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Antibiotic susceptibility of Listeria monocytogenes in Denmark 1958-2001.

https://arctichealth.org/en/permalink/ahliterature176428
Source
APMIS. 2005 Jan;113(1):31-6
Publication Type
Article
Date
Jan-2005
Author
Joanna M Hansen
Peter Gerner-Smidt
Brita Bruun
Author Affiliation
Department of Clinical Microbiology, Hillerød Hospital, Hillerød, Denmark. jmh07@dadlnet.dk
Source
APMIS. 2005 Jan;113(1):31-6
Date
Jan-2005
Language
English
Publication Type
Article
Keywords
Biological Evolution
Denmark
Drug Resistance, Bacterial
Humans
Listeria monocytogenes - drug effects
Listeriosis - drug therapy - epidemiology
Retrospective Studies
Abstract
In order to see whether the susceptibility of Danish Listeria monocytogenes strains has changed over the years we examined a collection of human isolates from the period 1958-2001. We, furthermore, wanted to compare L. monocytogenes susceptibility testing using a disc diffusion assay with MIC measurements performed by the E-test. 106 strains isolated predominantly from blood cultures and cerebrospinal fluids were examined together with three reference strains. Susceptibility to the following antibiotics was tested by the E-test and by Oxoid discs using Iso-sensitest agar: penicillin G, ampicillin, meropenem, gentamicin, sulphamethoxazole, trimethoprim, ciprofloxacin, erythromycin, vancomycin, linezolid, chloramphenicol and tetracycline. The strains were in the main sensitive to all antibiotics examined using both methods, except for ciprofloxacin, where the strains were intermediate sensitive. However, for penicillin, ampicillin and sulphamethoxazole, while the disc diffusion assay found the strains to be sensitive, MIC measurements generally placed the strains one dilution above the breakpoint for sensitivity in the intermediate sensitive group. Based on the MIC measurements, the antibiotic susceptibility of L. monocytogenes has not changed in Denmark from 1958 to 2001, and the multiresistant strains found in human infections elsewhere have not been found in Denmark.
PubMed ID
15676012 View in PubMed
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