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An outbreak of Listeria monocytogenes serotype 3a infections from butter in Finland.

https://arctichealth.org/en/permalink/ahliterature198523
Source
J Infect Dis. 2000 May;181(5):1838-41
Publication Type
Article
Date
May-2000
Author
O. Lyytikäinen
T. Autio
R. Maijala
P. Ruutu
T. Honkanen-Buzalski
M. Miettinen
M. Hatakka
J. Mikkola
V J Anttila
T. Johansson
L. Rantala
T. Aalto
H. Korkeala
A. Siitonen
Author Affiliation
Department of Infectious Disease Epidemiology, National Public Health Institute, FIN-00300 Helsinki, Finland. outi.lyytikainen@ktl. fi.
Source
J Infect Dis. 2000 May;181(5):1838-41
Date
May-2000
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Butter - microbiology
Case-Control Studies
Child
Cross Infection - epidemiology
Dairying
Disease Outbreaks
Female
Finland - epidemiology
Humans
Incidence
Listeria monocytogenes - classification
Listeriosis - epidemiology - etiology - transmission
Male
Middle Aged
Serotyping
Abstract
In February 1999, an outbreak of listeriosis caused by Listeria monocytogenes serotype 3a occurred in Finland. All isolates were identical. The outbreak strain was first isolated in 1997 in dairy butter. This dairy began delivery to a tertiary care hospital (TCH) in June 1998. From June 1998 to April 1999, 25 case patients were identified (20 with sepsis, 4 with meningitis, and 1 with abscess; 6 patients died). Patients with the outbreak strain were more likely to have been admitted to the TCH than were patients with other strains of L. monocytogenes (60% vs. 8%; odds ratio, 17.3; 95% confidence interval, 2.8-136.8). Case patients admitted to the TCH had been hospitalized longer before cultures tested positive than had matched controls (median, 31 vs. 10 days; P=.008). An investigation found the outbreak strain in packaged butter served at the TCH and at the source dairy. Recall of the product ended the outbreak.
PubMed ID
10823797 View in PubMed
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Diversity of Listeria monocytogenes isolates of human and food origin studied by serotyping, automated ribotyping and pulsed-field gel electrophoresis.

https://arctichealth.org/en/permalink/ahliterature179719
Source
Clin Microbiol Infect. 2004 Jun;10(6):562-8
Publication Type
Article
Date
Jun-2004
Author
S. Lukinmaa
K. Aarnisalo
M-L Suihko
A. Siitonen
Author Affiliation
Laboratory of Enteric Pathogens, National Public Health Institute, Helsinki, Finland.
Source
Clin Microbiol Infect. 2004 Jun;10(6):562-8
Date
Jun-2004
Language
English
Publication Type
Article
Keywords
Animals
Automation
Bacterial Typing Techniques
Electrophoresis, Gel, Pulsed-Field
Finland - epidemiology
Food Microbiology
Humans
Listeria monocytogenes - classification - genetics - isolation & purification
Listeriosis - microbiology
Ribotyping
Serotyping
Abstract
Automated ribotyping, pulsed-field gel electrophoresis (PFGE) and serotyping were evaluated for the epidemiological study of isolates of Listeria monocytogenes collected in Finland in 1997-1999 from human blood (n = 116) and the food industry (n = 72). The isolates divided into six serotypes, 23 EcoRI ribotypes, 54 AscI PFGE types, and 57 final subtypes if all results were combined. The discrimination index of ribotyping was lower (0.873) than that of PFGE (0.946). Two final subtypes dominated among human isolates, and identical subtypes were also found among food industry isolates. All PFGE types were serotype-specific, whereas two ribotypes included isolates of two serotypes. Isolates of serotype 3a, involved in an outbreak in Finland in 1999, matched one of these ribotypes, which also included some food industry isolates of serotype 1/2a. Ribotyping with EcoRI would not have been sufficient to define the outbreak in Finland caused by serotype 3a isolates. Although ribotyping is applicable as the first method in outbreak situations, human and food isolates with identical ribotypes should be investigated further by PFGE.
PubMed ID
15191386 View in PubMed
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Listeria monocytogenes isolates from invasive infections: variation of sero- and genotypes during an 11-year period in Finland.

https://arctichealth.org/en/permalink/ahliterature185899
Source
J Clin Microbiol. 2003 Apr;41(4):1694-700
Publication Type
Article
Date
Apr-2003
Author
Susanna Lukinmaa
Maria Miettinen
Ulla-Maija Nakari
Hannu Korkeala
Anja Siitonen
Author Affiliation
Laboratory of Enteric Pathogens, National Public Health Institute, FIN-00300 Helsinki, Finland.
Source
J Clin Microbiol. 2003 Apr;41(4):1694-700
Date
Apr-2003
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Bacterial Typing Techniques
Child
Child, Preschool
Electrophoresis, Gel, Pulsed-Field
Female
Finland - epidemiology
Genetic Variation
Genotype
Humans
Infant
Infant, Newborn
Listeria monocytogenes - classification - genetics
Listeriosis - epidemiology - microbiology
Male
Middle Aged
Serotyping
Abstract
Listeria monocytogenes strains that were isolated from 314 human listeriosis cases in Finland during an 11-year period were analyzed by O:H serotyping and pulsed-field gel electrophoresis (PFGE). Serotyping divided the isolates into five serotypes, the most common being 1/2a (53%) and 4b (27%). During the study period, the number of cases caused by serotype 1/2a increased from 22% in 1990 to 67% in 2001, and those caused by serotype 4b decreased from 61 to 27%, respectively. PFGE with restriction enzyme AscI divided the strains into 81 PFGE genotypes; among strains of serotypes 1/2a and 4b, 49 and 18 PFGE types were seen, respectively. PFGE type 1 (serotype 1/2a) was the most prevalent single type (37 strains). Together with six other, closely related PFGE types, PFGE type 1 formed a group of 71 strains, representing 23% of all 314 strains. Strains of PFGE type 1 have also been isolated from cold smoked fish, suggesting a source of human infections caused by this type. Moreover, PFGE type 24 (serotype 1/2c) was significantly associated with gender: 5% of 180 male subjects but none of 132 female subjects (P = 0.012). An electronic database library was created from the PFGE profiles to make possible the prompt detection of new emerging profiles and the tracing of potential infection clusters in the future.
Notes
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PubMed ID
12682162 View in PubMed
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Molecular epidemiology of an outbreak of febrile gastroenteritis caused by Listeria monocytogenes in cold-smoked rainbow trout.

https://arctichealth.org/en/permalink/ahliterature201835
Source
J Clin Microbiol. 1999 Jul;37(7):2358-60
Publication Type
Article
Date
Jul-1999
Author
M K Miettinen
A. Siitonen
P. Heiskanen
H. Haajanen
K J Björkroth
H J Korkeala
Author Affiliation
Department of Food and Environmental Hygiene, 00014 University of Helsinki, Finland. msjoman@vetmed.helsinki.fi
Source
J Clin Microbiol. 1999 Jul;37(7):2358-60
Date
Jul-1999
Language
English
Publication Type
Article
Keywords
Adult
Animals
Child, Preschool
Disease Outbreaks
Electrophoresis, Gel, Pulsed-Field
Female
Fever
Finland - epidemiology
Food Handling
Food Microbiology
Gastroenteritis - epidemiology - microbiology
Humans
Listeria monocytogenes - classification - genetics - isolation & purification
Listeriosis - epidemiology - microbiology - transmission
Male
Middle Aged
Molecular Epidemiology - methods
Oncorhynchus mykiss - microbiology
Serotyping
Abstract
Febrile gastroenteritis in five healthy persons was associated with the consumption of vacuum-packed cold-smoked rainbow trout containing Listeria monocytogenes. L. monocytogenes isolates from the incriminated fish product lot and the stool samples were all of serotype 1/2a and were indistinguishable by pulsed-field gel electrophoresis employing AscI and SmaI.
Notes
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PubMed ID
10364616 View in PubMed
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Occurrence, Persistence, and Contamination Routes of Listeria monocytogenes Genotypes on Three Finnish Dairy Cattle Farms: a Longitudinal Study.

https://arctichealth.org/en/permalink/ahliterature297944
Source
Appl Environ Microbiol. 2018 02 15; 84(4):
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
02-15-2018
Author
Hanna Castro
Anniina Jaakkonen
Marjaana Hakkinen
Hannu Korkeala
Miia Lindström
Author Affiliation
Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Source
Appl Environ Microbiol. 2018 02 15; 84(4):
Date
02-15-2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Animals
Cattle
DNA, Bacterial - genetics
Dairying
Disease Reservoirs - microbiology - veterinary
Electrophoresis, Gel, Pulsed-Field
Farms
Feces - microbiology
Female
Finland - epidemiology
Genotype
Humans
Listeria monocytogenes - genetics - isolation & purification
Listeriosis - epidemiology - microbiology - veterinary
Longitudinal Studies
Mammary Glands, Animal - microbiology
Milk - microbiology
Abstract
The molecular epidemiology of Listeria monocytogenes was investigated in a longitudinal study of three Finnish dairy farms during 2013 to 2016. A total of 186 bulk tank milk (BTM), 224 milk filter sock (MFS), and 1,702 barn environment samples were analyzed, and isolates of L. monocytogenes were genotyped using pulsed-field gel electrophoresis. L. monocytogenes occurred throughout the year in all sample types, and the prevalence in MFS increased significantly during the indoor season. L. monocytogenes was more prevalent in MFS (29%) than in BTM (13%) samples. However, the prevalence of L. monocytogenes varied more between farms in samples of MFS (13 to 48%) than in BTM (10 to 16%). For each farm, the L. monocytogenes genotypes detected were classified by persistence (defined as persistent if isolated from =3 samples during =6 months) and predominance (defined as predominant if >5% prevalence on at least one farm visit). The prevalence of sporadic genotypes was 4 to 5% on all three farms. In contrast, the prevalence of persistent predominant genotypes varied between farms by 4% to 16%. The highest prevalence of persistent predominant genotypes was observed on the farm with the poorest production hygiene. Persistent predominant genotypes were most prevalent on feeding surfaces, water troughs, and floors. Genotypes isolated from the milking system or from cow udders had a greater relative risk of occurring in BTM and MFS than genotypes that only occurred elsewhere in the farm, supporting the hypothesis that L. monocytogenes is transmitted to milk from contamination on the udder surface or in the milking equipment.IMPORTANCEListeria monocytogenes is a ubiquitous environmental bacterium and the causative agent of a serious foodborne illness, listeriosis. Dairy products are common vehicles of listeriosis, and dairy cattle farms harbor L. monocytogenes genotypes associated with human listeriosis outbreaks. Indeed, dairy cattle farms act as a reservoir of L. monocytogenes, and the organism is frequently detected in bulk tank milk (BTM) and in the feces of clinically healthy cows. The ecology of L. monocytogenes in the farm environment is complex and poorly understood. Isolates of the same L. monocytogenes genotype can occur in the farm for years, but the factors contributing to the persistence of genotypes on dairy farms are unknown. Knowledge of the persistence patterns and contamination routes of L. monocytogenes on dairy farms can improve management of the contamination pressure in the farm environment and aid in the development of focused control strategies to reduce BTM contamination.
PubMed ID
29222098 View in PubMed
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Outbreak of hospital-acquired gastroenteritis and invasive infection caused by Listeria monocytogenes, Finland, 2012.

https://arctichealth.org/en/permalink/ahliterature283336
Source
Epidemiol Infect. 2016 Oct;144(13):2732-42
Publication Type
Article
Date
Oct-2016
Author
A. Jacks
A. Pihlajasaari
M. Vahe
A. Myntti
S-S Kaukoranta
N. Elomaa
S. Salmenlinna
L. Rantala
K. Lahti
S. Huusko
M. Kuusi
A. Siitonen
R. Rimhanen-Finne
Source
Epidemiol Infect. 2016 Oct;144(13):2732-42
Date
Oct-2016
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Animals
Cross Infection - microbiology
Female
Finland
Food Microbiology
Foodborne Diseases - microbiology
Gastroenteritis - microbiology
Gelatin - analysis
Humans
Listeria monocytogenes - isolation & purification
Listeriosis - microbiology
Male
Meat Products - microbiology
Middle Aged
Abstract
During one week in July 2012, two patients from the same ward at the municipal hospital in Vaasa, Finland, were diagnosed with septicaemia caused by Listeria monocytogenes. An outbreak investigation revealed eight concomitant cases of febrile gastroenteritis caused by L. monocytogenes on the same ward. Median age of the cases was 82 years and median incubation time for listerial gastroenteritis was 21 h (range 9-107). An additional 10 cases of invasive listeriosis caused by the same outbreak strain were identified across the whole country during the summer of 2012. Environmental investigation at the affected municipal hospital ward revealed ready-sliced meat jelly as the suspected source of the infection. During inspection of the meat jelly production plant, one pooled sample taken from a floor drain and a trolley wheel in the food processing environment was positive for the outbreak strain of L. monocytogenes. After the producer stopped the production of meat jelly, no further cases of listeriosis with the outbreak strain were identified via nationwide surveillance.
PubMed ID
26493730 View in PubMed
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Surveillance of listeriosis in Finland during 1995-2004.

https://arctichealth.org/en/permalink/ahliterature168646
Source
Euro Surveill. 2006;11(6):82-5
Publication Type
Article
Date
2006
Author
O. Lyytikäinen
U M Nakari
S. Lukinmaa
E. Kela
N. Nguyen Tran Minh
A. Siitonen
Author Affiliation
Department of Infectious Disease Epidemiology, National Public Health Institute (KTL), Helsinki, Finland.
Source
Euro Surveill. 2006;11(6):82-5
Date
2006
Language
English
Publication Type
Article
Keywords
Age Distribution
Aged
Cluster analysis
Disease Outbreaks
Female
Finland - epidemiology
Fish Products - microbiology
Genotype
Humans
Incidence
Infant, Newborn
Listeria monocytogenes - classification - genetics - isolation & purification
Listeriosis - epidemiology - microbiology - mortality
Population Surveillance
Pregnancy
Registries
Serotyping
Abstract
We analysed the surveillance data from listeriosis cases notified to the Finnish National Infectious Diseases Register between 1995 and 2004 and describe our recent experience in investigating clusters of listeriosis cases. The number of annual cases varied between 18 and 53 but no trends in incidence were identified (average annual incidence was 7 cases per million inhabitants). Only a few cases affected pregnant women or newborns. Most of the patients were elderly people with non-malignant underlying illnesses; 25% of them died from their infections. By routine sero- and genotyping of the listeria isolates, we detected several clusters; the vehicle for infection was only identified for two outbreaks. At least one quarter of listeriosis cases (78/315) was caused by a certain sero-genotype or closely related genotypes, which have also been found from vacuum-packed cold-smoked or cold-salted fish products. During 2000-2003, Finnish consumers were repeatedly informed about food precautions for risk groups. The information was also given to attending physicians and prenatal clinics.
PubMed ID
16801696 View in PubMed
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7 records – page 1 of 1.