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Childhood-to-adolescence evolution of IgE antibodies to pollens and plant foods in the BAMSE cohort.

https://arctichealth.org/en/permalink/ahliterature106480
Source
J Allergy Clin Immunol. 2014 Feb;133(2):580-2
Publication Type
Article
Date
Feb-2014

Impact of IgE sensitization and rhinitis on inflammatory biomarkers and lung function in adolescents with and without asthma.

https://arctichealth.org/en/permalink/ahliterature298925
Source
Pediatr Allergy Immunol. 2019 02; 30(1):74-80
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
02-2019
Author
Jenny Hallberg
Natalia Ballardini
Catarina Almqvist
Marit Westman
Marianne van Hage
Gunnar Lilja
Anna Bergström
Inger Kull
Erik Melén
Author Affiliation
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Source
Pediatr Allergy Immunol. 2019 02; 30(1):74-80
Date
02-2019
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adolescent
Asthma - physiopathology
Biomarkers - blood
Cohort Studies
Eosinophils - immunology
Female
Humans
Immunization
Immunoglobulin E - blood - immunology
Longitudinal Studies
Lung - physiopathology
Male
Oscillometry - methods
Rhinitis - physiopathology
Spirometry - methods
Sweden
Abstract
Both allergic and non-allergic rhinitis are associated with worse asthma control. However, it is unclear how IgE sensitization and/or rhinitis are associated with lung function. We therefore evaluated the effect of rhinitis and sensitization on lung function, including the periphery of the airway system, and inflammatory biomarkers in individuals with and without asthma.
Participants in the BAMSE longitudinal birth cohort study underwent measures of spirometry, impulse oscillometry, and FeNO at age 16 years. Questionnaires were used to obtain data on asthma and rhinitis. Blood samples were analyzed for eosinophils and allergen-specific IgE.
Groups based on the combination of asthma, rhinitis, and sensitization were compared to a healthy reference group. Lower FEV1 /FVC levels were seen for groups with asthma only (adjusted mean difference -2.8% units (95% CI -4.7; -1.0), P 
PubMed ID
30341960 View in PubMed
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Natural course and comorbidities of allergic and nonallergic rhinitis in children.

https://arctichealth.org/en/permalink/ahliterature129870
Source
J Allergy Clin Immunol. 2012 Feb;129(2):403-8
Publication Type
Article
Date
Feb-2012
Author
Marit Westman
Pär Stjärne
Anna Asarnoj
Inger Kull
Marianne van Hage
Magnus Wickman
Elina Toskala
Author Affiliation
CLINTEC, Karolinska Institutet, Stockholm, Sweden. marit.westman@ki.se
Source
J Allergy Clin Immunol. 2012 Feb;129(2):403-8
Date
Feb-2012
Language
English
Publication Type
Article
Keywords
Allergens - immunology
Child
Child, Preschool
Cohort Studies
Comorbidity
Female
Humans
Immunoglobulin E - blood
Male
Rhinitis - blood - epidemiology - immunology
Rhinitis, Allergic, Perennial - blood - epidemiology - immunology
Sweden - epidemiology
Abstract
Not much data are available from large, unselected, birth cohort studies on the natural course and comorbidities of rhinitis in children.
To study phenotypes of rhinitis in relation to the natural course and comorbidities of allergic diseases in preschool-age and early school-age children.
We analyzed data from a birth cohort of 2024 children, for whom information on IgEs against 8 common inhaled allergens was available, collected at age 4 and 8 years. The children were assigned to groups of allergic rhinitis (rhinitis with sensitization to allergens), nonallergic rhinitis (rhinitis without sensitization), allergic sensitization but no rhinitis, or neither rhinitis nor sensitization.
The proportion of children with allergic rhinitis increased from 5% to 14% from age 4 to 8 years, whereas the proportion of children with nonallergic rhinitis decreased slightly over the same period of development, from 8% to 6%. Of the children with allergic rhinitis when they were 4 years old, 12% underwent remission by the time they were 8 years old; of the children with nonallergic rhinitis, 73% underwent remission during this period of development. Among 4-year-olds without rhinitis who were sensitized to allergen, 56% had allergic rhinitis when they were 8 years old. Among 4- and 8-year-olds, allergic rhinitis and nonallergic rhinitis were associated with asthma, eczema, and food hypersensitivity. Twenty-five percent of 8-year-olds with allergic rhinitis also had oral allergy syndrome.
Fewer preschool-age children with allergic rhinitis undergo remission than do those with nonallergic rhinitis. Sensitization to inhaled allergens at an early age (4 years) precedes the development of allergic rhinitis, whereas symptoms of rhinitis do not. Oral allergy syndrome is common among 8-year-olds with allergic rhinitis.
PubMed ID
22056609 View in PubMed
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Risk factors and markers of asthma control differ between asthma subtypes in children.

https://arctichealth.org/en/permalink/ahliterature265217
Source
Pediatr Allergy Immunol. 2014 Oct;25(6):558-64
Publication Type
Article
Date
Oct-2014
Author
Björn Nordlund
Erik Melén
Erica S Schultz
Hans Grönlund
Gunilla Hedlin
Inger Kull
Source
Pediatr Allergy Immunol. 2014 Oct;25(6):558-64
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Asthma - classification - diagnosis - epidemiology
Biological Markers - metabolism
Child
Cohort Studies
Disease Progression
Female
Follow-Up Studies
Humans
Immunoglobulin E - blood
Male
Population
Respiratory Function Tests
Risk factors
Sex Factors
Sweden
Abstract
There is limited understanding about risk factors for asthma, and few studies have presented an overall picture of factors associated with asthma subtypes in schoolchildren. The aim of this study was to evaluate risk factors and markers of asthma control associated with asthma subtypes up to preadolescence.
A Swedish birth cohort of 3015 children was followed for 12 yr using repeated parental questionnaires. At 8 yr, clinical investigation was performed, specifically evaluating lung function, allergic sensitization (IgE > 0.35 kUA /l), and body mass index (BMI). Children were categorized into three subtypes: transient asthma - asthma at 4 and 8, but not at 12 yr (n = 71), late-onset asthma - asthma at 12 yr, but not earlier (n = 103), and persistent asthma - asthma at 4, 8 and 12 yr (n = 125).
At 8 yr of age, high BMI (>85th percentile), sensitization, and rhinitis were significantly associated with late-onset asthma (p
PubMed ID
25201243 View in PubMed
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Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life.

https://arctichealth.org/en/permalink/ahliterature129476
Source
J Allergy Clin Immunol. 2012 Jan;129(1):240-6
Publication Type
Article
Date
Jan-2012
Author
Olena Gruzieva
Tom Bellander
Kristina Eneroth
Inger Kull
Erik Melén
Emma Nordling
Marianne van Hage
Magnus Wickman
Vitaliy Moskalenko
Olesya Hulchiy
Göran Pershagen
Author Affiliation
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. olena.gruzieva@ki.se
Source
J Allergy Clin Immunol. 2012 Jan;129(1):240-6
Date
Jan-2012
Language
English
Publication Type
Article
Keywords
Air Pollutants - analysis - toxicity
Air Pollution - adverse effects
Allergens - immunology
Child
Child, Preschool
Cohort Studies
Environmental Exposure
Female
Food Hypersensitivity - epidemiology - immunology
Humans
Hypersensitivity - epidemiology - etiology - immunology
Immunoglobulin E - blood - immunology
Infant
Male
Particulate Matter - analysis - toxicity
Prevalence
Risk factors
Sweden - epidemiology
Vehicle Emissions
Abstract
The role of exposure to air pollution in the development of allergic sensitization remains unclear.
We sought to assess the development of sensitization until school age related to longitudinal exposure to air pollution from road traffic.
More than 2500 children in the birth cohort BAMSE (Children, Allergy, Milieu, Stockholm, Epidemiological Survey) from Stockholm, Sweden, were followed with repeated questionnaires and blood sampling until 8 years of age. Outdoor concentrations of nitrogen oxides, as a marker of exhaust particles, and particles with an aerodynamic diameter of less than 10 µm (PM(10)), mainly representing road dust, were assigned to residential, day care, and school addresses by using dispersion models. Time-weighted average exposures were linked to levels of IgE against common inhalant and food allergens at 4 and 8 years of age.
Air pollution exposure during the first year of life was associated with an increased risk of pollen sensitization at 4 years of age (odds ratio, 1.83; 95% confidence interval, 1.02-3.28) for a 5th to 95th difference in exposure to nitrogen oxides. At 8 years, there was no general increase in the risk of sensitization; however, the risk of food sensitization was increased, particularly among children free of sensitization at 4 years of age (odds ratio, 2.30; 95% confidence interval, 1.10-4.82). Results were similar by using PM(10). No associations between air pollution exposure after the first year of life and sensitization were seen.
Traffic-related air pollution exposure does not seem to increase the overall risk of sensitization to common inhalant and food allergens up to school age, but sensitization to certain allergens might be related to exposure during infancy.
PubMed ID
22104609 View in PubMed
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