Skip header and navigation

Refine By

3 records – page 1 of 1.

Association study of 15 novel single-nucleotide polymorphisms of the T-bet locus among Finnish asthma families.

https://arctichealth.org/en/permalink/ahliterature179237
Source
Clin Exp Allergy. 2004 Jul;34(7):1049-55
Publication Type
Article
Date
Jul-2004
Author
E. Ylikoski
R. Kinos
N. Sirkkanen
M. Pykäläinen
J. Savolainen
L A Laitinen
J. Kere
T. Laitinen
R. Lahesmaa
Author Affiliation
Centre for Biotechnology, University of Turku and Abo Akademi University, Finland. emmi.ylikoski@btk.utu.fi
Source
Clin Exp Allergy. 2004 Jul;34(7):1049-55
Date
Jul-2004
Language
English
Publication Type
Article
Keywords
Asthma - genetics - immunology
Chi-Square Distribution
Female
Finland
Humans
Immunoglobulin E - blood
Linkage Disequilibrium
Male
Polymorphism, Single Nucleotide
T-Box Domain Proteins
Transcription Factors - genetics - immunology
Abstract
T-box expressed in T cells (T-bet) is a transcription factor regulating the commitment of T helper (Th) cells by driving the cells into the Th1 direction. Abnormal Th1/Th2 balance may lead to complex disorders like asthma or autoimmune diseases. Recent studies have suggested that T-bet might be a candidate gene for asthma. This led us to screen 23 Finnish individuals for single-nucleotide polymorphisms (SNPs) in the T-bet locus and study the association between the SNPs and high serum IgE level and asthma.
We screened all six exons, adjacent intronic areas and 2 kb of the 5'-flanking region from 23 individuals utilizing WAVE trade mark technology. To explore whether T-bet is associated in serum IgE regulation or asthma we genotyped the SNPs in a Finnish asthmatic founder population. The association analyses were made using haplotype pattern mining.
Fifteen novel SNPs were found in the T-bet gene. Within the Finnish asthmatic founder population, there was no association between T-bet SNPs and high serum IgE level or asthma.
The genetic variability in the T-bet gene does not play a role in the pathogenesis of human asthma. Our results provide a novel panel of SNPs in T-bet and will help determine whether the SNPs have a functional role in other T cell-mediated diseases.
PubMed ID
15248849 View in PubMed
Less detail

Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population.

https://arctichealth.org/en/permalink/ahliterature207467
Source
Hum Mol Genet. 1997 Nov;6(12):2069-76
Publication Type
Article
Date
Nov-1997
Author
T. Laitinen
P. Kauppi
J. Ignatius
T. Ruotsalainen
M J Daly
H. Kääriäinen
L. Kruglyak
H. Laitinen
A. de la Chapelle
E S Lander
L A Laitinen
J. Kere
Author Affiliation
Department of Medical Genetics, Haartman Institute, Haartmaninkatu 3, 00014 University of Helsinki, Helsinki, Finland.
Source
Hum Mol Genet. 1997 Nov;6(12):2069-76
Date
Nov-1997
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Asthma - blood - genetics
Chromosome Mapping
Female
Finland
Genetic Linkage
Haplotypes
Humans
Immunoglobulin E - blood - genetics
Interleukin-9 - genetics
Linkage Disequilibrium
Male
Middle Aged
Pedigree
Selection Bias
Abstract
Immunoglobulin E (IgE) concentration in serum is elevated in atopic diseases such as asthma. A large genomic region on chromosome 5 has previously been implicated in the control of IgE levels and bronchial hyperreactivity and may, therefore, harbor genes predisposing to asthma. In an effort to confirm this linkage and to delimit the critical region, we took advantage of an isolated founder subpopulation in Finland to study genetic linkage and haplotype associations. Sixteen polymorphic markers, including the Interleukin-4 and -9 genes (IL4, IL9), were physically ordered and genotyped in 157 nuclear families. Genetic linkage studies involving sib- and cousin-pair analyses found no evidence of genetic linkage between markers in 5q and either serum IgE levels or asthma. Haplotype association studies were also performed. Although initial inspection suggested the possibility of linkage disequilibrium in the region of IL9, we developed a rigorous permutation test for assessing association and determined that the association was no greater than would be expected by chance. Sequence analysis of the IL9 gene in three patients sharing a possibly conserved haplotype revealed a T113M coding polymorphism, but this variant showed no association with either serum IgE levels or asthma. We conclude that allelic variation at chromosome 5q31 is not likely to contribute to inheritance of serum IgE levels or the development of asthma in this Finnish subpopulation.
PubMed ID
9328470 View in PubMed
Less detail

Introduction of complementary foods in infancy and atopic sensitization at the age of 5 years: timing and food diversity in a Finnish birth cohort.

https://arctichealth.org/en/permalink/ahliterature115410
Source
Allergy. 2013 Apr;68(4):507-16
Publication Type
Article
Date
Apr-2013
Author
B I Nwaru
H-M Takkinen
O. Niemelä
M. Kaila
M. Erkkola
S. Ahonen
H. Tuomi
A-M Haapala
M G Kenward
J. Pekkanen
R. Lahesmaa
J. Kere
O. Simell
R. Veijola
J. Ilonen
H. Hyöty
M. Knip
S M Virtanen
Author Affiliation
School of Health Sciences, University of Tampere, Tampere, Finland. bright.nwaru@uta.fi
Source
Allergy. 2013 Apr;68(4):507-16
Date
Apr-2013
Language
English
Publication Type
Article
Keywords
Age Factors
Allergens - immunology
Breast Feeding
Child, Preschool
Diet
Female
Finland
Food Hypersensitivity - immunology
Humans
Hypersensitivity, Immediate - immunology
Immunoglobulin E - blood - immunology
Infant
Infant Food
Infant, Newborn
Male
Odds Ratio
Prospective Studies
Time Factors
Abstract
To study the associations between timing and diversity of introduction of complementary foods during infancy and atopic sensitization in 5-year-old children.
In the Finnish DIPP (type 1 diabetes prediction and prevention) birth cohort (n = 3781), data on the timing of infant feeding were collected up to the age of 2 years and serum IgE antibodies toward four food and four inhalant allergens measured at the age of 5 years. Logistic regression was used for the analyses.
Median duration of exclusive and total breastfeeding was 1.4 (interquartile range: 0.2-3.5) and 7.0 (4.0-11.0) months, respectively. When all the foods were studied together and adjusted for confounders, short duration of breastfeeding decreased the risk of sensitization to birch allergen; introduction of oats
PubMed ID
23510377 View in PubMed
Less detail