilson's disease is associated with heavy copper overload, primarily in the liver. Copper is a toxic metal, and might be expected to be associated with cancer induction, as iron is in haemochromatosis. However, liver cancer is currently believed to be extremely rare in this disease, and other intra-abdominal malignancies have not been reported. AIM: To assess the frequency of abdominal malignant disease in patients with Wilson's disease on long-term follow-up. DESIGN: Retrospective study in two specialist Wilson's disease clinics: Cambridge/London and Uppsala. METHODS: We reviewed the case records of 363 patients seen at three centres: Addenbrooke's Hospital, Cambridge, 1955-1987; the Middlesex Hospital, London, 1987-2000; and the University Hospital, Uppsala, Sweden, 1966-2002. Patients were grouped by length of follow-up: 10-19 years; 20-29 years; 30-39 years; and 40 years or more. RESULTS: No cancers were seen in patients followed for
PubMed ID
12925721 View in PubMed
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Abdominal trauma during thirty years: analysis of a large case series.

https://arctichealth.org/en/permalink/ahliterature40679
Source
Injury. 1981 Sep;13(2):93-9
Publication Type
Article
Date
Sep-1981
Author
D. Bergqvist
H. Hedelin
G. Karlsson
B. Lindblad
T. Mätzsch
Source
Injury. 1981 Sep;13(2):93-9
Date
Sep-1981
Language
English
Publication Type
Article
Keywords
Abdominal Injuries - epidemiology - etiology
Accidents, Traffic
Adolescent
Adult
Aged
Child
Child, Preschool
Female
Humans
Infant
Kidney - injuries
Liver - injuries
Male
Middle Aged
Retrospective Studies
Seasons
Spleen - injuries
Sweden
Abstract
Studies have been made in 1407 patients of the causes, the organs involved and the outcome of injury to the abdomen in patients needing admission to hospital in an area of Southern Sweden, between 1950 and the end of 1979. The proportion of female patients and those aged over 60 increased significantly. The seasonal distribution of the injuries showed significant change, with a drop in the initially high frequency sustained during the summer months. Penetrating injuries were rare, but increased in the 1970s. Road traffic accidents as the cause of abdominal injuries rose to a maximum of 56 per cent in the late 1960s. The numbers of injured organs and the frequency of other associated injuries rose gradually until the mid-1970s, after which there was a slight decrease. The spleen, liver and large blood vessels were the organs which were increasingly often injured. The annual incidence of various visceral injuries per 100 000 population was calculated. The number of patients with a delay of at least 24 hours before operation fell significantly and there was a tendency to shorter hospital stay. The mortality curve showed a peak in the late 1960s.
PubMed ID
7327735 View in PubMed
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Ablation therapy guided by contrast-enhanced sonography with Sonazoid for hepatocellular carcinoma lesions not detected by conventional sonography.

https://arctichealth.org/en/permalink/ahliterature86820
Source
J Ultrasound Med. 2008 Mar;27(3):395-406
Publication Type
Article
Date
Mar-2008
Author
Numata Kazushi
Morimoto Manabu
Ogura Takashi
Sugimori Kazuya
Takebayashi Shigeo
Okada Masahiro
Tanaka Katsuaki
Author Affiliation
Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa 232-0024, Japan. kz-numa@zero.ad.jp
Source
J Ultrasound Med. 2008 Mar;27(3):395-406
Date
Mar-2008
Language
English
Publication Type
Article
Keywords
Aged
Analysis of Variance
Biopsy
Carcinoma, Hepatocellular - radiography - surgery - ultrasonography
Catheter Ablation
Chi-Square Distribution
Contrast Media
Female
Ferric Compounds - diagnostic use
Humans
Iron - diagnostic use
Liver Neoplasms - radiography - surgery - ultrasonography
Male
Middle Aged
Oxides - diagnostic use
Tomography, X-Ray Computed
Treatment Outcome
Ultrasonography, Interventional
Abstract
OBJECTIVE: We evaluated the usefulness of contrast-enhanced harmonic gray scale sonography with a newly developed sonographic contrast medium as a means of guidance for percutaneous ablation therapy of hepatocellular carcinoma lesions not detected by conventional sonography. METHODS: We examined 85 patients with 108 hepatocellular carcinoma lesions that were identified as hypervascular by multidetector-row computed tomography by using contrast-enhanced harmonic gray scale sonography after injection of Sonazoid (GE Healthcare, Oslo, Norway), a lipid-stabilized suspension of a perfluorobutane gas microbubble contrast agent. We scanned the whole liver by this modality at a low mechanical index in the late phase to detect lesions not detected by conventional sonography and then scanned the lesions again by this modality at a high mechanical index to visualize tumor vessels and enhancement. We also performed percutaneous ablation therapy guided by this modality to treat viable hepatocellular carcinoma lesions that could not be detected by conventional sonography. RESULTS: Conventional sonography identified 90 (83%) of 108 hepatocellular carcinoma lesions; 15 (14%) additional viable lesions not detected by conventional sonography were detected in the late phase of contrast-enhanced harmonic gray scale sonography at a low mechanical index, and tumor vessels and enhancement were observed in the late phase at a high mechanical index. Contrast-enhanced harmonic gray scale sonography diagnosed 105 (97%) of the 108 viable hepatocellular carcinoma lesions, and 14 (93%) of the 15 lesions not detected by conventional sonography were successfully treated by percutaneous ablation therapy guided by this modality. CONCLUSIONS: Contrast-enhanced harmonic gray scale sonography is useful for guidance of percutaneous ablation therapy of hepatocellular carcinoma lesions not detected by conventional sonography.
PubMed ID
18314518 View in PubMed
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Abnormality of energy metabolism in the skeletal muscle of patients with liver cirrhosis and changes under administration of glucose and branched-chain amino acids.

https://arctichealth.org/en/permalink/ahliterature5271
Source
Tokai J Exp Clin Med. 2004 Dec;29(4):191-8
Publication Type
Article
Date
Dec-2004
Author
Jun Doi
Koichi Shiraishi
Munetaka Haida
Shohei Matsuzaki
Author Affiliation
Department of Gastroenterology, Tokai University Hachioji Hospital, Hachioji, Tokyo 192-0032, Japan.
Source
Tokai J Exp Clin Med. 2004 Dec;29(4):191-8
Date
Dec-2004
Language
English
Publication Type
Article
Keywords
Aged
Amino Acids, Branched-Chain - administration & dosage
Case-Control Studies
Citric Acid Cycle
Comparative Study
Energy Metabolism
Exercise
Fasting
Female
Glucose - administration & dosage - metabolism
Humans
Hydrogen-Ion Concentration
Liver Cirrhosis - metabolism
Magnetic Resonance Spectroscopy
Male
Middle Aged
Muscle, Skeletal - metabolism
Oxygen - metabolism
Phosphocreatine - metabolism
Spectroscopy, Near-Infrared
Abstract
We assessed changes in skeletal muscle energy metabolism by 31P-magnetic resonance spectroscopy (31P-MRS) and oxygen supply by near-infrared spectroscopy (NIR), after exercise and after administration of glucose and a branched-chain amino acids (BCAA), in healthy volunteers and patients with liver cirrhosis. As for the patients with liver cirrhosis, 4 were classified in Child-Pugh Grade A and the other 4 in Grade B. In patients with liver cirrhosis, the intramuscular pH and PCr index (PCr/PCr + Pi) were lower than in healthy subjects after exercise in the fasting state; the deltapH and deltaPCr index were statistically siginificant (p
PubMed ID
15717491 View in PubMed
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ABO-incompatible liver transplantation for critically ill adult patients.

https://arctichealth.org/en/permalink/ahliterature163388
Source
Transpl Int. 2007 Aug;20(8):675-81
Publication Type
Article
Date
Aug-2007
Author
Christian Toso
Mohammed Al-Qahtani
Faisal A Alsaif
David L Bigam
Glenda A Meeberg
A M James Shapiro
Vincent G Bain
Norman M Kneteman
Author Affiliation
Department of Surgery, Section of Hepatobiliary, Pancreatic and Transplant Surgery, University of Alberta, Edmonton, Canada.
Source
Transpl Int. 2007 Aug;20(8):675-81
Date
Aug-2007
Language
English
Publication Type
Article
Keywords
ABO Blood-Group System - immunology
Adolescent
Adult
Aged
Alberta - epidemiology
Critical Illness
Female
Follow-Up Studies
Graft Rejection - blood - epidemiology - prevention & control
Graft Survival
Humans
Immunosuppressive Agents - therapeutic use
Incidence
Liver Failure - blood - surgery
Liver Transplantation - adverse effects
Male
Middle Aged
Prognosis
Retrospective Studies
Survival Rate
Abstract
ABO incompatible (ABO-In) liver transplant remains a controversial solution to acute liver failure in adults. Adult liver recipients with acute liver failure or severely decompensated end-stage disease, intubated and/or in the intensive care unit, were grouped as ABO-In (n = 14), ABO-compatible (n = 29, ABO-C) and ABO-identical (n = 65, ABO-Id). ABO-In received quadruple immunosuppression with antibody-depleting induction agents (except two), calcineurin inhibitors, antimetabolites and steroids. No significant difference of patient and graft survivals was observed among ABO-In, ABO-C and ABO-Id: graft survivals were 64%, 62% and 67%, respectively, in 1 year and 56%, 54% and 60%, respectively, in 5 years; patient survivals 86%, 69% and 67%, respectively, in 1 year and 77%, 61% and 62%, respectively, in 5 years. Three ABO-In grafts were lost (one hyper-acute rejection and two hepatic artery thrombosis). Surgical and infectious complications were similarly distributed between groups, except the hepatic artery thrombosis, more frequent in ABO-In (2, 14%) than ABO-I (1, 1.5%, P
PubMed ID
17521384 View in PubMed
Less detail

Absence of association between genetic variation in the LIPC gene promoter and plasma lipoproteins in three Canadian populations.

https://arctichealth.org/en/permalink/ahliterature5558
Source
Atherosclerosis. 1999 Sep;146(1):153-60
Publication Type
Article
Date
Sep-1999
Author
R A Hegele
S B Harris
J H Brunt
T K Young
A J Hanley
B. Zinman
P W Connelly
Author Affiliation
Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, Department of Medicine, London, Ont., Canada. robert.hegele@rri.on.ca
Source
Atherosclerosis. 1999 Sep;146(1):153-60
Date
Sep-1999
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Arteriosclerosis - genetics
Canada
Female
Gene Frequency
Humans
Indians, North American - genetics
Lipase - blood - genetics
Lipoproteins, HDL Cholesterol - blood
Liver - enzymology
Male
Middle Aged
Phenotype
Population Surveillance
Promoter Regions (Genetics)
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Sensitivity and specificity
Trans-Activation (Genetics)
Variation (Genetics)
Abstract
The promoter sequence variant -480T in the hepatic lipase gene (LIPC) has been shown to be significantly associated with low post-heparin hepatic lipase activity. Some studies have also found that the -480T variant is associated with elevation in plasma HDL cholesterol. We tested for associations of LIPC -480T with plasma lipoprotein traits in samples taken from three distinct Canadian populations: 657 Alberta Hutterites, 328 Ontario Oji-Cree and 210 Keewatin Inuit. Plasma HL activity was not available for analyses. The LIPC -480T allele frequencies in these three groups, respectively, were 0.219, 0.527 and 0.383, and the prevalence of LIPC -480T/T homozygotes was, respectively, 0.042, 0.274 and 0.167. No significant association was found between LIPC -480T and plasma HDL cholesterol or apolipoprotein AI concentration, after adjusting for covariates including gender and body mass index. There was no consistent relationship between the population mean plasma HDL cholesterol concentration and the population LIPC -480T frequency. Our findings are consistent with the idea that the common promoter variation in LIPC, which has been reported to be associated with variation in post heparin HL activity and HDL triglyceride concentration, is not always associated with variation in plasma HDL cholesterol concentration, possibly due to yet unspecified environmental or genetic factors.
PubMed ID
10487498 View in PubMed
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1623 records – page 1 of 163.