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A 10-Year Follow-Up of Adiposity and Dementia in Swedish Adults Aged 70 Years and Older.

https://arctichealth.org/en/permalink/ahliterature300956
Source
J Alzheimers Dis. 2018; 63(4):1325-1335
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
2018
Author
Ilse A C Arnoldussen
Valter Sundh
Kristoffer Bäckman
Silke Kern
Svante Östling
Kaj Blennow
Henrik Zetterberg
Ingmar Skoog
Amanda J Kiliaan
Deborah R Gustafson
Author Affiliation
Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
Source
J Alzheimers Dis. 2018; 63(4):1325-1335
Date
2018
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adiponectin - blood
Adiposity
Aged
Aged, 80 and over
Anthropometry
Body mass index
Dementia - blood - epidemiology - pathology
Fasting
Female
Humans
Independent living
Leptin - blood
Longitudinal Studies
Male
Psychiatric Status Rating Scales
Sex Factors
Sweden - epidemiology
Waist-Hip Ratio
Abstract
Adiposity measured in mid- or late-life and estimated using anthropometric measures such as body mass index (BMI) and waist-to-hip ratio (WHR), or metabolic markers such as blood leptin and adiponectin levels, is associated with late-onset dementia risk. However, during later life, this association may reverse and aging- and dementia-related processes may differentially affect adiposity measures.
We explored associations of concurrent BMI, WHR, and blood leptin and high molecular weight adiponectin levels with dementia occurrence.
924 Swedish community-dwelling elderly without dementia, aged 70 years and older, systematically-sampled by birth day and birth year population-based in the Gothenburg city region of Sweden. The Gothenburg Birth Cohort Studies are designed for evaluating risk and protective factors for dementia. All dementias diagnosed after age 70 for 10 years were identified. Multivariable logistic regression models were used to predict dementia occurrence between 2000-2005, 2005-2010, and 2000-2010 after excluding prevalent baseline (year 2000) dementias. Baseline levels of BMI, WHR, leptin, and adiponectin were used.
Within 5 years of baseline, low BMI (
PubMed ID
29758945 View in PubMed
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Amount and type of alcohol consumption and missing teeth among community-dwelling older adults: findings from the Copenhagen Oral Health Senior study.

https://arctichealth.org/en/permalink/ahliterature127155
Source
J Public Health Dent. 2011;71(4):318-26
Publication Type
Article
Date
2011
Author
Karen Heegaard
Kirsten Avlund
Poul Holm-Pedersen
Ulla A Hvidtfeldt
Allan Bardow
Morten Grønbaek
Author Affiliation
Copenhagen Gerontological Oral Health Research Centre, University of Copenhagen, Copenhagen, Denmark. karen.heegaard@mail.tele.dk
Source
J Public Health Dent. 2011;71(4):318-26
Date
2011
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Alcohol drinking - epidemiology
Alcoholic Beverages - classification - statistics & numerical data
Beer - statistics & numerical data
Cross-Sectional Studies
Denmark - epidemiology
Educational Status
Female
Follow-Up Studies
Humans
Income - statistics & numerical data
Independent Living - statistics & numerical data
Longitudinal Studies
Male
Population Surveillance
Sedentary lifestyle
Sex Factors
Smoking - epidemiology
Social Class
Temperance - statistics & numerical data
Tooth Loss - epidemiology
Wine - statistics & numerical data
Abstract
To study if an association between total weekly intake of alcohol, type-specific weekly alcohol intake, alcoholic beverage preference, and the number of teeth among older people exists.
A cross-sectional study including a total of 783 community-dwelling men and women aged 65-95 years who were interviewed about alcohol drinking habits and underwent a clinical oral and dental examination. Multiple regression analyses were applied for studying the association between total weekly alcohol consumption, beverage-specific alcohol consumption, beverage preference (defined as the highest intake of one beverage type compared with two other types), and the number of remaining teeth (= 20 versus >20 remaining teeth).
The odds ratio (OR) of having a low number of teeth decreased with the total intake of alcohol in women, with ORs for a low number of teeth of 0.40 [95 percent confidence interval (CI) 0.22-0.76] in women drinking 1-14 drinks per week and 0.34 (95 percent CI 0.16-0.74) in women with an intake of more than 14 drinks per week compared with abstainers. Similar relations could also be obtained for type-specific alcohol intake of wine and for wine and spirits preference among women. Men who preferred beer showed a decreased risk for a low number of teeth compared with men with other alcohol preferences.
In this study, alcohol consumption, wine drinking, and wine and spirits preference among women were associated with a higher number of teeth compared with abstainers. Among men, those who preferred beer also had a higher number of teeth.
PubMed ID
22320290 View in PubMed
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An evaluation by elderly people living at home of the prepared meals distributed by their municipality - a study with focus on the Swedish context.

https://arctichealth.org/en/permalink/ahliterature264566
Source
Glob J Health Sci. 2015 May;7(3):59-68
Publication Type
Article
Date
May-2015
Author
Oleg Pajalic
Zada Pajalic
Source
Glob J Health Sci. 2015 May;7(3):59-68
Date
May-2015
Language
English
Publication Type
Article
Keywords
Aged
Consumer Behavior
Female
Food Services
Home Care Services
Homebound Persons - statistics & numerical data
Humans
Independent living
Male
Quality of Life
Sex Factors
Sweden
Time Factors
Abstract
Prepared meals distributed by municipalities is a service to elderly people, or persons with health related impairments, who live in their own home, have difficulties preparing their own food and cannot meet their food requirements in any other way. This study aimed to provide a brief picture of how elderly people living at home perceive the food they receive through their municipal food service and what is important to them. The data was collected using questionnaires. 274 out of 276 participants answered the questionnaire (n=173 women 62% and n=101 man 37%). The data was analyzed using Principal Component Analysis (PCA). The results showed that the elderly persons receiving meals through the service were often satisfied, especially with the size of the portions and the delivery time. Those who had been using the food delivery service for a longer time were not satisfied with the alternative dishes they were been offered. There was no significant difference between the views of either gender. Further, those who were receiving special food were, in general, unsatisfied with the meals delivered. Development of the food distribution service by systematic quality insurance and interactive knowledge exchange between the producers and consumers seems to be a way to promote a more holistic and individual adjusted service. Evaluation of the municipal FD service is a powerful tool that can contribute to the development of this service. The food service can be improved and consequently even the quality of life and health of its receivers. The present survey should be revisited and developed in order to detect differences between genders.
PubMed ID
25948451 View in PubMed
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Antibiotic resistance patterns of bacteria causing urinary tract infections in the elderly living in nursing homes versus the elderly living at home: an observational study.

https://arctichealth.org/en/permalink/ahliterature269775
Source
BMC Geriatr. 2015;15:98
Publication Type
Article
Date
2015
Author
Mark Fagan
Morten Lindbæk
Nils Grude
Harald Reiso
Maria Romøren
Dagfinn Skaare
Dag Berild
Source
BMC Geriatr. 2015;15:98
Date
2015
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Anti-Infective Agents, Urinary - classification - pharmacology
Cross-Sectional Studies
Drug Resistance, Bacterial
Escherichia coli - drug effects
Escherichia coli Infections - diagnosis - drug therapy - epidemiology
Female
Homes for the Aged - statistics & numerical data
Humans
Independent Living - statistics & numerical data
Male
Norway - epidemiology
Nursing Homes - statistics & numerical data
Practice Guidelines as Topic
Proteus Infections - diagnosis - drug therapy - epidemiology
Proteus mirabilis - drug effects
Sex Factors
Urinalysis - methods
Urinary Tract Infections - diagnosis - drug therapy - epidemiology - microbiology
Abstract
Antibiotic resistance is a problem in nursing homes. Presumed urinary tract infections (UTI) are the most common infection. This study examines urine culture results from elderly patients to see if specific guidelines based on gender or whether the patient resides in a nursing home (NH) are warranted.
This is a cross sectional observation study comparing urine cultures from NH patients with urine cultures from patients in the same age group living in the community.
There were 232 positive urine cultures in the NH group and 3554 in the community group. Escherichia coli was isolated in 145 urines in the NH group (64%) and 2275 (64%) in the community group. There were no clinically significant differences in resistance. Combined, there were 3016 positive urine cultures from females and 770 from males. Escherichia coli was significantly more common in females 2120 (70%) than in males 303 (39%) (p?
Notes
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PubMed ID
26238248 View in PubMed
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Are high school students living in lodgings at an increased risk for internalizing problems?

https://arctichealth.org/en/permalink/ahliterature98963
Source
J Adolesc. 2010 Jun;33(3):439-47
Publication Type
Article
Date
Jun-2010
Author
Wenche Wannebo
Lars Wichstrøm
Author Affiliation
Faculty of Health Sciences, Nord-Trøndelag University College, Steinkjer, Norway. wenche.wannebo@hint.no
Source
J Adolesc. 2010 Jun;33(3):439-47
Date
Jun-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Age Factors
Behavioral Symptoms - diagnosis - psychology
Depression - diagnosis - psychology
Female
Health Surveys
Humans
Independent Living - psychology
Internal-External Control
Loneliness - psychology
Male
Norway
Object Attachment
Personality Inventory - statistics & numerical data
Psychometrics
Sex Factors
Social Environment
Students - psychology
Young Adult
Abstract
This study aimed to investigate whether leaving home to live in lodgings during senior high school can be a risk factor for the development of internalizing problems. Utilizing two large-scale prospective community studies of 2399 and 3906 Norwegian students (age range 15-19 years), respectively, the difference in internalizing symptoms between adolescents living in lodgings and adolescents living with their parents during senior high school was examined. Female students living in lodgings had higher scores on internalizing problems than female students living at home, whereas no differences were found for males. Living in lodgings did not predict later internalizing problems, and prior internalizing problems did not predict moving into lodgings. It is therefore suggested that the negative effect of living in lodgings on high school students' well-being is temporary.
PubMed ID
19631976 View in PubMed
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Can we move beyond burden and burnout to support the health and wellness of family caregivers to persons with dementia? Evidence from British Columbia, Canada.

https://arctichealth.org/en/permalink/ahliterature132042
Source
Health Soc Care Community. 2012 Jan;20(1):103-12
Publication Type
Article
Date
Jan-2012
Author
Meredith B Lilly
Carole A Robinson
Susan Holtzman
Joan L Bottorff
Author Affiliation
Department of Economics and Centre for Health Economics and Policy Analysis, McMaster University, Hamilton, Ontario, Canada. meredith.lilly@mcmaster.ca
Source
Health Soc Care Community. 2012 Jan;20(1):103-12
Date
Jan-2012
Language
English
Publication Type
Article
Keywords
Age Factors
Aged
British Columbia
Burnout, Professional - epidemiology
Caregivers - psychology
Dementia - therapy
Family - psychology
Family Relations
Female
Home Care Services
Humans
Independent living
Male
Middle Aged
Qualitative Research
Sex Factors
Socioeconomic Factors
Abstract
After more than a decade of concerted effort by policy-makers in Canada and elsewhere to encourage older adults to age at home, there is recognition that the ageing-in-place movement has had unintended negative consequences for family members who care for seniors. This paper outlines findings of a qualitative descriptive study to investigate the health and wellness and support needs of family caregivers to persons with dementia in the Canadian policy environment. Focus groups were conducted in 2010 with 23 caregivers and the health professionals who support them in three communities in the Southern Interior of British Columbia. Thematic analysis guided by the constant comparison technique revealed two overarching themes: (1) forgotten: abandoned to care alone and indefinitely captures the perceived consequences of caregivers' failed efforts to receive recognition and adequate services to support their care-giving and (2) unrealistic expectations for caregiver self-care relates to the burden of expectations for caregivers to look after themselves. Although understanding about the concepts of caregiver burden and burnout is now quite developed, the broader sociopolitical context giving rise to these negative consequences for caregivers to individuals with dementia has not improved. If anything, the Canadian homecare policy environment has placed caregivers in more desperate circumstances. A fundamental re-orientation towards caregivers and caregiver supports is necessary, beginning with viewing caregivers as a critical health human resource in a system that depends on their contributions in order to function. This re-orientation can create a space for providing caregivers with preventive supports, rather than resorting to costly patient care for caregivers who have reached the point of burnout and care recipients who have been institutionalised.
PubMed ID
21851447 View in PubMed
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Different patterns in use of antibiotics for lower urinary tract infection in institutionalized and home-dwelling elderly: a register-based study.

https://arctichealth.org/en/permalink/ahliterature121293
Source
Eur J Clin Pharmacol. 2013 Mar;69(3):665-71
Publication Type
Article
Date
Mar-2013
Author
Ylva Haasum
Johan Fastbom
Kristina Johnell
Author Affiliation
Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet and Stockholm University, Gävlegatan 16, 113 30 Stockholm, Sweden. Ylva.Haasum@ki.se
Source
Eur J Clin Pharmacol. 2013 Mar;69(3):665-71
Date
Mar-2013
Language
English
Publication Type
Article
Keywords
Age Factors
Aged
Anti-Bacterial Agents - adverse effects - therapeutic use
Drug Prescriptions
Drug Utilization - trends
Drug Utilization Review
Female
Guideline Adherence
Homes for the Aged
Humans
Independent living
Institutionalization
Logistic Models
Lower Urinary Tract Symptoms - diagnosis - drug therapy - microbiology
Male
Multivariate Analysis
Odds Ratio
Physician's Practice Patterns - trends
Polypharmacy
Practice Guidelines as Topic
Registries
Sex Factors
Sweden
Urinary Tract Infections - diagnosis - drug therapy - microbiology
Abstract
We compared the quality and pattern of use of antibiotics to treat urinary tract infection (UTI) between institutionalized and home-dwelling elderly.
We analyzed the quality of use of UTI antibiotics in Swedish people aged = 65 years at 30 September 2008 (1,260,843 home-dwelling and 86,721 institutionalized elderly). Data regarding drug use, age and sex were retrieved from the Swedish Prescribed Drug Register and information about type of housing from the Social Services Register. In women, we assessed: (1) the proportion who use quinolones (should be as low as possible); (2) the proportion treated with the recommended drugs (pivmecillinam, nitrofurantoin, or trimethoprim) (proportions should be about 40 %, 40 % and 15-20 %, respectively); In men, we assessed: (1) the proportion who used quinolones or trimethoprim (should be as high as possible).
The 1-day point prevalence for antibiotic use for UTI was 1.6 % among institutionalized and 0.9 % among home-dwelling elderly. Of these, about 15 % of institutionalized and 19 % of home-dwelling women used quinolones. The proportion of women treated with the recommended drugs pivmecillinam, nitrofurantoin or trimethoprim was 29 %, 27 % and 45 % in institutions and 40 %, 28 % and 34 % for home-dwellers. In men treated with antibiotics for UTI, quinolones or trimethoprim were used by about 76 % in institutions and 85 % in home-dwellers.
Our results indicate that recommendations for UTI treatment with antibiotics are not adequately followed. The high use of trimethoprim amongst institutionalized women and the low use of quinolones or trimethoprim among institutionalized men need further investigation.
PubMed ID
22922683 View in PubMed
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Duration of new antidepressant use and factors associated with discontinuation among community-dwelling persons with Alzheimer's disease.

https://arctichealth.org/en/permalink/ahliterature300475
Source
Eur J Clin Pharmacol. 2019 Mar; 75(3):417-425
Publication Type
Journal Article
Date
Mar-2019
Author
Reetta Kettunen
Heidi Taipale
Anna-Maija Tolppanen
Antti Tanskanen
Jari Tiihonen
Sirpa Hartikainen
Marjaana Koponen
Author Affiliation
School of Pharmacy, University of Eastern Finland, PO Box 1627, 70211, Kuopio, Finland.
Source
Eur J Clin Pharmacol. 2019 Mar; 75(3):417-425
Date
Mar-2019
Language
English
Publication Type
Journal Article
Keywords
Age Factors
Aged
Aged, 80 and over
Alzheimer Disease - drug therapy
Antidepressive Agents - administration & dosage - therapeutic use
Antipsychotic Agents - administration & dosage - therapeutic use
Cohort Studies
Female
Finland
Humans
Independent living
Male
Proportional Hazards Models
Registries
Sex Factors
Time Factors
Abstract
To study how long antidepressants initiated after diagnoses of Alzheimer's disease (AD) were used and factors associated with discontinuation of use among persons with Alzheimer's disease (AD). In addition, differences in duration of use between the antidepressants groups were compared.
Register-based Medication use and Alzheimer's disease (MEDALZ) cohort included 70,718 community-dwelling people with AD who were diagnosed during the years 2005-2011. For this study, the new antidepressant users were included after 1-year washout period (N?=?16,501; 68.6% females, mean age 80.9). The duration of antidepressant use was modeled with the PRE2DUP method. Factors associated with treatment discontinuation were assessed with Cox proportional hazard models and included age, gender, comorbid conditions and concomitant medications.
Median duration of the new antidepressant use period was 309 days (IQR 93-830). For selective serotonin reuptake inhibitor (SSRI) use, the median duration was 331 days (IQR 101-829), for mirtazapine 202 days (IQR 52-635), and for serotonin and norepinephrine reuptake inhibitors (SNRIs) 134 days (IQR 37-522). After 1-year follow-up, 40.8% had discontinued antidepressant use, 54.6% after 2 years and 64.1% after 3 years. Factors associated with treatment discontinuation were age over 85, male gender, diabetes, and use of memantine, opioids, and antiepileptics whereas benzodiazepines and related drugs and antipsychotic use were inversely associated with discontinuation.
Antidepressants are used for long-term among people with AD. Need and indication for antidepressant use should be assessed regularly as evidence on their efficacy for behavioral and psychological symptoms of dementia is limited.
PubMed ID
30413841 View in PubMed
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Factors associated with active aging in Finland, Poland, and Spain.

https://arctichealth.org/en/permalink/ahliterature260487
Source
Int Psychogeriatr. 2014 Aug;26(8):1363-75
Publication Type
Article
Date
Aug-2014
Author
Perales J
Martin S
Ayuso-Mateos JL
Chatterji S
Garin N
Koskinen S
Leonardi M
Miret M
Moneta V
Olaya B
Tobiasz-Adamczyk B
Haro JM
Source
Int Psychogeriatr. 2014 Aug;26(8):1363-75
Date
Aug-2014
Language
English
Publication Type
Article
Keywords
Age Factors
Aged
Aging - physiology - psychology
Cross-Cultural Comparison
Cross-Sectional Studies
Educational Status
Ethnopsychology - methods
Female
Finland - epidemiology
Health status
Health Surveys
Humans
Independent Living - psychology - statistics & numerical data
Male
Marital Status - statistics & numerical data
Middle Aged
Occupations - statistics & numerical data
Poland - epidemiology
Sex Factors
Social Behavior
Spain - epidemiology
Abstract
Continuous population aging has raised international policy interest in promoting active aging (AA). AA theoretical models have been defined from a biomedical or a psychosocial perspective. These models may be expanded including components suggested by lay individuals. This paper aims to study the correlates of AA in three European countries, namely, Spain, Poland, and Finland using four different definitions of AA.
The EU COURAGE in Europe project was a cross-sectional general adult population survey conducted in a representative sample of the noninstitutionalized population of Finland, Poland, and Spain. Participants (10,800) lived in the community. This analysis focuses on individuals aged 50 years old and over (7,987). Four definitions (two biomedical, one psychosocial, and a complete definition including biomedical, psychosocial, and external variables) of AA were analyzed.
Differences in AA were found for country, age, education, and occupation. Finland scored consistently the highest in AA followed by Spain and Poland. Younger age was associated with higher AA. Higher education and occupation was associated with AA. Being married or cohabiting was associated with better AA compared to being widowed or separated in most definitions. Gender and urbanicity were not associated with AA, with few exceptions. Men scored higher in AA only in Spain, whereas there was no gender association in the other two countries. Being widowed was only associated with lower AA in Poland and not being married was associated with lower AA in Poland and Finland but not Spain.
Associations with education, marital status, and occupation suggest that these factors are the most important components of AA. These association patterns, however, seem to vary across the three countries. Actions to promote AA in these countries may be addressed at reducing inequalities in occupation and education or directly tackling the components of AA lacking in each country.
PubMed ID
24735743 View in PubMed
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Kynurenines as predictors of acute coronary events in the Hordaland Health Study.

https://arctichealth.org/en/permalink/ahliterature272283
Source
Int J Cardiol. 2015;189:18-24
Publication Type
Article
Date
2015
Author
Simone J P M Eussen
Per Magne Ueland
Stein E Vollset
Ottar Nygård
Øivind Midttun
Gerhard Sulo
Arve Ulvik
Klaus Meyer
Eva Ringdal Pedersen
Grethe S Tell
Source
Int J Cardiol. 2015;189:18-24
Date
2015
Language
English
Publication Type
Article
Keywords
Acute Coronary Syndrome - blood - mortality - physiopathology
Age Factors
Aged
Angina Pectoris - blood - mortality - physiopathology
Biomarkers - metabolism
Cohort Studies
Confidence Intervals
Female
Geriatric Assessment - methods
Health Surveys
Humans
Independent living
Kynurenine - metabolism
Male
Myocardial Infarction - blood - mortality - physiopathology
Norway
Predictive value of tests
Prognosis
Proportional Hazards Models
Prospective Studies
Risk assessment
Severity of Illness Index
Sex Factors
Statistics, nonparametric
Survival Analysis
Abstract
The kynurenine pathway, the main metabolic route of tryptophan degradation, has been related to inflammatory responses. Some of its metabolites, referred to as kynurenines, have been associated with prevalence of coronary heart disease (CHD) in cross-sectional studies. This prospective study aims to investigate whether increased concentrations of kynurenines are associated with risk of acute coronary events, defined as unstable angina pectoris, acute myocardial infarction, and/or sudden death in community-dwelling elderly.
The baseline examinations included 2819 individuals aged 71-74 years recruited into the Hordaland Health Study. Participants with known CHD at baseline were excluded from analyses. Baseline plasma concentrations of tryptophan, kynurenine, kynurenic acid, anthranilic acid, 3-hydroxykynurenine, xanthurenic acid, and 3-hydroxyanthranilic acid were measured by LC-MS/MS. During a median follow-up period of 10.8 years, with linkage to acute coronary event endpoints through the CVDNOR project, hazard ratios (HRs) for acute coronary events (n = 376) were estimated using Cox proportional hazard analyses.
After adjustment for established cardiovascular risk factors, HRs (95% CI) comparing the 4th vs 1st quartile were 1.86 (1.19-2.92) for kynurenine and 1.72 (1.19-2.49) for 3-hydroxykynurenine. Tryptophan, kynurenic acid, anthranilic acid, xanthurenic acid and 3-hydroxyanthranilic acid were not associated with acute coronary events.
Kynurenine and 3-hydroxykynurenine were associated with increased risk of acute coronary events in community-dwelling elderly without a known history of CHD. These results suggest the involvement of the kynurenine pathway in the early development of CHD, and their potential usefulness to estimate CHD risk.
PubMed ID
25885868 View in PubMed
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16 records – page 1 of 2.