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286 records – page 1 of 29.

A 1-year randomized study to evaluate the effects of a dose reduction in oral contraceptives on lipids and carbohydrate metabolism: 20 microg ethinyl estradiol combined with 100 microg levonorgestrel.

https://arctichealth.org/en/permalink/ahliterature176202
Source
Contraception. 2005 Feb;71(2):111-7
Publication Type
Article
Date
Feb-2005
Author
Sven O Skouby
Jan Endrikat
Bernd Düsterberg
Werner Schmidt
Christoph Gerlinger
Jens Wessel
Henri Goldstein
Joergen Jespersen
Author Affiliation
Department of Obstetrics and Gynecology, Frederiksberg Hospital, University of Copenhagen, DK 2000 Copenhagen F, Denmark. sven.skouby@fh.hosp.dk
Source
Contraception. 2005 Feb;71(2):111-7
Date
Feb-2005
Language
English
Publication Type
Article
Keywords
Adult
Blood Glucose - metabolism
C-Peptide - blood
Carbohydrate Metabolism - drug effects
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Contraceptive Agents, Female - administration & dosage - pharmacology
Contraceptives, Oral, Combined - administration & dosage - pharmacology
Denmark
Dose-Response Relationship, Drug
Ethinyl Estradiol - administration & dosage - pharmacology
Fatty Acids, Nonesterified - blood
Female
Humans
Insulin - blood
Levonorgestrel - administration & dosage - pharmacology
Lipid Metabolism - drug effects
Prospective Studies
Time Factors
Treatment Outcome
Triglycerides - blood
Abstract
To evaluate the impact on lipid and carbohydrate variables of a combined one-third ethinyl estradiol (EE)/levonorgestrel (LNG) dose reduction in oral contraceptives.
In an open-label, randomized study, a dose-reduced oral contraceptive containing 20 microg EE and 100 microg LNG (20 EE/100 LNG) was compared with a reference preparation containing 30 microg EE and 150 microg LNG (30 EE/150 LNG). One-year data from 48 volunteers were obtained.
We found a decrease of HDL2 cholesterol and increases of low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol and total triglycerides in both treatment groups from baseline to the 13th treatment cycle. Although for four of six variables, the changes in the 20 EE group were lower compared with the 30 EE group, none of the differences between the two treatments were statistically significant. The median values for the fasting levels of insulin, C-peptide and free fatty acids slightly increased or remained unchanged while the fasting glucose levels slightly decreased after 13 treatment cycles. While the glucose area under the curve (AUC) (0-3 h) was similar in both groups during the OGTT, the insulin AUC(0-3 h) was less increased in the 20 EE/100 LNG group compared with the 30 EE/150 LNG group. None of the differences between the treatment groups for any of the carbohydrate metabolism variables were statistically significant at any time point. Both study treatments were safe and well tolerated by the volunteers.
Similar effects on the lipid and carbohydrate profiles were found for both preparations. The balanced one-third EE dose reduction in this new oral contraceptive caused slightly lower, but insignificant, changes in the lipid and carbohydrate variables compared with the reference treatment.
PubMed ID
15707560 View in PubMed
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Aberrations in plasma phospholipid fatty acids in lung cancer patients.

https://arctichealth.org/en/permalink/ahliterature128904
Source
Lipids. 2012 Apr;47(4):363-9
Publication Type
Article
Date
Apr-2012
Author
Rachel A Murphy
Taylor F Bureyko
Marina Mourtzakis
Quincy S Chu
M Thomas Clandinin
Tony Reiman
Vera C Mazurak
Author Affiliation
Department of Agricultural, Food and Nutritional Science, University of Alberta, 4-126A Li Ka Shing Centre, Edmonton, AB T6G 2E1, Canada.
Source
Lipids. 2012 Apr;47(4):363-9
Date
Apr-2012
Language
English
Publication Type
Article
Keywords
Adenocarcinoma - drug therapy - metabolism - mortality
Aged
Antineoplastic Agents - administration & dosage - therapeutic use
Body mass index
Canada
Fatty Acids - analysis
Female
Humans
Lipid Metabolism - drug effects
Longitudinal Studies
Lung Neoplasms - drug therapy - metabolism - mortality
Male
Middle Aged
Neoplasm Staging
Phospholipids - analysis
Survival Rate
Weight Loss
Abstract
Abnormalities in lipid metabolism have been frequently observed in cancer and are associated with a poor prognosis. However, a detailed, longitudinal characterization of fatty acid status is lacking. This study aimed to assess plasma phospholipid fatty acids before chemotherapy, immediately after and 1 month following chemotherapy in a group of 50 patients newly diagnosed with lung cancer and explore factors which may contribute to aberrations in fatty acids. Their mean ± SD characteristics: age 64 ± 8.5 years, 75% advanced stage disease, body mass index 27.0 ± 5.4 kg/m², 6 month weight loss -4.6 ± 6.1%. Compared to patients with early stage disease, patients with advanced disease had abnormal fatty acid profiles including significantly lower (P
PubMed ID
22160451 View in PubMed
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[A cross-sectional study of lipid metabolism in postmenopausal women]

https://arctichealth.org/en/permalink/ahliterature93656
Source
Kardiologiia. 2007;47(6):37-40
Publication Type
Article
Date
2007
Author
Izmozherova N V
Popov A A
Andreev A N
Source
Kardiologiia. 2007;47(6):37-40
Date
2007
Language
Russian
Publication Type
Article
Keywords
Adult
Cross-Sectional Studies
Dyslipidemias - blood - epidemiology
Female
Humans
Lipid Metabolism - physiology
Lipids - blood
Middle Aged
Postmenopause - blood
Prevalence
Risk factors
Siberia - epidemiology
Urban Population
Abstract
AIM: To assess frequency of atherogenic dyslipidemia in postmenopausal residents of Ekateringurg. METHODS: Cross-sectional study included 1100 female patients of outpatient menopausal clinic. All were residents of Ekaterinburg aged from 28 to 64 years. The participants of the study were divided into 3 groups; the 1st group consisted of women younger than 45 years, the 2nd group included persons aged between 45 and 54 years, in the 3rd group comprized patients aged from 55 to 64 years. RESULTS: Normal lipid metabolism parameters were found in 18% of women. Most frequent dyslipidemias were 2A (44%) and 2B (26%) types. Frequencies of stable angina on exertion, transitory cerebral ischemic attacks, and myocardial infarction increased after the age of 45 years. CONCLUSION: More than 80% of symptomatic postmenopausal women had atherogenic dyslipidemias. The percentage of postmenopausal women who had indication for lipid lowering therapy was high.
PubMed ID
18260873 View in PubMed
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[Activation of reparative processes by phospholipid preparation in the affected organs and tissues in neonathal enteropathology of calves]

https://arctichealth.org/en/permalink/ahliterature83018
Source
Ukr Biokhim Zh. 2004 Nov-Dec;76(6):111-6
Publication Type
Article
Author
Hryshchenko V A
Source
Ukr Biokhim Zh. 2004 Nov-Dec;76(6):111-6
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Animals, Newborn
Cattle
Cattle Diseases - blood - drug therapy
Dyspepsia - blood - drug therapy - veterinary
Lipid Metabolism - drug effects
Phospholipids - chemistry - therapeutic use
Treatment Outcome
Abstract
The peculiarities of dynamics of quantitative changes of some classes of lipid and phospholipid spectra of blood plasma of calves recovered after dyspepsia were studied. Obtained reliable changes of the blood plasma lipidogrammas testify to development of dyslipidemia. It is characterized by hypercholesterolemia and hypertriacylglycerolemia of recovered 30 days old calves 3 weeks after diseases symptoms past. These changes give evidence concerning deficiency of phosphatides choline fraction - main structural components of cell membranes. It was established that changes of lipid and phospholipid spectra of blood plasma caused by enteropathology can be corrected by the inclusion of reparative therapy preparations to dyspepsia treatment plan in particular--experimental phospholipid containing a drug, which is prepared on the basis of milk phospholipids--its natural source for newborn calves.
PubMed ID
16350753 View in PubMed
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[Activity of the hemostasis and some indications of lipid metabolism in children with diabetes]

https://arctichealth.org/en/permalink/ahliterature44598
Source
Pediatr Akus Ginekol. 1968;6:15-6
Publication Type
Article
Date
1968

Adaptive changes of membrane lipid composition in humans living in the north.

https://arctichealth.org/en/permalink/ahliterature11886
Source
Arctic Med Res. 1992 Apr;51(2):98-102
Publication Type
Article
Date
Apr-1992
Author
A. Marachev
L. Solovenchuk
A. Lapinski
Author Affiliation
Pulmonological Research Center, Ministry of Health of Russian Republic, Moscow.
Source
Arctic Med Res. 1992 Apr;51(2):98-102
Date
Apr-1992
Language
English
Publication Type
Article
Keywords
Adaptation, Physiological
Adult
Cold Climate
Erythrocyte Membrane - metabolism
Humans
Lipid Peroxidation
Male
Membrane Lipids - metabolism
Middle Aged
Abstract
Some parameters of red cell membrane lipid composition as well as intensiveness of lipid peroxidation and activity of its regulatory factors were assessed in northern aborigines, newcomers and alcohol abusers. It is proposed that the increased lipid peroxidation is responsible for the cholesterol and monoenic fatty acid accumulation in membranes of all groups studied. The data obtained make it possible to consider the lipid peroxidation as a mechanism for adaptive membrane lipid modification in humans.
PubMed ID
1622534 View in PubMed
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[Adaptive reactions of lipid metabolism in native and alien female representatives of Tofalaria population living under extreme environmental conditions].

https://arctichealth.org/en/permalink/ahliterature262349
Source
Zh Evol Biokhim Fiziol. 2014 Sep-Oct;50(5):343-8
Publication Type
Article
Author
L I Kolesnikova
M A Darenskaya
L A Grebenkina
M I Dolgikh
N V Semenova
Source
Zh Evol Biokhim Fiziol. 2014 Sep-Oct;50(5):343-8
Language
Russian
Publication Type
Article
Keywords
Adaptation, Physiological - genetics - physiology
Adolescent
Adult
Case-Control Studies
Cold Climate
Emigrants and Immigrants
Female
Humans
Lipid Metabolism
Lipid Peroxidation
Siberia
Abstract
Peculiarities of the state of lipid metabolism and of processes of lipid peroxidation--the antioxidant protection have been considered in female representatives of the native and alien population of Tofalaria in the age aspects. The obtained data indicate specificity of changes of level of parameters lipid metabolism not only in response to duration of effect of climatic factors, but also depending on belonging to different ethnic groups. Thus, in girls of the natural population of Tofalaria there is noted activation of adaptational-compensatory processes as compared with the alien ones, which is expressed as a significant decrease of atherogenic blood fractions and the general activation of the system of antioxidant protection. However, with age, in both ethnic groups a change of character of reactions of lipid peroxidation and lipid metabolism is noted, which is more expressed in the alien population.
PubMed ID
25786316 View in PubMed
Less detail

[Age-dependent characteristics of signaling lipids in the liver and brain of rats]

https://arctichealth.org/en/permalink/ahliterature78590
Source
Fiziol Zh. 2006;52(6):79-84
Publication Type
Article
Date
2006
Author
Khassunekh L X M
Semenova Ia O
Krasyl'nykova O A
Babenko N O
Source
Fiziol Zh. 2006;52(6):79-84
Date
2006
Language
Ukrainian
Publication Type
Article
Keywords
Aging - metabolism
Animals
Ceramides - metabolism
Diglycerides - metabolism
Fatty Acids, Nonesterified - metabolism
Hippocampus - metabolism
Lipid Metabolism - physiology
Liver - metabolism
Male
Neocortex - metabolism
Phosphatidylserines - metabolism
Rats
Rats, Wistar
Signal Transduction
Sphingomyelins - metabolism
Abstract
The effect of age on signaling lipids contents in rat liver and different brain regions (hippocampus, neocortex) were studied. The contents of free fatty acids in the brain, diacylglycerol in liver and ceramide in all tissues studied have been found to increase with age. Age-dependent accumulation of neutral and sphingolipids evokes the violation of cell sensitivity to extracellular signals.
PubMed ID
17333627 View in PubMed
Less detail

Age-dependent metabolic effects of second-generation antipsychotics in second-generation antipsychotic-naïve French Canadian patients.

https://arctichealth.org/en/permalink/ahliterature138355
Source
J Child Adolesc Psychopharmacol. 2010 Dec;20(6):479-87
Publication Type
Article
Date
Dec-2010
Author
Geneviève Roy
Alain Bedard
Paul-André Desmarais
France Jourdain
Sylvie Allen
Danielle Michaud
Leila Ben Amor
Author Affiliation
CHAU Hotel Dieu de Levis, Department of Psychiatry, Laval University, Levis, Quebec, Canada.
Source
J Child Adolesc Psychopharmacol. 2010 Dec;20(6):479-87
Date
Dec-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Antipsychotic Agents - adverse effects - therapeutic use
Blood Glucose - drug effects
Body mass index
Canada
Child
Child, Preschool
Female
Follow-Up Studies
Humans
Lipid Metabolism - drug effects
Lipids - blood
Male
Metabolic Diseases - chemically induced - epidemiology
Middle Aged
Retrospective Studies
Time Factors
Weight Gain - drug effects
Young Adult
Abstract
Patients receiving second-generation antipsychotics (SGAs) may experience secondary metabolic effects such as weight gain, as well as changes in lipid and glucose metabolism. These effects are well documented in adults; however, fewer studies are available concerning their occurrence and their evolution in children and adolescents.
The aim of this study was to determine if there is an age-dependent variation in the metabolic effects of SGAs in a drug-naïve population.
Charts of 232 French Canadian patients participating in a program monitoring the metabolic effects of SGAs were retrospectively reviewed. A total of 85 SGA-naïve patients were selected, including 58 youths and 27 adults. Changes, relative to baseline, in weight, body mass index, lipid metabolism (total cholesterol, low-density lipoprotein, high-density lipoprotein, and triglyceride), and fasting blood glucose were assessed, with follow-up at 3, 6, 12, and 24 months.
With respect to weight gain, in both the youth and adult groups, body mass index significantly increased from baseline at 3 months (10.1% [p?
PubMed ID
21186966 View in PubMed
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[Age-related aspects of the extent of lipid metabolism and post-traumatic stress disorders among veterans of modern warfare].

https://arctichealth.org/en/permalink/ahliterature117757
Source
Adv Gerontol. 2013;26(3):525-32
Publication Type
Article
Date
2013
Author
M N Torgashov
V S Miakotnykh
A I Pal'tsev
Source
Adv Gerontol. 2013;26(3):525-32
Date
2013
Language
Russian
Publication Type
Article
Keywords
Adult
Afghan Campaign 2001-
Aged
Aging - blood
Follow-Up Studies
Humans
Incidence
Lipid Metabolism - physiology
Lipid Metabolism Disorders - blood - epidemiology - etiology
Lipids - blood
Male
Middle Aged
Military Personnel
Russia - epidemiology
Stress Disorders, Post-Traumatic - blood - complications
Veterans
Abstract
The peculiarities of violations of lipid metabolism and symptoms of post-traumatic stress disorder (PTSD) in 161 patients of 25-69 years, veterans of the military actions on the territory of Afghanistan and the Northern Caucasus were investigated. The dependence of the formation of dyslipidemia and related changes of atherosclerosis in the young age on neuroendocrine effects, accompanying the effects of combat stress and promoting accelerated aging was determined. On the other hand, with the time, after 15-25 years after participating in hostilities, the intensity of PTSD and its influence on the development of violations of lipid spectrum may decline. The leading role in the pathogenesis of dyslipidemia goes to age-related changes, accompanying a process of accelerated aging of veterans of combat operations, and to pathological disorders of metabolism in liver associated with alcohol abuse and the consequences of infectious diseases.
PubMed ID
24640705 View in PubMed
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286 records – page 1 of 29.