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Occurrence of cirrhosis and primary liver cancer in an Eskimo population hyperendemically infected with hepatitis B virus.

https://arctichealth.org/en/permalink/ahliterature294007
Source
American Journal of Epidemiology. 1978 Aug;108(2):121-5.
Publication Type
Article
Date
1978
Author
Skinhøj P
Hart Hansen JP
Nielsen NH
Mikkelsen F
Source
American Journal of Epidemiology. 1978 Aug;108(2):121-5.
Date
1978
Language
English
Geographic Location
Greenland
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Child
Child, Preschool
Disease Outbreaks
Epidemiology
Female
Greenland
Hepatitis B
Humans
Infant
Infant, Newborn
Inuits
Liver Cirrhosis
Liver Neoplasms
Male
Middle Aged
Population Surveillance
Abstract
Hepatitis type B is hyperendemic in Greenland with serologic evidence of infection in 54% of adults and a hepatitis B surface antigen (HBsAg) carrier rate of 7--25%. The impact of this infection rate on the occurrence of cirrhosis and primary liver cancer (PLC) was studied. Mortality rates for cirrhosis were obtained from official mortality statistics, 1951--1975. PLC was identified by a study of all biopsy and necropsy material taken in the study area during the same period. Neither cirrhosis nor PLC was found to be a more prevalent cause of death in this population than in Northern Europe where hepatitis B is at least 10-fold less prevalent. It is concluded that hepatitis B infection per se does not contribute significantly to the development of cirrhosis or to PLC, at least in the Eskimo population of Greenland.
PubMed ID
707473 View in PubMed
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