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[2 women--2 parents. Interview by Lisbet Harstad.]

https://arctichealth.org/en/permalink/ahliterature59428
Source
Jordmorbladet. 1994;(5):18-20
Publication Type
Article
Date
1994

7-Alkoxyquinoline O-dealkylation by microsomes from human liver and placenta.

https://arctichealth.org/en/permalink/ahliterature64902
Source
Br J Clin Pharmacol. 1992 Nov;34(5):415-20
Publication Type
Article
Date
Nov-1992
Author
J. Hakkola
J. Mäenpää
R T Mayer
S S Park
H V Gelboin
O. Pelkonen
Author Affiliation
Department of Pharmacology and Toxicology, University of Oulu, Finland.
Source
Br J Clin Pharmacol. 1992 Nov;34(5):415-20
Date
Nov-1992
Language
English
Publication Type
Article
Keywords
Animals
Antibodies, Monoclonal - diagnostic use
Benzyl Compounds - metabolism
Cytochrome P-450 Enzyme System - antagonists & inhibitors - metabolism
Dealkylation
Female
Humans
In Vitro
Male
Mice
Mice, Inbred Strains
Microsomes - enzymology - metabolism
Microsomes, Liver - enzymology - metabolism
Placenta - enzymology - metabolism
Pregnancy
Quinolines - metabolism
Rats
Rats, Wistar
Research Support, Non-U.S. Gov't
Smoking - metabolism
Abstract
1. The O-dealkylation of seven 7-alkoxyquinoline derivatives by human hepatic and placental microsomes and the effect of maternal cigarette smoking on placental 7-alkoxyquinoline metabolism was studied. 2. None of several monoclonal antibodies to isoenzymes of cytochrome P450 had a clear effect on metabolism of the compounds by liver microsomes. 3. Maternal cigarette smoking induced the O-dealkylation of all of the 7-alkoxyquinoline derivatives, being greatest for 7-butoxy- and 7-benzyloxyquinoline. 4. Placental 7-alkoxyquinoline metabolism induced by smoking was partially inhibited by the monoclonal antibody 1-7-1 raised against 3-methylcholanthrene-induced rat liver P450. 5. None of the 7-alkoxyquinoline O-dealkylations could be assigned specifically to any known P450 isoenzyme in human liver or placenta.
PubMed ID
1467136 View in PubMed
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86 successful births and 9 ongoing pregnancies worldwide in women transplanted with frozen-thawed ovarian tissue: focus on birth and perinatal outcome in 40 of these children.

https://arctichealth.org/en/permalink/ahliterature282764
Source
J Assist Reprod Genet. 2017 Mar;34(3):325-336
Publication Type
Article
Date
Mar-2017
Author
Annette Klüver Jensen
Kirsten Tryde Macklon
Jens Fedder
Erik Ernst
Peter Humaidan
Claus Yding Andersen
Source
J Assist Reprod Genet. 2017 Mar;34(3):325-336
Date
Mar-2017
Language
English
Publication Type
Article
Keywords
Cryopreservation
Denmark
Female
Fertility Preservation
Fertilization in Vitro - methods
Humans
Infant, Newborn
Ovary - transplantation
Pregnancy
Pregnancy outcome
Premature Birth
Primary Ovarian Insufficiency - physiopathology
Transplantation, Autologous
Abstract
This study aims to make an account of the children born following transplantation of frozen-thawed ovarian tissue worldwide with specific focus on the perinatal outcome of the children. Furthermore, perinatal outcome of seven deliveries (nine children) from Denmark is reported.
PubMed was searched for papers of deliveries resulting from ovarian tissue cryopreservation (OTC). Seven women underwent OTC prior to chemotherapy. Four of these women still had low ovarian function and had tried to conceive. They therefore had tissue autotransplanted to augment their fertility. The other three women had developed premature ovarian insufficiency (POI) after the end of treatment.
Worldwide, approximately 95 children have been born or will be born in the near future from OTC, including these 9 new children. Information on the perinatal outcome was found on 40 children. The mean gestational age was 39 weeks and the mean birth weight was 3168 g of the singleton pregnancies, which is within internationally recognized normal standards. Furthermore, half the singletons resulted from natural conception and all twins resulted from in vitro fertilization treatment. All seven Danish women became pregnant within 1-3 years after transplantation. They gave birth to nine healthy children.
The data is reassuring and further suggests that cryopreservation of ovarian tissue is becoming an established fertility preservation method. The seven Danish women reported in this study were all in their early thirties when OTC was performed. Most other reported cases were in the women's twenties. This suggests that the follicular pool in the thirties is large enough and sufficient to sustain fertility.
Notes
Erratum In: J Assist Reprod Genet. 2017 Mar;34(3):33728120130
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PubMed ID
28028773 View in PubMed
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[Absorption of ephedrine hydrochloride in the presence of auxiliary high-molecular compounds in the intestines of rats]

https://arctichealth.org/en/permalink/ahliterature8855
Source
Farm Zh. 1978 Jan-Feb;(1):89
Publication Type
Article

ABT-761 attenuates bronchoconstriction and pulmonary inflammation in rodents.

https://arctichealth.org/en/permalink/ahliterature15808
Source
J Pharmacol Exp Ther. 1997 Mar;280(3):1366-73
Publication Type
Article
Date
Mar-1997
Author
R L Bell
R R Harris
P E Malo
J B Bouska
T K Shaughnessy
K I Hulkower
C D Brooks
G W Carter
Author Affiliation
Immunosciences Research Area, Abbott Laboratories, Abbott Park, Illinois 60064, USA.
Source
J Pharmacol Exp Ther. 1997 Mar;280(3):1366-73
Date
Mar-1997
Language
English
Publication Type
Article
Keywords
Animals
Arachidonate 5-Lipoxygenase - antagonists & inhibitors
Bronchoconstriction - drug effects
Enzyme Inhibitors - pharmacology - therapeutic use
Eosinophils - pathology
Guinea Pigs
Humans
Hydroxyurea - analogs & derivatives - pharmacology - therapeutic use
In Vitro
Leukotriene E4 - antagonists & inhibitors
Macaca fascicularis
Male
Mice
Muscle Contraction - drug effects
Pneumonia - drug therapy - pathology
Rats
Abstract
Our primary goal has been to discover leukotriene biosynthesis inhibitors with characteristics that are appropriate for use as clinical agents. The success of the use of zileuton in the treatment of asthma led us to explore further the use of the N-hydroxyurea class of 5-lipoxygenase inhibitors as longer-acting compounds with good lung penetration. A variety of in vitro and in vivo methods were used to evaluate a large number of compounds, from which ABT-761 [(R)-N-(3-(5-(4-fluorophenylmethyl)thien-2-yl)-1-methyl-2-pr opynyl)-N-hydroxyurea] was selected for study. ABT-761 exhibited potent and selective inhibition of leukotriene formation both in vitro and in vivo. More importantly, the compound potently inhibited antigen-induced bronchospasm in guinea pigs when given either prophylactically or therapeutically. In addition, ABT-761 was a potent inhibitor of eosinophil influx into the lungs of Brown Norway rats. These data provide added support for the role of leukotrienes in both bronchospasm and eosinophilic inflammation and characterize ABT-761 as a particularly potent inhibitor of leukotrienes formed in pulmonary tissues. These data combined with the excellent pharmacokinetic characteristics of the compound indicate its potential use in the treatment of leukotriene-dependent human disease.
PubMed ID
9067325 View in PubMed
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Acetate-induced changes in cardiac energy metabolism and hemodynamics in the rat.

https://arctichealth.org/en/permalink/ahliterature12462
Source
Basic Res Cardiol. 1988 Jul-Aug;83(4):431-44
Publication Type
Article
Author
K T Kiviluoma
M. Karhunen
T. Lapinlampi
K J Peuhkurinen
I E Hassinen
Author Affiliation
Department of Medical Biochemistry, University of Oulu, Finland.
Source
Basic Res Cardiol. 1988 Jul-Aug;83(4):431-44
Language
English
Publication Type
Article
Keywords
Acetic Acid
Acetic Acids - pharmacology
Adenosine - metabolism
Animals
Cardiac Output - drug effects
Epinephrine - blood
Heart - drug effects - physiology
Heart Rate - drug effects
Hemodynamic Processes
In Vitro
Myocardium - metabolism
Oxygen Consumption - drug effects
Phosphorylation
Rats
Rats, Inbred Strains
Time Factors
Abstract
The hemodynamic and metabolic effects of acetate were studied in rats in vivo and in the isolated perfused heart. Hemodynamic parameters, myocardial phosphagens, inorganic phosphate, and adenosine were measured in vivo. Acetate uptake, coronary flow, O2 consumption, parameters of the cellular energy state, and hypoxanthine compounds and their washout were measured in heart perfusion experiments. Heart rate (HR), cardiac output, and the peak derivative of the left ventricular pressure rise (dP/dtmax) increased significantly during acetate infusion in vivo, but mean arterial pressure, systolic arterial pressure, and systemic vascular resistance decreased. Heart muscle ATP concentrations decreased after 7 min of acetate infusion. In vivo cardiac work load (HR.(peak left ventricular pressure] showed a positive correlation with tissue adenosine concentration and a negative correlation with phosphorylation potential. Acetate uptake in the perfused hearts was about 2.5 mumol/min per gram wet weight. Acetate perfusion increased O2 consumption and coronary flow concomitantly with a decrease in tissue ATP concentration. Tissue AMP and perfusate effluent adenosine concentration and adenosine output increased significantly, perfusate adenosine showing a non-linear positive correlation with coronary flow. The results demonstrate that acetate induces considerable changes in hemodynamics and metabolism in the heart.
PubMed ID
3190660 View in PubMed
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[Action of some polysaccharide containing complexes of microbial origin on the tobacco mosaic virus and on the influenza virus]

https://arctichealth.org/en/permalink/ahliterature69128
Source
Mikrobiol Zh. 1976;38(3):347-50
Publication Type
Article
Date
1976

Activation of mu-opiate receptors as a factor of regulation of heart resistance to ischemia-reperfusion and oxidative stress.

https://arctichealth.org/en/permalink/ahliterature53983
Source
Bull Exp Biol Med. 2000 Aug;130(8):752-5
Publication Type
Article
Date
Aug-2000
Author
T V Lasukova
T Y Rebrova
S V Tam
Author Affiliation
Laboratory of Experimental Cardiology, Institute of Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk.
Source
Bull Exp Biol Med. 2000 Aug;130(8):752-5
Date
Aug-2000
Language
English
Publication Type
Article
Keywords
Animals
Enkephalin, Ala(2)-MePhe(4)-Gly(5)- - pharmacology
In Vitro
Male
Myocardial Contraction - drug effects - physiology
Myocardial Reperfusion Injury - etiology - physiopathology - prevention & control
Oxidative Stress
Rats
Rats, Wistar
Receptors, Opioid, mu - agonists - physiology
Abstract
Intravenous injection of the selective mu-opiate receptor agonist DAMGO (0.1 mg/kg, 15 min before isolation of the heart) improved resistance of isolated perfused rat heart to ischemia (45 min) and reperfusion (60 min) damages. In vivo administration of DAMGO prevented reperfusion-induced damages to cardiomyocytes and decreased the content of conjugated dienes in the myocardium during ischemia-reperfusion in vitro. Furthermore, stimulation of mu-opiate receptors promoted recovery of myocardial contractility during reoxygenation, but had no effect on heart resistance to free radical-induced damages during perfusion of isolated heart with a solution containing Fe2+ and ascorbic acid.
PubMed ID
11177234 View in PubMed
Less detail

Activation of potassium channels in erythrocytes of marine teleost Scorpaena porcus.

https://arctichealth.org/en/permalink/ahliterature10059
Source
Membr Cell Biol. 2001;14(6):773-82
Publication Type
Article
Date
2001
Author
Y A Silkin
E N Silkina
A O Sherstobitov
G P Gusev
Author Affiliation
Karadag Natural Reserve, Ukrainian Academy of Sciences, Feodosia, Crimean Region.
Source
Membr Cell Biol. 2001;14(6):773-82
Date
2001
Language
English
Publication Type
Article
Keywords
Animals
Calcimycin - pharmacology
Erythrocytes - metabolism
Fishes - blood
Humans
In Vitro
Ion Transport - drug effects
Ionophores - pharmacology
Lead - pharmacology
Potassium - metabolism
Potassium Channels - blood
Propranolol - pharmacology
Sodium - metabolism
Vanadates - pharmacology
Abstract
To assess the possibility of stimulating Ca2+-activated K+ channels, marine fish erythrocytes were incubated at 20-22 degrees C in saline containing a Ca2+-ATPase inhibitor (orthovanadate), a Ca2+ ionophore (A23187), propranolol or Pb2+. Incubation of the cells for up to 2 h under control conditions or in the presence of 5 mM NH4VO3 and 1 mM Ca2+ did not affect the intracellular K+ and Na+ concentrations. About 50% cellular K+ was lost from erythrocytes incubated in the presence of 0.01 mM A23187, 1 mM EGTA and 0.4-1.0 mM Ca2+. There was a significant loss of cellular K+ after the addition of 0.05-0.2 mM propranolol to the incubation medium. The stimulatory effect of propranolol on the K+ efflux was independent of external Ca2+. Blockers of Ca2+ transport, verapamil and Co2+, caused only a small decrease in the K+ loss induced by propranolol. The treatment of erythrocytes with 1-2 microM Pb2+ led to a minor K+ loss, but at a Pb2+ concentration of 20-50 microM, about 70% cellular K+ was lost. The K+ efflux induced by propranolol or Pb2+ was completely blocked by 1 mM quinine. The induced K+ loss from the erythrocytes was accompanied by a slight increase in the intracellular Na+ concentration. These data indicate the possibility of inducing Ca2+- and Pb2+-activated potassium channels in erythrocytes of S. porcus. A distinctive feature of the cells is a high sensitivity to propranolol, which activates K+ channels in the absence of external Ca2+.
PubMed ID
11817573 View in PubMed
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653 records – page 1 of 66.