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Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism-The Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature292130
Source
Sci Rep. 2016 12 05; 6:38262
Publication Type
Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Date
12-05-2016
Author
Emma Raitoharju
Ilkka Seppälä
Leo-Pekka Lyytikäinen
Jorma Viikari
Mika Ala-Korpela
Pasi Soininen
Antti J Kangas
Melanie Waldenberger
Norman Klopp
Thomas Illig
Jaana Leiviskä
Britt-Marie Loo
Niku Oksala
Mika Kähönen
Nina Hutri-Kähönen
Reijo Laaksonen
Olli Raitakari
Terho Lehtimäki
Author Affiliation
Department of Clinical Chemistry, Pirkanmaa Hospital District, Fimlab Laboratories, and University of Tampere, School of Medicine, Tampere, Finland.
Source
Sci Rep. 2016 12 05; 6:38262
Date
12-05-2016
Language
English
Publication Type
Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Keywords
Adolescent
Adult
Child
Child, Preschool
Fatty Liver - blood - diagnostic imaging - epidemiology
Female
Finland - epidemiology
Follow-Up Studies
Genome-Wide Association Study
Humans
Lipoproteins - blood
Male
MicroRNAs - blood
Middle Aged
Ultrasonography
Abstract
MicroRNAs are involved in disease development and may be utilized as biomarkers. We investigated the association of blood miRNA levels and a) fatty liver (FL), b) lipoprotein and lipid pathways involved in liver lipid accumulation and c) levels of predicted mRNA targets in general population based cohort. Blood microRNA profiling (TaqMan OpenArray), genome-wide gene expression arrays and nuclear magnetic resonance metabolomics were performed for Young Finns Study participants aged 34-49 years (n?=?871). Liver fat status was assessed ultrasonographically. Levels of hsa-miR-122-5p and -885-5p were up-regulated in individuals with FL (fold change (FC)?=?1.55, p?=?1.36?*?10-14 and FC?=?1.25, p?=?4.86?*?10-4, respectively). In regression model adjusted with age, sex and BMI, hsa-miR-122-5p and -885-5p predicted FL (OR?=?2.07, p?=?1.29?*?10-8 and OR?=?1.41, p?=?0.002, respectively). Together hsa-miR-122-5p and -885-5p slightly improved the detection of FL beyond established risk factors. These miRNAs may be associated with FL formation through the regulation of lipoprotein metabolism as hsa-miR-122-5p levels associated with small VLDL, IDL, and large LDL lipoprotein subclass components, while hsa-miR-885-5p levels associated inversely with XL HDL cholesterol levels. Hsa-miR-885-5p levels correlated inversely with oxysterol-binding protein 2 (OSBPL2) expression (r?=?-0.143, p?=?1.00?*?10-4) and suppressing the expression of this lipid receptor and sterol transporter could link hsa-miR-885-5p with HDL cholesterol levels.
Notes
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PubMed ID
27917915 View in PubMed
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