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50bp deletion in the promoter for superoxide dismutase 1 (SOD1) reduces SOD1 expression in vitro and may correlate with increased age of onset of sporadic amyotrophic lateral sclerosis.

https://arctichealth.org/en/permalink/ahliterature156293
Source
Amyotroph Lateral Scler. 2008 Aug;9(4):229-37
Publication Type
Article
Date
Aug-2008
Author
Wendy J Broom
Matthew Greenway
Ghazaleh Sadri-Vakili
Carsten Russ
Kristen E Auwarter
Kelly E Glajch
Nicolas Dupre
Robert J Swingler
Shaun Purcell
Caroline Hayward
Peter C Sapp
Diane McKenna-Yasek
Paul N Valdmanis
Jean-Pierre Bouchard
Vincent Meininger
Betsy A Hosler
Jonathan D Glass
Meraida Polack
Guy A Rouleau
Jang-Ho J Cha
Orla Hardiman
Robert H Brown
Author Affiliation
Day Neuromuscular Research Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. wendy.broom@gmail.com
Source
Amyotroph Lateral Scler. 2008 Aug;9(4):229-37
Date
Aug-2008
Language
English
Publication Type
Article
Keywords
Age of Onset
Amyotrophic Lateral Sclerosis - enzymology - epidemiology - genetics
Base Sequence
DNA Mutational Analysis
Female
Gene Expression
Genetic Predisposition to Disease
Genotype
Homozygote
Humans
Ireland - epidemiology
Male
Middle Aged
Phenotype
Polymorphism, Genetic
Promoter Regions, Genetic
Quebec - epidemiology
Risk factors
Scotland - epidemiology
Sequence Deletion
Sp1 Transcription Factor - metabolism
Superoxide Dismutase - genetics - metabolism
United States - epidemiology
Abstract
The objective was to test the hypothesis that a described association between homozygosity for a 50bp deletion in the SOD1 promoter 1684bp upstream of the SOD1 ATG and an increased age of onset in SALS can be replicated in additional SALS and control sample sets from other populations. Our second objective was to examine whether this deletion attenuates expression of the SOD1 gene. Genomic DNA from more than 1200 SALS cases from Ireland, Scotland, Quebec and the USA was genotyped for the 50bp SOD1 promoter deletion. Reporter gene expression analysis, electrophoretic mobility shift assays and chromatin immunoprecipitation studies were utilized to examine the functional effects of the deletion. The genetic association for homozygosity for the promoter deletion with an increased age of symptom onset was confirmed overall in this further study (p=0.032), although it was only statistically significant in the Irish subset, and remained highly significant in the combined set of all cohorts (p=0.001). Functional studies demonstrated that this polymorphism reduces the activity of the SOD1 promoter by approximately 50%. In addition we revealed that the transcription factor SP1 binds within the 50bp deletion region in vitro and in vivo. Our findings suggest the hypothesis that this deletion reduces expression of the SOD1 gene and that levels of the SOD1 protein may modify the phenotype of SALS within selected populations.
PubMed ID
18608091 View in PubMed
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Abortion debates in Finland and the Republic of Ireland: textual analysis of experiential thinking and argumentation in parliamentary and layperson discussions.

https://arctichealth.org/en/permalink/ahliterature294699
Source
Reprod Health. 2017 Dec 02; 14(1):163
Publication Type
Journal Article
Date
Dec-02-2017
Author
Anne-Mari Mustonen
Tommi Paakkonen
Esko Ryökäs
Petteri Nieminen
Author Affiliation
University of Eastern Finland, Faculty of Health Sciences, School of Medicine, Institute of Biomedicine/Anatomy, P.O. Box 1627, FI-70211, Kuopio, Finland.
Source
Reprod Health. 2017 Dec 02; 14(1):163
Date
Dec-02-2017
Language
English
Publication Type
Journal Article
Keywords
Abortion, Induced - legislation & jurisprudence - psychology
Attitude
Blogging
Dissent and Disputes
Finland
Humans
Ireland
Abstract
The ethical discussion about abortion has been polarized in Finland and the Republic of Ireland, two European countries with very different abortion legislation (liberal vs. highly restrictive). The aim of the present study was to analyze experiential thinking patterns and argumentative strategies in political and layperson debates regarding induced abortion.
The content of Finnish and Irish texts (n?=?493), consisting of transcripts of parliamentary debates and online texts, such as blogs, was analyzed systematically. The texts were investigated for the aspects of experiential thinking, for selected argumentative moves and for any differences in the prevalence of these features between countries or between political vs. layperson debates.
The Finnish and Irish discussions about induced abortion relied heavily on experiential thinking patterns and emotionally laden arguments instead of objective research data. This was evident in the very high prevalence of testimonials, narratives, loaded language and appeals to emotion in both political and layperson debates regardless of the country or the debater's position on abortion issue. Research data that did not support the position of the debater were relatively often omitted by confirmation bias. The Irish debaters appealed to popularity more often than the Finnish ones, while magical/religious thinking was mainly observed in the Finnish layperson discussion. The national history and the prevailing cultural and religious atmosphere of the two countries could explain these differences.
The abortion debate mostly reinforces the opinions of one's peer group rather than convinces the opposite party to change their position. The stalemate and continuation of the same arguments being repeated could be associated with experiential thinking and emotional argumentative strategies in both political and layperson debates.
Notes
Cites: Eur J Contracept Reprod Health Care. 2013 Aug;18(4):231-3 PMID 23848269
Cites: Br J Soc Psychol. 2015 Sep;54(3):500-18 PMID 25418861
Cites: Bioethics. 2012 Feb;26(2):84-92 PMID 20377572
Cites: Lancet. 2013 May 11;381(9878):1614 PMID 23671917
Cites: J Med Humanit. 2004 Spring;25(1):7-19 PMID 15055386
Cites: Reprod Health. 2015 Jun 25;12:58 PMID 26108479
Cites: Am Psychol. 1994 Aug;49(8):709-24 PMID 8092614
Cites: Contraception. 2017 Mar;95(3):269-278 PMID 27745910
Cites: Eur J Contracept Reprod Health Care. 2011 Aug;16(4):233-40 PMID 21557713
Cites: PLoS One. 2015 Mar 03;10(3):e0118314 PMID 25734650
Cites: Fem Rev. 1998 Autumn;(60):61-83 PMID 12348945
Cites: J Psychiatr Res. 2017 Jan;84:200-206 PMID 27760409
Cites: Scand J Psychol. 1998 Dec;39(4):257-65 PMID 9883101
Cites: J Relig Health. 2010 Dec;49(4):513-35 PMID 19641993
Cites: BMC Med Ethics. 2015 Mar 25;16:17 PMID 25885698
Cites: BJOG. 2017 Jul;124(8):1208-1215 PMID 27748001
Cites: Proc Natl Acad Sci U S A. 2014 Sep 16;111 Suppl 4:13614-20 PMID 25225368
Cites: Int J Gynaecol Obstet. 2015 Jul;130(1):93-7 PMID 25939525
Cites: Cult Health Sex. 2014;16(4):366-80 PMID 24617662
PubMed ID
29197399 View in PubMed
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Accounting for Irish Catholic ill health in Scotland: a qualitative exploration of some links between 'religion', class and health.

https://arctichealth.org/en/permalink/ahliterature179028
Source
Sociol Health Illn. 2004 Jul;26(5):527-56
Publication Type
Article
Date
Jul-2004
Author
Patricia Walls
Rory Williams
Author Affiliation
MRC Social and Public Health Sciences Unit, University of Glasgow. WallsAMP@aol.com
Source
Sociol Health Illn. 2004 Jul;26(5):527-56
Date
Jul-2004
Language
English
Publication Type
Article
Keywords
Adult
Aged
Career Choice
Career Mobility
Catholicism - psychology
Emigration and Immigration - statistics & numerical data
Employment - psychology - statistics & numerical data
Female
Health status
Health Surveys
Humans
Ireland - ethnology
Male
Middle Aged
Minority Groups - education - psychology - statistics & numerical data
Motivation
Prejudice
Protestantism - psychology
Qualitative Research
Questionnaires
Residence Characteristics
Scotland - epidemiology
Social Class
Socioeconomic Factors
Urban Health - statistics & numerical data
Abstract
This paper considers the ways in which accounts from Glasgow Catholics diverge from those of Protestants and explores the reasons why people leave jobs, including health grounds. Accounts reveal experiences distinctive to Catholics, of health-threatening stress, obstacles to career progression within (mainly) private-sector organisations, and interactional difficulties which create particular problems for (mainly) middle class men. This narrows the employment options for upwardly mobile Catholics, who may then resort to self-employment or other similarly stressful options. The paper considers whether the competence of Catholics or Catholic cultural factors are implicated in thwarting social mobility among Catholics or, alternatively, whether institutional sectarianism is involved. We conclude that, of these options, theories of institutional sectarianism provide the hypothesis which currently best fits these data. In Glasgow, people of indigenous Irish descent are recognisable from their names and Catholic background and are identified as Catholic by others. Overt historical exclusion of Catholics from middle class employment options now seems to take unrecognised forms in routine assumptions and practices which restrict Catholic employment opportunities. It is argued that younger Catholics use education to overcome the obstacles to mobility faced by older people and circumvent exclusions by recourse to middle class public-sector employment. This paper aims to link historical, structural and sectarian patterns of employment experience to accounts of health and work, and in so doing to contribute to an explanation for the relatively poor health of Catholic Glaswegians with Irish roots.
PubMed ID
15283776 View in PubMed
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[Active management of labor--the long way is popular again...]

https://arctichealth.org/en/permalink/ahliterature64458
Source
Ugeskr Laeger. 1996 Jul 22;158(30):4307-8
Publication Type
Article
Date
Jul-22-1996
Author
O B Rasmussen
Source
Ugeskr Laeger. 1996 Jul 22;158(30):4307-8
Date
Jul-22-1996
Language
Danish
Publication Type
Article
Keywords
Denmark
Female
Humans
Ireland
Labor, Obstetric
Pregnancy
Quality Assurance, Health Care
Time Factors
Notes
Comment On: Ugeskr Laeger. 1996 Feb 26;158(9):1235-68644431
PubMed ID
8757903 View in PubMed
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Acute effects of the Chernobyl nuclear accident on Irish mortality?

https://arctichealth.org/en/permalink/ahliterature38051
Source
Ir Med J. 1989 Sep;82(3):119-21
Publication Type
Article
Date
Sep-1989
Author
S. Allwright
L. Daly
Source
Ir Med J. 1989 Sep;82(3):119-21
Date
Sep-1989
Language
English
Publication Type
Article
Keywords
Accidents
Adolescent
Adult
Aged
Air Pollution, Radioactive - adverse effects
Cause of Death
Child
Child, Preschool
Humans
Infant
Infant, Newborn
Ireland
Middle Aged
Nuclear Reactors
Time Factors
Ukraine
Abstract
This report examines the claim that Irish mortality in the second quarter (April-June) of 1986 increased due to the cloud of radioactive material released by the damaged reactor in Chernobyl. Over the period 1971-1987, based on date of registration, the death rates in the second quarter showed marked year to year variation often exceeding that expected on the basis of chance alone. In 1986 the percentage of annual deaths occurring between April and June, and the death rate itself, were both significantly higher than in most other years between 1981 and 1987. The 1986 figures were not however, significantly higher than those observed in years prior to 1981. Since the distribution of mortality by cause was not consistent with the hypothesis relating low level radiation to immediate mortality, and since causality cannot be inferred from a temporal association per se, the Chernobyl accident cannot be implicated in the excess mortality observed in the second quarter of 1986.
PubMed ID
2599835 View in PubMed
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Adenocarcinoma of the uterine cervix in Ireland and Sweden: human papillomavirus infection and biologic alterations.

https://arctichealth.org/en/permalink/ahliterature20911
Source
Mod Pathol. 1999 Jul;12(7):675-82
Publication Type
Article
Date
Jul-1999
Author
B M Skyldberg
E. Murray
H. Lambkin
P. Kelehan
G U Auer
Author Affiliation
Department of Oncology-Pathology, Cancer Center Karolinska, Huddinge Hospital, Karolinska Institute, Stockholm, Sweden. Barbro.Skyldberg@cck.ki.se
Source
Mod Pathol. 1999 Jul;12(7):675-82
Date
Jul-1999
Language
English
Publication Type
Article
Keywords
Adenocarcinoma - genetics - pathology - virology
Adult
Aged
Aged, 80 and over
Aneuploidy
Cell Division
Cervix Uteri - chemistry - metabolism - virology
Cyclin A - analysis
Cyclin-Dependent Kinase Inhibitor p21
Cyclins - analysis
DNA, Neoplasm - genetics
DNA, Viral - genetics
Female
Humans
Immunohistochemistry
Ireland
Ki-67 Antigen - analysis
Middle Aged
Papillomavirus - genetics
Papovaviridae Infections - virology
Polyploidy
Sweden
Tumor Suppressor Protein p53 - analysis
Tumor Virus Infections - virology
Uterine Cervical Neoplasms - genetics - pathology - virology
Abstract
Paraffin-embedded samples from cervical adenocarcinomas, 19 cases from Irish patients and 19 cases from Swedish patients, were analyzed by polymerase chain reaction for the presence of infection with human papillomavirus (HPV). The results were compared with DNA ploidy, proliferation activity, and p53 and p21/WAF1 expression. The studies were performed to discover whether high-risk HPV infection in adenocarcinomas of the uterine cervix is associated with an increased proliferative activity and genomic instability. The results show that the majority (84.6%) of patients 59 years of age or younger showed HPV infection. The overall prevalence of HPV DNA was 60.5%, with the high-risk types, 16 and 18, the most frequent. HPV-16 had a prevalence of 23.7% (9 of 38), and HPV-18 had a prevalence of 26.3% (10 of 38). The HPV-positive tumors predominantly showed a tetraploid DNA distribution pattern, whereas HPV-negative tumors more frequently showed highly scattered aneuploid DNA profiles. Both HPV-positive and HPV-negative cases displayed high proliferative activity, as indicated by high Ki-67 and cyclin A immunoreactivity. Tumor suppressor gene analysis detected low p53 expression and high p21/WAF1 expression in HPV-positive patients and high p53 expression without simultaneously increased p21/WAF1 (indicative of mutated p53) in HPV-negative cases in the groups of women older than 59 years of age.
PubMed ID
10430271 View in PubMed
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The adequacy of dietary fibre intake in 5-8 year old children.

https://arctichealth.org/en/permalink/ahliterature92983
Source
Ir Med J. 2008 Apr;101(4):118-20
Publication Type
Article
Date
Apr-2008
Author
Glackin L M
Fraser M.
O Neill M B
Author Affiliation
Department of Paediatrics, Mayo General Hospital, Castlebar, Co Mayo.
Source
Ir Med J. 2008 Apr;101(4):118-20
Date
Apr-2008
Language
English
Publication Type
Article
Keywords
Child
Child, Preschool
Constipation - prevention & control
Dietary Fiber
Female
Food Habits
Health promotion
Hospitalization - statistics & numerical data
Humans
Ireland
Male
Nutrition Surveys
Nutritional Status
Risk factors
Abstract
Despite its health implications, the fibre intake of Irish children is unknown. The North/South Ireland Food Consumption Survey indicated that 77% of Irish adults do not consume adequate fibre and surveys of children and adolescents in Canada and Sweden have confirmed suboptimal fibre intake in these groups. This study undertook to assess fibre intake and the incidence of constipation in Irish children aged 5-8 years. Children admitted to hospital with an acute self-limiting medical illness were included in the study. Three day food diaries were recorded on discharge from hospital. The presence of constipation was ascertained Seventy six per cent of 135 children s diets did not contain adequate fibre. The incidence of constipation was 13.6% in those with inadequate fibre intake as opposed to 6% in those with adequate fibre intake. Poor dietary fibre needs to be addressed in the context of health promotion and disease prevention involving parents, health care professionals and government public policy.
PubMed ID
18557515 View in PubMed
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Aerobic fitness and body fat of young British males entering the army.

https://arctichealth.org/en/permalink/ahliterature68108
Source
Eur J Appl Physiol Occup Physiol. 1979 Jan 10;40(2):73-83
Publication Type
Article
Date
Jan-10-1979
Author
J A Vogel
J P Crowdy
Source
Eur J Appl Physiol Occup Physiol. 1979 Jan 10;40(2):73-83
Date
Jan-10-1979
Language
English
Publication Type
Article
Keywords
Adipose Tissue
Adolescent
Adult
England
Humans
Male
Military Medicine
Northern Ireland
Oxygen consumption
Physical Fitness
Scotland
Sports Medicine
Wales
Abstract
Aerobic fitness and percent body fat were measured in a sample of 438 male Army recruits between the ages of 17 and 30 prior to the commencement of training. The sample came from all areas of England and Wales. Aerobic fitness, as represented by maximal oxygen uptake (VO2 max), was predicted from the Astrand submaximal bicycle heart rate test. Body fat was predicted from four skinfold measurements. Total group means +/- SD were: age, 19.5 +/- 2.5 years; VO2 max 41.7 +/- 8.3 ml/kg . min; and body fat, 14.5 +/- 4.8% of body weight. VO2 max varied with age, athletic participation and aptitude score. No relationship was found with occupation of parent, prior civilian occupation or smoking severity. When adjusted for methodological differences, VO2 max was slightly below similar Army entrants in Norway and the United States.
PubMed ID
428371 View in PubMed
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Age standardised incidence rates of lip, tongue and mouth cancers in three regions of Ireland, 1984-1988.

https://arctichealth.org/en/permalink/ahliterature24254
Source
J Ir Dent Assoc. 1993;39(5):122-4
Publication Type
Article
Date
1993

[AIDS and drug addicts in the view of an epidemiologist]

https://arctichealth.org/en/permalink/ahliterature8724
Source
AIDS Forsch. 1987 Jun;(6):323-34
Publication Type
Article
Date
Jun-1987
Author
B. Velimirovic
Source
AIDS Forsch. 1987 Jun;(6):323-34
Date
Jun-1987
Language
German
Publication Type
Article
Keywords
Acquired Immunodeficiency Syndrome
Asia
Asia, Western
Austria
Behavior
Belgium
Denmark
Developed Countries
Disease
English Abstract
Europe
Germany, West
Great Britain
Greece
HIV Infections
Ireland
Israel
Italy
Malta
Netherlands
Norway
Pharmaceutical Preparations
Portugal
Scandinavia
Sexual Behavior
Social Problems
Spain
Substance-Related Disorders
Sweden
Switzerland
Therapeutics
Virus Diseases
Abstract
Data from 12 different European countries show a rapid increase in HIV antibody positivity among drug users or a high degree of contamination already reached wherever studies have been made. Until 31 December 1986, 698 (18%) of AIDS cases were among drug users, of which 600 (15%) of AIDS cases were solely drug users, and 98 (3%) were in addition homosexual or bisexual. A further increase is expected. Because of the epidemiological importance for transmission to the heterosexual population, this problem has become a focus of attention. Drug abusing prostitutes constitute a major source of infection for the heterosexual population and newborns. The increase in the number of AIDS cases in 1986 among male drug abusers was 98 - that is up 61% compared to previous years; among women, the increase was 56%. The 3 main approaches to solution of this problem, i.e. interdiction of the drug trade, availability of sterile needles, and an education program have not proven as successful as anticipated. Relevant indications of the progress of infection in society can only be obtained by systematic observation of conversion rates in differential subgroups, i.e. drug abusers, newly incarcerated drug abusers, male and female prostitutes who use drugs, and individuals newly reporting for treatment. Separation of HIV antibody positives and negatives in therapeutic communities which are not drug free is recommended for epidemiological purposes in view of the developments to date. Nor should forced segregation of the infected from noninfected be dismissed out of hand.
PubMed ID
12281241 View in PubMed
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274 records – page 1 of 28.