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Activity of lysosomal apparatus in rat myocardium during experimental coronary and noncoronary myocardial damage.

https://arctichealth.org/en/permalink/ahliterature10354
Source
Bull Exp Biol Med. 2000 Jun;129(6):530-2
Publication Type
Article
Date
Jun-2000
Author
S D Mayanskaya
N N Mayanskaya
A V Efremov
G S Yakobson
Author Affiliation
Novosibirsk State Medical Academy, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Source
Bull Exp Biol Med. 2000 Jun;129(6):530-2
Date
Jun-2000
Language
English
Publication Type
Article
Keywords
Acid Phosphatase - blood
Animals
Cathepsin D - blood
Comparative Study
Coronary Vessels - surgery
Deoxyribonucleases - blood
Hydrolases - blood
Ligation
Lysosomes - enzymology
Male
Myocardial Infarction - chemically induced - enzymology - pathology
Myocardium - enzymology - pathology
Norepinephrine - pharmacology
Rats
Rats, Wistar
Vasoconstrictor Agents - pharmacology
beta-Galactosidase - blood
Abstract
Cardiac and plasma activities of marker lysosomal enzymes were studied in Wistar rats with metabolic (epinephrine) and occlusion (ligation of coronary arteries) myocardial infarction. Activity of all examined lysosomal enzymes significantly increased in the myocardium and blood plasma starting from the first day after ligation of the coronary arteries and was accompanied by leukocytic infiltration of the myocardium. Enzyme activity gradually decreased to postoperation day 14. In metabolic infarction leukocytic infiltration and specific activity of lysosomal enzymes rose gradually and attained maximum to postoperation day 14, while the signs of labilization of lysosomal membranes appeared from the first postoperation day. Plasma activity of lysosomal enzymes in metabolic infarction increased smoothly and peaked on day 14.
PubMed ID
11022240 View in PubMed
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Arterial ligation in anterior resection for rectal cancer: A validation study of the Swedish Colorectal Cancer Registry.

https://arctichealth.org/en/permalink/ahliterature267277
Source
Acta Oncol. 2014 Jul;53(7):892-7
Publication Type
Article
Date
Jul-2014
Author
Petrus Boström
Jörgen Rutegård
Markku Haapamäki
Peter Matthiessen
Martin Rutegård
Source
Acta Oncol. 2014 Jul;53(7):892-7
Date
Jul-2014
Language
English
Publication Type
Article
Keywords
Aged
Arteries - surgery
Cohort Studies
Female
Humans
Ligation
Male
Rectal Neoplasms - pathology - surgery
Sweden - epidemiology
Abstract
The level of arterial ligation has been a variable of the Swedish Colorectal Cancer Registry since 2007. The aim of this study is to evaluate the accuracy of this registry variable in relation to anterior resection for rectal cancer.
The operative charts of all cardiovascularly compromised patients who underwent anterior resection during the period 2007-2010 in Sweden were retrieved and compared to the registry. We selected the study population to reflect the common assumption that these patients would be more sensitive to a compromised visceral blood flow. Levels of vascular ligation were defined, both oncologically and functionally, and their sensitivity, specificity, positive and negative predictive values, level of agreement and Cohen's kappa were calculated.
Some 744 (94.5%) patients were eligible for analysis. Functional high tie level showed a sensitivity of 80.2% and a specificity of 90.1%. Positive and negative predictive values were 87.7 and 83.8%, respectively. Level of agreement was 85.5% and Cohen's kappa 0.70. The corresponding calculations for oncologic tie level yielded similar results.
The suboptimal validity of the Swedish Colorectal Cancer Registry regarding the level of vascular ligation might be problematic. For analyses with rare positive outcomes, such bowel ischaemia, or with minor expected differences in outcomes, it would be beneficial to collect data directly from the operative charts of the medical records in order to increase the chance of identifying clinically relevant differences.
PubMed ID
24954367 View in PubMed
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Cervical incompetence and cerclage in Denmark 1980-1990. A register based epidemiological survey.

https://arctichealth.org/en/permalink/ahliterature64753
Source
Acta Obstet Gynecol Scand. 1994 Jan;73(1):35-8
Publication Type
Article
Date
Jan-1994
Author
O. Lidegaard
Author Affiliation
Department of Obstetrics and Gynecology, Hvidovre Hospital, University of Copenhagen, Denmark.
Source
Acta Obstet Gynecol Scand. 1994 Jan;73(1):35-8
Date
Jan-1994
Language
English
Publication Type
Article
Keywords
Abortion, Spontaneous - epidemiology
Adult
Age Factors
Cross-Sectional Studies
Denmark - epidemiology
Epidemiologic Methods
Female
Humans
Ligation
Pregnancy
Registries
Retrospective Studies
Uterine Cervical Incompetence - epidemiology - therapy
Abstract
OBJECTIVE. To assess the incidence rate of cervical incompetence diagnoses in Denmark 1980-1990 according to maternal age, to analyse regional variations, to investigate how often cerclage is applied, and finally to estimate abortion rates among women with cervical incompetence with and without cerclage. DESIGN. A register-based retrospective cross section study. SETTING. All Danish gynecological departments. MATERIAL AND METHODS. Since 1977, all hospitalized patients in Denmark have been centrally recorded by diagnosis according to the ICD classification and by operation codes in The National Patient Register. From this database, all women with cervical incompetence (CI) and cerclage in the period 1980-1990 were identified. From the same database all cases of spontaneous abortions were registered. RESULTS. A total of 2756 cases of cervical incompetence were registered in the period 1980-1990, corresponding to an incidence rate of 4.6/1000 births. The risk of cervical incompetence increased from 2/1000 births among women 15-19 years old to 7.5/1000 births among women 35-39 years old. The incidence rate of the CI-diagnosis fell 44% from 1980 to 1990. The incidence rates in different counties ranged from 1.7/1000 births to 10.0/1000 births. The average length of stay in hospital among patients with cervical incompetence was three weeks. Among patients with cervical incompetence, 61% were treated with cerclage. This per cent increased from 29% among women 15-19 years old to 68% among women 35-39 years old. 13.5% of women with CI experienced spontaneous abortion. This percentage increased from 12% for women 15-19 years old to 17% among women 40-44 years old (p
PubMed ID
8304022 View in PubMed
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[Cervical insufficiency and cerclage in Denmark 1980-1990. A registry-based epidemiological study]

https://arctichealth.org/en/permalink/ahliterature64660
Source
Ugeskr Laeger. 1994 Nov 28;156(48):7200-2
Publication Type
Article
Date
Nov-28-1994
Author
O. Lidegaard
Author Affiliation
Gynaekologisk-obstetrisk afdeling, Hvidovre Hospital, København.
Source
Ugeskr Laeger. 1994 Nov 28;156(48):7200-2
Date
Nov-28-1994
Language
Danish
Publication Type
Article
Keywords
Adolescent
Adult
Cervix Uteri - surgery
Cross-Sectional Studies
Denmark - epidemiology
English Abstract
Female
Humans
Incidence
Ligation
Pregnancy
Registries
Retrospective Studies
Uterine Cervical Incompetence - diagnosis - epidemiology - surgery
Abstract
The objective of this analysis was to assess the incidence rate of cervical incompetence diagnoses in Denmark 1980-1990 according to maternal age, to analyze regional variations, to investigate how often cervical cerclage is applied, and finally to estimate abortion rates among women with cervical incompetence with and without cervical cerclage. The design was a register-based retrospective cross sectional study, including all Danish gynaecological departments. Since 1977, all hospitalized patients in Denmark have been centrally recorded by diagnosis according to the ICD classification and by operation codes in The National Patient Register. From this database, all women with cervical incompetence (CI) and cerclage in the period 1980-1990 were identified. From the same database all cases of spontaneous abortions were registered. A total of 2756 cases of cervical incompetence were registered in the period 1980-1990, corresponding to an incidence rate of 4.6/1000 births. The risk of cervical incompetence increased from 2/1000 births among women 15-19 years old to 7.5/1000 births among women 35-39 years old. The incidence rate of the CI-diagnosis fell by 44% from 1980 to 1990. The incidence rates in different counties ranged from 1.7/1000 births to 10.0/1000 births. The average length of stay in hospital among patients with cervical incompetence was three weeks. Among patients with cervical incompetence, 61% were treated with cervical cerclage. This percentage increased from 29% among women 15-19 years old to 68% among women 35-39 years old. 13.5% of women with CI experienced spontaneous abortion.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
7817428 View in PubMed
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Characteristics and period prevalence of self-induced disorder in patients referred to a pain clinic with the diagnosis of complex regional pain syndrome.

https://arctichealth.org/en/permalink/ahliterature159242
Source
Clin J Pain. 2008 Feb;24(2):176-85
Publication Type
Article
Date
Feb-2008
Author
Angela Mailis-Gagnon
Keith Nicholson
Daniel Blumberger
Mateusz Zurowski
Author Affiliation
Comprehensive Pain Program, Toronto Western Hospital, Toronto, Ontario, Canada. angela.mailis@uhn.on.ca
Source
Clin J Pain. 2008 Feb;24(2):176-85
Date
Feb-2008
Language
English
Publication Type
Article
Keywords
Adult
Comorbidity
Complex Regional Pain Syndromes - diagnosis - epidemiology - psychology
Diagnosis, Differential
Diagnostic Errors - prevention & control
Factitious Disorders - diagnosis - epidemiology - psychology
Female
Humans
Interpersonal Relations
Ligation - adverse effects
Male
Malingering - diagnosis - epidemiology - psychology
Ontario - epidemiology
Pain Measurement
Prevalence
Psychology
Retrospective Studies
Self-Injurious Behavior - diagnosis - epidemiology - psychology
Somatoform Disorders - diagnosis - epidemiology - psychology
Wounds and Injuries - epidemiology - psychology
Abstract
Although there have been a few case reports in the literature of self-inflicted symptoms presenting as complex regional pain syndrome (CRPS), there has been no systematic study. This report investigates the period prevalence and characteristics of self-induced disorders in patients referred to a comprehensive pain clinic with a diagnosis of CRPS.
Retrospective chart review was conducted for all cases referred as "neuropathic pain" to a comprehensive pain clinic over a period of 2 years.
Out of 175 consecutive neuropathic pain referrals over a 2-year period, 41 were specifically referred as CRPS. Application of (modified) 1994 IASP CRPS criteria confirmed the diagnosis of CRPS in 11/15 men and in 15/26 women. Four of the 15 women had evidence of active self-induced signs and symptoms (eg, ligation of the limb, ulcerations, bizarre migrating wounds), which abated with casting, strict observation, discussion with the patient, or other intervention. The characteristics of these cases are presented and compared with other similar cases seen in previous years.
This is the first report of a case series of patients diagnosed as CRPS with self-induced symptoms. We discuss in detail limitations of the study, factors that contribute to the index of suspicion, and the complex nature of the behavior including the overlap between factitious disorder, somatoform disorders, and malingering, whereas we stress the legitimacy of CRPS as a diagnosis.
PubMed ID
18209524 View in PubMed
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Compression therapy versus surgery in the treatment of patients with varicose veins: A RCT.

https://arctichealth.org/en/permalink/ahliterature104609
Source
Eur J Vasc Endovasc Surg. 2014 Jun;47(6):670-7
Publication Type
Article
Date
Jun-2014
Author
H. Sell
P. Vikatmaa
A. Albäck
M. Lepäntalo
A. Malmivaara
O. Mahmoud
M. Venermo
Author Affiliation
Department of Vascular Surgery, Helsinki University Hospital and Institute of Clinical Medicine, Faculty of Medicine, University of Helsinki, Finland.
Source
Eur J Vasc Endovasc Surg. 2014 Jun;47(6):670-7
Date
Jun-2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Disability Evaluation
Female
Finland
Humans
Intention to Treat Analysis
Ligation
Male
Middle Aged
Pressure
Quality of Life
Questionnaires
Saphenous Vein - surgery - ultrasonography
Severity of Illness Index
Stockings, Compression
Time Factors
Treatment Outcome
Ultrasonography, Doppler, Duplex
Varicose Veins - diagnosis - surgery - therapy
Vascular Surgical Procedures
Abstract
Superficial venous reflux and varicose veins are common. The aim of this randomized controlled trial was to assess effectiveness of compression therapy compared with surgery for superficial venous reflux.
153 patients with CEAP class C2-C3 and superficial venous reflux were randomized to receive either conservative treatment (compression stockings) (n = 77) or surgery (n = 76). Clinical examination including duplex ultrasound (DUS) was performed at entry and 1 and 2 years after randomization (compression group) or surgery (surgery group). Venous Clinical Severity Score without compression stockings (VCSS-S), Venous Segmental Disease Score (VSDS), Venous Disability Score (VDS), and health-related quality of life (HRQoL) were assessed at entry and at the follow-ups. Data were analysed on an intention-to-treat basis and according to the actual treatment performed.
At 2 years, 70/76 patients in the surgery group and 11/77 patients in the compression group had been operated on. VCSS-S decreased from 4.6 to 3.5 in the compression group (p
Notes
Comment In: Eur J Vasc Endovasc Surg. 2014 Jun;47(6):67824703009
PubMed ID
24675145 View in PubMed
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Coronary artery perfusion and myocardial performance after patent ductus arteriosus ligation.

https://arctichealth.org/en/permalink/ahliterature128961
Source
J Thorac Cardiovasc Surg. 2012 Jun;143(6):1271-8
Publication Type
Article
Date
Jun-2012
Author
Arvind Sehgal
Patrick J McNamara
Author Affiliation
Monash Newborn, Monash Medical Centre, Victoria, Australia; Monash University, Victoria, Australia.
Source
J Thorac Cardiovasc Surg. 2012 Jun;143(6):1271-8
Date
Jun-2012
Language
English
Publication Type
Article
Keywords
Analysis of Variance
Blood pressure
Cardiac Surgical Procedures - adverse effects
Cardiotonic Agents - therapeutic use
Chi-Square Distribution
Coronary Circulation
Ductus Arteriosus, Patent - physiopathology - surgery - ultrasonography
Echocardiography, Doppler
Gestational Age
Humans
Hypotension - drug therapy - etiology - physiopathology
Infant
Infant, Newborn
Infant, Premature
Ligation
Linear Models
Myocardial Contraction - drug effects
Ontario
Predictive value of tests
Prospective Studies
Risk assessment
Risk factors
Time Factors
Treatment Outcome
Ventricular Function, Left - drug effects
Abstract
To study coronary artery (CA) perfusion and myocardial performance after patent ductus arteriosus (PDA) ligation. The postoperative course in premature infants undergoing surgical ligation of PDA is often complicated by cardiorespiratory instability secondary to impaired left ventricular performance.
Serial echocardiography was performed before and after (1, 8, and 24 hours) PDA ligation to assess systolic (left ventricular output [LVO]) and diastolic (isovolumic relaxation time, E and A wave peak velocity) myocardial performance, and CA diastolic flow (CA velocity time integral and flow). The ratio of CA flow to LVO was calculated as a surrogate of coronary flow.
A total of 20 infants (gestational age at birth, 26.3 ± 0.7 weeks) requiring PDA ligation at a median of 28.5 days (range, 9-40) after birth and weight of 780 g (range, 570-2840) were studied. A postoperative increase in the CA flow/LVO ratio was demonstrated. An early decrease in E and A wave peak velocity (P
PubMed ID
22153859 View in PubMed
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Decreased renal perfusion after correction of experimental coarctation.

https://arctichealth.org/en/permalink/ahliterature55556
Source
Pediatr Res. 1987 Oct;22(4):445-8
Publication Type
Article
Date
Oct-1987
Author
M. Tarkka
M. Uhari
J. Heikkilä
A. Pakarinen
Author Affiliation
Department of Surgery, University of Oulu, Finland.
Source
Pediatr Res. 1987 Oct;22(4):445-8
Date
Oct-1987
Language
English
Publication Type
Article
Keywords
Animals
Aorta, Thoracic - surgery
Aortic Coarctation - physiopathology - surgery
Disease Models, Animal
Dogs
Follow-Up Studies
Glomerular Filtration Rate
Hypertension - etiology
Ligation
Renal Circulation
Renin - blood
Reoperation - adverse effects
Research Support, Non-U.S. Gov't
Surgical Flaps
Abstract
Hemodynamical changes in coarctation were studied with an experimental model. Coarctation of the thoracic aorta was induced in seven puppies at the age of 8 wk. After a 7-month follow-up period a corrective operation with a venous patch was performed. Two dogs were lost a few hours after the correction operation. The remaining five dogs were followed for 12 months postoperatively. Renal perfusion was measured with a 133Xenon washout method just prior to the operation, 1 h, 6 and 12 months postoperatively. The glomerular filtration rate was measured using the 51Cr-EDTA method 1 wk before the operation, 3 wk, 2, 6, and 12 months after it. Six healthy adult dogs were used as controls for glomerular filtration rate measurements. Peripheral renin activity was measured at operation, just before the correction of aortic coarctation, 1/2, 1 h, 1, 3, 7 days, 2 and 6 months after the correction operation. Renal perfusion decreased significantly (p less than 0.05) immediately after the correction operation and rose again during the follow-up. Peripheral renin activity rose significantly (p less than 0.01) from the preoperative values and was at its greatest 1 day after the operation. Later on, peripheral renin activity values returned to normal. Coarctated dogs had significantly (p less than 0.01) lower glomerular filtration rate values than controls in each measurement except at the 2 months postoperative measurement. These results support decreased renal perfusion with resultant increased peripheral renin activity as part of the pathomechanism of the paradoxical hypertension observed after correction of coarctation.
PubMed ID
3317256 View in PubMed
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The effect of aminophylline on right heart function in young pigs after ligation of the right coronary artery.

https://arctichealth.org/en/permalink/ahliterature54098
Source
Pharmacol Toxicol. 2000 Apr;86(4):192-6
Publication Type
Article
Date
Apr-2000
Author
M B Spalding
T I Ala-Kokko
K. Kiviluoma
H. Ruskoaho
S. Alahuhta
Author Affiliation
Department of Anaesthesiology, University Hospital of Oulu, Finland. spami@sun3.oulu.fi
Source
Pharmacol Toxicol. 2000 Apr;86(4):192-6
Date
Apr-2000
Language
English
Publication Type
Article
Keywords
Aminophylline - pharmacology
Animals
Blood Pressure - drug effects
Cardiotonic Agents - pharmacology
Coronary Vessels - drug effects - physiopathology - surgery
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Heart - drug effects - physiopathology
Heart Rate - drug effects
Heart Ventricles - drug effects - pathology - physiopathology
Hemodynamic Processes - drug effects
Ligation - adverse effects
Male
Myocardial Infarction - etiology - pathology - physiopathology
Stroke Volume - drug effects
Swine
Vascular Resistance - drug effects
Abstract
An experimental model of right heart failure was developed to determine the effects of fluid loading and aminophylline on right heart function. We hypothesised that aminophylline would specifically improve right heart function through a decrease in pulmonary vascular resistance and, possibly, an increase in cardiac contractility. Right heart infarct was induced in ten experimental pigs and seven control pigs by ligating branches of the right coronary artery. The effect of fluid loading with a colloid solution and subsequent bolus doses of aminophylline on haemodynamics was observed. Fluid loading improved haemodynamics as expected. Aminophylline transiently improved cardiac index and pulmonary vascular resistance, but simultaneously caused an increase in heart rate and a decrease in stroke volume. Although aminophylline may reduce right heart afterload, it did not improve overall cardiac function in this experimental model of right heart infarction.
PubMed ID
10815753 View in PubMed
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47 records – page 1 of 5.