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Admission base deficit and lactate levels in Canadian patients with blunt trauma: are they useful markers of mortality?

https://arctichealth.org/en/permalink/ahliterature123467
Source
J Trauma Acute Care Surg. 2012 Jun;72(6):1532-5
Publication Type
Article
Date
Jun-2012
Author
Jean-Francois Ouellet
Derek J Roberts
Corina Tiruta
Andrew W Kirkpatrick
Michelle Mercado
Vincent Trottier
Elijah Dixon
David V Feliciano
Chad G Ball
Author Affiliation
Regional Trauma Services, Department of Surgery University of Calgary, Foothills Medical Centre, Calgary, Alberta, Canada.
Source
J Trauma Acute Care Surg. 2012 Jun;72(6):1532-5
Date
Jun-2012
Language
English
Publication Type
Article
Keywords
Acid-Base Imbalance - blood - mortality
Adult
Aged
Alberta
Analysis of Variance
Biological Markers - analysis
Blood Gas Analysis
Cohort Studies
Diagnostic Tests, Routine - methods
Female
Hospital Mortality - trends
Humans
Injury Severity Score
Lactic Acid - blood
Male
Middle Aged
Prognosis
Registries
Retrospective Studies
Sensitivity and specificity
Statistics, nonparametric
Survival Analysis
Trauma Centers
Wounds, Nonpenetrating - blood - diagnosis - mortality
Abstract
Elevated base deficit (BD) and lactate levels at admission in patients with injury have been shown to be associated with increased mortality. This relationship is undefined in the Canadian experience. The goal of this study was to define the association between arterial blood gas (ABG) values at admission and mortality for Canadians with severe blunt injury.
A retrospective review of 3,000 consecutive adult major trauma admissions (Injury Severity Score, = 12) to a Canadian academic tertiary care referral center was performed. ABG values at the time of arrival were analyzed with respect to associated mortality and length of stay.
A total of 2,269 patients (76%) had complete data available for analysis. After exclusion of patients who sustained a penetrating injury or were admitted for minor falls (ground levels or low height), 445 had an ABG drawn within 2 hours of arrival. Patients who died displayed a higher median lactate (3.6 vs. 2.2, p
PubMed ID
22695417 View in PubMed
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An economic evaluation of treatments for HIV-associated facial lipoatrophy: a cost-utility analysis.

https://arctichealth.org/en/permalink/ahliterature143939
Source
Curr HIV Res. 2010 Jul;8(5):386-95
Publication Type
Article
Date
Jul-2010
Author
Sirianong Peyasantiwong
Mona R Loutfy
Audrey Laporte
Peter C Coyte
Author Affiliation
Department of Health Policy, Management and Evaluation, Faculty of Medicine, 155 College Street 4th Floor, University of Toronto, Toronto, Ontario M5T 3M6, Canada.
Source
Curr HIV Res. 2010 Jul;8(5):386-95
Date
Jul-2010
Language
English
Publication Type
Article
Keywords
Adipose Tissue - pathology
Atrophy - economics - surgery
Cost-Benefit Analysis
Face - pathology
HIV-Associated Lipodystrophy Syndrome - economics - surgery
Humans
Lactic Acid - therapeutic use
Middle Aged
Ontario
Polymers - therapeutic use
Quality-Adjusted Life Years
Questionnaires
Surgery, Plastic - methods
Treatment Outcome
Abstract
HIV-associated facial lipoatrophy (FLA) is a stigmatizing hallmark for persons living with HIV [PLWH], and can lead to poor social functioning, social isolation, and reduced labour force participation. Treatments for this condition are prohibitively expensive and are not publicly insured in the Province of Ontario, Canada. Information gleaned from an economic evaluation of treatments for FLA could inform policy decision making concerning coverage.
Decision-analytic techniques were used to estimate the lifetime incremental costs and quality-adjusted life years (QALYs) gained from use of either Poly-l-lactic acid or Polyalkylimide gel from the perspectives of society and the Ontario Ministry of Health. Disease progression probabilities and utilities were derived from the literature. Costs were obtained through interviews with product distributors and physicians who perform these treatments. Costs were valued in 2009 Canadian Dollars. Costs and outcomes were discounted annually at 3%.
Treatments using Polyalkylimide gel exhibit such a cost advantage over those using Poly-l-lactic acid that they more than compensate for the health-related quality of life advantages of Poly-l-lactic acid. From a Ministry of Health perspective, the incremental cost-utility ratios for Polyalkylimide gel or Poly-l-lactic acid compared to no treatment were $45,457 CAD or $57,352 CAD per QALY, respectively, $1.00 CAD = $0.876 USD). From a societal perspective the equivalent ratios were $48,583 CAD and $66,608 CAD respectively. These findings were not altered in the sensitivity analyses.
FLA treatments for PLWH enhance QALYs and meet conventional cost-utility thresholds. The incremental cost per QALY for Polyalkylimide gel was lower than that for Poly-l-lactic acid.
PubMed ID
20426758 View in PubMed
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Antimicrobial action of some GRAS compounds against Vibrio vulnificus.

https://arctichealth.org/en/permalink/ahliterature217449
Source
Food Addit Contam. 1994 Sep-Oct;11(5):549-58
Publication Type
Article
Author
Y. Sun
J D Oliver
Author Affiliation
Department of Biology, University of North Carolina at Charlotte 28223.
Source
Food Addit Contam. 1994 Sep-Oct;11(5):549-58
Language
English
Publication Type
Article
Keywords
Animals
Anti-Bacterial Agents - pharmacology
Benzoates - pharmacology
Benzoic Acid
Butylated Hydroxyanisole - pharmacology
Butylated Hydroxytoluene - pharmacology
Diacetyl - pharmacology
Food Microbiology
Humans
Lactates - pharmacology
Lactic Acid
Microbial Sensitivity Tests
Ostreidae - microbiology
Parabens - pharmacology
Propionates - pharmacology
Propyl Gallate - pharmacology
Seafood
Sorbic Acid - pharmacology
United States
United States Food and Drug Administration
Vibrio - drug effects - pathogenicity
Abstract
Vibrio vulnificus is a bacterium indigenous to estuarine waters and is known to be a significant human pathogen. Infections are generally associated with the consumption of raw oyster. In an attempt to identify possible antimicrobial agents against this organism that might be used in foods, ten compounds that are generally recognized as safe (GRAS) by the FDA were tested against both the opaque and translucent morphotypes of V. vulnificus. Eight of those compounds had a lethal effect for both morphotypes of this bacterium. Diacetyl had the lowest lethal concentration (50 ppm) of the GRAS compounds tested within 24 h. Lactic acid and butylated hydroxyanisole possessed lethal activities at 300 ppm and 400 ppm, respectively, within 3 h. The mode of action of lactic acid against V. vulnificus appears to be an effect primarily of pH, while the antimicrobial activities of diacetyl and BHA appeared not to be affected by pH. No significant differences were found for opaque to translucent, or from translucent to opaque switching, in examining the possible effects of the GRAS compounds on colonial morphology.
PubMed ID
7835469 View in PubMed
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Assessment of plasma opioid peptides, beta-endorphin and met-enkephalin, at the end of an international nordic ski race.

https://arctichealth.org/en/permalink/ahliterature50375
Source
Eur J Appl Physiol Occup Physiol. 1987;56(3):281-6
Publication Type
Article
Date
1987
Author
C. Mougin
A. Baulay
M T Henriet
D. Haton
M C Jacquier
D. Turnill
S. Berthelay
R C Gaillard
Source
Eur J Appl Physiol Occup Physiol. 1987;56(3):281-6
Date
1987
Language
English
Publication Type
Article
Keywords
Adult
Endorphins - blood
Enkephalin, Methionine - blood
Humans
Hydrocortisone - blood
Lactates - blood
Lactic Acid
Male
Physical Education and Training
Research Support, Non-U.S. Gov't
Skiing
Time Factors
beta-Endorphin
Abstract
Plasma met-enkephalin, beta-endorphin, cortisol and lactic acid concentrations were measured in seventeen volunteer male subjects at rest and after a long-distance nordic ski race. Immediately after the race, mean plasma met-enkephalin did not show any significant change, but significant rises in beta-endorphin, cortisol and lactic acid were noted in all skiers. The change in beta-endorphin with exercise was significantly related to the change in cortisol (r = 0.68; p less than 0.001) and to the change in plasma lactic acid (r = 0.60; p less than 0.001). Furthermore, the experienced skiers training over 150 km X week-1 of nordic ski had significantly faster skiing times in this event and showed greater beta-endorphin, cortisol and lactic acid levels than the recreational skiers who trained for 20 km X week-1. Our results imply that the changes in plasma beta-endorphin depend on the intensity of exercise. However the significance of higher levels of skiing training or previous nordic ski experience in the release of beta-endorphin is expected and cannot be excluded.
PubMed ID
2952498 View in PubMed
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Assessment of Traub formula and ketone bodies in cause of death investigations.

https://arctichealth.org/en/permalink/ahliterature106879
Source
Int J Legal Med. 2013 Nov;127(6):1131-7
Publication Type
Article
Date
Nov-2013
Author
Terhi Keltanen
Antti Sajantila
Jukka U Palo
Teija Partanen
Tiina Valonen
Katarina Lindroos
Author Affiliation
Laboratory of Forensic Biology, Department of Forensic Medicine, Hjelt Institute, PO Box 40, FI-00014, University of Helsinki, Finland, terhi.keltanen@helsinki.fi.
Source
Int J Legal Med. 2013 Nov;127(6):1131-7
Date
Nov-2013
Language
English
Publication Type
Article
Keywords
3-Hydroxybutyric Acid - blood
Acetoacetates - blood
Acetone - blood
Alcoholism - blood - pathology
Algorithms
Autopsy
Biological Markers - blood
Blood Glucose - analysis
Cause of Death
Diabetes Mellitus - blood - pathology
Diabetic Ketoacidosis - blood - pathology
Diagnosis, Differential
Finland
Hemoglobin A, Glycosylated - analysis
Humans
Hyperglycemia - blood - pathology
Ketone Bodies - blood
Lactic Acid - blood
Postmortem Changes
Predictive value of tests
Abstract
Diabetes and alcohol abuse may cause severe metabolic disturbances that can be fatal. These may be difficult to diagnose in autopsies based solely on macroscopical and histological findings. In such cases, metabolic markers, such as postmortem glucose and ketone levels, can provide supporting information. Glucose or combined glucose and lactate, the Traub value, is often used to indicate hyperglycemia. The use of the Traub value, however, has been questioned by some, because the lactate levels are known to elevate in postmortem samples also due to other reasons than glycolysis of glucose molecules. Ketoacidosis can be detected by analyzing ketone body levels, especially beta-hydroxybutyric acid (BHB). Acetone is also elevated in severe cases of ketoacidosis. Here, we have evaluated the value of these biomarkers for postmortem determination of the metabolic disturbances. Retrospective data of 980 medico-legal autopsies performed in Finland, where glucose, lactate and ketone bodies were analyzed, was collected. Our findings show that the Traub value indicates hyperglycemia, even when glucose levels are low. For diagnosis, evaluation of complementing markers, e.g. ketone bodies and glycated hemoglobin is needed. Our results show that BHB can be used for screening and diagnosis of ketoacidosis. Acetone alone is not sufficient, since it is elevated only in the most severe cases. We also found that alcohol abuse rarely causes severe ketoacidosis. However, sporadic cases do exist where ketone body levels are extremely high. Despite this, alcoholic ketoacidosis is very rarely diagnosed as the cause of death.
PubMed ID
24091723 View in PubMed
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Association between lactate concentration in amniotic fluid and dysfunctional labor.

https://arctichealth.org/en/permalink/ahliterature92395
Source
Acta Obstet Gynecol Scand. 2008;87(9):924-8
Publication Type
Article
Date
2008
Author
Wiberg-Itzel Eva
Pettersson Hans
Cnattingius Sven
Nordström Lennart
Author Affiliation
Department of Clinical Science and Education, Section of Obstetrics and Gynaecology, Karolinska Institute at Stockholm Söder Hospital, Sweden. eva.itzel@telia.com
Source
Acta Obstet Gynecol Scand. 2008;87(9):924-8
Date
2008
Language
English
Publication Type
Article
Keywords
Amniotic Fluid - chemistry - metabolism
Dystocia - metabolism
Female
Humans
Lactic Acid - metabolism
Predictive value of tests
Pregnancy
Prospective Studies
ROC Curve
Sensitivity and specificity
Abstract
OBJECTIVES: To assess whether there is an association between high lactate concentration in amniotic fluid (AF) and labor dystocia. DESIGN: Prospective observational study. SETTING: Labor ward at General South Hospital, Stockholm, Sweden. POPULATION AND METHODS: Women in active labor attending labor ward, having at least two consecutive measurements of lactate concentration in AF, measured 60 minutes apart. MAIN OUTCOME MEASURE: Dysfunctional labor, defined as instrumental or operative delivery due to dystocia. RESULTS: Among women with spontaneous vaginal deliveries (n=23) the mean lactate concentration in AF during labor was 8.9 mmol/l (range 6.6-10.8), and among women with operative delivery due to labor dystocia (n=31) the corresponding value was 10.9 mmol/l (range 8.0-16.1) (p or =10.1 mmol/l) in at least two consecutive measures collected at least 60 minutes apart, 25 (86%) were delivered instrumentally/operatively due to dystocia. Using this definition of a positive test, the diagnostic accuracy to predict operative delivery due to dystocia was: sensitivity 81% (25/31), specificity 83% (19/23), positive predictive value 86% (25/29), and negative predictive value 76% (19/25). The likelihood ratio was 5.0 for a positive test and 0.2 for a negative test. CONCLUSIONS: High lactate concentration (> or =10.1mmol/l) in at least two consecutive samples of AF collected during labor 60 minutes apart is strongly associated with dystocia. This method might be useful in clinical management to identify labor dystocia at an early stage of labor.
PubMed ID
18720033 View in PubMed
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Association between lactate in vaginal fluid and time to spontaneous onset of labour for women with suspected prelabour rupture of the membranes.

https://arctichealth.org/en/permalink/ahliterature80457
Source
BJOG. 2006 Dec;113(12):1426-30
Publication Type
Article
Date
Dec-2006
Author
Wiberg-Itzel E.
Pettersson H.
Cnattingius S.
Nordstrom L.
Author Affiliation
Department of Obstetrics and Gynaecology, Söder Hospital, Stockholm, Sweden. eva.itzel@telia.com
Source
BJOG. 2006 Dec;113(12):1426-30
Date
Dec-2006
Language
English
Publication Type
Article
Keywords
Adult
Biological Markers - analysis
Body Fluids - chemistry
Female
Fetal Membranes, Premature Rupture - diagnosis
Humans
Labor Onset
Lactic Acid - analysis
Middle Aged
Predictive value of tests
Pregnancy
Pregnancy outcome
Prenatal Diagnosis - methods - standards
Prospective Studies
Sensitivity and specificity
Vagina - chemistry
Abstract
OBJECTIVES: To assess whether lactate determination in vaginal fluid is associated with, and can predict, onset of labour for women with suspected prelabour rupture of the membranes (PROM). DESIGN: Prospective observational study. SETTING: Labour ward at Soder Hospital, Stockholm, Sweden. POPULATION: Women with suspected PROM after 34 weeks of gestation, who later had spontaneous onset of labour (n = 179). METHODS: All women underwent a speculum examination and a test for determining lactate concentration in vaginal fluid. We used logistic regression to estimate the association between lactate concentration in vaginal fluid and time to onset of labour. MAIN OUTCOME MEASURES: Time from examination to onset of labour (cervix > or =4 cm), within 24 hours and 48 hours. RESULTS: The median time interval between examination and spontaneous onset of labour was 8.4 hours for women with 'high' lactate (> or =4.5 mmol/l) and 54 hours for those with 'low' lactate concentrations ( or =4.5 mmol/l) in vaginal fluid can be used to predict whether a woman with suspected PROM will commence spontaneous onset of labour within 24 or 48 hours.
Notes
Comment In: BJOG. 2007 May;114(5):652-3; author reply 65317439576
PubMed ID
17010116 View in PubMed
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Biochemical variation: The development of biochemical normal ranges for Eskimo populations

https://arctichealth.org/en/permalink/ahliterature1371
Source
Pages 114-124 in P.L. Jamison, S.L. Zegura, and F.A. Milan, eds. Eskimos of Northwestern Alaska: A biological perspective. Dowden, Hutchinson & Ross, Inc., Stroudsburg, PA. US/IBP Synthesis Series 8.
Publication Type
Book/Book Chapter
Date
1978
Author
Laessig, RH
Pauls, FP
Paskey, TA
Schwartz, TH
Author Affiliation
University of Wisconsin
Source
Pages 114-124 in P.L. Jamison, S.L. Zegura, and F.A. Milan, eds. Eskimos of Northwestern Alaska: A biological perspective. Dowden, Hutchinson & Ross, Inc., Stroudsburg, PA. US/IBP Synthesis Series 8.
Date
1978
Language
English
Geographic Location
U.S.
Publication Type
Book/Book Chapter
Physical Holding
Alaska Medical Library
University of Alaska Anchorage
Keywords
Albumin
Alkaline phosphatase
Aspartate aminotransferase
Barrow
Bilirubin
Calcium
Cholesterol
Creatinine
Lactic acid dehydrogenase (LDH)
Phosphorus
Point Hope
Protein, serum
Urea nitrogen, blood
Uric acid
Wainwright
Abstract
In this study we evaluate apparent normal ranges for three Alaskan Eskimo village populations sampled during the International Biological Program. The normal ranges so developed are referenced for comparison to Wisconsin populations matched for age and sex, including children. The purpose is twofold: to derive specific Eskimo population normal ranges, and possibly to evaluate, via the tests, the health status of the Eskimo population.
Notes
Alaska Medical Library - From: Fortuine, Robert et al. 1993. The Health of the Inuit of North America: A Bibliography from the Earliest Times through 1990. University of Alaska Anchorage. Citation number 963.
UAA Consortium Library - Alaska Collection: E99.E7 E75.
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Candidemia as a cause of septic shock and multiple organ failure in nonimmunocompromised patients.

https://arctichealth.org/en/permalink/ahliterature189116
Source
Crit Care Med. 2002 Aug;30(8):1808-14
Publication Type
Article
Date
Aug-2002
Author
Susan Hadley
Winnie W Lee
Robin Ruthazer
Stanley A Nasraway
Author Affiliation
Department of Medicine, the Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, USA.
Source
Crit Care Med. 2002 Aug;30(8):1808-14
Date
Aug-2002
Language
English
Publication Type
Article
Keywords
APACHE
Adult
Aged
Canada - epidemiology
Candidiasis - blood
Cohort Studies
Double-Blind Method
Female
Humans
Immunocompromised Host - immunology
Lactic Acid - blood
Male
Middle Aged
Multiple Organ Failure - microbiology - mortality
Prospective Studies
Shock, Septic - microbiology - mortality
Survival Analysis
Time Factors
United States - epidemiology
Abstract
To describe outcomes of septic shock and multiple organ failure arising from candidemia.
Secondary cohort analysis of data from the placebo arm of the North American Septic Shock Trial (NORASEPT II), the largest prospective, randomized, double-blind, controlled multiple center study of septic shock conducted to date, with predetermined end point analysis of outcomes.
Adult intensive care units in 105 hospitals in the United States and Canada.
A cohort of ten purely candidemic patients in septic shock were compared with a cohort of 376 purely bacteremic patients in septic shock. Patients were not immunocompromised, because patients on corticosteroids, with neutropenia, or posttransplantation were excluded from enrollment in NORASEPT II.
Demographic variables, baseline characteristics, 28-day mortality rates, and multiple organ failure were compared for the two cohorts. Candidemic patients were more likely to have a history of underlying renal failure at baseline and to require dialysis at onset of septic shock. Both causes of septic shock are associated with an extremely high severity of illness (Acute Physiology and Chronic Health Evaluation II: candidemic septic shock, 32 +/- 10; bacteremic septic shock, 30 +/- 8; p =.44). More than 70% of patients with candidemia and septic shock were in multiple organ failure at days 3, 7, and 14; patients with candidemic septic shock sustained persistent multiple organ failure and showed delayed recovery from multiple organ failure compared with patients with bacteremic septic shock. Mortality rate at 28 days was 60% in candidemic septic shock and 46% in bacteremic septic shock (p =.38).
Candidemia with septic shock is infrequent in nonimmunocompromised patients but has a very high mortality rate, a high likelihood of associated multiple organ failure, and possibly a delayed recovery from multiple organ failure. Patients with candidemic septic shock are more likely to have underlying renal failure at baseline.
PubMed ID
12163798 View in PubMed
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Cardiovascular health profile of elite female football players compared to untrained controls before and after short-term football training.

https://arctichealth.org/en/permalink/ahliterature112461
Source
J Sports Sci. 2013;31(13):1421-31
Publication Type
Article
Date
2013
Author
Morten Bredsgaard Randers
Lars Juel Andersen
Christina Orntoft
Mads Bendiksen
Lars Johansen
Joshua Horton
Peter Riis Hansen
Peter Krustrup
Author Affiliation
University of Copenhagen, Department of Nutrition, Exercise and Sports (NEXS), Copenhagen Centre for Team Sport and Health, Universitetsparken 13, Kbh Ø, 2100, Denmark.
Source
J Sports Sci. 2013;31(13):1421-31
Date
2013
Language
English
Publication Type
Article
Keywords
Adipose Tissue - metabolism
Adult
Cardiovascular System
Cholesterol, HDL - blood
Denmark
Exercise Test
Female
Football
Heart - anatomy & histology - physiology
Heart Ventricles
Humans
Lactic Acid - blood
Oxygen consumption
Physical Conditioning, Human - physiology
Physical Endurance - physiology
Physical Fitness
Soccer - physiology
Tricuspid Valve - physiology
Ventilation
Young Adult
Abstract
This study examined the intermittent exercise performance and cardiovascular health profile in elite female football players in comparison to untrained young women, as well as a subgroup subjected to football training 2x1 h · week(-1) for 16 weeks. Twenty-seven Danish national team players (elite trained, ET) and 28 untrained women (UT) underwent dual-energy X-ray absorptiometry-scanning (DXA), comprehensive transthoracic echocardiography, treadmill and Yo-Yo Intermittent Endurance level 2 (IE2) testing. Eight women in UT were also tested after the football training period. Maximal oxygen uptake rate (VO2max), peak ventilation and peak lactate were 40, 18 and 51% higher (P
PubMed ID
23829646 View in PubMed
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96 records – page 1 of 10.