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271 records – page 1 of 28.

[3',5'-cAMP phosphodiesterase inhibitors in the combined treatment of patients with rheumatoid arthritis]

https://arctichealth.org/en/permalink/ahliterature14188
Source
Lik Sprava. 1998 Aug;(6):34-7
Publication Type
Article
Date
Aug-1998
Author
O I Bakaliuk
M I Shved
M V Hrebenyk
Source
Lik Sprava. 1998 Aug;(6):34-7
Date
Aug-1998
Language
Ukrainian
Publication Type
Article
Keywords
3',5'-Cyclic-Nucleotide Phosphodiesterase - antagonists & inhibitors
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - drug therapy - immunology - metabolism
Combined Modality Therapy
Comparative Study
Drug Evaluation
English Abstract
Glucosephosphate Dehydrogenase - blood - drug effects
Humans
Immunity, Cellular - drug effects
Immunity, Natural - drug effects
Lipid Peroxidation - drug effects
Papaverine - therapeutic use
Phosphodiesterase Inhibitors - therapeutic use
Prospidium - therapeutic use
Abstract
A study was made of clinical effectiveness and mechanism of action of the inhibitor of the specific 3',5'-cAMP phosphodiesterase papaverine in a therapeutic complex of measures designed to treat RA patients involving an immunodepressive preparation free from any cytopenic effect prospidin as a basic mediator. It has been shown that the papaverine antiarthritic action is associated with its positive effects on the unspecific component of the immune-complex inflammation, viz. processes of lipid peroxidation, activity of the antioxidant system of defence as well as on the vascular tone and microcirculation. All this improves tissue metabolism, and in this way enhances efficiency of RA basic therapy.
PubMed ID
9844866 View in PubMed
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[Accelerated senescence of armed conflicts participants suffering from the consequences of war cranial-cerebral trauma and alcoholism].

https://arctichealth.org/en/permalink/ahliterature160567
Source
Adv Gerontol. 2007;20(1):112-7
Publication Type
Article
Date
2007
Author
V S Miakotnykh
V V Iampol'skaia
V N Samoilova
A A Bal'bert
T A Borovkova
V N Meshchaninov
O N Matveeva
Source
Adv Gerontol. 2007;20(1):112-7
Date
2007
Language
Russian
Publication Type
Article
Keywords
Adult
Aging, Premature - diagnosis - etiology
Alcoholism - complications
Antioxidants - analysis - metabolism
Brain Injuries - complications
Female
Heart rate
Humans
Lipid Peroxidation
Male
Middle Aged
Russia
War
Abstract
The matter under studies was the way accelerated senescence of armed conflicts participants with brain injuries depends on alcohol addiction developed after the injuries and on dysfunction of neurohumoral regulation of heart activity. It has been established that the posttraumatic alcohol addiction considerably activates the processes of accelerated senescence and lipid peroxidation connected with it, depresses the system of antioxidant protection and enhances the progress of dysfunctions in neurohumoral regulation of heart activity.
PubMed ID
17969594 View in PubMed
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[A comparative evaluation of the effect of different types of sapropel on dynamic liver function in intact rats and in the modelling of toxic hepatitis]

https://arctichealth.org/en/permalink/ahliterature56727
Source
Vopr Kurortol Fizioter Lech Fiz Kult. 1998 Mar-Apr;(2):37-8
Publication Type
Article
Author
D I Kuz'menko
G N Sidorenko
E F Levitskii
B I Laptev
E I Dzhuraeva
Source
Vopr Kurortol Fizioter Lech Fiz Kult. 1998 Mar-Apr;(2):37-8
Language
Russian
Publication Type
Article
Keywords
Animals
Benzopyrans - pharmacology - therapeutic use
Carbon Tetrachloride Poisoning - metabolism - rehabilitation
Comparative Study
Disease Models, Animal
English Abstract
Hepatitis, Toxic - metabolism - rehabilitation
Humic Substances - pharmacology - therapeutic use
Lipid Peroxidation - drug effects
Liver - drug effects - metabolism
Mud Therapy
Rats
Rats, Wistar
Reference Values
Seasons
Siberia
Abstract
A course of silicic sapropel applications compared to calcareous sapropel induced a reversible fall of total lipid concentration in blood serum of intact rats. Sapropels of different kinds and of the same kind but obtained from different depths of the same deposit varied by their ability to correct hepatic function in rats with toxic hepatitis. The highest benefit was registered in application of carbonate sapropels taken from the depth of 1.5-2.5 m.
PubMed ID
9643147 View in PubMed
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[A comparative study of the hemodynamic and antioxidant effects of Capoten and prazosin in patients with refractory heart failure]

https://arctichealth.org/en/permalink/ahliterature54537
Source
Lik Sprava. 1997 Mar-Apr;(2):72-6
Publication Type
Article
Author
R O Sabadyshyn
B I Rudyk
N H Blinova
O Ia Slipak
Source
Lik Sprava. 1997 Mar-Apr;(2):72-6
Language
Ukrainian
Publication Type
Article
Keywords
Aged
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Antihypertensive Agents - therapeutic use
Antioxidants - therapeutic use
Captopril - therapeutic use
Cardiomyopathy, Dilated - complications - drug therapy - physiopathology
Comparative Study
Drug Evaluation
English Abstract
Female
Heart Failure, Congestive - drug therapy - etiology - physiopathology
Hemodynamic Processes - drug effects
Humans
Hypertension - complications - drug therapy - physiopathology
Lipid Peroxidation - drug effects
Male
Middle Aged
Myocardial Ischemia - complications - drug therapy - physiopathology
Prazosin - therapeutic use
Abstract
Overall fifty one patients with chronic cardiac insufficiency (ChCI) were studied for changes in parameters characterizing hemodynamics and lipid peroxidation (LPO) under treatment with kapoten and prazosin. Kapoten was found to be capable of exerting an antioxidant effect and working in ways beneficial for the pulmonary circulation, while prazosin is generally indicated to patients with ChCI presenting with increased end diastolic pressure in the left ventricle. Prazosin activates LPO, for which reason its pro-oxidant action needs to be drug-corrected. Because of marked pharmacologic effects of both drugs in dealing with refractory circulatory insufficiency it is advisable that further studies be made in order that we might be able to determine indications for kapoten and prazosin therapy in coronary patients as well as those with arterial hypertension, cardiomyopathies, valvular defects, ChCI with complications more accurately.
PubMed ID
9333490 View in PubMed
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[A correction of lipid peroxidation and antioxidant defense by enterosorption with the use of polysorbates during the combined treatment of the III/IV stage ovarian cancer]

https://arctichealth.org/en/permalink/ahliterature10804
Source
Klin Khir. 1998;(5):30-1
Publication Type
Article
Date
1998
Author
O I Temchenko
I M Klishch
Source
Klin Khir. 1998;(5):30-1
Date
1998
Language
Ukrainian
Publication Type
Article
Keywords
Antineoplastic Agents - therapeutic use
Antioxidants - metabolism
Combined Modality Therapy
English Abstract
Enterosorption - methods
Female
Humans
Lipid Peroxidation - drug effects
Neoplasm Staging
Ovarian Neoplasms - therapy
Polysorbates - pharmacology - therapeutic use
Surface-Active Agents - pharmacology - therapeutic use
Abstract
In 62 patients with ovarial cancer of III-IV stage under the influence of enterosorption using polysorb the contents of primary and intermediate products of peroxidal oxidation of lipids have reduced and the antioxidant system indexes did not change.
PubMed ID
9787568 View in PubMed
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[Activity of enzymatic antioxidant system in the rat tissues under conditions of over- and restricted nutrition]

https://arctichealth.org/en/permalink/ahliterature97370
Source
Ukr Biokhim Zh. 2009 Nov-Dec;81(6):104-10
Publication Type
Article
Author
Iu V Nikitchenko
V M Dziuba
A S Popovych
V V Bondar
H O Sheremet
Source
Ukr Biokhim Zh. 2009 Nov-Dec;81(6):104-10
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Animals, Newborn
Antioxidants - metabolism
Caloric Restriction
Glutathione Peroxidase - metabolism
Lipid Peroxides - blood - metabolism
Liver - enzymology - metabolism
Male
Overnutrition - blood - enzymology
Oxidation-Reduction
Rats
Rats, Wistar
Thyroid Hormones - blood
Abstract
The state of enzymatic antioxidant system and thyroid status in the rat tissues under early postnatal overnutrition leading to shortening of life-span and calorie-restricted diet extending lifespan have been studied. It was found that the concentration of thyroxine, body weight and content of lipid hydroperoxides in the blood serum and liver post-mitochondrial fraction of rats had been reliably increased. At the same time the concentration of GSH and GSSG, superoxide dismutase, Se-dependent glutathione peroxidase (GP) activities in the liver and GP activity in the blood serum of experimental rats were reduced. The use of calorie-restricted diet for 2 months showed considerable decrease of thyroxine and triiodothyronine concentration, body weight and the content of lipid hydroperoxides in the blood serum of experimental rats compared with control. At the same time GP activity in the liver, Se-dependent GP activity and content of ceruloplasmin in blood of experimental rats were essentially enhanced. The obtained results allow to conclude that from all studied indices the activity of GSH-dependent antioxidant system (especially Se-dependent GP activity) and thyroid status revealed the most sensible changes in response to the used kind of nutrition. Unlike hypocaloric diet overnutrition results in a decrease of Se-dependent GP activity in the liver and blood of rats. That may be the most crucial moment in the maintenance of prooxidant-antioxidant balance of tissues.
PubMed ID
20387664 View in PubMed
Less detail

[Activity of tubular enzymes and lipoperoxidation processes in patients with progressive diabethic nephropathy]

https://arctichealth.org/en/permalink/ahliterature82251
Source
Lik Sprava. 2006 Jan-Sep;(1-2):18-22
Publication Type
Article
Author
Myhal' L Ia
Korol' L V
Dudar I O
Zheltovs'ka N I
Kindii T V
Source
Lik Sprava. 2006 Jan-Sep;(1-2):18-22
Language
Ukrainian
Publication Type
Article
Keywords
Adult
Diabetic Nephropathies - blood - enzymology - urine
Female
Humans
Kidney Function Tests
Kidney Tubules - enzymology - metabolism
Lipid Peroxidation
Lipid Peroxides - blood - urine
Male
Middle Aged
Abstract
The article summarises data on the activity of tubular enzymes having marked organ-specific characteristics related to kidneys. They are N-acetyl-beta-D-glucosaminidase (NAG), its thermostable isoenzyme NAG B and beta-galactosidase localised in lysosomes. L-canavinine, ornithine aminotransferase having mitochondrial localization have also been discussed in the article. The authors have dealt also with the activity of lipoperaxidation processes having been assessed by an ammount of malonic dialdehyde in blood serum, erythrocytes and urine of 51 patients with progressive diabetes mellitus at the late stages of diabetic nephropathy.
PubMed ID
16689087 View in PubMed
Less detail

[Adaptation-compensatory response in adolescents, indigenous people North of Irkutsk region].

https://arctichealth.org/en/permalink/ahliterature257305
Source
Fiziol Cheloveka. 2014 Mar-Apr;40(2):80-6
Publication Type
Article
Author
L I Kolesnikova
M A Darenskaia
L A Grebenkina
E V Osipova
M I Dolgikh
N V Semenova
Source
Fiziol Cheloveka. 2014 Mar-Apr;40(2):80-6
Language
Russian
Publication Type
Article
Keywords
Adaptation, Physiological
Adolescent
Antioxidants - metabolism
Child
Ethnic Groups
Female
Humans
Lipid Peroxidation - physiology
Male
Siberia
Abstract
A study of pro- and antioxidant status in healthy boys and girls adolescents' representatives Tofalars and Evenks compared to Caucasians newcomers. Revealed activation of the adaptive-compensatory processes in the body young men and women, indigenous peoples of the North as compared to Caucasians alien population, which was reflected statistically significant increase in non-enzymatic components of antioxidant defense system.
PubMed ID
25272710 View in PubMed
Less detail

Adaptive changes of membrane lipid composition in humans living in the north.

https://arctichealth.org/en/permalink/ahliterature11886
Source
Arctic Med Res. 1992 Apr;51(2):98-102
Publication Type
Article
Date
Apr-1992
Author
A. Marachev
L. Solovenchuk
A. Lapinski
Author Affiliation
Pulmonological Research Center, Ministry of Health of Russian Republic, Moscow.
Source
Arctic Med Res. 1992 Apr;51(2):98-102
Date
Apr-1992
Language
English
Publication Type
Article
Keywords
Adaptation, Physiological
Adult
Cold Climate
Erythrocyte Membrane - metabolism
Humans
Lipid Peroxidation
Male
Membrane Lipids - metabolism
Middle Aged
Abstract
Some parameters of red cell membrane lipid composition as well as intensiveness of lipid peroxidation and activity of its regulatory factors were assessed in northern aborigines, newcomers and alcohol abusers. It is proposed that the increased lipid peroxidation is responsible for the cholesterol and monoenic fatty acid accumulation in membranes of all groups studied. The data obtained make it possible to consider the lipid peroxidation as a mechanism for adaptive membrane lipid modification in humans.
PubMed ID
1622534 View in PubMed
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[Adaptive reactions of lipid metabolism in native and alien female representatives of Tofalaria population living under extreme environmental conditions].

https://arctichealth.org/en/permalink/ahliterature262349
Source
Zh Evol Biokhim Fiziol. 2014 Sep-Oct;50(5):343-8
Publication Type
Article
Author
L I Kolesnikova
M A Darenskaya
L A Grebenkina
M I Dolgikh
N V Semenova
Source
Zh Evol Biokhim Fiziol. 2014 Sep-Oct;50(5):343-8
Language
Russian
Publication Type
Article
Keywords
Adaptation, Physiological - genetics - physiology
Adolescent
Adult
Case-Control Studies
Cold Climate
Emigrants and Immigrants
Female
Humans
Lipid Metabolism
Lipid Peroxidation
Siberia
Abstract
Peculiarities of the state of lipid metabolism and of processes of lipid peroxidation--the antioxidant protection have been considered in female representatives of the native and alien population of Tofalaria in the age aspects. The obtained data indicate specificity of changes of level of parameters lipid metabolism not only in response to duration of effect of climatic factors, but also depending on belonging to different ethnic groups. Thus, in girls of the natural population of Tofalaria there is noted activation of adaptational-compensatory processes as compared with the alien ones, which is expressed as a significant decrease of atherogenic blood fractions and the general activation of the system of antioxidant protection. However, with age, in both ethnic groups a change of character of reactions of lipid peroxidation and lipid metabolism is noted, which is more expressed in the alien population.
PubMed ID
25786316 View in PubMed
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271 records – page 1 of 28.