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8 records – page 1 of 1.

[Activity of cytoplasmic proteinases from rat liver in Heren's carcinoma during tumor growth and treatment with medicinal herbs]

https://arctichealth.org/en/permalink/ahliterature20009
Source
Ukr Biokhim Zh. 2000 May-Jun;72(3):91-4
Publication Type
Article
Author
M M Marchenko
H P Kopyl'chuk
O V Hrygor'ieva
Author Affiliation
Yu. Fedkovich Chernivtsi State University, Ukraine.
Source
Ukr Biokhim Zh. 2000 May-Jun;72(3):91-4
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Cytoplasm - enzymology
English Abstract
Hydrolysis
Liver - enzymology - pathology
Liver Neoplasms - enzymology
Organ Size - drug effects
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Rats
Abstract
The dynamics of the acid and neutral proteinases general enzymes activity change in the hepatocytes postnuclear fraction in the rats suffering from the Heren's carcinoma was investigated. It was determined that in the tumor development of the enzyme activity level of both the acid and neutral proteinases increased 2,6-fold. The natural preparation of the herbs (Calendula officinalis L., Echinacea purpurea L., Scorzonera humilis L., Aconitum moldavicum Hacq.) normalizes both the activity of the investigated enzymes and coefficients of the liver weights of the sick animals. The chemical medicinal preparation 5,6-benzcumarine-5-uracil normalizes the activity of the neutral cytoplasmatic proteinases and reduces the level of the proteolytic activity of the acid enzymes in comparison with the control group of the animals as well as increases of the liver weight coefficients.
PubMed ID
11200483 View in PubMed
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Clinical pharmacology consultations: consultation requests may be misleading -- an organized approach to drug-induced hepatitis.

https://arctichealth.org/en/permalink/ahliterature184347
Source
Can J Clin Pharmacol. 2003;10(2):59-62
Publication Type
Article
Date
2003
Author
Maria Valois
Mary Anne Cooper
Neil H Shear
Author Affiliation
Division of Clinical Pharmacology, Sunnybrook & Women's College Health Science Centre, University of Toronto Medical School, Toronto, Canada.
Source
Can J Clin Pharmacol. 2003;10(2):59-62
Date
2003
Language
English
Publication Type
Article
Keywords
Adverse Drug Reaction Reporting Systems
Dalteparin - adverse effects
Diagnosis, Differential
Drug-Induced Liver Injury - diagnosis - etiology
Histamine H2 Antagonists - adverse effects
Humans
Liver - enzymology - pathology
Male
Middle Aged
Ontario
Pharmaceutical Services
Ranitidine - adverse effects
Referral and Consultation
Abstract
The present case report describes a consultation with the Clinical Pharmacology Consultation Service at the Sunnybrook & Women's College Health Sciences Centre, Toronto, Ontario, for drug-induced hepatitis in a patient with multiple drug exposures. The original question to be addressed was whether dalteparin was responsible for an acute rise in liver transaminases. The approach involved establishing a best possible diagnosis of the adverse event, obtaining a comprehensive history of drug exposure and evaluating the possible contributory role of alternate etiologies supported by a literature search. On balance, based on temporal relationships and previous case reports, ranitidine was considered to be the most likely causal agent. The initial consultation request was to investigate the likelihood that daltaperin caused hepatitis; however, a systematic and comprehensive approach led to the conclusion that it was more likely to be ranitidine-induced hepatitis.
PubMed ID
12879142 View in PubMed
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[Comparative analysis of the effects of alcoholism and opium addiction on liver function]

https://arctichealth.org/en/permalink/ahliterature10213
Source
Fiziol Zh. 2001;47(2):81-6
Publication Type
Article
Date
2001
Author
N K Kharchenko
V N Synyts'kyi
T V Kovtun
Author Affiliation
Ukrainian Scientific Research Institute of Social and Forensic Psychiatry and Narcology, Ministry of Public Health of Ukraine, Kiev.
Source
Fiziol Zh. 2001;47(2):81-6
Date
2001
Language
Ukrainian
Publication Type
Article
Keywords
Adult
Alanine Transaminase - blood
Alcohol Dehydrogenase - blood
Alcoholism - enzymology - physiopathology
Aldehyde Dehydrogenase - blood
Aspartate Aminotransferases - blood
Comparative Study
English Abstract
Hepatitis, Alcoholic - physiopathology
Humans
Liver - enzymology - pathology
Liver Function Tests
Male
Opioid-Related Disorders - enzymology - physiopathology
Opium
Thymol - chemistry - metabolism
Abstract
Groups of patients suffering alcoholism and narcomania were examined for the effect of intoxication on the blood serum enzymes of mainly liver origin: alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), as well as on thymol test. It has been shown that in patients with the first stage of alcoholism one could observe only functional disturbances in the liver: the increase of ADH activity which evidences for the induction of its synthesis. In patients with the first stage of opium narcomania one can record total hyperenzymenia, decrease of de-Rimis coefficient at the expense of more considerable increase of ALT activity than that of AST, as well as the sharp increase of thymol test--these are the signs of destructive and metabolic disturbances in the liver. In patients with the second stage of alcoholism one can observe the decrease of ALDH activity under the increase of ADH, AST, ALT activity and high thymol test-these are the signs of toxical hepatitis. Destructive and metabolic changes increase in the liver in the patients with the second stage of narcomania.
PubMed ID
11392120 View in PubMed
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Cytochrome P450 2D6 polymorphism is a molecular genetic marker of liver cirrhosis progression.

https://arctichealth.org/en/permalink/ahliterature122563
Source
Bull Exp Biol Med. 2012 Mar;152(5):633-6
Publication Type
Article
Date
Mar-2012
Author
D L Nepomnyashchikh
V A Vavilin
S V Aidagulova
S I Makarova
Yu Yu Karavaeva
E G Shchepotina
O A Postnikova
Zh V Nokhrina
E V Vinogradova
V V Lyakhovich
Author Affiliation
Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
Source
Bull Exp Biol Med. 2012 Mar;152(5):633-6
Date
Mar-2012
Language
English
Russian
Publication Type
Article
Keywords
Adult
Aged
Cytochrome P-450 CYP2D6 - genetics
Disease Progression
European Continental Ancestry Group
Female
Genetic markers
Genetic Predisposition to Disease
Hepacivirus - physiology
Hepatitis B - complications - genetics - pathology - virology
Hepatitis B virus - physiology
Hepatitis C - complications - genetics - pathology - virology
Hepatitis, Alcoholic - complications - genetics - pathology
Heterozygote
Homozygote
Humans
Liver - enzymology - pathology - virology
Liver Cirrhosis - etiology - genetics - pathology - virology
Male
Middle Aged
Polymorphism, Single Nucleotide
Siberia
Abstract
Patients with infectious viral or toxic cirrhosis of the liver participated in complex clinical pathomorphological and molecular-genetic study aimed at the search for markers of predisposition to accelerated liver fibrosis, in which the xenobiotic biotransformation system is involved. The results demonstrate association between CYP2D6 (1846G/A) genotype and rapid cirrhosis development and indicate the necessity of studying the mechanisms underlying this association.
PubMed ID
22803153 View in PubMed
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[Different responses of DD/He and CC57BR/Mv mice to fasting]

https://arctichealth.org/en/permalink/ahliterature17703
Source
Ross Fiziol Zh Im I M Sechenova. 2004 Mar;90(3):361-5
Publication Type
Article
Date
Mar-2004
Author
N V Baginskaia
E D Vasil'eva
S I Il'nitskaia
V I Kaledin
Author Affiliation
Institute of Cytology and Genetics, Russian Acad. Sci., Siberian Branch, 10 Pr. Lavrentyeva, Novosibirsk 630090, Russia.
Source
Ross Fiziol Zh Im I M Sechenova. 2004 Mar;90(3):361-5
Date
Mar-2004
Language
Russian
Publication Type
Article
Keywords
Animals
Body Weight
Comparative Study
Corticosterone - blood
English Abstract
Fasting
Lipids - analysis
Liver - enzymology - pathology
Liver Neoplasms, Experimental - enzymology - genetics - pathology
Male
Mice
Species Specificity
Testosterone - blood
Tyrosine Transaminase - metabolism
Abstract
Reaction to fasting of 2 mice strains differing in their sensitivity to spontaneous and induced hepatocarcinogenesis, has been investigated. It was shown that mice of both strains displayed similar stress reaction after 3-day fasting manifested in increase in blood corticosterone level; and decrease in testosterone level. At the same time, both strains demonstrated opposite changes at tissue- and enzyme levels in the liver. It was shown that DD/He mice, highly sensitive to induction of liver tumors, were characterized by significant increase in tyrosine aminotransferase (TAT) activity and reduction of lipid droplets in hepatocytes. CC57BR/Mv mice, demonstrating high frequency of spontaneous hepatomas and insensitive to induction of such tumors, were characterized by a decrease in the TAT activity and fatty infiltration of the liver.
PubMed ID
15152571 View in PubMed
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[Dopamine content in blood and activity of alcohol-transforming enzymes in alcoholism]

https://arctichealth.org/en/permalink/ahliterature11080
Source
Ukr Biokhim Zh. 1997 Mar-Apr;69(2):87-92
Publication Type
Article
Author
N K Kharchenko
Source
Ukr Biokhim Zh. 1997 Mar-Apr;69(2):87-92
Language
Ukrainian
Publication Type
Article
Keywords
Acetaldehyde - metabolism
Alanine Transaminase - blood
Alcohol Dehydrogenase - biosynthesis - blood
Alcoholism - blood - enzymology
Aldehyde Dehydrogenase - blood
Amino Acid Oxidoreductases - blood
Comparative Study
Dopamine - blood
English Abstract
Enzyme Induction
Humans
Liver - enzymology - pathology
Thymol - chemistry - metabolism
Abstract
An increase of alcohol dehydrogenase activity is observed in patients with chronic alcoholism at the first stage of the disease under normal indices of activity of aldehyde dehydrogenase, aspartate- and alanine aminotransferase and thymol sample that evidences for the induction of alcohol dehydrogenase synthesis in the liver. At the second stage of alcoholism the activity of alcohol dehydrogenase, aspartate- and alanine aminotransferase, the index of thymol sample increase while activity of aldehyde dehydrogenase decreases that indicates to organic destructive changes in the liver. At the third stage of alcoholism one can observe the decrease in activity of alcohol dehydrogenase, aldehyde dehydrogenase and alanine aminotransferase relative to activity of these enzymes at the second stage, that can evidence for the increase of the possibility of the processes of synthesis of the liver. The correlation of alcohol dehydrogenase activity to that of aldehyde dehydrogenase in the process of formation and development of alcoholism is shifted towards the progressive accumulation of acetaldehyde. Parallel increase of dopamine concentration in blood creates conditions for formation of morphine-like alcaloides--products of condensation of acetaldehide with dopamine.
PubMed ID
9463245 View in PubMed
Less detail

Increased liver echogenicity at ultrasound examination reflects degree of steatosis but not of fibrosis in asymptomatic patients with mild/moderate abnormalities of liver transaminases.

https://arctichealth.org/en/permalink/ahliterature188516
Source
Dig Liver Dis. 2002 Jul;34(7):516-22
Publication Type
Article
Date
Jul-2002
Author
U L Mathiesen
L E Franzén
H. Aselius
M. Resjö
L. Jacobsson
U. Foberg
A. Frydén
G. Bodemar
Author Affiliation
Department of Internal Medicine, County Hospital, Oskarshamn, Sweden. ulrma@ime.liu.se
Source
Dig Liver Dis. 2002 Jul;34(7):516-22
Date
Jul-2002
Language
English
Publication Type
Article
Keywords
Adult
Aged
Biological Markers - blood
Biopsy
Body mass index
Diagnosis, Differential
Fatty Liver - complications - diagnosis - enzymology
Female
Humans
Liver - enzymology - pathology - ultrasonography
Liver Cirrhosis - complications - diagnosis - enzymology
Male
Middle Aged
Obesity - complications - diagnosis - enzymology
Predictive value of tests
Sensitivity and specificity
Severity of Illness Index
Statistics as Topic
Sweden
Transaminases - metabolism
Ultrasonography, Interventional
Abstract
To investigate whether hyperechogenicity of liver can reliably be interpreted as liver steatosis and if any concomitant or isolated fibrosis can be disclosed.
A series of 165 patients with no signs or symptoms of liver disease referred because of slightly to moderately raised aminotransferases (alanine aminotransferase and/or aspartate aminotransferase 0.7-5.0 microkat/l) for more than 6 months were prospectively investigated with a comprehensive laboratory profile, ultrasound examination of liver and percutaneous liver biopsy Fibrosis was assessed quantitatively and according to Metavir. Steatosis was graded as none, mild, moderate or severe.
Of 98 (59.4%) patients with raised echogenicity, 85 (86.7%) had liver steatosis of at least moderate degree, 9 patients with same degree of steatosis had normal echogenicity and 13 patients with no or only mild steatosis had a hyperechogenic liver (sensitivity 0.90, specificity 0.82, positive predictive value 0.87, negative predictive value 0.87). About the same relations were found regardless of body mass index and degree of fibrosis. With increased echogenicity together with high attenuation (n = 591 and reduced portal vessel wall distinction (n = 79), positive predictive value increased to 0.93 and 0.94, respectively. Quantitatively assessed fibrosis (mean +/- SD) was 3.2 +/- 4.6% of biopsy area with normal and 2.3 +/- 1.8% with raised echogenicity (ns). Echogenicity was normal in 5 out of 9 patients with septal fibrosis and in 4 out of 6 patients with cirrhosis. Any structural, non-homogenous findings at ultrasound were not associated with architectural fibrotic changes and none had nodular contours of liver surface.
Assessment of liver echogenicity is of value for detection or exclusion of moderate to pronounced fatty infiltration (correct classification 86.6%) but cannot be relied upon in diagnosing fibrosis, not even cirrhosis in asymptomatic patients with mild to moderately elevated liver transaminases.
PubMed ID
12236486 View in PubMed
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Metabolic enzymes activity and histomorphology in the liver of whitefish (Coregonus lavaretus L.) and pike (Esox lucius L.) inhabiting a mineral contaminated lake.

https://arctichealth.org/en/permalink/ahliterature265481
Source
Environ Sci Pollut Res Int. 2014 Dec;21(23):13342-52
Publication Type
Article
Date
Dec-2014
Author
Maria V Churova
Svetlana A Murzina
Olga V Meshcheryakova
Nina N Nemova
Source
Environ Sci Pollut Res Int. 2014 Dec;21(23):13342-52
Date
Dec-2014
Language
English
Publication Type
Article
Keywords
Animals
Esocidae - metabolism
Fishes
Fresh Water
Glucosephosphate Dehydrogenase - metabolism
Industrial Waste
Lakes
Liver - enzymology - pathology
Minerals - metabolism
Mining
Russia
Salmonidae - metabolism
Water Pollutants, Chemical - metabolism
Water Pollution, Chemical - adverse effects
Abstract
The effects of wastewater from a mining and ore-dressing mill on fish in Lake Kostomukshskoe, which is used as a cesspool of circulating water and for storage of industrial wastes produced by the Kostomuksha mining and ore-dressing mill in northwest Russia, were studied. The lake is characterized by heavy mineralization, high pH, elevated levels of K(+), Li(+), SO4 (2-), NO(2-), Cl(-), Li, Mn, and Ni, and the presence of a fine-dispersed mechanical suspension. To assess the impact of contamination on fish and determine the mechanisms of their adaptation, we investigated the biochemical indices and histology of the liver of whitefish (Coregonus lavaretus L.) and pike (Esox lucius L.) inhabiting Lake Kostomukshskoe, downstream Lake Koyvas (64° 47' 30° 59'), and Lake Kamennoe, which is located in a nature preserve and has not been affected by anthropogenic activity (64° 28' 30° 13'). Changes were detected in the activity of metabolic enzymes (cytochrome c oxidase (COX), lactate dehydrogenase, and glucose-6-phosphate dehydrogenase) in the liver. Specifically, the COX activity in the liver of both fish species from the contaminated lake decreased, indicating a low level of aerobic metabolism. Lipid infiltration was the most visible and widespread change observed in the liver of both fish species; therefore, it can be considered a marker of such long-term contamination. Lesions in pike liver demonstrated a wider range of severity than in those of whitefish. In summary, metabolic enzyme activity and histomorphology of the liver of whitefish and pike differed among lakes in a species-specific manner. The changes in enzyme activity and histomorphological alterations in fish that were observed can be applied for evaluation of freshwater systems that may be subjected to mineral pollution.
PubMed ID
24865502 View in PubMed
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8 records – page 1 of 1.