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1H-MRS Measured Ectopic Fat in Liver and Muscle in Danish Lean and Obese Children and Adolescents.

https://arctichealth.org/en/permalink/ahliterature273208
Source
PLoS One. 2015;10(8):e0135018
Publication Type
Article
Date
2015
Author
Cilius Esmann Fonvig
Elizaveta Chabanova
Ehm Astrid Andersson
Johanne Dam Ohrt
Oluf Pedersen
Torben Hansen
Henrik S Thomsen
Jens-Christian Holm
Source
PLoS One. 2015;10(8):e0135018
Date
2015
Language
English
Publication Type
Article
Keywords
Adolescent
Anthropometry
Blood Glucose - analysis
Blood pressure
Body mass index
Body Weight
Cardiovascular Diseases - physiopathology
Child
Cross-Sectional Studies
Denmark
Dyslipidemias - blood
Fatty Liver - pathology
Female
Humans
Insulin - blood
Insulin Resistance
Intra-Abdominal Fat - pathology
Linear Models
Lipids - blood
Liver - metabolism - pathology
Male
Muscles - pathology
Overweight
Pediatric Obesity - blood - pathology
Proton Magnetic Resonance Spectroscopy
Puberty
Sex Factors
Subcutaneous Fat - pathology
Abstract
This cross sectional study aims to investigate the associations between ectopic lipid accumulation in liver and skeletal muscle and biochemical measures, estimates of insulin resistance, anthropometry, and blood pressure in lean and overweight/obese children.
Fasting plasma glucose, serum lipids, serum insulin, and expressions of insulin resistance, anthropometry, blood pressure, and magnetic resonance spectroscopy of liver and muscle fat were obtained in 327 Danish children and adolescents aged 8-18 years.
In 287 overweight/obese children, the prevalences of hepatic and muscular steatosis were 31% and 68%, respectively, whereas the prevalences in 40 lean children were 3% and 10%, respectively. A multiple regression analysis adjusted for age, sex, body mass index z-score (BMI SDS), and pubertal development showed that the OR of exhibiting dyslipidemia was 4.2 (95%CI: [1.8; 10.2], p = 0.0009) when hepatic steatosis was present. Comparing the simultaneous presence of hepatic and muscular steatosis with no presence of steatosis, the OR of exhibiting dyslipidemia was 5.8 (95%CI: [2.0; 18.6], p = 0.002). No significant associations between muscle fat and dyslipidemia, impaired fasting glucose, or blood pressure were observed. Liver and muscle fat, adjusted for age, sex, BMI SDS, and pubertal development, associated to BMI SDS and glycosylated hemoglobin, while only liver fat associated to visceral and subcutaneous adipose tissue and intramyocellular lipid associated inversely to high density lipoprotein cholesterol.
Hepatic steatosis is associated with dyslipidemia and liver and muscle fat depositions are linked to obesity-related metabolic dysfunctions, especially glycosylated hemoglobin, in children and adolescents, which suggest an increased cardiovascular disease risk.
Notes
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PubMed ID
26252778 View in PubMed
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7-Alkoxyquinoline O-dealkylation by microsomes from human liver and placenta.

https://arctichealth.org/en/permalink/ahliterature64902
Source
Br J Clin Pharmacol. 1992 Nov;34(5):415-20
Publication Type
Article
Date
Nov-1992
Author
J. Hakkola
J. Mäenpää
R T Mayer
S S Park
H V Gelboin
O. Pelkonen
Author Affiliation
Department of Pharmacology and Toxicology, University of Oulu, Finland.
Source
Br J Clin Pharmacol. 1992 Nov;34(5):415-20
Date
Nov-1992
Language
English
Publication Type
Article
Keywords
Animals
Antibodies, Monoclonal - diagnostic use
Benzyl Compounds - metabolism
Cytochrome P-450 Enzyme System - antagonists & inhibitors - metabolism
Dealkylation
Female
Humans
In Vitro
Male
Mice
Mice, Inbred Strains
Microsomes - enzymology - metabolism
Microsomes, Liver - enzymology - metabolism
Placenta - enzymology - metabolism
Pregnancy
Quinolines - metabolism
Rats
Rats, Wistar
Research Support, Non-U.S. Gov't
Smoking - metabolism
Abstract
1. The O-dealkylation of seven 7-alkoxyquinoline derivatives by human hepatic and placental microsomes and the effect of maternal cigarette smoking on placental 7-alkoxyquinoline metabolism was studied. 2. None of several monoclonal antibodies to isoenzymes of cytochrome P450 had a clear effect on metabolism of the compounds by liver microsomes. 3. Maternal cigarette smoking induced the O-dealkylation of all of the 7-alkoxyquinoline derivatives, being greatest for 7-butoxy- and 7-benzyloxyquinoline. 4. Placental 7-alkoxyquinoline metabolism induced by smoking was partially inhibited by the monoclonal antibody 1-7-1 raised against 3-methylcholanthrene-induced rat liver P450. 5. None of the 7-alkoxyquinoline O-dealkylations could be assigned specifically to any known P450 isoenzyme in human liver or placenta.
PubMed ID
1467136 View in PubMed
Less detail

[10 Canadian cases of angiosarcoma of the liver in vinyl chloride workers].

https://arctichealth.org/en/permalink/ahliterature249144
Source
Ann Anat Pathol (Paris). 1978;23(2):97-104
Publication Type
Article
Date
1978
Author
F. Delorme
Source
Ann Anat Pathol (Paris). 1978;23(2):97-104
Date
1978
Language
French
Publication Type
Article
Keywords
Adult
Environmental Exposure
Hemangiosarcoma - chemically induced - pathology
Humans
Liver - pathology
Liver Neoplasms - chemically induced - pathology
Male
Middle Aged
Occupational Diseases - chemically induced
Quebec
Vinyl Chloride - adverse effects
Vinyl Compounds - adverse effects
Abstract
Ten cases of angiosarcoma of the liver among vinyl chloride workers from a plant in Shawinigan, Québec, are reported. The author insist mostly on the occupational history of these workers and on the morphologic description of the lesions. A pathogenic hypothesis is submitted.
PubMed ID
567946 View in PubMed
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[99Tcm]MAG3 gamma camera nephrography in epidemic nephritis.

https://arctichealth.org/en/permalink/ahliterature227655
Source
Nucl Med Commun. 1991 Jan;12(1):15-25
Publication Type
Article
Date
Jan-1991
Author
R. Paul
H. Kiiliäinen
L. Tarssanen
M. Vorne
Author Affiliation
Department of Internal Medicine, Mikkeli Central Hospital, Finland.
Source
Nucl Med Commun. 1991 Jan;12(1):15-25
Date
Jan-1991
Language
English
Publication Type
Article
Keywords
Disease Outbreaks
Finland - epidemiology
Hemorrhagic Fever with Renal Syndrome - epidemiology - physiopathology
Humans
Liver - physiopathology
Oligopeptides - diagnostic use
Organotechnetium Compounds - diagnostic use
Radioisotope Renography
Technetium Tc 99m Mertiatide
Abstract
There is a lack of systematic nephrographic studies on epidemic nephritis (EN). We studied 10 patients with EN using [99Tcm]MAG3 gamma camera nephrography and followed up 9 of them 22-68 days later when they had clinically recovered. Variables for renal clearance of [99Tcm]MAG3 and the retention of radioactivity in the kidneys and blood were calculated. In all patients renal function was impaired acutely. There was marked reconstitution of renal function in the control studies. [99Tcm]MAG3 clearance was inversely related to serum creatinine. On visual inspection the nephrograms showed no focal changes. Nephrography was more sensitive than sonography at identifying renal impairment. [99Tcm]MAG3 nephrography is a sensitive method for identifying renal involvement and reconstitution of renal function in EN. It may be a valuable adjunct to the diagnostic arsenal, especially in nonendemic areas where EN occurs only sporadically and where there may be diagnostic uncertainty in patients presenting acutely with EN.
PubMed ID
1673780 View in PubMed
Less detail

210Pb and 210Po in tissues of some Alaskan residents as related to consumption of caribou or reindeer meat.

https://arctichealth.org/en/permalink/ahliterature5061
Source
Health Physics. 1970 Feb;18(2):127-134
Publication Type
Article
Date
Feb-1970

238Pu: accumulation, tissue distribution, and excretion in Mayak workers after exposure to plutonium aerosols.

https://arctichealth.org/en/permalink/ahliterature126152
Source
Health Phys. 2012 Mar;102(3):243-50
Publication Type
Article
Date
Mar-2012
Author
Klara G Suslova
Alexandra B Sokolova
Viktor V Khokhryakov
Scott C Miller
Author Affiliation
Southern Urals Biophysics Institute (SUBI), Ozyorskoe Shosse 19, Ozyorsk, Chelyabinsk Region, Russia. suslova@subi.su
Source
Health Phys. 2012 Mar;102(3):243-50
Date
Mar-2012
Language
English
Publication Type
Article
Keywords
Aerosols
Bone and Bones - metabolism - radiation effects
Health Physics
Humans
Liver - metabolism - radiation effects
Lung - metabolism - radiation effects
Occupational Exposure
Plutonium - administration & dosage - pharmacokinetics - toxicity - urine
Russia
Solubility
Tissue Distribution
Abstract
The alpha spectrometry measurements of specific activity of 238Pu and 239Pu in urine from bioassay examinations of 1,013 workers employed at the radiochemical and plutonium production facilities of the Mayak Production Association and in autopsy specimens of lung, liver, and skeleton from 85 former nuclear workers who died between 1974-2009, are summarized.The accumulation fraction of 238Pu in the body and excreta has not changed with time in workers involved in production of weapons-grade plutonium production (e.g., the plutonium production facility and the former radiochemical facility). The accumulation fraction of 238Pu in individuals exposed to plutonium isotopes at the newer Spent Nuclear Fuel Reprocessing Plant ranged from 0.13% up to 27.5% based on the autopsy data. No statistically significant differences between 238Pu and 239Pu in distribution by the main organs of plutonium deposition were found in the Mayak workers. Based on the bioassay data,the fraction of 238Pu activity in urine is on average 38-69% of the total activity of 238Pu and 239Pu, which correlates with the isotopic composition in workplace air sampled at the Spent Nuclear Fuel Reprocessing Plant. In view of the higher specific activity of 238Pu, the contribution of 238Pu to the total internal dose, particularly in the skeleton and liver, might be expected to continue to increase, and continued surveillance is recommended.
PubMed ID
22420016 View in PubMed
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Abdominal injuries sustained in severe traffic accidents by seatbelt wearers.

https://arctichealth.org/en/permalink/ahliterature235383
Source
J Trauma. 1987 Apr;27(4):393-7
Publication Type
Article
Date
Apr-1987
Author
E. Arajärvi
S. Santavirta
J. Tolonen
Source
J Trauma. 1987 Apr;27(4):393-7
Date
Apr-1987
Language
English
Publication Type
Article
Keywords
Abdominal Injuries - epidemiology - etiology - mortality
Accidents, Traffic
Adult
Aged
Aged, 80 and over
Deceleration
Female
Finland
Humans
Intestine, Small - injuries
Liver - injuries
Male
Seat Belts - adverse effects
Spleen - injuries
Thoracic Injuries - complications
Abstract
In Finland during the period 1972-1983, there were 3,564 severe traffic accidents involving one or more victims dying within 30 days of the accident. Forty-two of the victims had been wearing a seatbelt and had an abdominal trauma as the main cause of death or as first diagnosis of injury. Small intestine and colon injuries were more common in the severely injured victims than was the case with the fatally injured ones and in these accidents the injury mechanism was always deceleration or contusion, which was in most cases caused by the seatbelt. Liver injuries seem to be the major abdominal cause of fatality, and in the fatally injured group, half of the victims sustained the fatal abdominal injury through gross crushing impact. When the direction of the impact was analyzed, all the victims seated on the receiving side of the vehicle in lateral impact collisions sustained an abdominal injury with fatal outcome. It seems that the seatbelt is less effective in protecting wearers from severe or fatal abdominal injuries in lateral impact collisions.
PubMed ID
3573085 View in PubMed
Less detail

Abdominal malignancies in patients with Wilson's disease.

https://arctichealth.org/en/permalink/ahliterature18250
Source
QJM. 2003 Sep;96(9):657-62
Publication Type
Article
Date
Sep-2003
Author
J M Walshe
E. Waldenström
V. Sams
H. Nordlinder
K. Westermark
Author Affiliation
Department of Neurology, The Middlesex Hospital, London, UK. penicillamine@waitrose.com
Source
QJM. 2003 Sep;96(9):657-62
Date
Sep-2003
Language
English
Publication Type
Article
Keywords
Abdominal Neoplasms - complications - epidemiology - genetics
Adenocarcinoma - complications - epidemiology - genetics
Adolescent
Adult
Age of Onset
Biliary Tract Neoplasms - complications - epidemiology - genetics
Carcinoma, Hepatocellular - complications - epidemiology - genetics
Child
Cholangiocarcinoma - complications - epidemiology - genetics
Female
Hepatolenticular Degeneration - complications - epidemiology - genetics
Humans
Incidence
Liver Neoplasms - complications - epidemiology - genetics
Long-Term Care
Male
Mutation
Pancreatic Neoplasms - complications - epidemiology - genetics
Retrospective Studies
Sweden - epidemiology
Time Factors
Abstract
BACKGROUND: Wilson's disease is associated with heavy copper overload, primarily in the liver. Copper is a toxic metal, and might be expected to be associated with cancer induction, as iron is in haemochromatosis. However, liver cancer is currently believed to be extremely rare in this disease, and other intra-abdominal malignancies have not been reported. AIM: To assess the frequency of abdominal malignant disease in patients with Wilson's disease on long-term follow-up. DESIGN: Retrospective study in two specialist Wilson's disease clinics: Cambridge/London and Uppsala. METHODS: We reviewed the case records of 363 patients seen at three centres: Addenbrooke's Hospital, Cambridge, 1955-1987; the Middlesex Hospital, London, 1987-2000; and the University Hospital, Uppsala, Sweden, 1966-2002. Patients were grouped by length of follow-up: 10-19 years; 20-29 years; 30-39 years; and 40 years or more. RESULTS: No cancers were seen in patients followed for
PubMed ID
12925721 View in PubMed
Less detail
Source
Epidemiol Rev. 2007;29:77-87
Publication Type
Article
Date
2007
Author
M U Jakobsen
T. Berentzen
T I A Sørensen
K. Overvad
Author Affiliation
Institute of Preventive Medicine, Centre for Health And Society, Copenhagen University Hospital, Copenhagen, Denmark. muj@dce.au.dk
Source
Epidemiol Rev. 2007;29:77-87
Date
2007
Language
English
Publication Type
Article
Keywords
Abdominal Fat - metabolism
Denmark
Fatty Liver - metabolism
Humans
Obesity - metabolism
Abstract
It has been hypothesized that visceral fat releases free fatty acids and adipokines and thereby exposes the liver to fat accumulation. The authors aimed to evaluate current epidemiologic evidence for an association between abdominal fat and liver fat content. Clinical and epidemiologic studies with data on abdominal fat and liver fat content were reviewed. Studies using waist circumference to estimate abdominal fat mass suggested a direct association between abdominal fat and liver fat content. Studies using imaging methods suggested a direct association between intraabdominal fat and liver fat content, but not between subcutaneous abdominal fat and liver fat content. In conclusion, clinical and epidemiologic studies of abdominal fat and liver fat content suggest a direct association between abdominal fat and liver fat content which is probably accounted for by visceral fat. However, results from the included studies do not allow strong conclusions regarding the temporal sequence of events. Future longitudinal studies are recommended to obtain additional information on associations and mechanisms. Both abdominal fat depots and other body compartments of interest should be included to further investigate the association between specific fat depots and liver fat content. Biomarkers may provide insight into underlying mechanisms.
PubMed ID
17478441 View in PubMed
Less detail

Abdominal trauma during thirty years: analysis of a large case series.

https://arctichealth.org/en/permalink/ahliterature40679
Source
Injury. 1981 Sep;13(2):93-9
Publication Type
Article
Date
Sep-1981
Author
D. Bergqvist
H. Hedelin
G. Karlsson
B. Lindblad
T. Mätzsch
Source
Injury. 1981 Sep;13(2):93-9
Date
Sep-1981
Language
English
Publication Type
Article
Keywords
Abdominal Injuries - epidemiology - etiology
Accidents, Traffic
Adolescent
Adult
Aged
Child
Child, Preschool
Female
Humans
Infant
Kidney - injuries
Liver - injuries
Male
Middle Aged
Retrospective Studies
Seasons
Spleen - injuries
Sweden
Abstract
Studies have been made in 1407 patients of the causes, the organs involved and the outcome of injury to the abdomen in patients needing admission to hospital in an area of Southern Sweden, between 1950 and the end of 1979. The proportion of female patients and those aged over 60 increased significantly. The seasonal distribution of the injuries showed significant change, with a drop in the initially high frequency sustained during the summer months. Penetrating injuries were rare, but increased in the 1970s. Road traffic accidents as the cause of abdominal injuries rose to a maximum of 56 per cent in the late 1960s. The numbers of injured organs and the frequency of other associated injuries rose gradually until the mid-1970s, after which there was a slight decrease. The spleen, liver and large blood vessels were the organs which were increasingly often injured. The annual incidence of various visceral injuries per 100 000 population was calculated. The number of patients with a delay of at least 24 hours before operation fell significantly and there was a tendency to shorter hospital stay. The mortality curve showed a peak in the late 1960s.
PubMed ID
7327735 View in PubMed
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2830 records – page 1 of 283.