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Acarbose for the treatment of type II diabetes: the results of a Canadian multi-centre trial.

https://arctichealth.org/en/permalink/ahliterature214600
Source
Diabetes Res Clin Pract. 1995 Aug;28 Suppl:S167-72
Publication Type
Article
Date
Aug-1995
Author
R G Josse
Author Affiliation
Division of Endocrinology and Metabolism, St. Michael's Hospital, University of Toronto, Ontario, Canada.
Source
Diabetes Res Clin Pract. 1995 Aug;28 Suppl:S167-72
Date
Aug-1995
Language
English
Publication Type
Article
Keywords
Acarbose
Blood Glucose - drug effects - metabolism
Canada
Diabetes Mellitus, Type 2 - drug therapy
Diabetic diet
Female
Hemoglobin A, Glycosylated - analysis
Humans
Hypoglycemic agents - therapeutic use
Insulin - therapeutic use
Male
Metformin - therapeutic use
Middle Aged
Placebos
Sulfonylurea Compounds - therapeutic use
Time Factors
Trisaccharides - therapeutic use
Abstract
The treatment of Type II diabetes (NIDDM) includes an appropriate diet and prudent exercise program. If these measures are insufficient to control the blood sugar, oral agents (sulphonylureas or biguanides) or insulin are added to the therapeutic regimen. Although the diet prescription has undergone some changes and refinements, this approach has been the traditional treatment for NIDDM for nearly 40 years. Recently a new class of oral agents, the alpha-glucosidase inhibitors, has become available. These drugs are competitive inhibitors of the alpha-glucosidase enzymes in the brush border of the bowel wall. They act to slow and delay the rate of carbohydrate absorption, thereby decreasing postprandial hyperglycemia. A recent study was designed to evaluate the long-term efficacy of acarbose, an alpha-glucosidase inhibitor, in improving the glycemic control of patients with NIDDM who were sub-optimally controlled on either diet alone, or diet plus sulphonylurea, metformin or insulin. A total of 354 patients with NIDDM were studied, 77 on diet alone, 83 on metformin, 103 and sulphonylurea and 91 on insulin. Subjects in each treatment stratum were randomized, double-blind to either acarbose or placebo, for 1 year. At baseline and every 3 months thereafter, fasting and postprandial glucose and C-peptide, HbA1c and fasting lipids were measured. Compared to placebo, acarbose treatment resulted in a decrease in mean postprandial glucose in all four strata (19 +/- 0.8 to 15.3 +/- 0.7 mmol/l: P
Notes
Erratum In: Diabetes Res Clin Pract 1995 Sep;29(3):215
PubMed ID
8529510 View in PubMed
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[A case of transient diabetes mellitus in a 5-month old infant]

https://arctichealth.org/en/permalink/ahliterature49076
Source
Pediatr Akus Ginekol. 1970;3:28-9
Publication Type
Article
Date
1970

[A case report. Rosiglitazone treatment was highly effective yet had to be terminated]

https://arctichealth.org/en/permalink/ahliterature47573
Source
Lakartidningen. 2002 Jan 31;99(5):407-10
Publication Type
Article
Date
Jan-31-2002
Author
Martin Ridderstråle
Leif Groop
Author Affiliation
Endokrinologiska kliniken, Universitetssjukhuset MAS, Malmö. martin.ridderstrale@endo.mas.lu.se
Source
Lakartidningen. 2002 Jan 31;99(5):407-10
Date
Jan-31-2002
Language
Swedish
Publication Type
Article
Keywords
Administration, Oral
Diabetes Mellitus, Type 2 - complications - drug therapy
English Abstract
Female
Heart Failure, Congestive - complications - drug therapy
Hemoglobin A, Glycosylated - drug effects
Humans
Hypoglycemic Agents - administration & dosage - contraindications
Insulin - therapeutic use
Middle Aged
Thiazoles - administration & dosage - contraindications
Thiazolidinediones
Treatment Outcome
Abstract
The thiazolidinediones were introduced as oral hypoglycemic drugs in Sweden during the fall of 2000. A case is reported in which a woman with insulin-dependent type-2 diabetes and both macro- and microangiopathy and pronounced insulin resistance was treated with rosiglitazone (Avandia). Within three months insulin doses could be reduced by 36% (from 176 to 112 units insulin daily) and concomitantly Ery-HbA1c was reduced from 8.4 to 5.3%. In spite of this dramatic effect on glucose homeostasis administration of the drug had to be discontinued due to critical congestive heart failure.
PubMed ID
11881246 View in PubMed
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Adaptation of the Diabetes Health Profile (DHP-1) for use with patients with Type 2 diabetes mellitus: psychometric evaluation and cross-cultural comparison.

https://arctichealth.org/en/permalink/ahliterature47802
Source
Diabet Med. 2000 Aug;17(8):572-80
Publication Type
Article
Date
Aug-2000
Author
K A Meadows
C. Abrams
A. Sandbaek
Author Affiliation
Health and Survey Research Unit, Applied Statistics Centre, University of Hull, UK. k.a.meadows@maths.hull.ac.uk
Source
Diabet Med. 2000 Aug;17(8):572-80
Date
Aug-2000
Language
English
Publication Type
Article
Keywords
Affect
Comparative Study
Cross-Cultural Comparison
Denmark
Diabetes Mellitus, Type 2 - physiopathology - psychology - therapy
Diabetic diet
Female
Great Britain
Health status
Humans
Hypoglycemic agents - therapeutic use
Insulin - therapeutic use
Language
Male
Middle Aged
Psychometrics
Quality of Life
Questionnaires
Reproducibility of Results
Research Support, Non-U.S. Gov't
Social Behavior
Abstract
AIMS: To adapt the Diabetes Health Profile (DHP-1) for use with English speaking patients with Type 2 diabetes mellitus and to evaluate the psychometric properties of the adapted measure in a UK and Danish sample of insulin, tablet and diet-treated patients with Type 2 diabetes. METHODS: Following linguistic adaptation using the forward-backward translation procedure, the 32-item DHP-1 was sent to 650 and 800 consecutively selected UK and Danish patients with Type 2 diabetes. Construct validity was assessed using principal axis factoring. Factor stability was assessed across language groups using the coefficient of congruence. Reliability was evaluated using Cronbach's alpha and multi-trait analysis, including item convergent/discriminant validity. Subscale discriminant validity was assessed through known groups with one-way ANOVA and post hoc Scheffe tests for multiple comparisons. RESULTS: Eighteen items (56.25%) were retained following initial item analysis. A three-factor solution accounting for 45.6% and 40.3% of the total explained variance was identified in the UK and Danish samples, respectively. Factors were interpreted as psychological distress (PD), barriers to activity (BA) and disinhibited eating (DE). Factor congruence between language groups ranged from 0.98 to 0.99 and Cronbach's alpha ranged between 0.70 and 0.88. Item scaling success for both language versions was 88.9%. BA scores discriminated between treatment groups in both language groups (F = 24.24, P
PubMed ID
11073178 View in PubMed
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Adherence to self-care and glycaemic control among people with insulin-dependent diabetes mellitus.

https://arctichealth.org/en/permalink/ahliterature47709
Source
J Adv Nurs. 2001 Jun;34(6):780-6
Publication Type
Article
Date
Jun-2001
Author
M. Toljamo
M. Hentinen
Author Affiliation
Department of Nursing and Health Administration, Oulu University Hospital, Box 5000 University of Oulu, FIN-90 014, Finland. maisa.toljamo@oulu.fi
Source
J Adv Nurs. 2001 Jun;34(6):780-6
Date
Jun-2001
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Blood Glucose Self-Monitoring
Cross-Sectional Studies
Diabetes Mellitus, Type 1 - rehabilitation
Female
Finland
Hemoglobin A, Glycosylated - metabolism
Humans
Insulin - therapeutic use
Logistic Models
Male
Middle Aged
Patient compliance
Risk factors
Self Care - psychology
Abstract
AIM OF THE STUDY: Factors associated with adherence to self-care and glycaemic control were studied in 213 people with insulin-dependent diabetes mellitus using a self-report questionnaire and a biochemical indicator (glycosylated haemoglobin). METHODS: The data were collected in the Oulu Health Center and the Central Hospital of Lapland in Northern Finland. The response rate was 76%. In order to verify the reliability and validity of the instruments, we used correlation coefficients, factor analysis and item-total analysis. Internal consistency was checked by Cronbach's alpha. The connections between self-care and the background variables were examined by cross-tabulation. FINDINGS: The majority of subjects accomplished their insulin treatment as scheduled, but had more difficulties with the other aspects of self-care. According to the findings, a fifth (19%) of the respondents were neglecting their self-care. The others undertook flexible (46%), regimen-adherent (16%) or self-planned self-care (19%). The subjects who were adherent to self-care had better metabolic control than those who neglected self-care. According to logistic regression analysis, poor metabolic control (P=0.003), smoking (P=0.009) and living alone (P=0.014) were associated with neglect of self-care. Gender, concurrent diseases and complications as a result of diabetes increased the risk, but had no significant association with adherence to or neglect of self-care. CONCLUSION: The findings demonstrated that adherence to self-care does not always lead to good metabolic control, but neglect of self-care is likely to lead to poor metabolic control.
PubMed ID
11422548 View in PubMed
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Adiposity in 277 young adult male offspring of women with diabetes compared with controls: a Danish population-based cohort study.

https://arctichealth.org/en/permalink/ahliterature125402
Source
Acta Obstet Gynecol Scand. 2012 Jul;91(7):838-43
Publication Type
Article
Date
Jul-2012
Author
Gunnar Lauge Nielsen
Claus Dethlefsen
Søren Lundbye-Christensen
Jan Fog Pedersen
Lars Mølsted-Pedersen
Matt W Gillman
Author Affiliation
Department of Internal Medicine, Himmerland Hospital, Farsø, Denmark. guln@rn.dk
Source
Acta Obstet Gynecol Scand. 2012 Jul;91(7):838-43
Date
Jul-2012
Language
English
Publication Type
Article
Keywords
Adiposity - genetics
Case-Control Studies
Confidence Intervals
Denmark - epidemiology
Diabetes, Gestational - drug therapy - epidemiology
Female
Humans
Hypoglycemic agents - therapeutic use
Insulin - therapeutic use
Male
Military Personnel
Personnel Selection
Population Surveillance
Pregnancy
Pregnancy in Diabetics - drug therapy - epidemiology
Risk factors
Young Adult
Abstract
To examine the associations of maternal diabetes, overall and stratified according to treatment of diabetes, with weight-related outcomes at the time of military conscription, at age 18-20 years.
Cohort study of 277 Danish male offspring of mothers with recognized pre-gestational or gestational diabetes. As population-based controls we selected 870 men matched from the Civil Registration Office.
Data on weight-related outcomes were retrieved from the Danish military conscription registry.
Military rejection due to adiposity and body mass index (BMI) at conscription.
Army rejection rate due to adiposity was 5.8% (n= 16) among 277 diabetes mellitus-exposed men compared with 3.1% (n= 27) in 870 controls (risk difference 2.7 (95% confidence interval (CI) -0.3-5.7)) and mean BMI at conscription was 1.4 kg/m(2) (95%CI 0.8-2.0) higher among those diabetes mellitus-exposed men. In analyses adjusted for birthweight and gestational age, compared with controls, the BMI was 0.6 kg/m(2) (95%CI -0.3-1.5) higher in sons of mothers with pre-gestational and 2.7 kg/m(2) (95% (CI): 0.9-4.5) higher with gestational diabetes. The greatest BMI difference was in offspring of mothers with gestational diabetes in whom insulin was initiated during pregnancy. We found no difference in conscript height.
Compared with controls, male offspring of women with diabetes had a higher rejection rate due to adiposity and higher adult BMI. Subgroup analyses showed that the association was most pronounced in sons of mothers with gestational diabetes, whereas pre-gestational diabetes was only weakly associated with higher offspring BMI.
PubMed ID
22486385 View in PubMed
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Admission Hyperglycemia and Clinical Outcome in Cerebral Venous Thrombosis.

https://arctichealth.org/en/permalink/ahliterature273503
Source
Stroke. 2016 Feb;47(2):390-6
Publication Type
Article
Date
Feb-2016
Author
Susanna M Zuurbier
Sini Hiltunen
Turgut Tatlisumak
Guusje M Peters
Suzanne M Silvis
Elena Haapaniemi
Nyika D Kruyt
Jukka Putaala
Jonathan M Coutinho
Source
Stroke. 2016 Feb;47(2):390-6
Date
Feb-2016
Language
English
Publication Type
Article
Keywords
Adult
Anticoagulants - therapeutic use
Cerebral Hemorrhage - epidemiology - therapy
Cohort Studies
Coma - epidemiology
Comorbidity
Decompressive Craniectomy
Female
Finland - epidemiology
Humans
Hyperglycemia - drug therapy - epidemiology
Hypoglycemic agents - therapeutic use
Insulin - therapeutic use
Intensive Care Units - utilization
Intracranial Thrombosis - epidemiology - mortality - therapy
Logistic Models
Male
Middle Aged
Netherlands - epidemiology
Odds Ratio
Prognosis
Retrospective Studies
Severity of Illness Index
Sinus Thrombosis, Intracranial - epidemiology - mortality - therapy
Venous Thrombosis - epidemiology - mortality - therapy
Abstract
Admission hyperglycemia is associated with poor clinical outcome in ischemic and hemorrhagic stroke. Admission hyperglycemia has not been investigated in patients with cerebral venous thrombosis.
Consecutive adult patients with cerebral venous thrombosis were included at the Academic Medical Center, The Netherlands (2000-2014) and the Helsinki University Central Hospital, Finland (1998-2014). We excluded patients with known diabetes mellitus and patients without known admission blood glucose. We defined admission hyperglycemia as blood glucose =7.8 mmol/L (141 mg/dL) and severe hyperglycemia as blood glucose =11.1 mmol/L (200 mg/dL). We used logistic regression analysis to determine if admission hyperglycemia was associated with modified Rankin Scale (mRS) score of 3 to 6 or mortality at last follow-up. We adjusted for: age, sex, coma, malignancy, infection, intracerebral hemorrhage, deep cerebral venous thrombosis, and location of recruitment.
Of 380 patients with cerebral venous thrombosis, 308 were eligible. Of these, 66 (21.4%) had admission hyperglycemia with 8 (2.6%) having severe admission hyperglycemia. Coma (31.3% versus 5.0%, P
PubMed ID
26670083 View in PubMed
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An algorithm to differentiate diabetic respondents in the Canadian Community Health Survey.

https://arctichealth.org/en/permalink/ahliterature157393
Source
Health Rep. 2008 Mar;19(1):71-9
Publication Type
Article
Date
Mar-2008
Author
Edward Ng
Kaberi Dasgupta
Jeffrey A Johnson
Author Affiliation
Health Information and Research Division at Statistics Canada in Ottawa, Ontario K1A 0T6. Edward.Ng@statcan.ca
Source
Health Rep. 2008 Mar;19(1):71-9
Date
Mar-2008
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Algorithms
Canada
Decision Trees
Diabetes Mellitus - classification - diagnosis - drug therapy - physiopathology
Female
Health Surveys
Humans
Hypoglycemic agents - therapeutic use
Insulin - therapeutic use
Male
Pregnancy
Abstract
This article describes an algorithm to classify respondents to cycle 1.1 (2000/2001) of the Canadian Community Health Survey (CCHS) according to whether they have type 1, type 2 or gestational diabetes.
The data are from the chronic disease module and the drug module of cycle 1.1 of the CCHS.
A total of 6,361 respondents to cycle 1.1 of the CCHS reported that a health care professional had diagnosed them as having diabetes. The Ng-Dasgupta-Johnson algorithm classifies this group according to whether they have type 1, type 2 or gestational diabetes, based on their answers to CCHS questions about diabetes during pregnancy, use of oral medications to control diabetes, use of insulin, timing of initiation of insulin treatment, and age at diagnosis.
Application of an earlier algorithm to CCHS cycle 1.1 results in a 10%-90% split for type 1 and type 2 diabetes. By contrast, the Ng-Dasgupta-Johnson algorithm yields a 5%-95% split. This is not unreasonable, given the rapid rise in obesity, a major risk factor for type 2 diabetes, in Canada.
PubMed ID
18457213 View in PubMed
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Analyses of data quality in registries concerning diabetes mellitus--a comparison between a population based hospital discharge and an insulin prescription registry.

https://arctichealth.org/en/permalink/ahliterature48317
Source
J Med Syst. 1996 Feb;20(1):1-10
Publication Type
Article
Date
Feb-1996
Author
G L Nielsen
H T Sørensen
A B Pedersen
S. Sabroe
Author Affiliation
Department of Internal Medicine M, Aalborg Hospital, Denmark.
Source
J Med Syst. 1996 Feb;20(1):1-10
Date
Feb-1996
Language
English
Publication Type
Article
Keywords
Comparative Study
Denmark - epidemiology
Diabetes Mellitus - drug therapy - epidemiology
Humans
Insulin - therapeutic use
Medical Record Linkage
Patient Discharge - statistics & numerical data
Predictive value of tests
Prescriptions, Drug - statistics & numerical data
Registries - standards
Research Support, Non-U.S. Gov't
Abstract
To evaluate the data quality in the Danish National Registry of Patients (DNRP) and the Prescription Registry in the country of Northern Jutland (487,000 inhabitants) concerning insulin dependent diabetes mellitus (IDDM) and insulin treated diabetes mellitus, a comparison between data in the two registries was made. From the Regional Hospital Registry in the County of Northern Jutland, containing discharge diagnoses from all admissions to hospitals in the county, we identified all patients with the IDDM diagnosis between 1987 and 1993. From the Regional Prescription Registry all insulin prescriptions taken up at pharmacies in the county in 1993 were identified. All persons were identified by their individual identification number (CPR-number), and a record linkage between the two data sources was made. The predictive value of an IDDM-registration in the DNRP was 96% and the corresponding completeness 91%. In the Prescription Registry the completeness was 96%. Both registries seem to be valuable study bases for epidemiological research in diabetes mellitus.
PubMed ID
8708487 View in PubMed
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228 records – page 1 of 23.