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88 records – page 1 of 9.

[3',5'-cAMP phosphodiesterase inhibitors in the combined treatment of patients with rheumatoid arthritis]

https://arctichealth.org/en/permalink/ahliterature14188
Source
Lik Sprava. 1998 Aug;(6):34-7
Publication Type
Article
Date
Aug-1998
Author
O I Bakaliuk
M I Shved
M V Hrebenyk
Source
Lik Sprava. 1998 Aug;(6):34-7
Date
Aug-1998
Language
Ukrainian
Publication Type
Article
Keywords
3',5'-Cyclic-Nucleotide Phosphodiesterase - antagonists & inhibitors
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - drug therapy - immunology - metabolism
Combined Modality Therapy
Comparative Study
Drug Evaluation
English Abstract
Glucosephosphate Dehydrogenase - blood - drug effects
Humans
Immunity, Cellular - drug effects
Immunity, Natural - drug effects
Lipid Peroxidation - drug effects
Papaverine - therapeutic use
Phosphodiesterase Inhibitors - therapeutic use
Prospidium - therapeutic use
Abstract
A study was made of clinical effectiveness and mechanism of action of the inhibitor of the specific 3',5'-cAMP phosphodiesterase papaverine in a therapeutic complex of measures designed to treat RA patients involving an immunodepressive preparation free from any cytopenic effect prospidin as a basic mediator. It has been shown that the papaverine antiarthritic action is associated with its positive effects on the unspecific component of the immune-complex inflammation, viz. processes of lipid peroxidation, activity of the antioxidant system of defence as well as on the vascular tone and microcirculation. All this improves tissue metabolism, and in this way enhances efficiency of RA basic therapy.
PubMed ID
9844866 View in PubMed
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[A comparative evaluation of the effect of different types of sapropel on dynamic liver function in intact rats and in the modelling of toxic hepatitis]

https://arctichealth.org/en/permalink/ahliterature56727
Source
Vopr Kurortol Fizioter Lech Fiz Kult. 1998 Mar-Apr;(2):37-8
Publication Type
Article
Author
D I Kuz'menko
G N Sidorenko
E F Levitskii
B I Laptev
E I Dzhuraeva
Source
Vopr Kurortol Fizioter Lech Fiz Kult. 1998 Mar-Apr;(2):37-8
Language
Russian
Publication Type
Article
Keywords
Animals
Benzopyrans - pharmacology - therapeutic use
Carbon Tetrachloride Poisoning - metabolism - rehabilitation
Comparative Study
Disease Models, Animal
English Abstract
Hepatitis, Toxic - metabolism - rehabilitation
Humic Substances - pharmacology - therapeutic use
Lipid Peroxidation - drug effects
Liver - drug effects - metabolism
Mud Therapy
Rats
Rats, Wistar
Reference Values
Seasons
Siberia
Abstract
A course of silicic sapropel applications compared to calcareous sapropel induced a reversible fall of total lipid concentration in blood serum of intact rats. Sapropels of different kinds and of the same kind but obtained from different depths of the same deposit varied by their ability to correct hepatic function in rats with toxic hepatitis. The highest benefit was registered in application of carbonate sapropels taken from the depth of 1.5-2.5 m.
PubMed ID
9643147 View in PubMed
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[A comparative study of the hemodynamic and antioxidant effects of Capoten and prazosin in patients with refractory heart failure]

https://arctichealth.org/en/permalink/ahliterature54537
Source
Lik Sprava. 1997 Mar-Apr;(2):72-6
Publication Type
Article
Author
R O Sabadyshyn
B I Rudyk
N H Blinova
O Ia Slipak
Source
Lik Sprava. 1997 Mar-Apr;(2):72-6
Language
Ukrainian
Publication Type
Article
Keywords
Aged
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Antihypertensive Agents - therapeutic use
Antioxidants - therapeutic use
Captopril - therapeutic use
Cardiomyopathy, Dilated - complications - drug therapy - physiopathology
Comparative Study
Drug Evaluation
English Abstract
Female
Heart Failure, Congestive - drug therapy - etiology - physiopathology
Hemodynamic Processes - drug effects
Humans
Hypertension - complications - drug therapy - physiopathology
Lipid Peroxidation - drug effects
Male
Middle Aged
Myocardial Ischemia - complications - drug therapy - physiopathology
Prazosin - therapeutic use
Abstract
Overall fifty one patients with chronic cardiac insufficiency (ChCI) were studied for changes in parameters characterizing hemodynamics and lipid peroxidation (LPO) under treatment with kapoten and prazosin. Kapoten was found to be capable of exerting an antioxidant effect and working in ways beneficial for the pulmonary circulation, while prazosin is generally indicated to patients with ChCI presenting with increased end diastolic pressure in the left ventricle. Prazosin activates LPO, for which reason its pro-oxidant action needs to be drug-corrected. Because of marked pharmacologic effects of both drugs in dealing with refractory circulatory insufficiency it is advisable that further studies be made in order that we might be able to determine indications for kapoten and prazosin therapy in coronary patients as well as those with arterial hypertension, cardiomyopathies, valvular defects, ChCI with complications more accurately.
PubMed ID
9333490 View in PubMed
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[A correction of lipid peroxidation and antioxidant defense by enterosorption with the use of polysorbates during the combined treatment of the III/IV stage ovarian cancer]

https://arctichealth.org/en/permalink/ahliterature10804
Source
Klin Khir. 1998;(5):30-1
Publication Type
Article
Date
1998
Author
O I Temchenko
I M Klishch
Source
Klin Khir. 1998;(5):30-1
Date
1998
Language
Ukrainian
Publication Type
Article
Keywords
Antineoplastic Agents - therapeutic use
Antioxidants - metabolism
Combined Modality Therapy
English Abstract
Enterosorption - methods
Female
Humans
Lipid Peroxidation - drug effects
Neoplasm Staging
Ovarian Neoplasms - therapy
Polysorbates - pharmacology - therapeutic use
Surface-Active Agents - pharmacology - therapeutic use
Abstract
In 62 patients with ovarial cancer of III-IV stage under the influence of enterosorption using polysorb the contents of primary and intermediate products of peroxidal oxidation of lipids have reduced and the antioxidant system indexes did not change.
PubMed ID
9787568 View in PubMed
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[Antioxidant properties of novel preparations--bioflavonoid derivatives and tannins]

https://arctichealth.org/en/permalink/ahliterature56645
Source
Eksp Klin Farmakol. 2001 Mar-Apr;64(2):55-9
Publication Type
Article
Author
L V Iakovleva
O A Gerasimova
I V Karbusheva
A K Ivakhnenko
N D Buniatian
T S Sakharova
Author Affiliation
Central Research Laboratory, Ukrainian Pharmaceutical Academy, ul. Pushkinskaya 53, Kharkov, 310002 Ukraine.
Source
Eksp Klin Farmakol. 2001 Mar-Apr;64(2):55-9
Language
Russian
Publication Type
Article
Keywords
Animals
Antioxidants - pharmacology
Carbon Tetrachloride Poisoning - metabolism
Cell Membrane
Ellagic Acid - pharmacology
English Abstract
Female
Flavonoids - pharmacology
Hepatitis, Toxic - metabolism
Hepatocytes - drug effects - ultrastructure
Lipid Peroxidation - drug effects
Liver - drug effects - metabolism - ultrastructure
Male
Mice
Rats
Tannins - pharmacology
Abstract
New medicinal plant preparations of polyphenol nature, representing the derivatives of bioflavonoids (piflamin) and ellagotannins (altan and ellagic acid) were experimentally studied. The drugs exhibited antioxidant properties, which were manifested by inhibition of a pathological lipid peroxidation, restoration of the functional activity of the antioxidant system components, and stabilization of the hepatocyte membranes.
PubMed ID
11548450 View in PubMed
Less detail

The antioxidant response induced by Lonicera caerulaea berry extracts in animals bearing experimental solid tumors.

https://arctichealth.org/en/permalink/ahliterature92970
Source
Molecules. 2008;13(5):1195-206
Publication Type
Article
Date
2008
Author
Gruia Maria Iuliana
Oprea Eliza
Gruia Ion
Negoita Valentina
Farcasanu Ileana Cornelia
Author Affiliation
Institute of Oncology Bucharest, 252 Fundeni, 022338, Bucharest, Romania.
Source
Molecules. 2008;13(5):1195-206
Date
2008
Language
English
Publication Type
Article
Keywords
Animals
Antioxidants - metabolism
Cell Proliferation - drug effects
Ceruloplasmin - metabolism
Drug Screening Assays, Antitumor
Fruit - metabolism
Lipid Peroxidation - drug effects
Lonicera - metabolism
Male
Neoplasms, Experimental - drug therapy - pathology
Oxidation-Reduction - drug effects
Oxidative Stress - drug effects
Phytotherapy
Plant Extracts - pharmacology - therapeutic use
Rats
Rats, Wistar
Sulfhydryl Compounds - metabolism
Abstract
Lonicera caerulea is a species of bush native to the Kamchatka Peninsula (Russian Far East) whose berries have been extensively studied due to their potential high antioxidant activity. The aim of our work was to investigate the in vivo effects of the antioxidant action of Lonicera caerulea berry extracts on the dynamics of experimentally-induced tumors. Our data showed that aqueous Lonicera caerulaea extracts reduced the tumor volume when administered continuously during the tumor growth and development stages, but augmented the tumor growth when the administration of extracts started three weeks before tumor grafting. Prolonged administration of Lonicera caerulaea berry extracts induced the antioxidant defense mechanism in the tumor tissues, while surprisingly amplifying the peripheral oxidative stress.
Notes
Erratum In: Molecules. 2009;14(2):893
PubMed ID
18560338 View in PubMed
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[Antioxidants in the combined therapy of diabetic angiopathies]

https://arctichealth.org/en/permalink/ahliterature48104
Source
Eksp Klin Farmakol. 1998 Jan-Feb;61(1):74-80
Publication Type
Article
Author
L E Bobyreva
Author Affiliation
Ukranian Medical Stomatological Academy, Poltava, Ukraine.
Source
Eksp Klin Farmakol. 1998 Jan-Feb;61(1):74-80
Language
Russian
Publication Type
Article
Keywords
Animals
Antioxidants - therapeutic use
Diabetes Mellitus, Experimental - drug therapy - etiology - metabolism
Diabetic Angiopathies - drug therapy - etiology - metabolism
Drug Therapy, Combination
English Abstract
Free Radicals - metabolism
Humans
Hypoglycemic agents - therapeutic use
Lipid Peroxidation - drug effects
Oxidation-Reduction - drug effects
Abstract
The participation of free-radical oxidation of lipids and polymers in the pathogenesis of diabetic angiopathies is analysed. The structure of the system of antioxidant protection and the mechanisms of damage to the vascular wall macromolecules in diabetic angiopathies is suggested. The protective effects of antioxidants in experimental studies and clinical practice are discussed. The conditions for and the principles of applying antioxidants in complex therapy of diabetic angiopathies are suggested.
PubMed ID
9575419 View in PubMed
Less detail

Antioxidant systems of the developing quail embryo are compromised by mycotoxin aurofusarin.

https://arctichealth.org/en/permalink/ahliterature75528
Source
Comp Biochem Physiol C Toxicol Pharmacol. 2002 Feb;131(2):197-205
Publication Type
Article
Date
Feb-2002
Author
Julia E Dvorska
Peter F Surai
Brian K Speake
Nick H C Sparks
Author Affiliation
Department of Veterinary Medicine, Sumy State Agrarian University, Ukraine.
Source
Comp Biochem Physiol C Toxicol Pharmacol. 2002 Feb;131(2):197-205
Date
Feb-2002
Language
English
Publication Type
Article
Keywords
Animals
Animals, Newborn
Antioxidants - analysis
Carotenoids - analysis - metabolism
Comparative Study
Egg Yolk - chemistry - metabolism
Embryo, Nonmammalian - physiology
Female
Lipid Peroxidation - drug effects
Liver - chemistry - embryology - metabolism
Malondialdehyde - analysis
Mycotoxins - toxicity
Naphthoquinones - toxicity
Quail - embryology
Research Support, Non-U.S. Gov't
Tissue Distribution
Vitamin E - analysis - metabolism
Yolk Sac - chemistry - metabolism
Abstract
The effects of aurofusarin in the quail diet on the antioxidant systems of the developing embryo are investigated. Thirty eight 45-day-old Japanese quails (Coturnix japonica) were divided into two groups and were fed on a corn-soya diet or the same diet supplemented with aurofusarin at the level of 26.4 mg/kg feed in the form of Fusarium graminearum culture enriched with aurofusarin. Eggs obtained after 7 weeks of feeding were incubated. Samples of quail tissues were collected at day 17 of embryonic development and from day old hatchlings. Antioxidants and malondialdehyde were analysed by HPLC-based methods. Inclusion of aurofusarin in the maternal diet was associated with decreased concentrations of alpha- and gamma-tocopherols, alpha- and gamma-tocotrienols, retinol, lutein and zeaxanthin in egg yolk. The vitamin E (tocopherols and tocotrienols) concentration in the liver and yolk sac membrane (YSM) of the day 17 embryos and the hatchlings from aurofusarin-fed group was significantly decreased. Alpha-tocopherol concentration was also reduced in kidney, lung, heart, muscle and brain of day-old quails. In the liver of day-old quails, concentrations of lutein, zeaxanthin, retinol, retinyl linoleate, retinyl oleate, retinyl palmitate and retinyl stearate were also reduced. As a result of these diminished antioxidant concentrations, tissue susceptibility to lipid peroxidation was significantly increased. It is suggested that a compromised antioxidant system of the egg yolk and embryonic tissues could predispose quails to increased mortality at late stages of their embryonic development.
PubMed ID
11879787 View in PubMed
Less detail

Assessment of oxidative stress and histopathology in juvenile northern pike (Esox lucius) inhabiting lakes downstream of a uranium mill.

https://arctichealth.org/en/permalink/ahliterature89579
Source
Aquat Toxicol. 2009 May 17;92(4):240-9
Publication Type
Article
Date
May-17-2009
Author
Kelly Jocelyn M
Janz David M
Author Affiliation
Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, SK, Canada S7N 5B3.
Source
Aquat Toxicol. 2009 May 17;92(4):240-9
Date
May-17-2009
Language
English
Publication Type
Article
Keywords
Animals
Biological Markers - analysis
Esocidae - physiology
Fresh Water - analysis
Gills - drug effects - pathology
Industrial Waste
Kidney - drug effects - pathology
Lipid Peroxidation - drug effects
Liver - drug effects - pathology
Metals, Heavy - analysis
Muscles - chemistry - drug effects
Oxidative Stress - drug effects
Uranium - toxicity
Water Pollutants, Chemical - toxicity
Abstract
Lakes receiving effluent from the Key Lake uranium mill in northern Saskatchewan contain elevated trace metals, some of which are associated with increased reactive oxygen species (ROS) in cells and tissues causing oxidative stress. The potential for oxidative stress was assessed in juvenile (age 1+) northern pike (Esox lucius) collected from two exposure (high and low) and one reference lake near the Key Lake operation. The concentrations of total, reduced and oxidized glutathione and the ratio of oxidized to reduced glutathione in liver and kidney did not differ significantly among pike collected from exposure and reference lakes, with the exception of low exposure pike kidney that had significantly greater oxidized glutathione and ratio of oxidized to reduced glutathione. The concentrations of by-products of lipid peroxidation (malondialdehyde and 4-hydroxyalkenal) were significantly greater in kidney of pike collected from the reference lake compared to both exposure lakes. The activity of the antioxidant enzyme glutathione peroxidase in liver was greater in pike collected from the high exposure lake compared to the reference lake. Histopathological evaluations revealed greater pathology in reference lake pike as indicated by a greater number of pyknotic and fragmented nuclei and dilated tubules as well as a thickening of Bowman's capsule in kidney, and as a thickening of the primary filament epithelial padding in gills. In liver, hepatocyte morphology, including transsectional area and degree of vacuolation, differed among lakes without any clear signs of pathology. Trace metal analyses of muscle showed that eight elements (arsenic, cobalt, copper, iron, molybdenum, selenium, thallium, and uranium) were significantly elevated in pike collected from both exposure lakes compared to reference. These results provide only limited evidence of oxidative stress in exposure pike tissues and no evidence of histopathology despite indications that trace metals, most notably arsenic and selenium, were bioaccumulating in tissue.
PubMed ID
19304330 View in PubMed
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[Assessment of some oxidative stress parameters in bronchial asthma patients beyond add-on selenium supplementation]

https://arctichealth.org/en/permalink/ahliterature93859
Source
Biomed Khim. 2007 Sep-Oct;53(5):577-84
Publication Type
Article
Author
Voitsekhovskaia Iu G
Skesters A.
Orlikov G A
Silova A A
Rusakova N E
Larmane L T
Karpov Iu G
Ivanov A D
Maulins E.
Source
Biomed Khim. 2007 Sep-Oct;53(5):577-84
Language
Russian
Publication Type
Article
Keywords
Asthma - drug therapy - metabolism
Catalase - blood
Female
Glutathione Peroxidase - blood
Humans
Lipid Peroxidation - drug effects
Male
Oxidative Stress - drug effects
Prospective Studies
Selenium - deficiency - pharmacology - therapeutic use
Abstract
The goal of this study was to investigate the effect of selenium deficit replenishment in patients with bronchial asthma (BA) on manifestations of oxidative stress and conditions of the antioxidant system (AOS). The need of correction of selenium deficit in BA-patient is determined by the increased needs in antioxidants due to chronic inflammatory process responcible for pathogenesis of BA. Latvia and also Eastern Finland, Byelorussia, some regions of Ukraine, some regions of the NorthWestern Russia, New Zealand belong to endemic areas with marked selen deficit in soils and foodstuff. Twenty patients (7 men and 13 women) with selen deficit and verified diagnosis of BA have been examined. In addition to basic therapy all patients received organic selenium SelenoPRECISE, ("PharmaNord") 200 microg daily for 16 weeks. This caused statistically significant increase of plasma selenium from 50.94+/-7.58 microg/l to 63.59+/-10.87 microg/l (p
PubMed ID
18078072 View in PubMed
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88 records – page 1 of 9.