Skip header and navigation

Refine By

4 records – page 1 of 1.

Allergy gap between Finnish and Russian Karelia on increase.

https://arctichealth.org/en/permalink/ahliterature137706
Source
Allergy. 2011 Jul;66(7):886-92
Publication Type
Article
Date
Jul-2011
Author
Tiina Laatikainen
L. von Hertzen
J-P Koskinen
M J Mäkelä
P. Jousilahti
T U Kosunen
T. Vlasoff
M. Ahlström
E. Vartiainen
T. Haahtela
Author Affiliation
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland. tiina.laatikainen@thl.fi
Source
Allergy. 2011 Jul;66(7):886-92
Date
Jul-2011
Language
English
Publication Type
Article
Keywords
Adult
Allergens - adverse effects - immunology
Animals
Asthma - epidemiology - immunology
Betula - immunology
Cats - immunology
Finland - epidemiology
Health Surveys
Humans
Hypersensitivity, Immediate - epidemiology - immunology
Immunoglobulin E - blood - immunology
Middle Aged
Phleum - immunology
Prevalence
Questionnaires
Russia - epidemiology
Abstract
Multinational time-trend analyses of atopic disease have shown that the East-West gradients in prevalence are shrinking. We set out to clarify whether the disparities in the occurrence of atopy and atopic diseases in Finnish and Russian Karelia during the past 10 years have diminished and how the prevalence of atopy has evolved with successive years of birth.
Two surveys with identical methodology were performed in 1997/1998 and 2007. The study population comprised randomly selected adults, aged 25-54 years, from Finnish and Russian Karelia. Serum samples were collected for total and specific IgE measurements. Clinical data were obtained by questionnaires.
Sensitization rates to birch pollen increased from 7.8% to 14.8% (P
PubMed ID
21255037 View in PubMed
Less detail

A disparity in the association of asthma, rhinitis, and eczema with allergen-specific IgE between Finnish and Russian Karelia.

https://arctichealth.org/en/permalink/ahliterature165178
Source
Allergy. 2007 Mar;62(3):281-7
Publication Type
Article
Date
Mar-2007
Author
P T Pekkarinen
L. von Hertzen
T. Laatikainen
M J Mäkelä
P. Jousilahti
T U Kosunen
V. Pantelejev
E. Vartiainen
T. Haahtela
Author Affiliation
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland.
Source
Allergy. 2007 Mar;62(3):281-7
Date
Mar-2007
Language
English
Publication Type
Article
Keywords
Adolescent
Allergens - immunology
Antibody Specificity
Child
Dermatitis, Atopic - blood - prevention & control
Female
Finland - epidemiology
Humans
Immunoglobulin E - blood - immunology
Male
Questionnaires
Respiratory Hypersensitivity - blood - prevention & control
Russia - epidemiology
Abstract
A substantial variation in the association of asthma, rhinitis and eczema with elevated serum allergen-specific immunoglobulin E (sIgE) levels between different populations has been reported. Here, we wanted to clarify whether these proportions are different in Finnish and Russian Karelia, and compared the ability of questionnaires, skin prick tests (SPT) and sIgE measurements to detect atopic conditions in these adjacent areas with different living conditions.
Randomly selected schoolchildren, aged 6-16 years, and their mothers from Finland (n = 344 children, 344 mothers) and Russia (427 and 284 respectively) participated. SPTs and sIgE measurements to common inhalant and food allergens were performed. The occurrence of asthma, rhinitis, eczema and related symptoms was assessed with an International Study of Asthma and Allergies in Childhood-based questionnaire. Correlation between SPT and sIgE was estimated using the Spearman correlation coefficient.
The rate of positive sIgE results was significantly higher in Finland among both mothers and children. Seventy-seven per cent of Finnish children and 43% of Russian children with asthma were sIgE positive. The respective figures for hay fever were 94% and 67%, and for eczema 68% and 41%. This discrepancy was similar but of lower magnitude among mothers. The overall occurrence of asthma, rhinitis and eczema was very low in Russian Karelia. The correlation between SPT and sIgE results was generally good.
Asthma, rhinitis and eczema in Russian Karelia are not only rare but also, to a large extent, have no sIgE component. Therefore, the ability of questionnaires to detect sIgE-mediated atopic conditions in this area of Russia is poor.
PubMed ID
17298345 View in PubMed
Less detail

Green areas around homes reduce atopic sensitization in children.

https://arctichealth.org/en/permalink/ahliterature266308
Source
Allergy. 2015 Feb;70(2):195-202
Publication Type
Article
Date
Feb-2015
Author
L. Ruokolainen
L. von Hertzen
N. Fyhrquist
T. Laatikainen
J. Lehtomäki
P. Auvinen
A M Karvonen
A. Hyvärinen
V. Tillmann
O. Niemelä
M. Knip
T. Haahtela
J. Pekkanen
I. Hanski
Source
Allergy. 2015 Feb;70(2):195-202
Date
Feb-2015
Language
English
Publication Type
Article
Keywords
Adolescent
Agriculture
Allergens - immunology
Child
Child, Preschool
Environment
Environmental Exposure
Estonia - epidemiology
Female
Finland - epidemiology
Forests
Housing
Humans
Hypersensitivity, Immediate - epidemiology - etiology
Immunoglobulin E - blood - immunology
Infant
Male
Microbiota
Odds Ratio
Prevalence
Skin - immunology - microbiology
Young Adult
Abstract
Western lifestyle is associated with high prevalence of allergy, asthma and other chronic inflammatory disorders. To explain this association, we tested the 'biodiversity hypothesis', which posits that reduced contact of children with environmental biodiversity, including environmental microbiota in natural habitats, has adverse consequences on the assembly of human commensal microbiota and its contribution to immune tolerance.
We analysed four study cohorts from Finland and Estonia (n = 1044) comprising children and adolescents aged 0.5-20 years. The prevalence of atopic sensitization was assessed by measuring serum IgE specific to inhalant allergens. We calculated the proportion of five land-use types--forest, agricultural land, built areas, wetlands and water bodies--in the landscape around the homes using the CORINE2006 classification.
The cover of forest and agricultural land within 2-5 km from the home was inversely and significantly associated with atopic sensitization. This relationship was observed for children 6 years of age and older. Land-use pattern explained 20% of the variation in the relative abundance of Proteobacteria on the skin of healthy individuals, supporting the hypothesis of a strong environmental effect on the commensal microbiota.
The amount of green environment (forest and agricultural land) around homes was inversely associated with the risk of atopic sensitization in children. The results indicate that early-life exposure to green environments is especially important. The environmental effect may be mediated via the effect of environmental microbiota on the commensal microbiota influencing immunotolerance.
Notes
Cites: Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14691-620679230
Cites: Proc Natl Acad Sci U S A. 2012 May 22;109(21):8334-922566627
Cites: Nature. 2012 Sep 13;489(7415):231-4122972296
Cites: Br J Dermatol. 2013 Nov;169(5):983-9123782060
Cites: Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18360-724154724
Cites: Semin Immunol. 2013 Nov 30;25(5):378-8724209708
Cites: Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):805-1024344318
Cites: J Allergy Clin Immunol. 2014 Dec;134(6):1301-1309.e1125262465
Cites: Clin Exp Allergy. 2000 Sep;30(9):1230-410971468
Cites: Lancet. 2001 Oct 6;358(9288):1129-3311597666
Cites: Science. 2002 Apr 19;296(5567):490-411964470
Cites: JAMA. 2002 Aug 28;288(8):963-7212190366
Cites: BMJ. 1989 Nov 18;299(6710):1259-602513902
Cites: Clin Exp Allergy. 1999 May;29(5):611-710231320
Cites: Allergy. 2005 Nov;60(11):1357-6016197466
Cites: J Allergy Clin Immunol. 2006 Feb;117(2):334-4416461134
Cites: Int Arch Allergy Immunol. 2006;140(2):89-9516554659
Cites: Lancet. 2006 Aug 26;368(9537):733-4316935684
Cites: Nat Rev Immunol. 2006 Nov;6(11):869-7417063187
Cites: N Engl J Med. 2006 Nov 23;355(21):2226-3517124020
Cites: Environ Health Perspect. 2009 Jan;117(1):140-719165401
Cites: Sci Transl Med. 2009 Nov 11;1(6):6ra1420368178
Cites: Clin Exp Immunol. 2010 Apr;160(1):1-920415844
Cites: Clin Exp Immunol. 2010 Apr;160(1):70-920415854
Cites: Br J Dermatol. 2010 May;162(5):964-7320331459
Cites: FEMS Microbiol Lett. 2010 Jun;307(1):80-620412303
Cites: Nat Rev Immunol. 2010 Dec;10(12):861-821060319
Cites: EMBO Rep. 2011 Nov;12(11):1089-9321979814
PubMed ID
25388016 View in PubMed
Less detail

Increase of allergen-specific immunoglobulin E antibodies from 1973 to 1994 in a Finnish population and a possible relationship to Helicobacter pylori infections.

https://arctichealth.org/en/permalink/ahliterature190665
Source
Clin Exp Allergy. 2002 Mar;32(3):373-8
Publication Type
Article
Date
Mar-2002
Author
T U Kosunen
J. Höök-Nikanne
A. Salomaa
S. Sarna
A. Aromaa
T. Haahtela
Author Affiliation
Department of Bacteriology and Immunology, Haartman Institute and Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland. timo.kosunen@helsinki.fi
Source
Clin Exp Allergy. 2002 Mar;32(3):373-8
Date
Mar-2002
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Allergens - immunology
Antibodies, Anti-Idiotypic - blood - immunology
Antibody Specificity - immunology
Cross-Sectional Studies
Epitopes
Female
Finland - epidemiology
Helicobacter Infections - epidemiology - immunology - microbiology
Helicobacter pylori - immunology
Humans
Immunoglobulin E - blood - immunology
Male
Middle Aged
Prevalence
Sex Factors
Abstract
The prevalence of atopic diseases--hayfever, asthma and eczema--has increased over the past decades. The increase may be associated with decreased rates of infections such as measles, hepatitis A, tuberculosis, toxoplasmosis, and, as recently suggested, Helicobacter pylori gastritis.
Since the increase of atopy has been mainly based on clinical studies, we wanted to study the prevalence of allergen-specific Immunoglobulin (Ig)E antibodies in two cross-sectional, adult population-based serum samples two decades apart. Since the sera had been tested for H. pylori antibodies, we also had a chance to look for a possible relationship between these two findings.
We determined the prevalence rate of allergen-specific serum IgE antibodies against birch and timothy pollen, and cat and dog epithelium allergens by the radioallergosorbent test in a 15-54-years-old Finnish population using 326 sera collected in 1973 and 319 sera collected in 1994 from randomly selected subjects.
From 1973 to 1994 allergen-specific IgE prevalence rates and IgE antibody levels rose. In 1994, the prevalence rate of positive findings in 15-24-year-old population had increased from 11 to 38% (3.5-fold increase, P = 0.0001, OR 5.12, CI 95% 2.32-11.3). In older 10-year age groups similar trends did not reach significance, but the overall change was significant with all three cut-off levels of allergen-specific IgE analysed. The percentage of IgE-positive persons rose mainly in the subgroup with no H. pylori antibodies. In 1994 21% of the H. pylori-negative subjects had IgE antibodies compared with 5% of the H. pylori-positive subjects (in 1973 11% in both subgroups).
IgE-based evidence for an increase in IgE-mediated allergy was uncovered. The increase occurred mainly in the subgroup with no antibodies to H. pylori, which support the hypothesis that H. pylori could be one of the microbes counteracting atopy.
PubMed ID
11940066 View in PubMed
Less detail