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142 records – page 1 of 15.

7-Alkoxyquinoline O-dealkylation by microsomes from human liver and placenta.

https://arctichealth.org/en/permalink/ahliterature64902
Source
Br J Clin Pharmacol. 1992 Nov;34(5):415-20
Publication Type
Article
Date
Nov-1992
Author
J. Hakkola
J. Mäenpää
R T Mayer
S S Park
H V Gelboin
O. Pelkonen
Author Affiliation
Department of Pharmacology and Toxicology, University of Oulu, Finland.
Source
Br J Clin Pharmacol. 1992 Nov;34(5):415-20
Date
Nov-1992
Language
English
Publication Type
Article
Keywords
Animals
Antibodies, Monoclonal - diagnostic use
Benzyl Compounds - metabolism
Cytochrome P-450 Enzyme System - antagonists & inhibitors - metabolism
Dealkylation
Female
Humans
In Vitro
Male
Mice
Mice, Inbred Strains
Microsomes - enzymology - metabolism
Microsomes, Liver - enzymology - metabolism
Placenta - enzymology - metabolism
Pregnancy
Quinolines - metabolism
Rats
Rats, Wistar
Research Support, Non-U.S. Gov't
Smoking - metabolism
Abstract
1. The O-dealkylation of seven 7-alkoxyquinoline derivatives by human hepatic and placental microsomes and the effect of maternal cigarette smoking on placental 7-alkoxyquinoline metabolism was studied. 2. None of several monoclonal antibodies to isoenzymes of cytochrome P450 had a clear effect on metabolism of the compounds by liver microsomes. 3. Maternal cigarette smoking induced the O-dealkylation of all of the 7-alkoxyquinoline derivatives, being greatest for 7-butoxy- and 7-benzyloxyquinoline. 4. Placental 7-alkoxyquinoline metabolism induced by smoking was partially inhibited by the monoclonal antibody 1-7-1 raised against 3-methylcholanthrene-induced rat liver P450. 5. None of the 7-alkoxyquinoline O-dealkylations could be assigned specifically to any known P450 isoenzyme in human liver or placenta.
PubMed ID
1467136 View in PubMed
Less detail

Absence of association between genetic variation in the LIPC gene promoter and plasma lipoproteins in three Canadian populations.

https://arctichealth.org/en/permalink/ahliterature5558
Source
Atherosclerosis. 1999 Sep;146(1):153-60
Publication Type
Article
Date
Sep-1999
Author
R A Hegele
S B Harris
J H Brunt
T K Young
A J Hanley
B. Zinman
P W Connelly
Author Affiliation
Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, Department of Medicine, London, Ont., Canada. robert.hegele@rri.on.ca
Source
Atherosclerosis. 1999 Sep;146(1):153-60
Date
Sep-1999
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Arteriosclerosis - genetics
Canada
Female
Gene Frequency
Humans
Indians, North American - genetics
Lipase - blood - genetics
Lipoproteins, HDL Cholesterol - blood
Liver - enzymology
Male
Middle Aged
Phenotype
Population Surveillance
Promoter Regions (Genetics)
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Sensitivity and specificity
Trans-Activation (Genetics)
Variation (Genetics)
Abstract
The promoter sequence variant -480T in the hepatic lipase gene (LIPC) has been shown to be significantly associated with low post-heparin hepatic lipase activity. Some studies have also found that the -480T variant is associated with elevation in plasma HDL cholesterol. We tested for associations of LIPC -480T with plasma lipoprotein traits in samples taken from three distinct Canadian populations: 657 Alberta Hutterites, 328 Ontario Oji-Cree and 210 Keewatin Inuit. Plasma HL activity was not available for analyses. The LIPC -480T allele frequencies in these three groups, respectively, were 0.219, 0.527 and 0.383, and the prevalence of LIPC -480T/T homozygotes was, respectively, 0.042, 0.274 and 0.167. No significant association was found between LIPC -480T and plasma HDL cholesterol or apolipoprotein AI concentration, after adjusting for covariates including gender and body mass index. There was no consistent relationship between the population mean plasma HDL cholesterol concentration and the population LIPC -480T frequency. Our findings are consistent with the idea that the common promoter variation in LIPC, which has been reported to be associated with variation in post heparin HL activity and HDL triglyceride concentration, is not always associated with variation in plasma HDL cholesterol concentration, possibly due to yet unspecified environmental or genetic factors.
PubMed ID
10487498 View in PubMed
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[Activities of the liver microsome reductases in adult and aged rats during stress]

https://arctichealth.org/en/permalink/ahliterature10009
Source
Vopr Med Khim. 2001 Nov-Dec;47(6):599-604
Publication Type
Article
Author
N P Rud'ko
V V Davydov
Author Affiliation
State Medical University, Mayakowsky av., 26, Zaporozhye, 69035, Ukraine.
Source
Vopr Med Khim. 2001 Nov-Dec;47(6):599-604
Language
Russian
Publication Type
Article
Keywords
Aging - metabolism
Animals
Comparative Study
English Abstract
Hydrogen Peroxide - pharmacology
Immobilization
Male
Microsomes, Liver - enzymology
Quinone Reductases - metabolism
Rats
Rats, Wistar
Sodium Dodecyl Sulfate - pharmacology
Stress, Psychological - enzymology
Urea - pharmacology
Abstract
The influence of 0.01% sodium dodecyl sulphate, 1.5 and 6.0 M urea and 0.03 M hydrogen peroxide to the NAD(P)H: 2,6 dichlorphenolindophenol reductase activity in livers of adult and old Wistar rats during immobilizing stress was interested. Obtained results indicate that the NADPH--dependent reductase is more resistant to modulating effect of sodium dodecyl sulphate, hydrogen peroxide and urea than NADH-dependent enzyme. The significant decrease of NADH: 2.6 dichlorphenolindophenol reductase sensitivity to the action of all studied modulators occurs in old rats. The similar changes appears in the adult rats liver during stress. The old rats immobilization is accompanied by a decrease of this enzyme activity and the reduction of the influence of all studied modulators to NADH: 2.6 dichlorphenolindophenol reductase as compared with adult ones. These changes in the activity and properties of microsomal NADH: 2,6 dichlorphenolindophenol reductase promote more pronounced decrease of the substrate hydroxylation in the liver of old rats during stress compared to adult ones.
PubMed ID
11925750 View in PubMed
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Activity and concentration of cathepsin B as prognostic criteria for the development of mouse LS lymphosarcoma and Lewis lung adenocarcinoma.

https://arctichealth.org/en/permalink/ahliterature18997
Source
Bull Exp Biol Med. 2002 Apr;133(4):392-5
Publication Type
Article
Date
Apr-2002
Author
T A Korolenko
S Ya Zhyanaeva
O N Poteryaeva
O V Falameeva
O A Levina
V I Kaledin
I. Shandula
Author Affiliation
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. T.A.Korolenko@iph.ma.ru
Source
Bull Exp Biol Med. 2002 Apr;133(4):392-5
Date
Apr-2002
Language
English
Publication Type
Article
Keywords
Animals
Carcinoma, Lewis Lung - enzymology - pathology
Cathepsin B - metabolism
Liver - enzymology
Lymphoma, Diffuse - enzymology - pathology
Male
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Prognosis
Spleen - enzymology
Tumor Markers, Biological - metabolism
Abstract
We measured activity and content of cathepsin B in tumor tissues, liver, and spleen in mice with Lewis adenocarcinoma and LS-lymphosarcoma. Cathepsin B activity in Lewis adenocarcinoma cells was lower than in LS-lymphosarcoma cells, which was probably related to differences in their metastatic properties. Antitumor therapy increased activity and content of cathepsin B in tumor tissues. Changes in the content and activity of cathepsin B in tumor tissues can serve as a prognostic criterion for tumor regression during therapy. Cathepsin B is probably involved in apoptosis of tumor cells during chemotherapy of lymphosarcoma-LS with cyclophosphamide.
PubMed ID
12124655 View in PubMed
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Activity of 11beta-hydroxysteroid dehydrogenase in tissues of hypertensive NISAG rats.

https://arctichealth.org/en/permalink/ahliterature80964
Source
Bull Exp Biol Med. 2006 Jan;141(1):30-2
Publication Type
Article
Date
Jan-2006
Author
Cherkasova O P
Author Affiliation
Institute of Laser Physics, Siberian Division of the Russian Academy of Sciences, Novosibirsk. chrom@laser.nsc.ru
Source
Bull Exp Biol Med. 2006 Jan;141(1):30-2
Date
Jan-2006
Language
English
Publication Type
Article
Keywords
11-beta-Hydroxysteroid Dehydrogenases - analysis
Animals
Corticosterone - blood
Hypertension - diagnosis - enzymology
Kidney - enzymology
Liver - enzymology
Male
Rats
Rats, Inbred Strains
Abstract
11beta-Hydroxysteroid dehydrogenase activity in the kidneys of NISAG rats (rat strain with hereditary stress-induced arterial hypertension) was 1.5-fold higher than in WAG rats. An inverse relationship was observed in the liver of these animals. After stress exposure 11beta-hydroxysteroid dehydrogenase activity remained unchanged in the kidneys of NISAG and WAG rats, but significantly increased in the liver of NISAG rats. Functional activity of 11beta-hydroxysteroid dehydrogenase probably reflects the hypertensive state of NISAG rats.
PubMed ID
16929957 View in PubMed
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[Activity of cytoplasmic proteinases from rat liver in Heren's carcinoma during tumor growth and treatment with medicinal herbs]

https://arctichealth.org/en/permalink/ahliterature20009
Source
Ukr Biokhim Zh. 2000 May-Jun;72(3):91-4
Publication Type
Article
Author
M M Marchenko
H P Kopyl'chuk
O V Hrygor'ieva
Author Affiliation
Yu. Fedkovich Chernivtsi State University, Ukraine.
Source
Ukr Biokhim Zh. 2000 May-Jun;72(3):91-4
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Cytoplasm - enzymology
English Abstract
Hydrolysis
Liver - enzymology - pathology
Liver Neoplasms - enzymology
Organ Size - drug effects
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Rats
Abstract
The dynamics of the acid and neutral proteinases general enzymes activity change in the hepatocytes postnuclear fraction in the rats suffering from the Heren's carcinoma was investigated. It was determined that in the tumor development of the enzyme activity level of both the acid and neutral proteinases increased 2,6-fold. The natural preparation of the herbs (Calendula officinalis L., Echinacea purpurea L., Scorzonera humilis L., Aconitum moldavicum Hacq.) normalizes both the activity of the investigated enzymes and coefficients of the liver weights of the sick animals. The chemical medicinal preparation 5,6-benzcumarine-5-uracil normalizes the activity of the neutral cytoplasmatic proteinases and reduces the level of the proteolytic activity of the acid enzymes in comparison with the control group of the animals as well as increases of the liver weight coefficients.
PubMed ID
11200483 View in PubMed
Less detail

[Activity of enzymatic antioxidant system in the rat tissues under conditions of over- and restricted nutrition]

https://arctichealth.org/en/permalink/ahliterature97370
Source
Ukr Biokhim Zh. 2009 Nov-Dec;81(6):104-10
Publication Type
Article
Author
Iu V Nikitchenko
V M Dziuba
A S Popovych
V V Bondar
H O Sheremet
Source
Ukr Biokhim Zh. 2009 Nov-Dec;81(6):104-10
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Animals, Newborn
Antioxidants - metabolism
Caloric Restriction
Glutathione Peroxidase - metabolism
Lipid Peroxides - blood - metabolism
Liver - enzymology - metabolism
Male
Overnutrition - blood - enzymology
Oxidation-Reduction
Rats
Rats, Wistar
Thyroid Hormones - blood
Abstract
The state of enzymatic antioxidant system and thyroid status in the rat tissues under early postnatal overnutrition leading to shortening of life-span and calorie-restricted diet extending lifespan have been studied. It was found that the concentration of thyroxine, body weight and content of lipid hydroperoxides in the blood serum and liver post-mitochondrial fraction of rats had been reliably increased. At the same time the concentration of GSH and GSSG, superoxide dismutase, Se-dependent glutathione peroxidase (GP) activities in the liver and GP activity in the blood serum of experimental rats were reduced. The use of calorie-restricted diet for 2 months showed considerable decrease of thyroxine and triiodothyronine concentration, body weight and the content of lipid hydroperoxides in the blood serum of experimental rats compared with control. At the same time GP activity in the liver, Se-dependent GP activity and content of ceruloplasmin in blood of experimental rats were essentially enhanced. The obtained results allow to conclude that from all studied indices the activity of GSH-dependent antioxidant system (especially Se-dependent GP activity) and thyroid status revealed the most sensible changes in response to the used kind of nutrition. Unlike hypocaloric diet overnutrition results in a decrease of Se-dependent GP activity in the liver and blood of rats. That may be the most crucial moment in the maintenance of prooxidant-antioxidant balance of tissues.
PubMed ID
20387664 View in PubMed
Less detail

[Activity of glutathione-dependent antioxidant system of the rat liver and blood depending on gamma-irradiation and diet]

https://arctichealth.org/en/permalink/ahliterature89398
Source
Ukr Biokhim Zh. 2008 Nov-Dec;80(6):66-73
Publication Type
Article
Author
Nikitchenko Iu V
Padalko V I
Tkachenko V M
Sheremet H O
Tovstiak V V
Source
Ukr Biokhim Zh. 2008 Nov-Dec;80(6):66-73
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Antioxidants - metabolism
Diet
Dietary Supplements
Gamma Rays
Glutathione Peroxidase - blood - metabolism
Glutathione Transferase - blood - metabolism
Liver - enzymology - metabolism - radiation effects
Male
Microsomes, Liver - enzymology - metabolism - radiation effects
Mitochondria, Liver - enzymology - metabolism - radiation effects
Photinia - chemistry
Plant Extracts - administration & dosage - isolation & purification - therapeutic use
Radiation Injuries, Experimental - blood - metabolism - prevention & control
Rats
Rats, Wistar
Abstract
The role of the glutathione-dependent antioxidant system in the prooxidant-antioxidant balance support was studied in the experiments with Wistar male rat under single gamma-irradiation (8 Gr dose), fed with unbalanced (as to animal proteins and antioxidant vitamins) diet and with addition of Aronia melanocarpa. Single gamma-irradiation of animals led to the decrease of selenium-dependent glutathione-peroxidase activity in the blood plasma and glutathione-S-transferase activity decrease in rat liver mitochondria. Animals which received the unbalanced food allowance under irradiation showed more expressed change of glutathione-dependent antioxidant enzymes activity, namely--proved decrease of glutathione-peroxidase and glutathione-S-transferase activity in liver microsomes and less expressed activation of selenium-dependent glutathione-peroxidase activity in the postmitochondrial fraction of laboratory animals liver. Introduction of the A. melanocarpa food supplement in the unbalanced diet of the laboratory animals which in vitro demonstrated expressed antioxidant and antiradical activity had no effect upon glutathione-peroxidase activity in the investigated tissues. Obtained data concerning significant decrease of the activity of glutathione-dependent antioxidant system and, particularly, of the selenium-dependent glutathione-peroxidase activity under the unbalanced diet condition may be useful in maintenance of prooxidant-antioxidant balance in the tissues of irradiated animals. Allowing for the above stated it is advisable to seek for new food additives which increase activity of the endogenous glutathione-dependent antioxidant enzymes for human tolerance improvement, especially under the unbalanced food allowance condition.
PubMed ID
19351059 View in PubMed
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[Activity of glutathione-S-transferase in the blood plasma, liver and crystalline lens tissues as affected by low doses of ionizing radiation and polychromatic light]

https://arctichealth.org/en/permalink/ahliterature51029
Source
Ukr Biokhim Zh. 1997 May-Jun;69(3):54-9
Publication Type
Article
Author
N F Leus
S G Kolomiichuk
V B Lishchenko
Author Affiliation
V.P. Filatov Institute of Eye Diseases and Tissue Therapy, Academy of Medical Sciences of Ukraine, Odessa.
Source
Ukr Biokhim Zh. 1997 May-Jun;69(3):54-9
Language
Russian
Publication Type
Article
Keywords
Animals
Dose-Response Relationship, Radiation
English Abstract
Glutathione Transferase - blood - metabolism - radiation effects
Lens, Crystalline - enzymology - radiation effects
Light
Liver - enzymology - radiation effects
Male
Rabbits
Abstract
The developmental dynamics of pathologic changes in the lenses and activity of glutathione-S-transferase in the blood plasma, liver and lens tissues of rabbits under chronic influence (2 months) of small doses of X-ray radiation (total dose 2 Gy) and polychromatic light have been researched. It was shown, that polychromatic light and X-ray irradiation of rabbits significantly affected the lens nativity and increased the developmental frequency and the intensity of lens opacities. It was determined, that activity of glutathione-S-transferase in blood plasma increased for 1 month after the beginning of X-ray effects. The same effect on the enzymatic activity was shown by the summary influence of polychromatic light and X-ray irradiation. Glutathione-S-transferase activity decreased during 2 months as compared with the initial values, before irradiation of the animals. The enzymatic activity was increased in rabbit-liver cytoplasm by X-ray irradiation in 2 months. A decrease of glutathione-S-transferase activity in the liver, cortex and lens nucleus was determined under the influence of both X-ray radiation and polychromatic light.
PubMed ID
9505362 View in PubMed
Less detail

[Activity of organ specific enzymes in animals with liver damage following administration of antihepatocytotoxic serum]

https://arctichealth.org/en/permalink/ahliterature57079
Source
Fiziol Zh. 1976 Sep-Oct;22(5):611-5
Publication Type
Article

142 records – page 1 of 15.