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Adoptive transfer of alveolar macrophages abrogates bronchial hyperresponsiveness.

https://arctichealth.org/en/permalink/ahliterature15196
Source
Am J Respir Cell Mol Biol. 2004 Jul;31(1):22-7
Publication Type
Article
Date
Jul-2004
Author
Eric Careau
Elyse Y Bissonnette
Author Affiliation
Centre de Recherche, Hôpital Laval, Institut universitaire de Cardiologie et de Pneumologie de l'Université Laval, Québec, Canada. eric.careau@crhl.ulaval.ca
Source
Am J Respir Cell Mol Biol. 2004 Jul;31(1):22-7
Date
Jul-2004
Language
English
Publication Type
Article
Keywords
Adoptive Transfer
Animals
Asthma - physiopathology
Bronchi - drug effects - immunology - physiopathology
Bronchial Hyperreactivity - genetics - physiopathology - therapy
Bronchial Provocation Tests
Clodronic Acid
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Resistance - physiology
Genetic Predisposition to Disease - genetics
Immunoglobulin E - blood
Immunoglobulin G - blood
Liposomes
Macrophages, Alveolar - drug effects - immunology - transplantation
Male
Methacholine Chloride - pharmacology
Ovalbumin - immunology
Rats
Rats, Sprague-Dawley
Reaction Time - drug effects - physiology
Research Support, Non-U.S. Gov't
Abstract
Increasing evidence suggests that alveolar macrophages (AM) are involved in asthma pathogenesis. To better understand the role that these cells play, we investigated the capacity of AM from allergy-resistant rat, Sprague Dawley (SD), to modulate airway hyperresponsiveness of allergy-susceptible rat, Brown Norway (BN). AM of ovalbumin (OVA)-sensitized BN rats were eliminated by intratracheal instillation of liposomes containing clodronate. AM from OVA-sensitized SD rats were transferred into AM-depleted BN rats 24 h before allergen challenge. Airway responsiveness to methacholine was measured the following day. Instillation of liposomes containing clodronate in BN rats eliminated 85% AM after 3 d compared with saline liposomes. Methacholine concentration needed to increase lung resistance by 200% (EC200RL) was significantly lower in OVA-challenged BN rats (27.9 +/- 2.8 mg/ml) compared with SD rats (63.9 +/- 8.6 mg/ml). However, when AM from SD rats were transferred into AM-depleted BN rats, airway responsiveness (64.0 +/- 11.3 mg/ml) was reduced to the level of naïve rats (54.4 +/- 3.7 mg/ml) in a dose-dependent manner. Interestingly, transfer of AM from BN rats into SD rats did not modulate airway responsiveness. To our knowledge, this is the first direct evidence showing that AM may protect against the development of airway hyperresponsiveness.
Notes
Comment In: Am J Respir Cell Mol Biol. 2004 Jul;31(1):1-215208095
Comment In: Am J Respir Cell Mol Biol. 2004 Jul;31(1):3-715208096
PubMed ID
14962974 View in PubMed
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Advances in upper airway diseases and allergen immunotherapy.

https://arctichealth.org/en/permalink/ahliterature186402
Source
J Allergy Clin Immunol. 2003 Mar;111(3 Suppl):S793-8
Publication Type
Article
Date
Mar-2003
Author
Harold S Nelson
Author Affiliation
National Jewish Medical and Research Center, Denver, CO 80206, USA.
Source
J Allergy Clin Immunol. 2003 Mar;111(3 Suppl):S793-8
Date
Mar-2003
Language
English
Publication Type
Article
Keywords
Administration, Sublingual
Administration, Topical
Allergens - administration & dosage - chemistry
Anti-Inflammatory Agents - therapeutic use
Antibodies, Anti-Idiotypic
Antibodies, Monoclonal - administration & dosage - therapeutic use
Antibodies, Monoclonal, Humanized
Asthma - epidemiology - prevention & control - therapy
Finland - epidemiology
Humans
Hydrocortisone
Immunization - methods
Liposomes
Oligonucleotides - chemistry
Rhinitis - pathology - therapy
Risk factors
Russia - epidemiology
Skin Tests
Abstract
Epidemiologic studies continue to find an increased prevalence of rhinitis, asthma, and atopy in more westernized countries. Both allergic and nonallergic rhinitis are risk factors for development of asthma, particularly in adulthood. In patients who have both asthma and rhinitis, treatment of the latter decreases the likelihood of emergency department visits or hospitalization for asthma. The protective effect of intranasal cortico-steroids is much greater than that of antihistamines. This mirrors the effect on rhinitis symptoms, in which nasal corticosteroids are much more effective than antihistamines, leukotriene receptor antagonists, or the combination of both. In patients with severe asthma, sinus mucosal thickening on computed tomography (CT) correlates with the severity of lower airway disease indicated by sputum eosinophilia, exhaled nitrous oxide (NO), functional residual capacity, and diffusing capacity. Preseasonal specific immunotherapy (SIT) is less effective, but additive to treatment with omalizumab. It is also somewhat less effective in reducing nasal symptoms than nasal corticosteroids; however, it is superior to them for reducing lower airway inflammation. SIT in children with only allergic rhinitis reduces both the incidence of asthma and bronchial hyperresponsiveness to methacholine. High-dose sublingual immunotherapy appears to be safe and effective, but less effective than injection immunotherapy. It is not clear that there are cost savings with sublingual immunotherapy, as home administration savings may be offset by the much larger amount of allergen extracts required. New approaches to allergen immunotherapy, designed to increase efficacy and safety, include conjugation of allergens to immunostimulatory sequences and encapsulation in liposomes. Cross-reactivity between inhalants and foods demonstrated by skin prick tests is more predictive of clinically important sensitivity than is that demonstrated by RAST testing. The latter, because of cross-reacting profilins, is often clinically irrelevant.
PubMed ID
12618745 View in PubMed
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An intrinsically disordered domain in Polaribacter irgensii KOPRI 22228 CspB confers extraordinary freeze-tolerance.

https://arctichealth.org/en/permalink/ahliterature289779
Source
Biochem Biophys Res Commun. 2018 02 05; 496(2):374-380
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
02-05-2018
Author
Youn Hong Jung
Ji-Hyun Uh
Kyunghee Lee
Hana Im
Author Affiliation
Department of Molecular Biology, Sejong University, 209 Neungdong-ro, Gunja-dong, Gwangjin-gu, Seoul 05006, Republic of Korea.
Source
Biochem Biophys Res Commun. 2018 02 05; 496(2):374-380
Date
02-05-2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adaptation, Physiological - genetics
Bacterial Proteins - chemistry - genetics - metabolism
Cloning, Molecular
Cold Temperature
DNA-Binding Proteins - chemistry - genetics - metabolism
Escherichia coli - genetics - metabolism
Flavobacteriaceae - genetics - metabolism
Gene Expression
Intrinsically Disordered Proteins - chemistry - genetics - metabolism
Liposomes - chemistry - metabolism
Mutation
Protein Binding
Protein Domains
Recombinant Proteins - chemistry - genetics - metabolism
Stress, Physiological
Abstract
Organisms living in extremely cold environments possess mechanisms to survive low temperatures. Among the known cold-induced genes, cold-shock proteins (Csps) are the most prominent. A csp-homologous gene, cspBPi, has been cloned from the Arctic bacterium Polaribacter irgensii KOPRI 22228, and overexpression of this gene greatly increased the freezing tolerance of its host. This protein consists of a unique N-terminal domain and a well conserved C-terminal cold shock domain. To elucidate the detailed mechanisms involved in the extraordinary freeze-tolerance conferred by CspBPi, we identified the responsible domain by mutational analysis. Changes of residues in the cold shock domain that are crucial for binding RNA or single-stranded DNA did not impair the ability of the host to survive freezing stress. All domain-shuffled CspBPi variants containing the N-terminal domain retained the ability to confer superior freeze-tolerance. Slow electrophoretic mobility and far-UV circular dichroism spectra of the N-terminal domain suggested an intrinsically disordered structure for this region. The N-terminal domain also bound to lipid vesicles in vitro. This lipid vesicle binding characteristic is shared with other intrinsically disordered proteins, such as a-synuclein and plant dehydrins, known to confer cold-tolerance when overexpressed, suggesting a mechanism for cold-survival through membrane binding.
PubMed ID
29330047 View in PubMed
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[Antisense oligonucleotides as potential drugs for prophylaxis of prion infections]

https://arctichealth.org/en/permalink/ahliterature97378
Source
Ukr Biokhim Zh. 2009 Jul-Aug;81(4):112-6
Publication Type
Article
Author
V V Stadnyk
L A Iziumova
Iu A Rzhepets'kyi
Kh Ia Maior
P I Verbyts'kyi
V V Vlizlo
Source
Ukr Biokhim Zh. 2009 Jul-Aug;81(4):112-6
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Brain - drug effects - metabolism
Cell Line, Tumor
Codon, Initiator - genetics
Intestine, Small - drug effects - metabolism
Leukemia L1210
Liposomes
Mice
Oligodeoxyribonucleotides, Antisense - administration & dosage - pharmacology - therapeutic use
PrPC Proteins - biosynthesis - genetics
Prion Diseases - prevention & control
Rats
Spleen - drug effects - metabolism
Abstract
Prion mRNA translation inhibition by antisense oligodeoxynucleotides (asODN) incorporated into immunoliposomes was investigated. It was shown that asODN complementary to cap region, start-codon region and a part of open reading frame can decrease the prion expression by 80% in L1210 cell line and by 60% in prion-replicating organs of laboratory rats. These results give grounds for further research asODN to be used as a means of prevention and treatment of prion infections.
PubMed ID
20387641 View in PubMed
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Arrhythmogenic peroxynitrite-induced alterations in mammalian heart contractility and its prevention with quercetin-filled liposomes.

https://arctichealth.org/en/permalink/ahliterature53663
Source
Cardiovasc Toxicol. 2002;2(2):129-39
Publication Type
Article
Date
2002
Author
A. Soloviev
A. Stefanov
A. Parshikov
A. Khromov
A. Moibenko
L. Kvotchina
G. Balavoine
Yu Geletii
Author Affiliation
Institute of Pharmacology and Toxicology, Academy of Medical Sciences, 03057 Kiev, Ukraine. s.a.pharm@naverex.kiev.ua
Source
Cardiovasc Toxicol. 2002;2(2):129-39
Date
2002
Language
English
Publication Type
Article
Keywords
Animals
Arrhythmia - chemically induced - physiopathology - prevention & control
Blood Pressure - drug effects
Comparative Study
Coronary Vessels - physiopathology
Disease Models, Animal
Dogs
Dose-Response Relationship, Drug
Drug Evaluation
Heart Ventricles - physiopathology
Incidence
Liposomes
Models, Cardiovascular
Myocardial Contraction - drug effects
Myocardial Ischemia - chemically induced - physiopathology - prevention & control
Myocardial Reperfusion Injury - chemically induced - physiopathology - prevention & control
Papillary Muscles - drug effects - physiopathology
Peroxynitrous Acid - adverse effects
Quercetin - administration & dosage
Rats
Rats, Inbred WKY
Research Support, Non-U.S. Gov't
Severity of Illness Index
Ventricular Pressure - drug effects
Abstract
The aim of the present study was to evaluate the effects of quercetin-filled phosphatidylcholine liposomes (PCLs) on peroxynitrite (ONOO-)-induced cardiac arrhythmias. Experiments were done using different experimental models, including isolated rat papillary muscle, Langendorff perfused rat hearts, and anesthetized animals. Being exogenously applied in a concentration greater than 50 microM, ONOO- caused inhibition of isometric twitch amplitude in isolated papillary muscles and led to an appearance of arrhythmias. Decomposed ONOO- had no similar effects and reversibly increased twitch amplitude. Authentic nitric oxide (NO, 100 microM) did not produce arrhythmias and had no significant effect on twitch amplitude. Verapamil and ruthenium red were with-out effect on ONOO- -induced arrhythmias, whereas tetrodotoxin and nicorandil effectively prevented arrhythmias development. Ouabain increased the arrhythmogenic effect of ONOO-. ONOO- significantly decreased coronary perfusion pressure (CPP) and mean left-ventricular pressure (MLVP) in the Langendorff perfused rat heart and produced severe arrhythmias. Authentic nitric oxide (NO) decreased CPP and MLVP insignificantly and resulted in a low incidence of arrhythmias. The NO donor SIN-1 in doses greater than 50 microM led to the appearance of low-incidence arrhythmias in anesthetized rats. Intraventricular injection of ONOO- promotes the appearance of a high incidence of arrhythmias in anesthetized rats and decreased MLVP. PCLs filled with the antioxidant quercetin restored normal cardiac contractility in both isolated tissues and anesthetizes animals. In conclusion, we hypothesized that ONOO-, but not its decomposed products, can initiate membrane lipid peroxidation and damage the phospholipid environment of ionic channels in myocardial cell plasma membranes inducing abnormal cardiac action potentials, arrhythmogenesis, and contractile dysfunction. Quercetin-filled PCL provide reliable protection against peroxynitrite-induced myocardial injury in isolated cardiac tissues and anesthetized animals primarily as a result of the decomposition of endogenously formed ONOO-.
PubMed ID
12271156 View in PubMed
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Biodistribution analysis of cisplatin in liposomal form in animals with cisplatin-resistant and cisplatin-sensitive carcinoma.

https://arctichealth.org/en/permalink/ahliterature99413
Source
Exp Oncol. 2010 Mar;32(1):40-3
Publication Type
Article
Date
Mar-2010
Author
M M Nosko
V M Pivnyuk
G I Solyanik
G I Kulik
I N Todor
V Ya Momot
O R Melnikov
O V Ponomareva
V F Chekhun
Author Affiliation
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv 03022, Ukraine. mykhailo.nosko@gmail.com
Source
Exp Oncol. 2010 Mar;32(1):40-3
Date
Mar-2010
Language
English
Publication Type
Article
Keywords
Animals
Antineoplastic Agents - administration & dosage - pharmacokinetics
Biological Availability
Carcinoma - blood - drug therapy - metabolism - pathology
Cisplatin - administration & dosage - pharmacokinetics
Drug Resistance, Neoplasm - drug effects
Female
Liposomes
Rats
Rats, Wistar
Tissue Distribution
Tumor Burden - drug effects
Abstract
AIM: To analyze the relation between pharmacokinetics of cisplatin in liposomal form and antitumor efficacy toward cisplatin-resistant and cisplatin-sensitive variants of Guerin carcinoma. METHODS: Concentration of platinum was measured by atomic absorption spectrophotometry (C115M1 "Selmi", Ukraine). Elimination constant was calculated based on the dynamics of cisplatin concentration in time period between 1 h to 24 h using nonlinear regression analysis. Area under curve (AUC24) was calculated by the trapezium method. RESULTS: It was shown that for liposomal form of cisplatin (LCp) AUC24 in tumor practically didn't depend on the level of the tumor sensitivity, while in animals with the resistant variant (CpRGC), AUC24 for free cisplatin (FCp) decreased by 70% less (p
PubMed ID
20355294 View in PubMed
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[Biological properties of liposomes and their practical application]

https://arctichealth.org/en/permalink/ahliterature90948
Source
Fiziol Zh. 2008;54(5):99-108
Publication Type
Article
Date
2008
Author
Halyts'ka S M
Nikol's'kyi I S
Source
Fiziol Zh. 2008;54(5):99-108
Date
2008
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Drug Carriers - administration & dosage - chemistry
Humans
Liposomes - administration & dosage - chemistry - pharmacology - therapeutic use
Pharmaceutical Preparations - administration & dosage - chemistry
Abstract
In the review the information about biological properties of liposomes and their application perspectives as independent medications so as transmitters of medicinal preparations is generalized. Approaches to the directed transport of biologically active matters by the different liposome types are discussed. Simultaneously solving of two important tasks on the decline of preparation toxicity and increase of their efficiency are proposed. The data about liposome distributing features at the different ways of their infusion in an organism and the mechanisms of interaction of corpuscles with the surface of target cells are provided. The most perspective aspects of liposomes and drugs in liposomal form at the modern stage of development of biotechnology, pharmacology and immunopharmacology and their practical application in oncology, antibiotic therapies, chemotherapy of infectious diseases, diabetes, gene engineering, treatment of Parkinson's syndrome, creation of artificial oxygen transporters, immunotherapy, allergology, vaccination and other are discussed.
PubMed ID
19058519 View in PubMed
Less detail

Cost-effectiveness analysis of pegylated-liposomal doxorubicin and liposomal daunorubicin treatments in patients with Kaposi's sarcoma.

https://arctichealth.org/en/permalink/ahliterature7546
Source
Acta Oncol. 1999;38(8):1063-7
Publication Type
Article
Date
1999
Author
C. Hjortsberg
U. Persson
E. Lidbrink
C. Bennett
Author Affiliation
Swedish Institute for Health Economics, Lund. ch@ihe.se
Source
Acta Oncol. 1999;38(8):1063-7
Date
1999
Language
English
Publication Type
Article
Keywords
Antibiotics, Antineoplastic - administration & dosage - adverse effects - economics
Antineoplastic Agents - administration & dosage - adverse effects - economics
Comparative Study
Cost-Benefit Analysis
Daunorubicin - administration & dosage - adverse effects - economics
Doxorubicin - administration & dosage - adverse effects - economics
Drug Carriers
Drug Costs
HIV Infections - complications
Humans
Liposomes
Polyethylene Glycols
Randomized Controlled Trials
Retrospective Studies
Sarcoma, Kaposi - complications - drug therapy - economics
Sweden
Abstract
Economic evaluations of new AIDS treatment drugs are important. For physicians treating patients with Kaposi's sarcoma, these issues are especially meaningful since cancer treatment costs for this group of patients are high. Kaposi's sarcoma is the most frequently occurring neoplasm in AIDS patients, affecting about 15% of this population. In our study, a retrospective economic evaluation has been made based on data from two randomized phase III clinical studies of severely immune-compromised HIV-infected individuals and which compares liposomal doxorubicin with liposomal daunorubicin. We have estimated the cost and cost effectiveness of the two drugs. The costs per complete or partial response are USS 18340 for daunorubicin and USS 8871 for doxorubicin. The incremental cost per additional responder by using liposomal doxorubicin instead of liposomal daunorubicin is USS 1910. Sensitivity analysis shows that these results hold over a wide range of assumptions.
PubMed ID
10665764 View in PubMed
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Delivery of plasmid DNA to glial cells using pH-sensitive immunoliposomes.

https://arctichealth.org/en/permalink/ahliterature4102
Source
Biochem Biophys Res Commun. 1994 Jun 15;201(2):888-93
Publication Type
Article
Date
Jun-15-1994
Author
E G Holmberg
Q R Reuer
E E Geisert
J L Owens
Author Affiliation
Department of Chemistry/Physics, University of Alaska Anchorage 99508.
Source
Biochem Biophys Res Commun. 1994 Jun 15;201(2):888-93
Date
Jun-15-1994
Language
English
Publication Type
Article
Keywords
3T3 Cells
Animals
Animals, Newborn
Antibodies, Monoclonal
Cells, Cultured
Comparative Study
DNA, Bacterial - administration & dosage - metabolism
Drug Carriers
Escherichia coli - enzymology
Glioma - metabolism
Kidney Cortex - cytology
Liposomes
Mice
Neuroglia - metabolism
Plasmids - administration & dosage
Rats
Research Support, Non-U.S. Gov't
Transfection - methods
Tumor Cells, Cultured
beta-Galactosidase - biosynthesis - genetics
Abstract
Immunoliposomes were constructed with an antibody specific to glial cells. They were used to examine the specificity and efficacy of cell type plasmid transfection. Liposomes contained a beta-galactosidase gene under control of an SV-40 promotor. Two different monoclonal antibodies of a different subclass, IgM and IgG, were examined for their targeting ability using immunoliposomes. Cultured C6 glioma (specific target cell type) and NIH 3T3 (control cell type, fibroblast) cells were transfected using these immunoliposomes. Results indicate a three-fold increase in transfection by the glial specific immunoliposomes, "gliasomes", in glial cell culture over control liposomes. Gliasomes were exposed to NIH 3T3 cells and showed no enhanced transfection over control liposomes. Gliasomes were tested for their specificity by the addition of excess antibody to the cell culture in order to saturate specific receptors on C6 glioma cells. Results indicate a reduced transfection, nearly three-fold, in cells that were saturated with excess antibody prior to exposure to the immunoliposomes.
PubMed ID
8003028 View in PubMed
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[Effect of liposomal antitumor preparation 5-(5',6'-benzocoumarin-3')-methylaminouracil hydrobromide on cytochrome P-450 in the microsomal liver fraction of tumor bearing rats]

https://arctichealth.org/en/permalink/ahliterature77748
Source
Ukr Biokhim Zh. 2006 Nov-Dec;78(6):86-92
Publication Type
Article
Author
Marchenko M M
Kopyl'chuk H P
Ketsa O V
Shmarakov I O
Source
Ukr Biokhim Zh. 2006 Nov-Dec;78(6):86-92
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Antineoplastic Agents - administration & dosage - pharmacology - therapeutic use
Cytochrome P-450 Enzyme System - metabolism
Female
Liposomes
Microsomes, Liver - drug effects - enzymology - metabolism
Neoplasm Transplantation
Neoplasms, Experimental - drug therapy - enzymology
Phosphatidylcholines - administration & dosage
Rats
Sulfhydryl Compounds - metabolism
Uracil - administration & dosage - analogs & derivatives - pharmacology - therapeutic use
Abstract
Cytochrome P-450 thermal inactivation rate, and content of protein sulfhydryl groups and cytochrome P-450 in the microsomal liver fraction of rats at different stages of Huerin's carcinoma growth were investigated. Liposomal form of BCU administration on the background of preliminary (for 2 hours) administration of phosphatidylcholine liposomes suspension was performed. The low level of cytochrome P-450, protein SH-groups in microsomal liver fraction and increase of the rate of transition of microsomal cytochrome P-450 in P-420 was shown in the dynamics of Huerin's carcinoma growth in an organism. Low microsomal cytochrome P-450 distraction was shown in the rat liver under conditions of antitumor liposomal preparation BCU injection on the 21st day after the transplantation of Huerin's carcinoma. At the same time nonliposomal BCU caused the opposite effect. The preliminary administration of phosphatidylcholine liposomes favours the approach of the investigated parameters to the control values on the terminal stages of tumour growth.
PubMed ID
17494323 View in PubMed
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28 records – page 1 of 3.