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Correlates of mucosal immunity and upper respiratory tract infections in girls.

https://arctichealth.org/en/permalink/ahliterature141902
Source
J Pediatr Endocrinol Metab. 2010 Jun;23(6):579-87
Publication Type
Article
Date
Jun-2010
Author
Lauren Corbett
Cameron Muir
Izabella A Ludwa
Matthew Yao
Brian W Timmons
Bareket Falk
Panagiota Klentrou
Author Affiliation
Faculty of Applied Health Sciences, Department of Psychology, Brock University, Ontario, Canada.
Source
J Pediatr Endocrinol Metab. 2010 Jun;23(6):579-87
Date
Jun-2010
Language
English
Publication Type
Article
Keywords
Adiposity - immunology
Adolescent
Canada - epidemiology
Child
Female
Humans
Hydrocortisone - metabolism
Immunity, Mucosal - physiology
Immunoglobulin A, Secretory - analysis
Motor Activity - immunology
Puberty, Precocious - immunology
Respiratory Tract Infections - epidemiology - immunology
Risk factors
Saliva - immunology
Testosterone - metabolism
Abstract
In this study we examined whether salivary hormones, physical activity and adiposity were correlated with secretory immunoglobulin A (sIgA) and frequency of upper respiratory tract infections (URTI) in 43 early-pubertal and 59 late-pubertal girls. Physical activity was measured using accelerometers and relative body fat was assessed using bioelectrical impendence. Resting saliva samples were obtained between 1500 and 1800 hr and assayed for sIgA, cortisol and testosterone. Participants completed a one-month health log to record URTI frequency. Early-pubertal girls were more physically active, had less adiposity, but lower concentrations of sIgA than late-pubertal adolescents (122.7 +/- 91.6 vs 201.9 +/- 102.9 pg/ml, respectively). The frequency of URTI was similar in the two groups. Neither sIgA nor URTI were correlated with salivary hormones, physical activity or adiposity within the early-pubertal girls. In the late-pubertal group, sIgA was negatively associated (r = -0.44; p
PubMed ID
20662331 View in PubMed
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Development of immunoglobulin A in infancy and childhood.

https://arctichealth.org/en/permalink/ahliterature30632
Source
Scand J Immunol. 2003 Dec;58(6):642-8
Publication Type
Article
Date
Dec-2003
Author
C. Weemaes
I. Klasen
J. Göertz
M. Beldhuis-Valkis
O. Olafsson
A. Haraldsson
Author Affiliation
Department of Pediatrics, University Hospital Nijmegen, Nijmegen, The Netherlands. c.weemaes@cukz.umcn.nl
Source
Scand J Immunol. 2003 Dec;58(6):642-8
Date
Dec-2003
Language
English
Publication Type
Article
Keywords
Age Factors
Child
Child, Preschool
Humans
Immunoglobulin A - analysis - blood
Immunoglobulin A, Secretory - analysis
Infant
Infant, Newborn
Saliva - immunology
Abstract
Serum and salivary concentrations of immunoglobulin A1 (IgA1) and IgA2 were studied in 105 Icelandic children aged 0-12 years. Serum concentrations of both IgA1 and IgA2 increased slightly (P
PubMed ID
14636420 View in PubMed
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Differences in level and avidity of secretory IgA antibodies in breast milk of Swedish, Indian and Japanese mothers to soybean protein.

https://arctichealth.org/en/permalink/ahliterature59779
Source
Int Arch Allergy Appl Immunol. 1991;95(1):13-6
Publication Type
Article
Date
1991
Author
A. Morikawa
U. Dahlgren
B. Carlsson
I. Narayanan
M. Hahn-Zoric
L A Hanson
S. Maeda
S. Tomizawa
T. Kuroume
Author Affiliation
Department of Clinical Immunology, University of Göteborg, Sweden.
Source
Int Arch Allergy Appl Immunol. 1991;95(1):13-6
Date
1991
Language
English
Publication Type
Article
Keywords
Antibody Affinity - immunology
Colostrum - chemistry
Comparative Study
Enzyme-Linked Immunosorbent Assay
Female
Globulins - immunology
Humans
Immunoglobulin A, Secretory - analysis
India
Japan
Milk, human - chemistry
Pregnancy
Research Support, Non-U.S. Gov't
Soybean Proteins
Sweden
Vegetable Proteins - immunology
Abstract
Colostrum was collected from Swedish, Indian and Japanese mothers. The samples were as a mean, collected 4.00-4.25 days after delivery of term infants. The level of specific IgA antibody to 2S, 7S and crude soybean antigen were measured by the enzyme-linked immunosorbent assay (ELISA). The avidity of the IgA antibodies to 7S soybean antigen was also measured with an ELISA system using different molarities of potassium thiocyanate for elution of the specific IgA antibody from solid phase-bound antigen. The level of specific IgA antibody to 7S and crude soybean antigen in the milk of the Indian mothers was significantly higher than in the milk of the Japanese mothers (p less than or equal to 0.01). In contrast, the avidity expressed as the molarity of KSCN for 50% elution of IgA antibody to 7S soybean antigen in the milk of the Japanese mothers was significantly higher than in the milk of the Indian mothers (p less than 0.01).
PubMed ID
1917106 View in PubMed
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[Disturbance of immune characteristics of the mucous membranes of the respiratory tract in bronchopulmonary diseases in children]

https://arctichealth.org/en/permalink/ahliterature15278
Source
Zh Mikrobiol Epidemiol Immunobiol. 2003 Jan-Feb;(1):72-4
Publication Type
Article
Author
I P Pan
L A Matveeva
T S Fedorova
Author Affiliation
Siberian State Medical University, Tomsk, Russia.
Source
Zh Mikrobiol Epidemiol Immunobiol. 2003 Jan-Feb;(1):72-4
Language
Russian
Publication Type
Article
Keywords
Acute Disease
Adolescent
Asthma - blood - immunology
Cell Count
Child
Comparative Study
English Abstract
Eosinophils - cytology
Epithelial Cells - pathology
Female
Humans
Immunoglobulin A - blood
Immunoglobulin A, Secretory - analysis
Immunoglobulin G - blood
Male
Neutrophils - cytology
Pneumonia - blood - immunology
Respiratory Mucosa - immunology - pathology - secretion
Saliva - immunology
Abstract
A total of 100 children with bronchopulmonary diseases were examined. Of these, in 80 bronchial asthma and in 20 children acute pneumonia were diagnosed. The deficiency of local cell mediated and humoral factors on the mucous membranes of the upper respiratory tracts was established. In the squamous and columnar epithelium cells an increased destruction and cytolysis was noted leading to disturbances in the integrity of the protective barrier of the epithelial cover. In addition, this study revealed the deficiency of neutrophilic leukocytes, pronounced local eosinophilia and the low level of humoral protective factors. In acute pneumonia an increase in the amount of neutrophilic leukocytes in the secretion of the nasal cavity together with the appearance of destructive processes in epithelial cells took place. Pronounced deficiency in serum IgA and IgG was accompanied by compensatory increase in secretory IgA.
PubMed ID
12630360 View in PubMed
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[Effect of climate exposure on immunologic indices during the treatment of gingivitis in children].

https://arctichealth.org/en/permalink/ahliterature231886
Source
Stomatologiia (Mosk). 1989 Jan-Feb;68(1):73-4
Publication Type
Article
Author
L I Urbanovich
A P Chubar'
I P Zarechnaia
Source
Stomatologiia (Mosk). 1989 Jan-Feb;68(1):73-4
Language
Russian
Publication Type
Article
Keywords
Adolescent
Camping
Child
Climate
Female
Gingivitis - immunology - therapy
Health Resorts
Humans
Immunoglobulin A, Secretory - analysis
Male
Russia
Saliva - immunology
Abstract
Physical and environmental impacts promoted a substantial improvement in the gingival conditions in children with catarrhal gingivitis. The content of SIgA increased in mixed unstimulated saliva, along with other positive laboratory and functional signs. The data suggest that aero-, helio and thalassotherapy are not only the factors of treatment, but also the natural unspecific stimulators important for the increase of an organism's tissues resistance.
PubMed ID
2526395 View in PubMed
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Effect of peroral immunization of humans with Streptococcus mutans on induction of salivary and serum antibodies and inhibition of experimental infection.

https://arctichealth.org/en/permalink/ahliterature239830
Source
Infect Immun. 1984 Dec;46(3):703-9
Publication Type
Article
Date
Dec-1984
Author
M F Cole
C G Emilson
S D Hsu
S H Li
W H Bowen
Source
Infect Immun. 1984 Dec;46(3):703-9
Date
Dec-1984
Language
English
Publication Type
Article
Keywords
Adult
Antibodies, Bacterial - biosynthesis
Cross Reactions
Dental Caries - microbiology - prevention & control
Escherichia coli - immunology
Humans
Immunization
Immunoglobulin A, Secretory - analysis
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Male
Middle Aged
Saliva - immunology
Streptococcus mutans - immunology
Abstract
Naturally occurring antibodies reactive with Streptococcus mutans whole cells were assayed in whole saliva, parotid saliva, and blood samples collected from eight human volunteers. The levels and serotypes of indigenous S. mutans in plaque and whole saliva samples were also determined. After baseline sampling the teeth were cleaned and the subjects were inoculated with streptomycin-resistant S. mutans strains Ingbritt (serotype c) and OMZ65 (serotype g). The level of implantation and duration of colonization were determined in plaque and saliva, and antibodies reactive with these strains were monitored in saliva and serum. After the implanted bacteria were shed, the subjects wee immunized by the daily ingestion of an enteric-coated capsule containing 25 mg of Formalin-killed, freeze-dried OMZ65 cells for 3 days and inoculation was repeated. The levels of antibodies and of implantation and the duration of colonization were monitored as before. One month after the bacteria could no longer be detected, the immunization and inoculation cycle was repeated except that the subjects were immunized for 7 days. Five of the eight subjects were successfully colonized by strains Ingbritt and OMZ65. The remaining three did not become colonized with either strain. Strain OMZ65 implanted at a higher level than did strain Ingbritt. Oral immunization did not result in a detectable antibody response in saliva or serum to whole bacterial cells. However, after both the first and second immunizations there were marked reductions in the peak levels of infection and the duration of colonization of both OMZ65 and Ingbritt.
Notes
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PubMed ID
6389359 View in PubMed
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Effect of saliva composition on growth of Candida albicans and Torulopsis glabrata.

https://arctichealth.org/en/permalink/ahliterature214586
Source
Oral Microbiol Immunol. 1995 Aug;10(4):233-40
Publication Type
Article
Date
Aug-1995
Author
M. Lenander-Lumikari
I. Johansson
Author Affiliation
Department of Cariology, Institute of Dentistry, University of Turku, Finland.
Source
Oral Microbiol Immunol. 1995 Aug;10(4):233-40
Date
Aug-1995
Language
English
Publication Type
Article
Keywords
Candida - growth & development
Candida albicans - growth & development
Colony Count, Microbial
Female
Glycoproteins - analysis
Humans
Hydrogen-Ion Concentration
Immunoglobulin A, Secretory - analysis
Lactoferrin - analysis
Male
Phosphates - analysis
Regression Analysis
Saliva - chemistry - physiology - secretion
Salivary Proteins and Peptides - analysis - physiology
Sialic Acids - analysis
Time Factors
Water-Electrolyte Balance
Abstract
Candida albicans and Torulopsis glabrata are the most prevalent yeasts in humans. The majority harbor C. albicans in the oral cavity, but only a few develop oral candidiasis. We have sought a possible relationship between indigenous salivary constituents, including antimicrobial and nutritive factors, and the growth rate and/or viability of inoculated fungi in glucose-supplemented sterilized saliva. Stimulated whole saliva was collected from 30 healthy donors. Saliva samples were sterilized, supplemented with glucose and inoculated with C. albicans or T glabrata. After incubation of the inoculates for 20 h, the number of viable cells were counted. All saliva samples were analyzed for different indigenous salivary components and Candida before as well as after sterilization. Besides a 4% reduction in calcium (Ca2+) and thiocyanate (SCN-) concentrations, sterilization did not affect the concentrations of saliva electrolytes, but the proteins were significantly reduced (19-85%). Indigenous candidal carriage (n=19) correlated with neither the growth of inoculated fungi nor any of the analyzed components in saliva. The growth of C. albicans and T. glabrata was similar at pH 5 but, at pH 6, C. albicans had a remarkably slower growth rate than T. glabrata. Statistical analysis showed that the 5-h growth of C. albicans at pH 5 was associated with water and electrolyte secretion, whereas the growth after 20 h was associated with variations in protein-glycoprotein content. The growth of T. glabrata was not related to variations in the salivary variables analyzed.
PubMed ID
8602336 View in PubMed
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[Eosinophilic reactions in bronchial asthma patients and the possibilities to neutralize them under sanatorium treatment]

https://arctichealth.org/en/permalink/ahliterature15874
Source
Lik Sprava. 1996 Jan-Feb;(1-2):132-5
Publication Type
Article
Author
V N Zorin
Iu F Babin
S V Trishina
S V Trishin
V V Kirzhoi
V S Skorobatskii
Source
Lik Sprava. 1996 Jan-Feb;(1-2):132-5
Language
Russian
Publication Type
Article
Keywords
Asthma - blood - immunology - rehabilitation
Combined Modality Therapy
Comparative Study
English Abstract
Eosinophilia - blood - immunology - rehabilitation
Eosinophils - cytology
Health Resorts
Humans
Immunoglobulin A, Secretory - analysis
Leukocyte Count
Saliva - cytology - immunology
Ukraine
Abstract
Patients with eosinophilic variant of bronchial asthma demonstrate high levels of fibrinolytic activity in their bronchial secretion along with low content in same of Ig A, as evidenced by findings obtained in the course of sanatorium treatment. There is usually no correlation between the above changes and routine methods of health resort treatment. The judicious employment in a complex of therapeutic measures of aerosols of hydrocarbonate of sodium and heparin promotes neutralization of cationic proteins and large major protein of eosinophiles in the bronchial lumen whereby there occurs normalization of Ig A levels in the sputum along with lowering of its fibrinolytic activity.
PubMed ID
9005073 View in PubMed
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Immune parameters in athletes before and after strenuous exercise.

https://arctichealth.org/en/permalink/ahliterature50416
Source
J Clin Immunol. 1982 Jul;2(3):173-8
Publication Type
Article
Date
Jul-1982
Author
T B Tomasi
F B Trudeau
D. Czerwinski
S. Erredge
Source
J Clin Immunol. 1982 Jul;2(3):173-8
Date
Jul-1982
Language
English
Publication Type
Article
Keywords
Adult
Antibody formation
B-Lymphocytes
Competitive Behavior - physiology
Exertion
Female
Humans
Immunity, Cellular
Immunoglobulin A - analysis
Immunoglobulin A, Secretory - analysis
Leukocyte Count
Lymphocytes, Null
Male
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Respiratory Tract Infections - immunology
Saliva - analysis
Skiing
T-Lymphocytes
Time Factors
Abstract
Secretory IgA levels were studied in nationally ranked Nordic skiers before and after the national cross-country races held in February 1981. Comparing the skiers with age-matched controls, there was significantly lower level of salivary IgA before the race. Concentrations of IgA decreased further following the competition (50 kn for males; 20 km for females) to very low levels. There also were a significant increase in the percentage of B lymphocytes and a decrease in the null population (non-T, non-B) in the athletes after the race compared with the controls. The mechanism responsible for these changes is unknown, but the low salivary IgA levels may result from depletion of nasal fluid and/or malfunction of the mucosal plasma cells due to a decrease temperature in the mucous membranes. We speculated that a temporary antibody deficiency on the mucosal surface might lead to a susceptibility to acquiring viral and bacterial infections, especially during the interval immediately following strenuous exercise.
PubMed ID
6981653 View in PubMed
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Immune responses of infants vaccinated with serotype 6B pneumococcal polysaccharide conjugated with tetanus toxoid.

https://arctichealth.org/en/permalink/ahliterature57599
Source
Pediatr Infect Dis J. 1997 Jul;16(7):667-74
Publication Type
Article
Date
Jul-1997
Author
S T Sigurdardottir
G. Vidarsson
T. Gudnason
S. Kjartansson
K G Kristinsson
S. Jonsson
H. Valdimarsson
G. Schiffman
R. Schneerson
I. Jonsdottir
Author Affiliation
Department of Immunology, National University Hospital, Reykjavik, Iceland.
Source
Pediatr Infect Dis J. 1997 Jul;16(7):667-74
Date
Jul-1997
Language
English
Publication Type
Article
Keywords
Antibodies, Bacterial - blood - immunology
Female
Humans
Immunoglobulin A, Secretory - analysis
Infant
Male
Nasopharynx - microbiology
Phagocytosis
Polysaccharides, Bacterial - adverse effects - immunology
Research Support, Non-U.S. Gov't
Saliva - immunology
Streptococcus pneumoniae - isolation & purification
Tetanus Toxoid - adverse effects - immunology
Vaccination
Vaccines, Conjugate - immunology
Abstract
BACKGROUND: Streptococcus pneumoniae is a major cause of meningitis, bacteremia, pneumonia and otitis media. Pneumococcal polysaccharides are not immunogenic in infants, but improved immunogenicity of polysaccharide-protein conjugates has been demonstrated. Antibiotic-resistant pneumococci have increased the need for an effective vaccine. OBJECTIVE: To study the safety and immunogenicity of a pneumococcal type 6B polysaccharidetetanus toxoid conjugate (Pn6B-TT) in infants and to assess the function of antibodies. METHODS: Healthy infants were injected, Group A at 3, 4 and 6 months (n = 21) and Group B at 7 and 9 months (n = 19). Booster injection was given at 18 months. Antibodies were measured by enzyme-linked immunosorbent assay and radioimmunoassay, and functional activity was measured by opsonization of radiolabeled pneumococci. Nasopharyngeal cultures were obtained. RESULTS: No significant adverse reactions were observed. Pn6B-IgG (enzyme-linked immunosorbent assay) increased to a geometric mean of 0.62 microgram/ml (P = 0.367, compared with prevaccination titers) in Group A at 7 months and 1.22 micrograms/ml (P 300 ng of antibody N/ml. Opsonic activity, after initial and booster vaccinations, correlated with Pn6B-antibody titers. Three infants with nasopharyngeal cultures repeatedly positive for serogroup 6 had poor serum IgG responses. CONCLUSION: Our results demonstrate that Pn6B-TT is safe, elicits functional antibodies and memory responses in infants.
PubMed ID
9239771 View in PubMed
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33 records – page 1 of 4.