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1,3-Butadiene and leukemia among synthetic rubber industry workers: exposure-response relationships.

https://arctichealth.org/en/permalink/ahliterature166384
Source
Chem Biol Interact. 2007 Mar 20;166(1-3):15-24
Publication Type
Article
Date
Mar-20-2007
Author
Hong Cheng
Nalini Sathiakumar
John Graff
Robert Matthews
Elizabeth Delzell
Author Affiliation
University of Alabama at Birmingham, Ryals School of Public Health, Department of Epidemiology, Birmingham, AL, USA. hcheng@ms.soph.uab.edu
Source
Chem Biol Interact. 2007 Mar 20;166(1-3):15-24
Date
Mar-20-2007
Language
English
Publication Type
Article
Keywords
Butadienes - adverse effects
Canada - epidemiology
Carcinogens - chemical synthesis - chemistry - toxicity
Chemical Industry - manpower - statistics & numerical data
Confidence Intervals
Dimethyldithiocarbamate - adverse effects
Humans
Leukemia, Lymphoid - chemically induced - epidemiology
Leukemia, Myeloid - chemically induced - epidemiology
Likelihood Functions
Male
Middle Aged
Occupational Exposure - statistics & numerical data
Proportional Hazards Models
Rubber - adverse effects - chemical synthesis - chemistry
United States - epidemiology
Abstract
Previous research updated the mortality experience of North American synthetic rubber industry workers during the period 1944-1998, determined if leukemia and other cancers were associated with several employment factors and carried out Poisson regression analysis to examine exposure-response associations between estimated exposure to 1,3-butadiene (BD) or other chemicals and cancer. The present study used Cox regression procedures to examine further the exposure-response relationship between several unlagged and lagged, continuous, time-dependent BD exposure indices (BD parts per million (ppm)-years, the total number of exposures to BD concentrations >100 ppm ("peaks") and average intensity of BD) and leukemia, lymphoid neoplasms and myeloid neoplasms. All three BD exposure indices were associated positively with leukemia. Using continuous, untransformed BD ppm-years the regression coefficient (beta) from an analysis that controlled only for age was 2.9 x 10(-4) (p
PubMed ID
17123495 View in PubMed
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Acute myeloid leukemia and clonal chromosome aberrations in relation to past exposure to organic solvents.

https://arctichealth.org/en/permalink/ahliterature20007
Source
Scand J Work Environ Health. 2000 Dec;26(6):482-91
Publication Type
Article
Date
Dec-2000
Author
M. Albin
J. Björk
H. Welinder
H. Tinnerberg
N. Mauritzson
B. Johansson
R. Billström
U. Strömberg
Z. Mikoczy
T. Ahlgren
P G Nilsson
F. Mitelman
L. Hagmar
Author Affiliation
Department of Occupational and Environmental Medicine, Lund University Hospital, Sweden. maria.albin@ymed.lu.se
Source
Scand J Work Environ Health. 2000 Dec;26(6):482-91
Date
Dec-2000
Language
English
Publication Type
Article
Keywords
Acute Disease
Chromosome Aberrations
Environmental Exposure
Humans
Leukemia, Myeloid - chemically induced - epidemiology - genetics
Occupational Exposure
Organic Chemicals - adverse effects
Research Support, Non-U.S. Gov't
Solvents - adverse effects
Sweden - epidemiology
Abstract
OBJECTIVES: The effects of occupational and leisure-time exposures on the risk of acute myeloid leukemia (AML) were investigated with emphasis on clonal chromosome aberrations (CCA) and morphological subtypes. METHODS: Consecutively diagnosed cases of AML (N=333) and 1 population referent per case were retrospectively included in the study. Information on worktasks, companies, and leisure-time activities was obtained with telephone interviews. Exposure probability and intensity were assessed by occupational hygienists. Associations were evaluated with logistic regression. RESULTS: Exposure to organic solvents was associated with an increased risk of AML [low exposure: OR 1.5 (95% confidence interval (95% CI) 1.0-2.3, moderate-high exposure: OR 2.3 (95% CI 1.0-5.0)]. For exposure to solvents, but not to benzene, the OR was 1.2 (95% CI 0.69-2.0) for "low" and 2.7 (95% CI 1.0-7.3) for "moderate-high" exposure. The observed effects increased with intensity and duration of exposure. The estimated effects were higher for patients >60 years of age at the time of diagnosis. The effect of exposure to organic solvents was not differential with regard to morphology [except possibly erythroleukemia: OR 4.2, 95% CI 1.0-17 or the presence of CCA in general]. No increased risk for AML with complex CCA or with total or partial losses of chromosomes 5 or 7 were observed, but a higher risk was found for AML with trisomy 8 (OR 11, 95% CI 2.7-42) as the sole aberration. CONCLUSIONS: Exposure to organic solvents was associated with an increased risk of AML. This association was not due to benzene exposure alone and may be modified by age. Furthermore, specific associations with trisomy 8, and possibly also erythroleukemia, were suggested.
PubMed ID
11201395 View in PubMed
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Clonal chromosome aberrations in myeloid leukemia after styrene exposure.

https://arctichealth.org/en/permalink/ahliterature22769
Source
Scand J Work Environ Health. 1996 Feb;22(1):58-61
Publication Type
Article
Date
Feb-1996
Author
H A Kolstad
B. Pedersen
J. Olsen
E. Lynge
G. Jensen
I. Lisse
P. Philip
N T Pedersen
Author Affiliation
University of Aarhus, Institute of Epidemiology and Social Medicine, Denmark.
Source
Scand J Work Environ Health. 1996 Feb;22(1):58-61
Date
Feb-1996
Language
English
Publication Type
Article
Keywords
Adult
Aged
Case-Control Studies
Chromosome Aberrations
Denmark - epidemiology
Humans
Leukemia, Myeloid - chemically induced - epidemiology - genetics
Logistic Models
Male
Middle Aged
Occupational Exposure - adverse effects
Odds Ratio
Research Support, Non-U.S. Gov't
Styrenes - adverse effects
Time Factors
Abstract
OBJECTIVES. The purpose of the study was to determine the risk of myeloid leukemia subclassified according to clonal chromosome aberrations in styrene-exposed workers. METHODS. A nested case-referent study was carried out on 19 myeloid leukemia patients, of which 12 showed clonal chromosome aberrations, and 57 referents ascertained within the Danish reinforced plastics industry and similar industries with no styrene exposure. RESULTS. A 2.5-fold increased risk for myeloid leukemia with clonal chromosome aberrations (95% confidence interval 0.2-25.0) was found among workers of companies with styrene exposure. CONCLUSIONS. The results suggest that styrene may cause leukemia through a clastogenic effect. But similar findings could also have been found if the exposure was associated with a specific subtype of leukemia prone to develop the chromosome aberrations in question. Due to the few observations and the lack of detailed exposure data, additional studies are needed to corroborate or refute the present suggestive findings.
PubMed ID
8685676 View in PubMed
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Pathoanatomical aspects of malignant haematological disorders among Danish patients exposed to thorium dioxide.

https://arctichealth.org/en/permalink/ahliterature23423
Source
APMIS. 1995 Jan;103(1):29-36
Publication Type
Article
Date
Jan-1995
Author
J. Visfeldt
M. Andersson
Author Affiliation
Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
Source
APMIS. 1995 Jan;103(1):29-36
Date
Jan-1995
Language
English
Publication Type
Article
Keywords
Acute Disease
Adolescent
Adult
Aged
Cerebral Angiography
Child
Child, Preschool
Cohort Studies
Comparative Study
Denmark
Europe
Follow-Up Studies
Humans
Infant
Japan
Leukemia - chemically induced - epidemiology
Leukemia, Myeloid - chemically induced - epidemiology
Lymphoma, Non-Hodgkin - chemically induced - epidemiology
Middle Aged
Multiple Myeloma - chemically induced - epidemiology
Myelodysplastic Syndromes - chemically induced - epidemiology
Myelofibrosis - chemically induced - epidemiology
Registries
Research Support, Non-U.S. Gov't
Thorium Dioxide - adverse effects
Time Factors
Abstract
The Danish Thorotrast Study was recently reestablished and improved. The cohort has been reidentified and followed up, and now comprises 1003 Thorotrast-exposed patients. For all suspected haematological cases, cytological and histological material has been revised and malignant diseases have been reclassified. The numbers of cases of leukemia and other related haematological disorders were as follows: 16 acute myeloid leukemia (AML); 8 myelodysplastic syndrome (MDS); 1 acute lymphatic leukemia (ALL); 3 chronic myeloid leukemia (CML); 4 non-Hodgkin's lymphoma (NHL); 2 multiple myeloma (MM); 2 myelofibrosis (MF); 2 chronic lymphatic leukemia (CLL). Except for CLL, all cases might be Thorotrast-induced. (Expected number of leukemias:
PubMed ID
7695889 View in PubMed
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