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Long-term use of opioids for nonmalignant pain among community-dwelling persons with and without Alzheimer disease in Finland: a nationwide register-based study.

https://arctichealth.org/en/permalink/ahliterature287023
Source
Pain. 2017 Feb;158(2):252-260
Publication Type
Article
Date
Feb-2017
Author
Aleksi Hamina
Heidi Taipale
Antti Tanskanen
Anna-Maija Tolppanen
Niina Karttunen
Liisa Pylkkänen
Jari Tiihonen
Sirpa Hartikainen
Source
Pain. 2017 Feb;158(2):252-260
Date
Feb-2017
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Alzheimer Disease - complications
Analgesics, Opioid - therapeutic use
Cohort Studies
Female
Finland - epidemiology
Humans
Independent living
Male
Pain - drug therapy - epidemiology - etiology
Prevalence
Registries - statistics & numerical data
Abstract
Persons with Alzheimer disease (AD) commonly present with chronic nonmalignant pain, but long-term use of opioids among this population has not been studied previously. Our aim was to investigate the prevalence of long-term (=180 days) use of opioids for nonmalignant pain and associated factors among community-dwelling persons with AD and to compare the prevalence with a matched cohort without AD. The Medication use and Alzheimer's disease (MEDALZ) cohort was used for this study, comprising all community-dwelling persons diagnosed with AD in Finland during 2005 to 2011 and their matched comparison persons without AD. After exclusion of persons with active cancer treatment, 62,074 persons with and 62,074 persons without AD were included in this study. Data were collected from nationwide registers. Opioids were used by 13,111 persons with and by 16,659 without AD. Overall long-term opioid use was more common among persons without AD (8.7%) than among persons with AD (7.2%, P
PubMed ID
28092324 View in PubMed
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