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12 records – page 1 of 2.

[Arborviruses of the California encephalitis serogroup 1N Russia and their contribution to infectious pathology].

https://arctichealth.org/en/permalink/ahliterature132730
Source
Vestn Ross Akad Med Nauk. 2011;(5):41-5
Publication Type
Article
Date
2011
Author
L V Kolobukhina
S D L'vov
Source
Vestn Ross Akad Med Nauk. 2011;(5):41-5
Date
2011
Language
Russian
Publication Type
Article
Keywords
Animals
Antibodies, viral
Central Nervous System - pathology - virology
Communicable Disease Control - methods
Disease Reservoirs - virology
Disease Vectors
Ecosystem
Encephalitis Virus, California - isolation & purification - pathogenicity - physiology
Encephalitis, California - epidemiology - pathology - physiopathology - virology
Humans
Kidney - pathology - virology
Liver - pathology - virology
Lung - pathology - virology
Mosquito control
Neutralization Tests
Periodicity
Russia - epidemiology
Severity of Illness Index
Viral Tropism
Virulence
Abstract
This review focuses on arborviral infections associated with California serocomplex (Bunyaviridae, Orthobunyavirus). Results of relevant eco-epidemiological and clinical studies in Russia are presented suggesting the ubiquitious nature of diseases caused by viruses of the California encephalitis serocomplex (Inko, Tahyna, Snowshoe Hare). The etiologic structure of these diseases in taiga and mixed woods of the European part and Western Siberia is dominated by the Inco virus and in southern regions by Tahina. The diseases have a well apparent seasonal pattern (July-August) in agreement with the peak summer activity of the pathogens. Two clinical forms of pathology are distinguished, influenza-like and generalized, the latter affecting lungs, kidneys, liver, and CNS. The Inco virus plays a key role in pathogenesis of the generalized form affecting CNS.
PubMed ID
21786596 View in PubMed
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[Chronic viral hepatitis in St.Petersburg].

https://arctichealth.org/en/permalink/ahliterature112719
Source
Zh Mikrobiol Epidemiol Immunobiol. 2013 Mar-Apr;(2):44-50
Publication Type
Article
Author
A G Rakhmanova
A A Iakovlev
V A Tsinzerling
Source
Zh Mikrobiol Epidemiol Immunobiol. 2013 Mar-Apr;(2):44-50
Language
Russian
Publication Type
Article
Keywords
Hepacivirus - isolation & purification
Hepatitis B virus - isolation & purification
Hepatitis B, Chronic - complications - mortality - pathology - virology
Hepatitis C, Chronic - complications - mortality - pathology - virology
Hepatitis D, Chronic - complications - mortality - pathology - virology
Hepatitis Delta Virus - isolation & purification
Humans
International Classification of Diseases
Liver - pathology - virology
Liver Cirrhosis - etiology - mortality - virology
Russia - epidemiology
Survival Analysis
Abstract
Morbidity data on chronic viral hepatitis including cirrhotic stages of disease and lethality indexes in St. Petersburg are provided. The necessity of isolation in ICD- 10 and statistical accounting of chronic viral hepatitis diagnosis with outcome into cirrhosis (cirrhotic stage) is shown. During use of viral etiology liver cirrhosis diagnosis the disease is registered in the structure of liver diseases which does not allow to have data on unfavorable outcomes of chronic viral hepatitis and for complete morbidity accounting.
PubMed ID
23805672 View in PubMed
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Clinical findings in a multi-ethnic adult hepatitis B virus patient population in Denmark with emphasis on genotypic characteristics.

https://arctichealth.org/en/permalink/ahliterature270497
Source
Scand J Gastroenterol. 2015 Aug;50(8):1032-8
Publication Type
Article
Date
Aug-2015
Author
Nanna-Sophie Brinck-Jensen
Purnima Erichsen
Britta Tarp
Jens Lindberg
Lena H Kristensen
Mogens Erlandsen
Eskild Petersen
Peter D C Leutscher
Source
Scand J Gastroenterol. 2015 Aug;50(8):1032-8
Date
Aug-2015
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
DNA, Viral - blood
Denmark
Ethnic Groups
Female
Genotype
Hepatitis B e Antigens - blood
Hepatitis B virus - genetics
Hepatitis B, Chronic - drug therapy - ethnology
Humans
Liver - pathology - virology
Logistic Models
Male
Middle Aged
Retrospective Studies
Young Adult
Abstract
Most knowledge about chronic hepatitis B virus (HBV) infection is based upon studies in high-endemic areas with one or two predominant genotype(s). The aim of the study was to describe clinical characteristics of a heterogeneous genotypic HBV patient population in a low-endemic European country.
Data from HBV patients currently followed in a Danish university hospital and affiliated regional clinics were reviewed in accordance to genotype status.
Of 540 HBV patients, 462 (86%) were of non-Danish ethnicity originating from 43 different countries. HBV genotype was known in 37% of the patients: A (11%), B (25%), C (25%), D (37%) and E (2%). Logistic regression analysis of pre-treatment data among genotype A-D patients receiving nucleos(t)ide analogue (NA) therapy revealed a decreased HBeAg rate by age (OR = 0.93; CI: 0.89-0.97; p
PubMed ID
25861877 View in PubMed
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Complete nucleotide sequence and phylogenetic analyses of hepatitis B virus isolated from two pileated gibbons.

https://arctichealth.org/en/permalink/ahliterature182850
Source
Virus Genes. 2003 Dec;27(3):219-26
Publication Type
Article
Date
Dec-2003
Author
Naoto Aiba
Hiroyuki Nishimura
Yasuyuki Arakawa
Kenji Abe
Author Affiliation
Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Source
Virus Genes. 2003 Dec;27(3):219-26
Date
Dec-2003
Language
English
Publication Type
Article
Keywords
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA, Viral - genetics
Genome, Viral
Hepatitis B - veterinary - virology
Hepatitis B virus - classification - genetics - isolation & purification
Humans
Hylobates - virology
Liver - pathology - virology
Molecular Sequence Data
Phylogeny
Sequence Homology, Amino Acid
Species Specificity
Viremia - veterinary - virology
Abstract
We analyzed full-length sequence of hepatitis B virus (HBV) recovered from two pileated gibbons (Hylobates pileatus) originally born in East Asia. Two animals possessed a viral genome of 3182 nt in length with a 33 nt deletion in the pre-S1 region, and designated HBV PG-Makiko and HBV PG-Yohko, respectively. Both sequences had 65-90% similarity to type A-G of human HBV isolates. Phylogenetic analysis demonstrated that both isolates were distinct from the human and other nonhuman primate HBV isolates, but could be classified into gibbon isolates that were previously reported by others. Small spherical and tubular particles and large particles with outer envelopes were observed in the serum under immunoelectron microscopic examination. By immunohistochemical staining, HBsAg and HBcAg were detected in the cytoplasm and nuclei of hepatocytes, respectively. Our results suggested that HBV found in these animals is indigenous to their respective hosts and not recent acquisitions from human.
PubMed ID
14618082 View in PubMed
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GB virus C/hepatitis G virus infection in patients investigated for chronic liver disease and in the general population in southern Sweden.

https://arctichealth.org/en/permalink/ahliterature56648
Source
Scand J Infect Dis. 2001;33(8):611-7
Publication Type
Article
Date
2001
Author
P. Björkman
A. Widell
B. Veress
H. Verbaan
G. Hoffmann
S. Elmståhl
S. Lindgren
Author Affiliation
Department of Infectious Diseases, Malmö University Hospital, Lund University, Malmö, Sweden.
Source
Scand J Infect Dis. 2001;33(8):611-7
Date
2001
Language
English
Publication Type
Article
Keywords
Biological Markers - analysis
Biopsy
Case-Control Studies
Chronic Disease
Female
Flaviviridae Infections - complications - epidemiology - virology
GB virus C - immunology - isolation & purification
Hepatitis Antibodies - blood
Hepatitis, Viral, Human - complications - epidemiology - virology
Humans
Incidence
Liver - pathology - virology
Liver Diseases - diagnosis - virology
Male
Middle Aged
Prospective Studies
Research Support, Non-U.S. Gov't
Sweden - epidemiology
Abstract
Serum samples from patients referred for liver biopsy for investigation of suspected chronic liver disease (n = 286) and from healthy middle-aged volunteers (n = 445) were analyzed for markers of exposure to GB virus C/hepatitis G virus (GBV-C/HGV), hepatitis B virus and hepatitis C virus. GBV-C/HGV analyses included GBV-C/HGV PCR for detection of viremia and GBV-C/HGV enzyme-linked immunosorbent assay for anti-GBV-C/HGV E2 antibodies. Liver biopsies were re-evaluated by a hepatopathologist. GBV-C/HGV markers were detected in 97/286 (34%) patients (GBV-C/HGV RNA = 26; anti-GBV-C/HGV E2 antibodies = 74) compared to 86/445 (19%; p
Notes
Erratum In: Scand J Infect Dis 2001;33(10):798
PubMed ID
11525357 View in PubMed
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[Hepatitis C: a clinical-histopathological study]

https://arctichealth.org/en/permalink/ahliterature93743
Source
Laeknabladid. 2008 Jan;94(1):13-7
Publication Type
Article
Date
Jan-2008
Author
Pálsson Pall Svavar
Jónasson Jón Gunnlaugur
Olafsson Sigurdur
Author Affiliation
Laeknadeild HI, lyflaekningasvii I Landspítala.
Source
Laeknabladid. 2008 Jan;94(1):13-7
Date
Jan-2008
Language
Icelandic
Publication Type
Article
Keywords
Adolescent
Adult
Age Distribution
Age Factors
Blood Transfusion - adverse effects
Child
Female
Hepatitis C - complications - epidemiology - etiology - pathology
Humans
Iceland - epidemiology
Liver - pathology - virology
Liver Cirrhosis - pathology - virology
Male
Middle Aged
Retrospective Studies
Risk factors
Severity of Illness Index
Substance Abuse, Intravenous - complications
Time Factors
Abstract
OBJECTIVE: Hepatitis C is a common cause of chronic hepatitis and cirrhosis in Western countries. In recent years a large group of individuals have been diagnosed with the disease in Iceland. The aim of this study was to investigate histological parameters of patients with hepatitis C and to correlate histological findings with clinical findings. MATERIALS AND METHODS: In this retrospective study, all patients diagnosed with hepatitis C in Iceland that had a liver biopsy in the years 1991-2001 were included. Data on age, route of infection, duration of infection and co-infection was obtained from medical records. Liver biopsy specimens were evaluated and inflammatory activity graded and the degree of fibrosis staged. RESULTS: In all 97 patients (58 males, 39 females) were included in the study. The mean age was 35.6 years (range 11-64). Risk factors were intravenous drug abuse in 70 (72.6%), blood transfusion in 12 (12.4%) and eight had no known risk factors. Estimated duration of infection was 8.85 years (range 1-31). Average inflammatory grade was 2.84 (range 0-8) and average fibrosis stage was 0.95 (range 0-6). The majority (72.6%) of patients had minimal or no inflammation and 85.5% had minimal or no fibrosis. Only four patients had cirrhosis. Significant correlation was observed between the age at infection and the degree of fibrosis. No correlation was detected between the duration of infection or route of infection and histopathological parameters. CONCLUSION: Patients with hepatitis C that underwent a liver biopsy in 1991-2000 had mild histopathological changes in the liver. This is most likely due to short duration of infection and young age of the patients in this study.
Notes
Comment In: Laeknabladid. 2008 Jan;94(1):718204105
PubMed ID
18204107 View in PubMed
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Hepatitis C Virus Infection and the Temporal Trends in the Risk of Liver Cancer: A National Register-Based Cohort Study in Sweden.

https://arctichealth.org/en/permalink/ahliterature308198
Source
Cancer Epidemiol Biomarkers Prev. 2020 01; 29(1):63-70
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
01-2020
Author
Nurgul Batyrbekova
Soo Aleman
Charlotte Lybeck
Scott Montgomery
Ann-Sofi Duberg
Author Affiliation
Scandinavian Development Services AB, Stockholm, Sweden.
Source
Cancer Epidemiol Biomarkers Prev. 2020 01; 29(1):63-70
Date
01-2020
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adult
Aged
Aged, 80 and over
Antiviral agents - therapeutic use
Cause of Death - trends
Epidemiological Monitoring
Female
Follow-Up Studies
Hepacivirus - pathogenicity
Hepatitis C, Chronic - drug therapy - epidemiology - pathology - virology
Humans
Incidence
Liver - pathology - virology
Liver Neoplasms - epidemiology - pathology - prevention & control - virology
Male
Middle Aged
Prevalence
Registries - statistics & numerical data
Risk Assessment - statistics & numerical data - trends
Risk factors
Sweden - epidemiology
Time Factors
Abstract
In many countries, including Sweden, the birth cohorts with the highest prevalence of hepatitis C virus (HCV) infection have now reached the ages with high risk of primary liver cancer (PLC). The aims of this study were to investigate the temporal trends in PLC incidence and the relative risks of PLC among people diagnosed with HCV infection between 1990 and 2015.
The HCV cohort (n = 52,853) was compared with a matched non-HCV comparison cohort (n = 523,649). Both the national Cancer Register (CR) and Cause of Death Register (DR) were used for follow-up. The crude and age-standardized PLC incidence rates were calculated. The relative risk was estimated as standardized incidence ratios (SIR) and as HRs using stratified Cox hazards regression.
There were 1,609 with PLC diagnosis in the HCV cohort; the annual number increased continuously with the crude incidence rate reaching 4.56 per 1,000 person-years in 2013 while remaining low and stable in the comparison cohort. In the HCV cohort, the age-standardized PLC incidence rates per 1,000 person-years remained relatively constant at 2.64 [95% confidence interval (CI), 1.54-3.75] in 2000 and 3.31 (2.51-4.12) in 2014. The highest SIR was 73 (65.9-79.5) among those infected for 35 to 40 years; and the highest HR was 65.9 (55.9-77.6) for men and 62.2 (31.9-121.1) for women.
There was a considerable increase in PLC incidence over time and an extremely high relative risk in the population with HCV infection for more than 35 years.
The national HCV-associated PLC incidence should be monitored in future studies to evaluate the effect of direct-acting antiviral (DAA) treatment.
PubMed ID
31719064 View in PubMed
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[Molecular epidemiology of hepatitis C in centers of hemodialysis in St. Petersburg].

https://arctichealth.org/en/permalink/ahliterature262081
Source
Zh Mikrobiol Epidemiol Immunobiol. 2014 Nov-Dec;(6):27-34
Publication Type
Article
Author
S L Mukomolov
T. Tallo
E V Sinaiskaia
P N Kislyi
G F Trifonova
V V Gerasimova
H. Norder
Source
Zh Mikrobiol Epidemiol Immunobiol. 2014 Nov-Dec;(6):27-34
Language
Russian
Publication Type
Article
Keywords
Adult
Cross Infection - epidemiology - transmission - virology
Female
Hepacivirus - classification - genetics
Hepatitis C - epidemiology - transmission - virology
Humans
Kidney - pathology - virology
Liver - pathology - virology
Male
Middle Aged
Molecular Epidemiology
Phylogeny
Renal Dialysis
Renal Insufficiency, Chronic - pathology - therapy - virology
Russia - epidemiology
Sequence Analysis, DNA
Viral Nonstructural Proteins - genetics
Abstract
Study molecular epidemiology of hepatitis C (HC) in 5 departments of hemodialysis (DH) in St. Petersburg.
Sequences of nucleotides of 93 isolates including 67 isolates from patents of 5 DH and 26 isolates from patients, who never had hemodialysis in anamnesis, were obtained in 2010 by a method of limited sequencing of NS5B region of HC virus genome. Phyologenetic analysis was carried out by using PHYLIP veision 3.69 program package. Evolution differences were evaluated in DNADIST program using F84 algorithm. Phylogenetic trees were constructed by using nearest neighbor and UOGMA methods in PHYLIP program package.
Subtype 1b was established to dominate in all the DH (69.2 - 92.9%) and the same isolates of HC virus were detected in DH, that were isolated for the first time in 1999. Comparatively higher proportion of isolates of HC subgenotype 3a (26.7 - 30.8%) was detected in 2 of 5 DH in 2010. The same proportion of 3a isolates was detected in the control group.
The fact that HC 3a virus isolates were detected in DH in a higher proportion is proof that they have successfully integrated into circulation among dialysis patients over the last decade. ,
PubMed ID
25816510 View in PubMed
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A new hepadnavirus endemic in arctic ground squirrels in Alaska.

https://arctichealth.org/en/permalink/ahliterature4047
Source
J Virol. 1996 Jul;70(7):4210-9
Publication Type
Article
Date
Jul-1996
Author
P. Testut
C A Renard
O. Terradillos
L. Vitvitski-Trepo
F. Tekaia
C. Degott
J. Blake
B. Boyer
M A Buendia
Author Affiliation
Unité de Recombinaison et Expression Génétique (INSERM U163), France.
Source
J Virol. 1996 Jul;70(7):4210-9
Date
Jul-1996
Language
English
Publication Type
Article
Keywords
Alaska
Amino Acid Sequence
Animals
Base Sequence
DNA, Viral
Genome, Viral
Hepatitis B Virus, Woodchuck - genetics
Hepatitis, Viral, Animal - blood - pathology - virology
Liver - pathology - virology
Liver Neoplasms - virology
Molecular Sequence Data
Orthohepadnavirus - classification - genetics - metabolism
Phylogeny
Research Support, Non-U.S. Gov't
Sciuridae - virology
Sequence Homology, Amino Acid
Viral Proteins - metabolism
Abstract
We present evidence for a novel member of the hepadnavirus family that is endemic in wild arctic ground squirrels (Spermophylus parryi kennicotti) in Alaska. This virus, designated arctic squirrel hepatitis virus (ASHV), was initially detected in the livers of animals bearing large hepatic nodules by nucleic acid hybridization with hepadnavirus probes and in plasma by cross-reactivity with antibodies to hepadnavirus surface and core antigens. The complete nucleotide sequence of the 3,302-bp-long ASHV genome was determined and compared with those of ground squirrel hepatitis virus (GSHV) and woodchuck hepatitis virus (WHV); all sequences were organized into four open reading frames, designated pre-C/C, pre-S/S, pol, and X. Despite roughly equivalent variability among the three rodent hepadnaviruses (around 16% base and 19% amino acid exchanges), ASHV appeared to be more closely related to GSHV than to WHV in phylogenetic analysis. Accordingly, preliminary studies of the pathology of ASHV infection suggested that ASHV may be a less efficient oncogenic agent than WHV. About one-third of aged animals maintained in captivity, including virus-infected as well as uninfected squirrels, developed large liver nodules, consisting of hepatocellular adenomas or carcinomas or nonmalignant lesions characterized by drastic microvesicular steatosis. ASHV-infected arctic ground squirrels may serve as a new model with which to analyze the contribution of hepadnavirus- and host-specific determinants to liver pathology and tumorigenesis.
PubMed ID
8676441 View in PubMed
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New virus of the family Flaviviridae detected in lumpfish (Cyclopterus lumpus).

https://arctichealth.org/en/permalink/ahliterature289896
Source
Arch Virol. 2018 Mar; 163(3):679-685
Publication Type
Journal Article
Date
Mar-2018
Author
Renate Hvidsten Skoge
Jarle Brattespe
Arnfinn Lodden Økland
Heidrun Plarre
Are Nylund
Author Affiliation
Department of Biology, University of Bergen, Thormøhlensgt. 55, Pb. 7803, 5020, Bergen, Norway. renate.skoge@uib.no.
Source
Arch Virol. 2018 Mar; 163(3):679-685
Date
Mar-2018
Language
English
Publication Type
Journal Article
Keywords
Amino Acid Sequence
Animals
Fish Diseases - epidemiology - virology
Flaviviridae - classification - genetics - isolation & purification
Flaviviridae Infections - epidemiology - veterinary - virology
Gene Expression
Gene Expression Regulation, Viral
Kidney - pathology - virology
Liver - pathology - virology
Norway - epidemiology
Perciformes - virology
Phylogeny
Protein Biosynthesis
Viral Nonstructural Proteins - genetics - metabolism
Abstract
In this study, we determined the complete coding sequence of a putative new member of the family Flaviviridae, named "Cyclopterus lumpus virus" (CLuV), which is associated with a serious disease in lumpfish (Cyclopterus lumpus). The virus was present in all tissues tested, but pathology was primarily observed in the liver and kidneys. CLuV shows low but distinct similarity to the unassigned Tamana bat virus (TABV). Unlike other known members of the family Flaviviridae, translation of the entire CLuV polyprotein is dependent on a - 1 ribosomal frameshift in the NS2A region.
Notes
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PubMed ID
29147783 View in PubMed
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12 records – page 1 of 2.