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Absence of association between an intercellular adhesion molecule 1 gene E469K polymorphism and Alzheimer's disease in Finnish patients.

https://arctichealth.org/en/permalink/ahliterature187031
Source
Neurosci Lett. 2003 Jan 30;337(1):61-3
Publication Type
Article
Date
Jan-30-2003
Author
Kari M Mattila
Mikko Hiltunen
Juha O Rinne
Arto Mannermaa
Matias Röyttä
Irina Alafuzoff
Pekka Laippala
Hilkka Soininen
Terho Lehtimäki
Author Affiliation
Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Finland. kari.m.mattila@uta.fi
Source
Neurosci Lett. 2003 Jan 30;337(1):61-3
Date
Jan-30-2003
Language
English
Publication Type
Article
Keywords
Alzheimer Disease - metabolism
Brain - metabolism
Female
Finland
Genetic Predisposition to Disease
Humans
Intercellular Adhesion Molecule-1 - genetics - metabolism
Male
Middle Aged
Polymorphism, Genetic
Abstract
Increased expression of intercellular adhesion molecule 1 (ICAM1), a protein known to contribute to inflammatory responses, has been detected in the brain tissue of patients with Alzheimer's disease (AD) and animals modelled to mimic AD or Parkinson's disease (PD). ICAM1 may, thus, be implicated in the pathogenesis of these disorders. Our purpose was to investigate whether genetic variants of the ICAM1 gene have a role in causing susceptibility to AD and/or PD. We genotyped the E469K polymorphism of ICAM1 in 196 AD, 52 PD and 202 control patients of Finnish origin. The distributions of the genotype and allele frequencies of the polymorphism did not differ significantly between the AD, PD or the control patients. We therefore conclude that the E469K polymorphism of ICAM1 is not a risk factor for AD or PD.
PubMed ID
12524171 View in PubMed
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alpha-Melanocyte-stimulating hormone protects the allograft in experimental heart transplantation.

https://arctichealth.org/en/permalink/ahliterature51606
Source
Transplantation. 2002 Dec 27;74(12):1678-84
Publication Type
Article
Date
Dec-27-2002
Author
Stefano Gatti
Gualtiero Colombo
Roberto Buffa
Flavia Turcatti
Letizia Garofalo
Nadia Carboni
Luca Ferla
Luigi R Fassati
James M Lipton
Anna Catania
Author Affiliation
Division of Liver Transplantation, Ospedale Maggiore di Milano IRCCS, Milano, Italy.
Source
Transplantation. 2002 Dec 27;74(12):1678-84
Date
Dec-27-2002
Language
English
Publication Type
Article
Keywords
Animals
Endothelin-1 - genetics
Gene Expression - drug effects
Graft Rejection - drug therapy - immunology - pathology
Graft Survival - drug effects - immunology
Heart Transplantation
Intercellular Adhesion Molecule-1 - genetics
Interferon Type II - genetics
Interleukin-1 - genetics
Male
Membrane Glycoproteins - genetics
Monocyte Chemoattractant Protein-1 - genetics
Nitrates - blood
Nitric Oxide - blood
Nitric Oxide Synthase - genetics
Nitric Oxide Synthase Type II
Nitrites - blood
Proto-Oncogene Proteins c-sis - genetics
RANTES - genetics
Rats
Rats, Inbred BN
Rats, Inbred Lew
Research Support, Non-U.S. Gov't
Transforming Growth Factor beta - genetics
Transplantation, Homologous
Tumor Necrosis Factor-alpha - genetics
Vascular Cell Adhesion Molecule-1 - genetics
alpha-MSH - pharmacology
Abstract
BACKGROUND: With the increasing need for organ transplantation and the use of "marginal" organs, novel approaches are sought to increase the efficiency and survival of transplanted tissue. We tested the idea that treatment with the anti-inflammatory peptide, alpha-melanocyte-stimulating hormone (alpha-MSH), an endogenous hormone that does not cause marked immunosuppression but does reduce reperfusion injury, may protect allografts and prolong their survival. METHODS: Donor cardiac grafts (Brown Norway) were transplanted heterotopically into the abdomen of recipient (Lewis) rats. Treatments consisted of intraperitoneal injections of Nle DPhe -alpha-MSH (NDP-alpha-MSH) or saline from the time of transplantation until sacrifice or spontaneous rejection. Allografts were removed on day 1, day 4, or at the time of rejection and examined for histopathology and expression of molecules prominent in reperfusion injury, transplant rejection, and apoptosis. RESULTS: NDP-alpha-MSH treatment caused a significant increase in allograft survival and a marked decrease in leukocyte infiltration. Expression of molecules such as endothelin 1, chemokines, and adhesion molecules, which are involved in allograft rejection, was significantly inhibited in NDP-alpha-MSH-treated rats. CONCLUSIONS: The results indicate that protection of the allograft from early injury with alpha-MSH can postpone rejection. Addition of this early protection with the peptide to usual treatment with immunosuppressive agents may, therefore, improve success of organ transplants.
PubMed ID
12499879 View in PubMed
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Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis.

https://arctichealth.org/en/permalink/ahliterature169013
Source
J Hepatol. 2006 Nov;45(5):704-10
Publication Type
Article
Date
Nov-2006
Author
Christopher L Bowlus
Tom H Karlsen
Ulrika Broomé
Erik Thorsby
Morten Vatn
Erik Schrumpf
Benedicte A Lie
Kirsten Muri Boberg
Author Affiliation
Division of Gastroenterology, University of California Davis Medical Center, 4150 V Street, PSSB3500, Sacramento, CA 95817, USA.
Source
J Hepatol. 2006 Nov;45(5):704-10
Date
Nov-2006
Language
English
Publication Type
Article
Keywords
Case-Control Studies
Cholangitis, Sclerosing - genetics - immunology
Genetic Predisposition to Disease
Humans
Immunoglobulins - genetics
Inflammatory Bowel Diseases
Intercellular Adhesion Molecule-1 - genetics
Linkage Disequilibrium
Molecular Sequence Data
Mucoproteins - genetics
Norway
Odds Ratio
Polymorphism, Single Nucleotide - genetics
Sweden
Abstract
Mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) has been implicated in the aberrant homing of intestinal lymphocytes to the liver in primary sclerosing cholangitis (PSC). Intercellular adhesion molecule-1 (ICAM-1) has also been implicated in the pathogenesis of PSC and the E/E genotype of the K469E polymorphism has been reported to be associated with PSC susceptibility. The aims of this study were to determine if MAdCAM-1 polymorphisms or the K469E polymorphism of ICAM-1 are associated with PSC in Scandinavia.
Seven single nucleotide polymorphisms (SNPs) in MAdCAM-1 and the G421R and K469E ICAM-1 SNPs were genotyped in 365 PSC patients from Norway and Sweden. 327 Norwegian ulcerative colitis (UC) patients and 368 Norwegian bone marrow donors served as controls.
No significant association with PSC was found for any of the MAdCAM-1 or ICAM-1 SNPs. Allele frequencies for these polymorphisms were not significantly different between PSC patients with UC, UC patients and healthy controls.
Polymorphisms in MAdCAM-1 are not likely to significantly affect PSC susceptibility. In addition, the E/E genotype of the K469E in ICAM-1 does not influence PSC susceptibility in Scandinavia.
Notes
Comment In: J Hepatol. 2006 Nov;45(5):633-516982108
PubMed ID
16750586 View in PubMed
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Antagonism of ICAM-1 attenuates airway and tissue responses to antigen in sensitized rats.

https://arctichealth.org/en/permalink/ahliterature15920
Source
Am J Respir Crit Care Med. 1995 Apr;151(4):1244-9
Publication Type
Article
Date
Apr-1995
Author
T. Nagase
Y. Fukuchi
T. Matsuse
E. Sudo
H. Matsui
H. Orimo
Author Affiliation
Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan.
Source
Am J Respir Crit Care Med. 1995 Apr;151(4):1244-9
Date
Apr-1995
Language
English
Publication Type
Article
Keywords
Airway Resistance
Animals
Antibodies, Monoclonal
Asthma - physiopathology
Bronchi - physiopathology
Bronchial Provocation Tests
Intercellular Adhesion Molecule-1 - physiology
Lung - physiopathology
Lymphocyte Function-Associated Antigen-1 - physiology
Rats
Rats, Inbred BN
Research Support, Non-U.S. Gov't
Time Factors
Abstract
Airway inflammation is involved in the pathogenesis of bronchial asthma. Intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen-1 alpha (LFA-1 alpha) and has been shown to be required for leukocyte migration into inflamed area. The purpose of this report was to investigate the role of ICAM-1/LFA-1 alpha pathway in a rat model of extrinsic asthma using monoclonal antibodies (mAbs). We chose to study ovalbumin (OA)-sensitized Brown-Norway rats, an animal model in which there is a high prevalence of both early (ER) and late responses (LR) after antigen challenge. We measured tracheal and alveolar pressure using alveolar capsules in open-chested, mechanically ventilated animals to calculate resistance of lung (RL), tissue (Rti), and airway (Raw). In the OA group, both ER (RL, Rti, Raw = 263 +/- 16, 235 +/- 10, 309 +/- 38% baseline) and LR (RL, Rti, Raw = 265 +/- 26, 238 +/- 13, 316 +/- 55% baseline) were observed. The administration of mAbs to ICAM-1 and LFA-1 alpha significantly attenuated the ER (RL, Rti, Raw = 146 +/- 9, 141 +/- 11, 156 +/- 8% baseline) and LR (RL, Rti, Raw = 128 +/- 8, 124 +/- 5, 137 +/- 1% baseline), indicating that both airway and lung tissues were involved in this mechanism. The current observations suggest that ICAM-1/LFA-1 alpha pathway is involved in both the early and late responses in a rat model of allergic asthma. The antagonism of ICAM-1 and LFA-1 alpha may provide a potential therapeutic approach to the early and late responses of bronchial asthma.
PubMed ID
7697260 View in PubMed
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The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules.

https://arctichealth.org/en/permalink/ahliterature13769
Source
Clin Immunol. 2005 Feb;114(2):154-63
Publication Type
Article
Date
Feb-2005
Author
Andrew Johnston
Johann Eli Gudjonsson
Hekla Sigmundsdottir
Björn Runar Ludviksson
Helgi Valdimarsson
Author Affiliation
Department of Immunology, Landspitali University Hospital, 101 Reykjavik, Iceland.
Source
Clin Immunol. 2005 Feb;114(2):154-63
Date
Feb-2005
Language
English
Publication Type
Article
Keywords
Adenosine - pharmacology
Anti-Inflammatory Agents - pharmacology
Antigens, Bacterial - immunology
Apoptosis - drug effects - immunology
Cell Adhesion Molecules - antagonists & inhibitors - immunology
Flow Cytometry
Fucosyltransferases - biosynthesis - genetics
Humans
Integrins - immunology
Intercellular Adhesion Molecule-1 - genetics - immunology
Leucovorin - pharmacology
Lymphocyte Activation - drug effects - immunology
Membrane Glycoproteins - genetics - immunology
Methotrexate - pharmacology
RNA - chemistry - genetics
RNA, Messenger - biosynthesis - genetics
Receptors, Interleukin-2 - antagonists & inhibitors - immunology
Research Support, Non-U.S. Gov't
Reverse Transcriptase Polymerase Chain Reaction
Streptococcus pyogenes - immunology
T-Lymphocytes - cytology - drug effects - immunology
Abstract
Low-dose methotrexate (MTX) is an established and highly effective treatment for severe psoriasis and rheumatoid arthritis; however, its mechanism of action remains unclear. We investigated the effects of low-dose MTX on antigen-stimulated peripheral blood mononuclear cells and explored through which cellular pathways these effects are mediated. We show that MTX caused a dose-dependent suppression of T cell activation and adhesion molecule expression, and this was not due to lymphocyte apoptosis. The suppression of intercellular adhesion molecule (ICAM)-1 was adenosine and folate-dependent, while MTX suppression of the skin-homing cutaneous lymphocyte-associated antigen (CLA) was adenosine-independent. The effect of MTX on CLA, but not ICAM-1, required the constant presence of MTX in cultures. Thus, the suppression of T cell activation and T cell adhesion molecule expression, rather than apoptosis, mediated in part by adenosine or polyglutamated MTX or both, are important mechanisms in the anti-inflammatory action of MTX.
PubMed ID
15639649 View in PubMed
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Baseline ICAM-1 and VCAM-1 are increased in initially healthy middle-aged men who develop cardiovascular disease during 6.6 years of follow-up.

https://arctichealth.org/en/permalink/ahliterature157012
Source
Angiology. 2009 Feb-Mar;60(1):108-14
Publication Type
Article
Author
Caroline Schmidt
Johannes Hulthe
Björn Fagerberg
Author Affiliation
Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden. caroline.schmidt@wlab.gu.se
Source
Angiology. 2009 Feb-Mar;60(1):108-14
Language
English
Publication Type
Article
Keywords
Atherosclerosis - immunology - ultrasonography
Biological Markers - blood
Cardiovascular Diseases - immunology - ultrasonography
Carotid Artery Diseases - immunology - ultrasonography
Disease Progression
Femoral Artery - ultrasonography
Follow-Up Studies
Humans
Intercellular Adhesion Molecule-1 - blood
Male
Middle Aged
Odds Ratio
Risk assessment
Risk factors
Sweden
Time Factors
Up-Regulation
Vascular Cell Adhesion Molecule-1 - blood
Abstract
The objective of the present study was to investigate if there was a difference in baseline serum concentrations of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) between groups with and without cardiovascular events during a mean follow-up of 6.6 years in a group of initially healthy 58-year-old men. A further aim was to examine if high serum concentrations of ICAM-1 and VCAM-1 were associated with carotid and femoral artery plaque occurrence, separately. Men with cardiovascular events during follow-up had higher median serum ICAM-I and VCAM-I than those without events (P
PubMed ID
18504269 View in PubMed
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Biomarkers of endothelial activation and thrombosis in tunnel construction workers exposed to airborne contaminants.

https://arctichealth.org/en/permalink/ahliterature285393
Source
Int Arch Occup Environ Health. 2017 May;90(4):309-317
Publication Type
Article
Date
May-2017
Author
Dag G Ellingsen
Ingebjørg Seljeflot
Yngvar Thomassen
Magny Thomassen
Berit Bakke
Bente Ulvestad
Source
Int Arch Occup Environ Health. 2017 May;90(4):309-317
Date
May-2017
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Biomarkers - blood
CD40 Ligand - blood
Carbon - analysis
Construction Industry
Fatty Acids - blood
Humans
Intercellular Adhesion Molecule-1 - blood
Male
Middle Aged
Norway
Occupational Exposure - analysis
P-Selectin - blood
Particulate Matter - analysis
Platelet Activation
Quartz - analysis
Thrombosis
Tumor Necrosis Factor-alpha - blood
Vehicle Emissions
Abstract
The aims were to study biomarkers of systemic inflammation, platelet/endothelial activation and thrombosis in tunnel construction workers (TCW).
Biomarkers and blood fatty acids were measured in blood of 90 TCW and 50 referents before (baseline) and towards the end (follow-up) of a 12 days work period. They had been absent from work for 9 days at baseline. Air samples were collected by personal sampling.
Personal thoracic air samples showed geometric mean (GM) particulate matter and a-quartz concentrations of 604 and 74 µg/m(3), respectively. The arithmetic mean (AM) concentration of elemental carbon was 51 µg/m(3). The GM (and 95% confidence interval) concentration of the pro-inflammatory cytokine TNF-a decreased from 2.2 (2.0-2.4) at baseline to 2.0 pg/mL (1.8-2.2) (p?=?0.02) at follow-up among the TCW. Also the platelet activation biomarkers P-selectin and CD40L decreased significantly [25.4 (24.1-26.6) to 24.4 (22.9-26.0)] ng/mL, p?=?0.04 and 125 (114-137) to 105 (96-115) pg/mL, p?
Notes
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PubMed ID
28124139 View in PubMed
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Biomarkers of inflammation in workers exposed to compost and sewage dust.

https://arctichealth.org/en/permalink/ahliterature284245
Source
Int Arch Occup Environ Health. 2016 Jul;89(5):711-8
Publication Type
Article
Date
Jul-2016
Author
Kari Kulvik Heldal
Lars Barregard
Dag G Ellingsen
Source
Int Arch Occup Environ Health. 2016 Jul;89(5):711-8
Date
Jul-2016
Language
English
Publication Type
Article
Keywords
Adult
Aerosols - analysis
Air Pollutants, Occupational - adverse effects
Biomarkers - blood
C-Reactive Protein - analysis
Dust
Endotoxins - blood
Environmental Monitoring - methods
Enzyme-Linked Immunosorbent Assay
Female
Fibrin Fibrinogen Degradation Products - analysis
Fibrinogen - analysis
Forced Expiratory Volume - physiology
Humans
Inflammation Mediators - blood
Inhalation Exposure - adverse effects
Intercellular Adhesion Molecule-1 - blood
Interleukin-6 - blood
Male
Middle Aged
Norway
Occupational Exposure - adverse effects
Sewage - adverse effects
Soil
Vascular Cell Adhesion Molecule-1 - blood
Abstract
The association between exposure during handling of sewage and compost and the serum concentration of inflammatory biomarkers was studied.
A total of 44 workers exposed to sewage dust, 47 workers exposed to compost dust and 38 referents from the administrative staff participated. Microbial aerosols were collected by personal inhalable samplers. The concentrations of bacterial cells, spores from fungi and bacteria (actinomycetes) and endotoxins were determined by fluorescence and scanning electron microscopy and the Limulus assay. Fibrinogen, D-dimer, ICAM-1, VCAM-1 and IL-6 were determined by ELISA and C-reactive protein (CRP) by HS-MicroCRP assay in blood samples collected post-shift.
The exposure to dust ranged from 0.02 to 11 mg/m(3), endotoxins from 1 to 3160 EU/m(3) and bacteria from 0 to 209 × 10(6) cells/m(3). Fungal (0-41 × 10(6) spores/m(3)) and actinomycetes spores (0-590 × 10(6) actinomycetes spores/m(3)) were observed only at compost plants. The exposed workers had significantly higher fibrinogen (arithmetic mean 3.3 mg/ml) and CRP (geometric mean 1.5 mg/L) compared to the referents (2.8 and 1.0 mg/L, respectively). The serum concentration of CRP was negatively associated with forced expiratory volume in one second (FEV1) in  % of predicted. Exposure to inhalable dust and bacteria was positively associated with the serum concentration of ICAM-1.
This study suggests that exposure to bacteria and dust when handling sewage and compost may initiate an inflammation shown by an increase in serum concentration of ICAM-1. The higher concentrations of fibrinogen and CRP in exposed workers compared to the referents may reflect a low-grade systemic inflammation.
PubMed ID
26700569 View in PubMed
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[Changes in cell adhesion molecules under the influence of surgical treatment in patients with acute thrombophlebitis of the subcutaneous veins in the lower extremities]

https://arctichealth.org/en/permalink/ahliterature52084
Source
Klin Khir. 2003 Aug;(8):35-7
Publication Type
Article
Date
Aug-2003
Author
I V Dmytriv
R V Kutsyk
S M Henyk
Source
Klin Khir. 2003 Aug;(8):35-7
Date
Aug-2003
Language
Ukrainian
Publication Type
Article
Keywords
Acute Disease
Adult
Aged
Combined Modality Therapy
English Abstract
Female
Fibrinolytic Agents - therapeutic use
Humans
Intercellular Adhesion Molecule-1 - metabolism
Lower Extremity - blood supply - surgery
Male
Middle Aged
Postoperative Period
Thrombophlebitis - drug therapy - metabolism - surgery
Vascular Surgical Procedures - methods
Abstract
The content of soluble molecules of intercellular adhesion-1 (sICAM-1) in 60 patients with an acute thrombophlebitis (TP) of the lower extremities subcutaneous veins was studied preoperatively and 7 days after the operation using method of a solid phase immunoenzymatic analysis (IEA). The sICAM-1 level before treatment in men was increased at average by 75.8% (P
PubMed ID
14610792 View in PubMed
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Contribution of intercellular-adhesion molecule-1 in allergen-induced airway hyperresponsiveness and inflammation in sensitised brown-Norway rats.

https://arctichealth.org/en/permalink/ahliterature15953
Source
Int Arch Allergy Immunol. 1994 Jul;104(3):291-5
Publication Type
Article
Date
Jul-1994
Author
J. Sun
W. Elwood
A. Haczku
P J Barnes
P G Hellewell
K F Chung
Author Affiliation
Department of Thoracic Medicine, National Heart and Lung Institute, London, UK.
Source
Int Arch Allergy Immunol. 1994 Jul;104(3):291-5
Date
Jul-1994
Language
English
Publication Type
Article
Keywords
Allergens - immunology
Animals
Asthma - immunology - prevention & control
Bronchial Hyperreactivity - immunology - prevention & control
Bronchial Provocation Tests
Bronchoalveolar Lavage Fluid - cytology
Cell Adhesion Molecules - immunology
Eosinophils - immunology
Female
Inflammation - pathology
Intercellular Adhesion Molecule-1
Leukocyte Count
Lymphocytes - immunology
Ovalbumin
Rats
Rats, Inbred BN
Research Support, Non-U.S. Gov't
Abstract
We investigated the potential role of intercellular-adhesion molecule-1 (ICAM-1) in allergen-induced bronchial hyperresponsiveness (BHR) and inflammation in sensitised Brown-Norway rats. Rats were sensitised with ovalbumin (OA) intraperitoneally and 21 days later they were either exposed to 0.9% NaCl or 1% OA aerosol for 15 min. Rats exposed to OA aerosol were pretreated either with ICAM-1 antibody (3 mg/kg i.p. and i.v., 45 min prior to OA exposure) or with the diluent for the antibody. Eighteen to twenty-four hours after OA or 0.9% NaCl exposure, rats were anaesthetised, tracheostomised and mechanically ventilated, and airway responsiveness to acetylcholine (ACh) aerosol was measured as the provocative concentration of ACh needed to increase pulmorary resistance by 100% (PC100). Mean -log PC100 was increased in rats exposed to OA but pretreated with diluent (2.75 +/- 0.06) compared to rats treated with ICAM-1 antibody (2.51 +/- 0.08;
PubMed ID
7913357 View in PubMed
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45 records – page 1 of 5.