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[Clinical and paraclinical correlations in late pregnancy toxicoses according to autonomic reactivity data]

https://arctichealth.org/en/permalink/ahliterature65989
Source
Pediatr Akus Ginekol. 1978 Nov-Dec;(6):38-9
Publication Type
Article

Insulin resistance, impaired early insulin response, and insulin propeptides as predictors of the development of type 2 diabetes: a population-based, 7-year follow-up study in 70-year-old men.

https://arctichealth.org/en/permalink/ahliterature47237
Source
Diabetes Care. 2004 Jun;27(6):1433-8
Publication Type
Article
Date
Jun-2004
Author
Björn Zethelius
C Nicholas Hales
Hans O Lithell
Christian Berne
Author Affiliation
Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University, Box 609, SE-75125 Uppsala, Sweden. bjorn.zethelius@pubcare.uu.se
Source
Diabetes Care. 2004 Jun;27(6):1433-8
Date
Jun-2004
Language
English
Publication Type
Article
Keywords
Aged
Anthropometry
Blood Glucose - drug effects - metabolism
Body Size
Diabetes Mellitus, Type 2 - blood - epidemiology
European Continental Ancestry Group
Follow-Up Studies
Glucose Clamp Technique
Health Surveys
Humans
Incidence
Insulin - diagnostic use - pharmacology
Insulin Resistance
Male
Models, Biological
Proinsulin - blood
Research Support, Non-U.S. Gov't
Sweden - epidemiology
Abstract
OBJECTIVE: Defects in insulin secretion and insulin action are the major abnormalities in the development of type 2 diabetes. In middle-aged subjects, elevated plasma proinsulin has been found to predict type 2 diabetes. Therefore, our aim was to study the longitudinal relationships between baseline determinations of insulin sensitivity index (S(i)) assessed by euglycemic insulin clamp, the early insulin response (EIR) at an oral glucose tolerance test (OGTT), fasting intact proinsulin, 32-33 split proinsulin and specific insulin, and the development of type 2 diabetes in a population-based cohort of 70-year-old nondiabetic men (n = 667) with 7-year follow-up. RESEARCH DESIGN AND METHODS: A euglycemic insulin clamp study and a 75-g OGTT were performed at baseline, and fasting peptide concentrations were measured using specific two-site immunometric assays. Results from logistic regression models are presented as odds ratios (ORs) with 95% CIs for a 1-SD increase in the predictor variable. RESULTS: In separate multivariate analyses adjusted for EIR (OR 0.72, 95% CI 0.59-0.89) and S(i) (0.68, 0.58-0.88), 32-33 split proinsulin (1.49, 1.18-1.88) or intact proinsulin (1.30, 1.04-1.63) were significantly associated with the development of type 2 diabetes, whereas specific insulin (1.24, 0.91-1.66) was not. The significant associations between 32-33 split or intact proinsulin and the development of type 2 diabetes were unaltered after adjustment for BMI and glucose tolerance. CONCLUSIONS: Insulin propeptides predicted type 2 diabetes over a 7-year period in elderly men, independent of the EIR and S(i).
PubMed ID
15161800 View in PubMed
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Pituitary size and function in children and adolescents with shunted hydrocephalus.

https://arctichealth.org/en/permalink/ahliterature34237
Source
Clin Endocrinol (Oxf). 1997 Jun;46(6):691-9
Publication Type
Article
Date
Jun-1997
Author
T. Löppönen
E. Pääkkö
J. Laitinen
A L Saukkonen
W. Serlo
P. Tapanainen
A. Ruokonen
P. Pirttiniemi
A. Poikela
M. Knip
Author Affiliation
Department of Paediatrics, University of Oulu, Finland.
Source
Clin Endocrinol (Oxf). 1997 Jun;46(6):691-9
Date
Jun-1997
Language
English
Publication Type
Article
Keywords
Adolescent
Arginine - diagnostic use
Body Height
Body mass index
Cerebrospinal Fluid Shunts
Child
Child, Preschool
Cross-Sectional Studies
Female
Follicle Stimulating Hormone - blood
Follow-Up Studies
Growth Hormone - blood
Humans
Hydrocephalus - pathology - physiopathology - surgery
Insulin - diagnostic use
Luteinizing Hormone - blood
Magnetic Resonance Imaging
Male
Pituitary Gland - pathology - physiopathology
Research Support, Non-U.S. Gov't
Abstract
OBJECTIVE: Most previous reports of endocrine disorders in children with shunted hydrocephalus have been case reports and there is a lack of systematic information on pituitary anatomy and function among these children. We have obtained these data in a large group of individuals with shunted hydrocephalus. DESIGN: A controlled cross-sectional study. PATIENTS: Fifty-four children and adolescents with shunted hydrocephalus were studied for pituitary anatomy and function. They had 54 age- and sex-matched controls (group I). The mean age of the patients and controls was 12.6 years and the mean shunting period 10.6 years. There was a second control group (II) for the magnetic resonance imaging (MRI) and a third control group (III) for the radiography of the sella turcica. MEASUREMENTS: The anatomy was visualized by MRI of the pituitary gland and by radiography of the sella turcica. The functional evaluation included an arginine-insulin test and a combined stimulation test with corticotrophin releasing factor (CRF), GnRH and TRH. RESULTS: The patients were shorter (height 148.4 cm vs 153.7 cm, P
PubMed ID
9274699 View in PubMed
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Prediction of the growth response of short prepubertal children treated with growth hormone. Swedish Paediatric Study Group for GH treatment.

https://arctichealth.org/en/permalink/ahliterature35512
Source
Acta Paediatr. 1995 Jan;84(1):51-7
Publication Type
Article
Date
Jan-1995
Author
B. Kriström
J. Karlberg
K. Albertsson-Wikland
Author Affiliation
Department of Paediatrics, University of Umeå, Sweden.
Source
Acta Paediatr. 1995 Jan;84(1):51-7
Date
Jan-1995
Language
English
Publication Type
Article
Keywords
Adolescent
Arginine - diagnostic use
Body Height - drug effects
Child
Child, Preschool
Female
Growth - drug effects
Growth Disorders - blood - drug therapy - physiopathology
Growth Hormone - blood - therapeutic use
Humans
Insulin - diagnostic use
Male
Predictive value of tests
Puberty
Regression Analysis
Research Support, Non-U.S. Gov't
Sweden
Abstract
The aim of this study was to identify predictors of the growth response to growth hormone (GH) during the first 2 years of GH treatment, using auxological data and the maximum GH response (GHmax) to provocation tests. The patients were 169 prepubertal short children (27F, 142M), with Gmax values ranging from 0 to 65 mU/l. Their mean age (+/- SD) was 8.3 +/- 2.4 years (range 3-13 years), mean height SDS -3.0 +/- 0.7 (range -1.5 to -6.0 SDS) and mean pretreatment height velocity was normal (+/- 0.0 SDS) (range -1.6 to +0.9 SDS). The increase in height SDS during the first 2 years of GH treatment (0.1 U/kg/day) varied from 0.10 to 3.75 SDS, with younger children having a better growth response. Individual growth responses correlated (p
PubMed ID
7734899 View in PubMed
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