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Kynurenines as predictors of acute coronary events in the Hordaland Health Study.

https://arctichealth.org/en/permalink/ahliterature272283
Source
Int J Cardiol. 2015;189:18-24
Publication Type
Article
Date
2015
Author
Simone J P M Eussen
Per Magne Ueland
Stein E Vollset
Ottar Nygård
Øivind Midttun
Gerhard Sulo
Arve Ulvik
Klaus Meyer
Eva Ringdal Pedersen
Grethe S Tell
Source
Int J Cardiol. 2015;189:18-24
Date
2015
Language
English
Publication Type
Article
Keywords
Acute Coronary Syndrome - blood - mortality - physiopathology
Age Factors
Aged
Angina Pectoris - blood - mortality - physiopathology
Biomarkers - metabolism
Cohort Studies
Confidence Intervals
Female
Geriatric Assessment - methods
Health Surveys
Humans
Independent living
Kynurenine - metabolism
Male
Myocardial Infarction - blood - mortality - physiopathology
Norway
Predictive value of tests
Prognosis
Proportional Hazards Models
Prospective Studies
Risk assessment
Severity of Illness Index
Sex Factors
Statistics, nonparametric
Survival Analysis
Abstract
The kynurenine pathway, the main metabolic route of tryptophan degradation, has been related to inflammatory responses. Some of its metabolites, referred to as kynurenines, have been associated with prevalence of coronary heart disease (CHD) in cross-sectional studies. This prospective study aims to investigate whether increased concentrations of kynurenines are associated with risk of acute coronary events, defined as unstable angina pectoris, acute myocardial infarction, and/or sudden death in community-dwelling elderly.
The baseline examinations included 2819 individuals aged 71-74 years recruited into the Hordaland Health Study. Participants with known CHD at baseline were excluded from analyses. Baseline plasma concentrations of tryptophan, kynurenine, kynurenic acid, anthranilic acid, 3-hydroxykynurenine, xanthurenic acid, and 3-hydroxyanthranilic acid were measured by LC-MS/MS. During a median follow-up period of 10.8 years, with linkage to acute coronary event endpoints through the CVDNOR project, hazard ratios (HRs) for acute coronary events (n = 376) were estimated using Cox proportional hazard analyses.
After adjustment for established cardiovascular risk factors, HRs (95% CI) comparing the 4th vs 1st quartile were 1.86 (1.19-2.92) for kynurenine and 1.72 (1.19-2.49) for 3-hydroxykynurenine. Tryptophan, kynurenic acid, anthranilic acid, xanthurenic acid and 3-hydroxyanthranilic acid were not associated with acute coronary events.
Kynurenine and 3-hydroxykynurenine were associated with increased risk of acute coronary events in community-dwelling elderly without a known history of CHD. These results suggest the involvement of the kynurenine pathway in the early development of CHD, and their potential usefulness to estimate CHD risk.
PubMed ID
25885868 View in PubMed
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