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A 5-year follow-up study of disease incidence in men with an abnormal hormone pattern.

https://arctichealth.org/en/permalink/ahliterature47352
Source
J Intern Med. 2003 Oct;254(4):386-90
Publication Type
Article
Date
Oct-2003
Author
R. Rosmond
S. Wallerius
P. Wanger
L. Martin
G. Holm
P. Björntorp
Author Affiliation
Cardiovascular Institute, Sahlgrenska University Hospital, Göteborg, Sweden.
Source
J Intern Med. 2003 Oct;254(4):386-90
Date
Oct-2003
Language
English
Publication Type
Article
Keywords
Angina Pectoris - epidemiology - metabolism
Biological Markers - blood
Blood pressure
Cardiovascular Diseases - epidemiology - metabolism
Cerebrovascular Accident - epidemiology - metabolism
Cohort Studies
Diabetes Mellitus, Type 2 - epidemiology - metabolism
Follow-Up Studies
Glucose - analysis
Humans
Hydrocortisone - analysis
Hypertension - epidemiology - metabolism
Incidence
Insulin - analysis
Male
Middle Aged
Myocardial Infarction - epidemiology - metabolism
Sweden - epidemiology
Testosterone - blood
Abstract
OBJECTIVES: Previous studies have suggested that abnormal levels of cortisol and testosterone might increase the risk of serious somatic diseases. To test this hypothesis, we conducted a 5-year follow-up study in middle-aged men. METHODS: A population-based cohort study conducted in 1995 amongst 141 Swedish men born in 1944, in whom a clinical examination supplemented by medical history aimed to disclose the presence of cardiovascular disease (CVD) (myocardial infarction, angina pectoris, stroke), type 2 diabetes and hypertension were performed at baseline and at follow-up in the year 2000. In addition, salivary cortisol levels were measured repeatedly over the day. Serum testosterone concentrations were also determined. Using the baseline data, an algorithm was constructed, which classified the secretion pattern of cortisol and testosterone from each individual as being normal or abnormal. RESULTS: By the end of follow-up, men with an abnormal hormone secretion pattern (n = 73) had elevated mean arterial pressure (P = 0.003), fasting insulin (P = 0.009) and insulin : glucose ratio (P = 0.005) compared with men with a normal secretion pattern (n = 68). Body mass index, waist circumference, and waist : hip ratio were significantly elevated in both groups. However, the 5-year incidence of CVD, type 2 diabetes, and hypertension were significantly higher (P
PubMed ID
12974877 View in PubMed
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Amniotic fluid phthalate levels and male fetal gonad function.

https://arctichealth.org/en/permalink/ahliterature264835
Source
Epidemiology. 2015 Jan;26(1):91-9
Publication Type
Article
Date
Jan-2015
Author
Morten Søndergaard Jensen
Ravinder Anand-Ivell
Bent Nørgaard-Pedersen
Bo A G Jönsson
Jens Peter Bonde
David M Hougaard
Arieh Cohen
Christian H Lindh
Richard Ivell
Gunnar Toft
Source
Epidemiology. 2015 Jan;26(1):91-9
Date
Jan-2015
Language
English
Publication Type
Article
Keywords
Adult
Amniotic Fluid - chemistry
Case-Control Studies
Cryptorchidism - epidemiology
Denmark - epidemiology
Diethylhexyl Phthalate - analysis
Environmental Exposure - statistics & numerical data
Female
Gonadal Steroid Hormones - analysis
Humans
Hydrocortisone - analysis
Hypospadias - epidemiology
Immunoassay
Infant, Newborn
Insulin - analysis
Leydig Cells
Linear Models
Logistic Models
Male
Mass Spectrometry
Phthalic Acids - analysis
Pregnancy
Proteins - analysis
Abstract
Prenatal exposure to phthalates may pose a threat to human male reproduction. However, additional knowledge about the in vivo effect in humans is needed, and reported associations with genital abnormalities are inconclusive. We aimed to study prenatal di(2-ethylhexyl) phthalate (DEHP) and diisononyl phthalate (DiNP) exposure in relation to cryptorchidism, hypospadias, and human fetal Leydig cell function.
We studied 270 cryptorchidism cases, 75 hypospadias cases, and 300 controls. Second-trimester amniotic fluid samples were available from a Danish pregnancy-screening biobank (n = 25,105) covering 1980-1996. We assayed metabolites of DEHP and DiNP (n = 645) and steroid hormones (n = 545) by mass spectrometry. We assayed insulin-like factor 3 by immunoassay (n = 475) and analyzed data using linear or logistic regression.
Mono(2-ethyl-5-carboxypentyl) phthalate (5cx-MEPP, DEHP metabolite) was not consistently associated with cryptorchidism or hypospadias. However, we observed an 18% higher (95% confidence interval [CI] = 5%-33%) testosterone level, and a 41% lower (-56% to -21%) insulin-like factor 3 level in the highest 5cx-MEPP tertile compared with the lowest. Mono(4-methyl-7-carboxyheptyl) phthalate (7cx-MMeHP, DiNP metabolite) showed elevated odds ratio point estimates for having cryptorchidism (odds ratio = 1.28 [95% CI = 0.80 to 2.01]) and hypospadias (1.69 [0.78 to 3.67]), but was not consistently associated with the steroid hormones or insulin-like factor 3.
Data on the DEHP metabolite indicate possible interference with human male fetal gonadal function. Considering the DiNP metabolite, we cannot exclude (nor statistically confirm) an association with hypospadias and, less strongly, with cryptorchidism.
PubMed ID
25384265 View in PubMed
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A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis.

https://arctichealth.org/en/permalink/ahliterature198421
Source
Obes Res. 2000 May;8(3):211-8
Publication Type
Article
Date
May-2000
Author
R. Rosmond
Y C Chagnon
G. Holm
M. Chagnon
L. Pérusse
K. Lindell
B. Carlsson
C. Bouchard
P. Björntorp
Author Affiliation
Department of Heart and Lung Diseases, Göteborg University, Sweden. rosmonr@pbrc.edu
Source
Obes Res. 2000 May;8(3):211-8
Date
May-2000
Language
English
Publication Type
Article
Keywords
Adipose Tissue - physiopathology
Alleles
Blood Glucose - analysis
Blood pressure
Body constitution
Body mass index
Cohort Studies
DNA - chemistry - isolation & purification
Dexamethasone - pharmacology
Eukaryotic Initiation Factor-1 - blood
Glucocorticoids - pharmacology
Humans
Hydrocortisone - secretion
Hypothalamo-Hypophyseal System - physiopathology
Insulin - analysis
Leptin - blood
Male
Middle Aged
Obesity - blood - epidemiology - genetics
Pituitary-Adrenal System - physiopathology
Polymorphism, Restriction Fragment Length
Receptors, Glucocorticoid - chemistry - genetics
Salivary Glands - secretion
Sweden - epidemiology
Testosterone - blood
Abstract
Abdominal obesity has a key role in the pathogenesis of prevalent and serious diseases and has been shown to be associated with an altered hypothalamic-pituitary-adrenal (HPA) axis function, which is regulated by endocrine feedback mediated via hippocampal glucocorticoid receptors (GR).
We examined the HPA axis function by repeated salivary samples for the assessment of cortisol, as well as other endocrine, anthropometric, metabolic, and circulatory variables in middle-aged Swedish men (n = 284). With the restriction enzyme BclI, variants of the GR gene (GRL) locus were identified and two alleles with fragment lengths of 4.5 and 2.3 kilobases (kb) were detected.
The observed frequencies were 40.1% for the 2.3- and 2.3-kb, 46.2% for the 4.5- and 2.3-kb, and 13.7% for the 4.5- and 4.5-kb genotypes. The larger allele (4.5 and 4.5 kb) was associated with elevated body mass index (BMI; p
PubMed ID
10832763 View in PubMed
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Insulin receptor is an independent predictor of a favorable outcome in early stage breast cancer.

https://arctichealth.org/en/permalink/ahliterature165653
Source
Breast Cancer Res Treat. 2007 Nov;106(1):39-47
Publication Type
Article
Date
Nov-2007
Author
Anna Marie Mulligan
Frances P O'Malley
Marguerite Ennis
I George Fantus
Pamela J Goodwin
Author Affiliation
Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada.
Source
Breast Cancer Res Treat. 2007 Nov;106(1):39-47
Date
Nov-2007
Language
English
Publication Type
Article
Keywords
Adult
Aged
Breast Neoplasms - blood - chemistry - mortality - pathology - therapy
Disease-Free Survival
Female
Follow-Up Studies
Humans
Immunohistochemistry
Insulin - blood
Kaplan-Meier Estimate
Middle Aged
Neoplasm Staging
Odds Ratio
Ontario
Receptor, IGF Type 1 - analysis
Receptor, Insulin - analysis
Receptor, erbB-2 - analysis
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Risk assessment
Time Factors
Tissue Array Analysis
Treatment Outcome
Tumor Markers, Biological - analysis
Abstract
Fasting insulin is related to outcome in early breast cancer. We evaluated the expression of insulin receptor (IR) and its prognostic significance in patients with early stage breast cancer. Tumors from 191 patients with T1-3, N0-1, M0 breast cancer who were enrolled at a single center of a multicenter cohort study were used to construct microarrays with subsequent immunohistochemical evaluation of IR, IGF-IR, ER, PgR and HER2/neu. Correlation of biomarker expression with traditional prognostic factors, serum biochemistry (notably insulin) and clinical outcome was assessed. IR was strongly positive (Allred score = 8) in 54% of tumors. High IR expression significantly correlated with favorable prognostic markers (low tumor grade, lymph node negativity and progesterone receptor positivity) but not with fasting levels of circulating insulin. At a median follow-up of 9.1 years, high vs. low IR expression (an Allred score of 8 vs. 0-7) was associated with statistically significant improved distant disease-free survival (multivariate hazard ratio (HR) = 0.4; P = 0.027) and overall survival (multivariate HR = 0.26; P = 0.005). IR is highly expressed in the majority of early stage breast cancers but this expression is not clearly down-regulated in the presence of high insulin levels. Furthermore, high expression of IR is independently and significantly associated with more favorable clinical outcomes. Follow-up intervention research is recommended.
PubMed ID
17221153 View in PubMed
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Insulin resistance as a predictor of incident asthma-like symptoms in adults.

https://arctichealth.org/en/permalink/ahliterature89780
Source
Clin Exp Allergy. 2009 May;39(5):700-7
Publication Type
Article
Date
May-2009
Author
Thuesen B H
Husemoen L L N
Hersoug L-G
Pisinger C.
Linneberg A.
Author Affiliation
Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark. beheth01@glo.regionh.dk
Source
Clin Exp Allergy. 2009 May;39(5):700-7
Date
May-2009
Language
English
Publication Type
Article
Keywords
Asthma - epidemiology - etiology
Body mass index
Denmark - epidemiology
Female
Follow-Up Studies
Humans
Incidence
Insulin - analysis
Insulin Resistance - immunology
Male
Middle Aged
Obesity - epidemiology - etiology
Questionnaires
Respiratory Sounds - physiology
Risk factors
Sex Factors
Waist Circumference
Abstract
BACKGROUND: There is accumulating evidence that obesity is associated with an increased risk of asthma. It has been hypothesized that insulin resistance may be involved in obesity-induced asthma, but till date there is no prospective data on this issue. OBJECTIVE: To investigate the association of obesity and insulin resistance with the incidence of asthma-like symptoms in adults. METHODS: Out of a random sample of 12 934 persons from a general population, 6784 (52.5%) were included and participated in a health examination in 1999-2001. After 5 years they were re-invited and 4516 (66.6%) participated at follow-up. At baseline three obesity measures were considered: body mass index, waist circumference, and waist-to-hip ratio. In addition, fasting glucose and insulin were measured for determination of insulin resistance. Information on asthma-like symptoms at baseline and follow-up were obtained by questionnaires. A total of 3441 participants defined as non-asthmatic at baseline and with complete information on all the considered variables were included in the analyses. Data were controlled for confounding by sex, age, social status, and smoking. RESULTS: All obesity measures were associated with incident wheezing and asthma-like symptoms. In addition, insulin resistance was associated with incident wheezing [odds ratio (OR) 1.87, 95% confidence interval (CI) 1.38-2.54] and asthma-like symptoms (OR 1.61, 95% CI 1.23-2.10). The effect of insulin resistance was stronger than that of obesity and was independent of sex. CONCLUSION: We found that insulin resistance was associated with an increased risk of developing asthma-like symptoms. This finding supports the hypothesis that obesity and asthma may be linked through inflammatory pathways also involved in insulin resistance.
PubMed ID
19260867 View in PubMed
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Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome.

https://arctichealth.org/en/permalink/ahliterature177231
Source
Diabetes. 2004 Dec;53(12):3107-14
Publication Type
Article
Date
Dec-2004
Author
Cale N Street
Jonathan R T Lakey
A M James Shapiro
Sharleen Imes
Ray V Rajotte
Edmond A Ryan
James G Lyon
Tatsuya Kin
Jose Avila
Toshiaki Tsujimura
Gregory S Korbutt
Author Affiliation
Surgical Medical Research Institute, University of Alberta, Edmonton, Canada.
Source
Diabetes. 2004 Dec;53(12):3107-14
Date
Dec-2004
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Alberta
Diabetes Mellitus, Type 1 - surgery
Follow-Up Studies
Humans
Insulin - analysis - secretion
Islets of Langerhans - cytology - physiology
Islets of Langerhans Transplantation - physiology
Middle Aged
Time Factors
Tissue and Organ Harvesting - methods
Treatment Outcome
Abstract
The success of the Edmonton Protocol for islet transplantation has provided new hope in the treatment of type 1 diabetes. This study reports on the assessment of 83 human islet grafts transplanted using the Edmonton Protocol since 1999. Cellular composition, as assessed by immunohistochemistry, showed a lower islet purity (approximately 40%) than has been reported in previous studies using dithizone staining to quantitate islet equivalents. Furthermore, grafts were found to contain substantial populations of exocrine and ductal tissue. Total cellular insulin transplanted was 8,097.6 +/- 3,164.4 microg/patient, and was significantly lower in bottom gradient layer grafts than top gradient layer or whole/combined grafts (P
PubMed ID
15561940 View in PubMed
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Metabolic risk factors associated with serum creatinine in a non-diabetic population.

https://arctichealth.org/en/permalink/ahliterature85227
Source
Eur J Epidemiol. 2007;22(10):707-13
Publication Type
Article
Date
2007
Author
Kronborg Jens
Jenssen Trond
Njølstad Inger
Toft Ingrid
Eriksen Bjørn O
Author Affiliation
Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway. kronborg@broadpark.no
Source
Eur J Epidemiol. 2007;22(10):707-13
Date
2007
Language
English
Publication Type
Article
Keywords
Aged
Albuminuria - blood
Cholesterol, HDL
Creatinine - blood - metabolism
Cross-Sectional Studies
Female
Glucose - analysis
Health Surveys
Humans
Insulin - analysis
Insulin Resistance
Life Style
Lipoproteins - analysis - blood
Male
Metabolic Syndrome X - etiology
Middle Aged
Norway
Prospective Studies
Risk factors
Abstract
Insulin resistance, low HDL-cholesterol and microalbuminuria are important components of the metabolic syndrome as defined by WHO. Insulin resistance and low HDL-cholesterol are also common in chronic kidney disease (CKD), but it is not clear whether they are early or late phenomenons in the development of renal failure. This study examined whether low-grade albuminuria (microalbuminuria), lipoprotein fractions, and the insulin/glucose ratio (IGR)-a surrogate marker of insulin resistance-were related to renal function (expressed as serum creatinine) in persons without diabetes and with apparently normal renal function. The study included 4,131 men and women aged 55-75 years from the cross-sectional Tromsø IV survey (1994-1995). Lifestyle factors, waist circumference and blood pressure were included in the analyses. Gender stratified multivariate analysis was used to assess the relationship between serum creatinine and microalbuminuria, lipoprotein fractions and IGR. Serum creatinine was positively associated with microalbuminuria in men (beta = 2.50, 95% confidence interval (CI) 0.66-4.34), but not in women. HDL-cholesterol and IGR were strongly associated with creatinine in both genders (HDL-cholesterol: Men: beta = -4.82, 95% CI -6.27 to -3.37; women: beta = -2.12, 95% CI -3.28 to -0.96. IGR: Second, third and fourth quartile compared with first quartile, men: beta = 0.94, 95% CI -0.63 to 2.51; 2.10, 95% CI 0.52-3.69 and 2.40, 95% CI 0.75-4.04; women: beta = 1.91, 95% CI 0.59-3.22; 2.61, 95% CI 1.28-3.95 and 3.20, 95% CI 1.80-4.60). These findings suggest that even early impairment of renal function may be associated with insulin resistance and dyslipidemia, regardless of renal albumin leakage.
PubMed ID
17653600 View in PubMed
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Obesity and metabolic correlates among the Inuit and a general Danish population

https://arctichealth.org/en/permalink/ahliterature5989
Source
Pages 77-85 in J. Lepp�¤luoto, ed. Circumpolar Health 2003. Proceedings of the 12th International Congress on Circumpolar Health, Nuuk, Greenland, September 10-14, 2003. International Journal of Circumpolar Health. 2004;63(Suppl.2)
Publication Type
Article
Date
2004
  1 document  
Author
J�¸rgensen, ME
Author Affiliation
Steno Diabetes Centre, Gentofte, Denmark. maej@steno.dk
Source
Pages 77-85 in J. Lepp�¤luoto, ed. Circumpolar Health 2003. Proceedings of the 12th International Congress on Circumpolar Health, Nuuk, Greenland, September 10-14, 2003. International Journal of Circumpolar Health. 2004;63(Suppl.2)
Date
2004
Language
English
Geographic Location
Greenland
Denmark
Publication Type
Article
Digital File Format
Text - PDF
Physical Holding
Alaska Medical Library
Keywords
Anthropometry
Blood Glucose - analysis
Blood pressure
Body mass index
BMI
Denmark
Female
Glucose Tolerance Test
Greenland
Humans
Insulin - analysis
Inuit - statistics & numerical data
Lipoproteins, HDL Cholesterol - blood
Male
Metabolic syndrome
Obesity - epidemiology - ethnology - metabolism
Triglycerides - blood
Abstract
OBEJECTIVES: Obesity and central fat pattern are associated with several cardiovascular risk factors incluy ding insulin resistance, glucose intolerance, hypertension and dyslipidemia in most populations. The study aims to assess the occurrence and metabolic correlates of obesity among Greenlanders and Danes. STUDY DESIGN: From 1999 to 2001, 917 adult Inuit participated in a health survey in Greenland. The examination included an oral glucose tolerance test. Body Mass Index, waist circumference, and blood pressure were measured. P-glucose, s-insulin, and lipids were measured. Data from the Danish study 'Inter99' (n=5606) conducted in 1999-2000 were used for comparison. RESULTS: Compared with the Inter99 population, a larger proportion of Inuit women were centrally obese (58.1% vs.17.8%, p
PubMed ID
15736626 View in PubMed
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Postnatal decrease in insulin binding to erythrocytes in infants of diabetic mothers.

https://arctichealth.org/en/permalink/ahliterature48789
Source
J Clin Endocrinol Metab. 1988 Apr;66(4):696-701
Publication Type
Article
Date
Apr-1988
Author
P. Lautala
R. Puukka
M. Knip
L. Perkkilä
M. Puukka
Author Affiliation
Department of Pediatrics, University of Oulu, Finland.
Source
J Clin Endocrinol Metab. 1988 Apr;66(4):696-701
Date
Apr-1988
Language
English
Publication Type
Article
Keywords
Birth weight
Diabetes Mellitus, Type 1 - blood
Erythrocytes - metabolism
Female
Fetal Blood - metabolism
Humans
Infant, Newborn
Insulin - blood
Male
Pregnancy
Pregnancy in Diabetics - blood
Receptor, Insulin - analysis
Research Support, Non-U.S. Gov't
Abstract
To clarify the role of insulin receptors in the macrosomia and the tendency to hypoglycemia in infants of mothers with insulin-treated diabetes mellitus (IDM) we studied insulin binding in erythrocytes from mixed umbilical blood and from peripheral venous blood collected when the infants were 3-14 days old. Normal infants were matched for gestational and postnatal age. The IDM infants were macrosomic, with significantly higher birth weights relative to gestational age than the control infants. Plasma free insulin concentrations in cord blood were 15-fold higher in the IDM than in the normal infants and more than 3-fold higher in the peripheral venous blood at the median age of 4 days. Hypoglycemia occurred in 12 of the 17 IDM and in none of the normal infants. In umbilical blood insulin binding to erythrocytes was similar in the IDM and normal infants. In both groups insulin binding decreased during the first postnatal weeks, but the decrease was significantly greater in the IDM than in the normal infants. The decrease in insulin binding to erythrocytes was a consequence of decreased receptor affinity as well as decreased receptor concentration in the IDM infants, but was mainly due to decreased receptor concentration in the normal infants. We conclude that insulin binding to its erythrocyte receptor in cord blood in IDM infants is similar to that in normal infants in spite of the simultaneous gross hyperinsulinemia in the IDM infants. The resulting increase in insulin action would then contribute to the tendency toward hypoglycemia and may be partly responsible for the macrosomia in IDM infants. The marked postnatal decrease in insulin binding in IDM infants is a possible explanation for their diminishing risk of hypoglycemia after the first few days of life in spite of persisting hyperinsulinemia.
PubMed ID
3279062 View in PubMed
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10 records – page 1 of 1.