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3018 records – page 1 of 302.

1,3-Butadiene and leukemia among synthetic rubber industry workers: exposure-response relationships.

https://arctichealth.org/en/permalink/ahliterature166384
Source
Chem Biol Interact. 2007 Mar 20;166(1-3):15-24
Publication Type
Article
Date
Mar-20-2007
Author
Hong Cheng
Nalini Sathiakumar
John Graff
Robert Matthews
Elizabeth Delzell
Author Affiliation
University of Alabama at Birmingham, Ryals School of Public Health, Department of Epidemiology, Birmingham, AL, USA. hcheng@ms.soph.uab.edu
Source
Chem Biol Interact. 2007 Mar 20;166(1-3):15-24
Date
Mar-20-2007
Language
English
Publication Type
Article
Keywords
Butadienes - adverse effects
Canada - epidemiology
Carcinogens - chemical synthesis - chemistry - toxicity
Chemical Industry - manpower - statistics & numerical data
Confidence Intervals
Dimethyldithiocarbamate - adverse effects
Humans
Leukemia, Lymphoid - chemically induced - epidemiology
Leukemia, Myeloid - chemically induced - epidemiology
Likelihood Functions
Male
Middle Aged
Occupational Exposure - statistics & numerical data
Proportional Hazards Models
Rubber - adverse effects - chemical synthesis - chemistry
United States - epidemiology
Abstract
Previous research updated the mortality experience of North American synthetic rubber industry workers during the period 1944-1998, determined if leukemia and other cancers were associated with several employment factors and carried out Poisson regression analysis to examine exposure-response associations between estimated exposure to 1,3-butadiene (BD) or other chemicals and cancer. The present study used Cox regression procedures to examine further the exposure-response relationship between several unlagged and lagged, continuous, time-dependent BD exposure indices (BD parts per million (ppm)-years, the total number of exposures to BD concentrations >100 ppm ("peaks") and average intensity of BD) and leukemia, lymphoid neoplasms and myeloid neoplasms. All three BD exposure indices were associated positively with leukemia. Using continuous, untransformed BD ppm-years the regression coefficient (beta) from an analysis that controlled only for age was 2.9 x 10(-4) (p
PubMed ID
17123495 View in PubMed
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3-D modeling substantiates perfluorinated theory.

https://arctichealth.org/en/permalink/ahliterature82705
Source
Environ Sci Technol. 2006 Feb 1;40(3):632-3
Publication Type
Article
Date
Feb-1-2006
Author
Renner Rebecca
Source
Environ Sci Technol. 2006 Feb 1;40(3):632-3
Date
Feb-1-2006
Language
English
Publication Type
Article
Keywords
Air Movements
Alcohols
Arctic Regions
Environmental Pollutants - analysis
Fluorocarbons - analysis - chemistry
Industry
Manufactured Materials
Models, Theoretical
Octanoic Acids - analysis - chemistry
Notes
Comment On: Environ Sci Technol. 2006 Feb 1;40(3):924-3016509338
PubMed ID
16509290 View in PubMed
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A 6-month follow-up study of 1048 patients diagnosed with an occupational skin disease.

https://arctichealth.org/en/permalink/ahliterature147641
Source
Contact Dermatitis. 2009 Nov;61(5):261-8
Publication Type
Article
Date
Nov-2009
Author
Tarja Mälkönen
Riitta Jolanki
Kristiina Alanko
Ritva Luukkonen
Kristiina Aalto-Korte
Antti Lauerma
Päivikki Susitaival
Author Affiliation
Finnish Institute of Occupational Health, Control of Hypersensitivity Diseases and Services for Statistics, Helsinki, Finland.
Source
Contact Dermatitis. 2009 Nov;61(5):261-8
Date
Nov-2009
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Dermatitis, Occupational - diagnosis - epidemiology - etiology - prevention & control
Female
Finland - epidemiology
Follow-Up Studies
Food Industry
Hand Dermatoses - diagnosis - epidemiology - etiology - prevention & control
Humans
Male
Middle Aged
Occupations - statistics & numerical data
Patch Tests
Respiratory Hypersensitivity - epidemiology
Risk factors
Sex Factors
Urticaria - diagnosis - epidemiology - etiology - prevention & control
Abstract
Occupational skin diseases (OSDs) often have considerable medical and occupational consequences. Previous data on prognostic factors have been derived from studies with fairly small sample sizes.
To determine the medical and occupational outcome in 1048 patients diagnosed with OSD at the Finnish Institute of Occupational Health and to identify the prognostic risk factors for the continuation of OSD.
Patients examined in 1994-2001 filled out a follow-up questionnaire 6 months after the diagnosis. Data on atopy, contact allergies, and occupation were analysed.
Six months after the diagnosis the skin disease had healed in 27% of the patients. The OSD had cleared up in 17% of those with no changes at work, and in 34% of those who had changed their job/occupation. The best clearing had occurred in the patients with contact urticaria (35%), whereas the healing of allergic (27%) and irritant (23%) contact dermatitis was similar. The risk factors for continuing occupational contact dermatitis (OCD) were no changes in work, age > 45 years, food-related occupations, respiratory atopy, and male sex.
The healing of OSD was associated with discontinuation of the causative exposure. A change in work and the presence of easily avoidable work-related allergies were associated with a good prognosis.
PubMed ID
19878240 View in PubMed
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A 13-year cohort study of musculoskeletal disorders treated in an autoplant, on-site physiotherapy clinic.

https://arctichealth.org/en/permalink/ahliterature160671
Source
J Occup Rehabil. 2007 Dec;17(4):610-22
Publication Type
Article
Date
Dec-2007
Author
Jackie Sadi
Joy C MacDermid
Bert Chesworth
Trevor Birmingham
Author Affiliation
School of Physical Therapy, University of Western Ontario, London, ON, Canada. jsadi2@uwo.ca
Source
J Occup Rehabil. 2007 Dec;17(4):610-22
Date
Dec-2007
Language
English
Publication Type
Article
Keywords
Adult
Automobiles
Female
Humans
Industry
Male
Musculoskeletal Diseases - epidemiology - therapy
Occupational Diseases - epidemiology - therapy
Occupational Health
Ontario - epidemiology
Physical Therapy Modalities
Retrospective Studies
Risk factors
Time Factors
Treatment Outcome
Abstract
The purpose of this study was to describe the rate and distribution of treatment visits provided in an on-site, automotive plant, physiotherapy clinic over a 13-year period.
A retrospective cohort study was conducted using data collected at an on-site physiotherapy clinic (1990-2002, 65,977 visits; n = 2,636 workers).
The average age of workers was 43 +/- 9 years; most remained at work (85%) when treated. Disorders most commonly affected the shoulder, lumbar, and cervical regions; the median number of visits for these was 7, 6, and 5, respectively. Elbow disorders occurred commonly only for work-related complaints and required a median of eight visits. Rate of utilization was higher for women, with 47% of the plant's female workers attending physiotherapy in 1 year. Women had higher rates of cervical spine (12 vs. 22%) and wrist (5 vs. 10%) disorders. The two most common causes of injury reported by workers with an industrial injury were "frank injury arising out of normal employment" (51%) and "gradual onset/no frank injury" (37%). The diagnosis most often reported by the physiotherapist after initial assessment was "strain" which was similar for both industrial (43%) and non-industrial (49%) injuries. The six main departments in this automotive plant account for 93% of all industrial injuries reported. Final Assembly accounted for the largest number and highest rate of injury, although shift variability was noted in utilization rates (13 vs. 26%), despite the same tasks, shift schedules, and demographics. Although there was no control group, the number of visits to discharge was lower than reported in the literature for off-site physical therapy; there was a large reduction in claims (441-275) following introduction of the clinic and reduced duration/costs of lost time were identified by the employer as a rationale to continue and enhance the service over time.
On-site physiotherapy services can provide early, cost-effective management of WRMSD in the automotive sector. Service utilization reflects the influence of gender, job task, and shift-dynamics on rates and location of WRMSD.
PubMed ID
17955347 View in PubMed
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32P-post-labelling of 7-(3-chloro-2-hydroxypropyl)guanine in white blood cells of workers occupationally exposed to epichlorohydrin.

https://arctichealth.org/en/permalink/ahliterature67496
Source
Carcinogenesis. 2000 Feb;21(2):275-80
Publication Type
Article
Date
Feb-2000
Author
K. Plna
S. Osterman-Golkar
E. Nogradi
D. Segerbäck
Author Affiliation
Center for Nutrition and Toxicology, Department of Biosciences, Karolinska Institute, Novum, S-141 57 Huddinge and Department of Molecular Genome Research, Stockholm University, S-106 91 Stockholm, Sweden. kamila.plna2cnt.ki.se
Source
Carcinogenesis. 2000 Feb;21(2):275-80
Date
Feb-2000
Language
English
Publication Type
Article
Keywords
Adult
Alkylating Agents - adverse effects - pharmacology
Biological Markers
Chemical Industry
Chromatography, High Pressure Liquid
Chromatography, Ion Exchange
Comparative Study
DNA Adducts - analysis
DNA Damage
Epichlorohydrin - adverse effects - pharmacology
Guanine - analogs & derivatives - blood
Humans
Isotope Labeling
Leukocytes - chemistry - drug effects
Middle Aged
Occupational Exposure
Occupations
Phosphorus Radioisotopes
Research Support, Non-U.S. Gov't
Sensitivity and specificity
Smoking - epidemiology
Solvents - adverse effects - pharmacology
Sweden
Abstract
Epichlorohydrin (ECH) is a simple 3-carbon epoxide of industrial importance. It has been shown to be genotoxic in several systems and carcinogenic in experimental animals. The aim of the present investigation was to study DNA adducts of ECH as a biomarker of occupational exposure to this chemical. 7-(3-Chloro-2-hydroxypropyl)guanine (7-CHP-guanine) was analysed in DNA from white blood cells using an anion exchange-based adduct enrichment protocol of the (32)P-post-labelling/HPLC-based assay. Blood samples were collected from seven workers handling ECH (exposed), nine workers not handling ECH but normally present in the premises where this chemical is used (potentially exposed) and 13 office and factory workers from locations in the plant where ECH is not handled (controls). 7-CHP-guanine was detected in five of the seven workers exposed to ECH (1.6-7.1 mol/10(9) mol nucleotides) and in two of the nine workers potentially exposed to ECH (0.8-1.5 mol/10(9) mol nucleotides). This adduct was not detected in any of the 13 controls. The difference in adduct levels between exposed workers and controls was statistically significant (Mann-Whitney test, P
PubMed ID
10657968 View in PubMed
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Aboriginal youth in Canada: a profile based upon 1981 census data.

https://arctichealth.org/en/permalink/ahliterature39493
Source
Can Stat Rev. 1985 Sep;60(9):vi-
Publication Type
Article
Date
Sep-1985
Author
G E Priest
Source
Can Stat Rev. 1985 Sep;60(9):vi-
Date
Sep-1985
Language
English
Publication Type
Article
Keywords
Americas
Canada
Censuses
Comparative Study
Culture
Demography
Developed Countries
Developing Countries
Educational Status
Emigration and Immigration
Employment
Ethnic Groups
Family Characteristics
Income
Indians, North American
Industry
North America
Occupations
Population
Population Characteristics
Research
Unemployment
Abstract
An analysis of the data from the 1981 census of Canada is presented concerning the aboriginal population aged 15 to 24, defined as including the Inuit, status Indian, non-status Indian, and Metis populations. Comparisons are made with the non-aboriginal population. Factors considered include geographic location, migration, family status, dependent children, educational status, labor force participation, unemployment, income, and industry.
PubMed ID
12340640 View in PubMed
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[About flavouring substances and flavouring preparations regulation in the field of manufacturing of flavourings and foodstuffs].

https://arctichealth.org/en/permalink/ahliterature112655
Source
Vopr Pitan. 2013;82(1):23-32
Publication Type
Article
Date
2013
Author
O V Bagriantseva
G N Shatrov
Source
Vopr Pitan. 2013;82(1):23-32
Date
2013
Language
Russian
Publication Type
Article
Keywords
Flavoring Agents - pharmacology - standards
Food Industry - legislation & jurisprudence - standards
Food Safety
Humans
Russia
Abstract
In article are given substantiation for modification of contemporary list of biologically active substances with undesirable toxicological qualities (namely included in this list of menthofuran, methyleugenol (4-Allyl-1,2-dimethoxybenzene), teucrin A, capsaicin, estragol1 (-Allyl-4-methoxybenzene) and excluded from the list of quinine, santonin, berberin) and developing the list of plants--natural sources of flavourings substances. The new criteria of European Union for including into the relevant for using in/on foodstuff list of flavouring substances, which was published in the Comission Implementing Regulation (EU) No 872/2012 concerning flavourings, listed the 11 flavouring substances for which have been established indexes of foodstuffs in manufacturing, which there are could using and criteria of their safety (caffeine, theobromine, neohesperidin dihydrocalcone, rebaudioside A, d-camphor, three quinine salts (FL 14.011, FL 14.152 and FL 14.155), glycyrrhizic acid and its ammoniated form, ammonium chloride, discussed the possibility of using R- and S-isomers of flavouring substances and L- and D-forms of aminoacids for preparing of flavours, are discussed. Improving of the system of safety using of flavourings in Russian Federation, harmonized with demands of European Union and FAQ/WHO, are, at first, connected with the necessity of reevaluation of the list flavouring substances, which could be use in/on foodstuff, developing of list of the plants--natural sources of flavourings substances and preparations and regulations of using flavourings preparations which can include biologically active substances.
PubMed ID
23808275 View in PubMed
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Abramson: direct-to-consumer advertising will erode health care.

https://arctichealth.org/en/permalink/ahliterature157621
Source
CMAJ. 2008 Apr 22;178(9):1126-7
Publication Type
Article
Date
Apr-22-2008
Author
Ann Silversides
Source
CMAJ. 2008 Apr 22;178(9):1126-7
Date
Apr-22-2008
Language
English
Publication Type
Article
Keywords
Advertising as Topic
Canada
Drug Industry
Drug Prescriptions
Humans
Pharmaceutical Preparations
PubMed ID
18427081 View in PubMed
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3018 records – page 1 of 302.